UniProtKB - P21675 (TAF1_HUMAN)
Transcription initiation factor TFIID subunit 1
TAF1
Functioni
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).
TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473).
TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473).
Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415).
Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659).
Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659).
Possesses DNA-binding activity (PubMed:25412659).
Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607).
Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
11 PublicationsMiscellaneous
Catalytic activityi
Cofactori
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1195 – 1273 | HMG box; involved in promoter bindingCombined sourcesAdd BLAST | 79 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- histone acetyltransferase activity Source: UniProtKB
- kinase activity Source: ParkinsonsUK-UCL
- lysine-acetylated histone binding Source: BHF-UCL
- nuclear receptor binding Source: ParkinsonsUK-UCL
- p53 binding Source: BHF-UCL
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- protein kinase activity Source: ParkinsonsUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- RNA polymerase I general transcription initiation factor activity Source: ARUK-UCL
- RNA polymerase II core promoter sequence-specific DNA binding Source: ParkinsonsUK-UCL
- RNA polymerase II general transcription initiation factor activity Source: BHF-UCL
- RNA polymerase II general transcription initiation factor binding Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
- sequence-specific DNA binding Source: BHF-UCL
- TBP-class protein binding Source: BHF-UCL
- transcription regulator inhibitor activity Source: ParkinsonsUK-UCL
- ubiquitin conjugating enzyme activity Source: ParkinsonsUK-UCL
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cellular response to ATP Source: ParkinsonsUK-UCL
- cellular response to DNA damage stimulus Source: ParkinsonsUK-UCL
- cellular response to UV Source: ParkinsonsUK-UCL
- midbrain development Source: ParkinsonsUK-UCL
- mRNA transcription by RNA polymerase II Source: ComplexPortal
- negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
- negative regulation of gene expression Source: ParkinsonsUK-UCL
- negative regulation of protein autoubiquitination Source: ParkinsonsUK-UCL
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
- negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
- negative regulation of ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
- peptidyl-serine phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: BHF-UCL
- positive regulation of androgen receptor activity Source: ParkinsonsUK-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
- positive regulation of protein binding Source: ParkinsonsUK-UCL
- positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
- protein autophosphorylation Source: ParkinsonsUK-UCL
- protein phosphorylation Source: ParkinsonsUK-UCL
- protein polyubiquitination Source: ParkinsonsUK-UCL
- protein stabilization Source: ParkinsonsUK-UCL
- regulation of cell cycle G1/S phase transition Source: ParkinsonsUK-UCL
- regulation of signal transduction by p53 class mediator Source: Reactome
- RNA polymerase II preinitiation complex assembly Source: ComplexPortal
- transcription by RNA polymerase II Source: BHF-UCL
- transcription factor catabolic process Source: ParkinsonsUK-UCL
- transcription initiation from RNA polymerase II promoter Source: BHF-UCL
- transcription initiation from RNA polymerase I promoter Source: ParkinsonsUK-UCL
- ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Acyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Host-virus interaction, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.3.1.48, 2681 |
PathwayCommonsi | P21675 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | P21675 |
SIGNORi | P21675 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 1 (EC:2.3.1.481 Publication, EC:2.7.11.1)Alternative name(s): Cell cycle gene 1 protein TBP-associated factor 250 kDa Short name: p250 Transcription initiation factor TFIID 250 kDa subunit Short name: TAF(II)250 Short name: TAFII-250 Short name: TAFII250 |
Gene namesi | Name:TAF1 Synonyms:BA2R, CCG1, CCGS, TAF2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11535, TAF1 |
MIMi | 313650, gene |
neXtProti | NX_P21675 |
VEuPathDBi | HostDB:ENSG00000147133 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- MLL1 complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: ParkinsonsUK-UCL
- transcription factor TFIID complex Source: UniProtKB
Other locations
- chromatin Source: ParkinsonsUK-UCL
- transcription regulator complex Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Dystonia 3, torsion, X-linked (DYT3)2 Publications
Intellectual developmental disorder, X-linked, syndromic 33 (MRXS33)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076394 | 575 | P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl. | 1 | |
Natural variantiVAR_076395 | 786 | C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl. | 1 | |
Natural variantiVAR_076396 | 955 | D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl. | 1 | |
Natural variantiVAR_076397 | 1225 | R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl. | 1 | |
Natural variantiVAR_076398 | 1316 | I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl. | 1 | |
Natural variantiVAR_076399 | 1431 | R → H in MRXS33; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_076400 | 1496 | N → H in MRXS33; unknown pathological significance. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 137 | S → A: No decrease in kinase activity. 1 Publication | 1 | |
Mutagenesisi | 145 | D → A: Reduces kinase activity; when associated with A-147; A-149; A-150; A-152 and A-154. 1 Publication | 1 | |
Mutagenesisi | 147 | D → A: Reduces kinase activity; when associated with A-145; A-149; A-150; A-152 and A-154. 1 Publication | 1 | |
Mutagenesisi | 149 | E → A: Reduces kinase activity; when associated with A-145; A-147; A-150; A-152 and A-154. 1 Publication | 1 | |
Mutagenesisi | 150 | D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-152 and A-154. 1 Publication | 1 | |
Mutagenesisi | 152 | D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-154. 1 Publication | 1 | |
Mutagenesisi | 154 | K → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-152. 1 Publication | 1 | |
Mutagenesisi | 305 | C → A: Reduces kinase activity; when associated with A-307; A-308; A-309 and A-310. 1 Publication | 1 | |
Mutagenesisi | 307 | S → A: Reduces kinase activity; when associated with A-305; A-308; A-309 and A-310. 1 Publication | 1 | |
Mutagenesisi | 308 | D → A: Reduces kinase activity; when associated with A-305; A-307; A-309 and A-310. 1 Publication | 1 | |
Mutagenesisi | 309 | D → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-310. 1 Publication | 1 | |
Mutagenesisi | 310 | E → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-309. 1 Publication | 1 | |
Mutagenesisi | 721 | E → Q: 25% decrease in histone acetylation. 1 Publication | 1 | |
Mutagenesisi | 827 – 829 | Missing : Dramatic decrease in histone acetylation. 1 Publication | 3 |
Keywords - Diseasei
Disease variant, Dystonia, Mental retardation, ParkinsonismOrganism-specific databases
DisGeNETi | 6872 |
GeneReviewsi | TAF1 |
MalaCardsi | TAF1 |
MIMi | 300966, phenotype 314250, phenotype |
Orphaneti | 53351, X-linked dystonia-parkinsonism 480907, X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome |
PharmGKBi | PA36310 |
Miscellaneous databases
Pharosi | P21675, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3217390 |
GuidetoPHARMACOLOGYi | 2231 |
Genetic variation databases
BioMutai | TAF1 |
DMDMi | 115942 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211215 | 1 – 1872 | Transcription initiation factor TFIID subunit 1Add BLAST | 1872 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 137 | Phosphoserine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 307 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | ||
Modified residuei | 544 | N6-acetyllysineBy similarity | 1 | ||
Cross-linki | 549 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 562 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 1669 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1672 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1778 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1781 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1799 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1826 | PhosphoserineCombined sources | 1 | ||
Isoform 3 (identifier: P21675-3) | |||||
Modified residuei | 1697 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: P21675-4) | |||||
Modified residuei | 1700 | PhosphoserineCombined sources | 1 | ||
Isoform 2a (identifier: P21675-5) | |||||
Modified residuei | 1700 | PhosphoserineCombined sources | 1 | ||
Isoform 2g (identifier: P21675-9) | |||||
Modified residuei | 1702 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P21675 |
jPOSTi | P21675 |
MassIVEi | P21675 |
MaxQBi | P21675 |
PaxDbi | P21675 |
PeptideAtlasi | P21675 |
PRIDEi | P21675 |
ProteomicsDBi | 3401 53886 [P21675-1] 53887 [P21675-2] 53888 [P21675-3] 53889 [P21675-4] |
PTM databases
GlyGeni | P21675, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P21675 |
PhosphoSitePlusi | P21675 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147133, Expressed in sural nerve and 226 other tissues |
ExpressionAtlasi | P21675, baseline and differential |
Genevisiblei | P21675, HS |
Organism-specific databases
HPAi | ENSG00000147133, Low tissue specificity |
Interactioni
Subunit structurei
Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:7680771, PubMed:33795473).
Interacts with TAF7; the interaction is direct (PubMed:25412659, PubMed:11592977). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53 (PubMed:15053879).
Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). RB1 interacts with the N-terminal domain of TAF1 (PubMed:9858607).
Interacts with ASF1A and ASF1B (PubMed:10759893, PubMed:12093919, PubMed:12842904).
Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (PubMed:22464331).
12 Publications(Microbial infection) Interacts with SV40 Large T antigen.
1 Publication(Microbial infection) Interacts with herpes simplex virus 1 ICP4.
1 PublicationBinary interactionsi
P21675
With | #Exp. | IntAct |
---|---|---|
GTF2F1 [P35269] | 3 | EBI-491289,EBI-457886 |
TBP [P20226] | 10 | EBI-491289,EBI-355371 |
P03255 from Human adenovirus C serotype 5. | 3 | EBI-491289,EBI-2603114 |
GO - Molecular functioni
- lysine-acetylated histone binding Source: BHF-UCL
- nuclear receptor binding Source: ParkinsonsUK-UCL
- p53 binding Source: BHF-UCL
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- RNA polymerase II general transcription initiation factor binding Source: BHF-UCL
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
- TBP-class protein binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112735, 220 interactors |
ComplexPortali | CPX-915, General transcription factor complex TFIID CPX-930, General transcription factor complex TFIID, TAF4B variant |
CORUMi | P21675 |
DIPi | DIP-147N |
IntActi | P21675, 55 interactors |
MINTi | P21675 |
STRINGi | 9606.ENSP00000406549 |
Chemistry databases
BindingDBi | P21675 |
Miscellaneous databases
RNActi | P21675, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P21675 |
SASBDBi | P21675 |
SMRi | P21675 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21675 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 414 | Protein kinase 1Add BLAST | 414 | |
Domaini | 1397 – 1467 | Bromo 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 1425 – 1872 | Protein kinase 2Add BLAST | 448 | |
Domaini | 1520 – 1590 | Bromo 2PROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 149 – 204 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 513 – 536 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 517 – 976 | Histone acetyltransferase (HAT)Add BLAST | 460 | |
Regioni | 969 – 988 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1107 – 1127 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1137 – 1156 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1233 – 1257 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1342 – 1629 | Interaction with ASF1A and ASF1B1 PublicationAdd BLAST | 288 | |
Regioni | 1630 – 1655 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1675 – 1872 | DisorderedSequence analysisAdd BLAST | 198 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1351 – 1358 | Nuclear localization signalSequence analysis | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 178 – 197 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1717 – 1733 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1737 – 1751 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1803 – 1822 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1848 – 1872 | Basic and acidic residuesSequence analysisAdd BLAST | 25 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Bromodomain, RepeatPhylogenomic databases
eggNOGi | KOG0008, Eukaryota |
HOGENOMi | CLU_000572_3_0_1 |
InParanoidi | P21675 |
OrthoDBi | 103411at2759 |
PhylomeDBi | P21675 |
TreeFami | TF313573 |
Family and domain databases
Gene3Di | 1.10.1100.10, 1 hit 1.20.920.10, 2 hits |
IDEALi | IID00545 |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR022591, TAF1_HAT_dom IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR041670, Znf-CCHC_6 |
PANTHERi | PTHR13900, PTHR13900, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit |
PIRSFi | PIRSF003047, TAF1_animal, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPGCDLLLR TAATITAAAI MSDTDSDEDS AGGGPFSLAG FLFGNINGAG
60 70 80 90 100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELTGT DGALVNDEGW
110 120 130 140 150
VRSTEDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHSDYD EDDYDADCED
160 170 180 190 200
IDCKLMPPPP PPPGPMKKDK DQDSITGEKV DFSSSSDSES EMGPQEATQA
210 220 230 240 250
ESEDGKLTLP LAGIMQHDAT KLLPSVTELF PEFRPGKVLR FLRLFGPGKN
260 270 280 290 300
VPSVWRSARR KRKKKHRELI QEEQIQEVEC SVESEVSQKS LWNYDYAPPP
310 320 330 340 350
PPEQCLSDDE ITMMAPVESK FSQSTGDIDK VTDTKPRVAE WRYGPARLWY
360 370 380 390 400
DMLGVPEDGS GFDYGFKLRK TEHEPVIKSR MIEEFRKLEE NNGTDLLADE
410 420 430 440 450
NFLMVTQLHW EDDIIWDGED VKHKGTKPQR ASLAGWLPSS MTRNAMAYNV
460 470 480 490 500
QQGFAATLDD DKPWYSIFPI DNEDLVYGRW EDNIIWDAQA MPRLLEPPVL
510 520 530 540 550
TLDPNDENLI LEIPDEKEEA TSNSPSKESK KESSLKKSRI LLGKTGVIKE
560 570 580 590 600
EPQQNMSQPE VKDPWNLSND EYYYPKQQGL RGTFGGNIIQ HSIPAVELRQ
610 620 630 640 650
PFFPTHMGPI KLRQFHRPPL KKYSFGALSQ PGPHSVQPLL KHIKKKAKMR
660 670 680 690 700
EQERQASGGG EMFFMRTPQD LTGKDGDLIL AEYSEENGPL MMQVGMATKI
710 720 730 740 750
KNYYKRKPGK DPGAPDCKYG ETVYCHTSPF LGSLHPGQLL QAFENNLFRA
760 770 780 790 800
PIYLHKMPET DFLIIRTRQG YYIRELVDIF VVGQQCPLFE VPGPNSKRAN
810 820 830 840 850
THIRDFLQVF IYRLFWKSKD RPRRIRMEDI KKAFPSHSES SIRKRLKLCA
860 870 880 890 900
DFKRTGMDSN WWVLKSDFRL PTEEEIRAMV SPEQCCAYYS MIAAEQRLKD
910 920 930 940 950
AGYGEKSFFA PEEENEEDFQ MKIDDEVRTA PWNTTRAFIA AMKGKCLLEV
960 970 980 990 1000
TGVADPTGCG EGFSYVKIPN KPTQQKDDKE PQPVKKTVTG TDADLRRLSL
1010 1020 1030 1040 1050
KNAKQLLRKF GVPEEEIKKL SRWEVIDVVR TMSTEQARSG EGPMSKFARG
1060 1070 1080 1090 1100
SRFSVAEHQE RYKEECQRIF DLQNKVLSST EVLSTDTDSS SAEDSDFEEM
1110 1120 1130 1140 1150
GKNIENMLQN KKTSSQLSRE REEQERKELQ RMLLAAGSAA SGNNHRDDDT
1160 1170 1180 1190 1200
ASVTSLNSSA TGRCLKIYRT FRDEEGKEYV RCETVRKPAV IDAYVRIRTT
1210 1220 1230 1240 1250
KDEEFIRKFA LFDEQHREEM RKERRRIQEQ LRRLKRNQEK EKLKGPPEKK
1260 1270 1280 1290 1300
PKKMKERPDL KLKCGACGAI GHMRTNKFCP LYYQTNAPPS NPVAMTEEQE
1310 1320 1330 1340 1350
EELEKTVIHN DNEELIKVEG TKIVLGKQLI ESADEVRRKS LVLKFPKQQL
1360 1370 1380 1390 1400
PPKKKRRVGT TVHCDYLNRP HKSIHRRRTD PMVTLSSILE SIINDMRDLP
1410 1420 1430 1440 1450
NTYPFHTPVN AKVVKDYYKI ITRPMDLQTL RENVRKRLYP SREEFREHLE
1460 1470 1480 1490 1500
LIVKNSATYN GPKHSLTQIS QSMLDLCDEK LKEKEDKLAR LEKAINPLLD
1510 1520 1530 1540 1550
DDDQVAFSFI LDNIVTQKMM AVPDSWPFHH PVNKKFVPDY YKVIVNPMDL
1560 1570 1580 1590 1600
ETIRKNISKH KYQSRESFLD DVNLILANSV KYNGPESQYT KTAQEIVNVC
1610 1620 1630 1640 1650
YQTLTEYDEH LTQLEKDICT AKEAALEEAE LESLDPMTPG PYTPQPPDLY
1660 1670 1680 1690 1700
DTNTSLSMSR DASVFQDESN MSVLDIPSAT PEKQVTQEGE DGDGDLADEE
1710 1720 1730 1740 1750
EGTVQQPQAS VLYEDLLMSE GEDDEEDAGS DEEGDNPFSA IQLSESGSDS
1760 1770 1780 1790 1800
DVGSGGIRPK QPRMLQENTR MDMENEESMM SYEGDGGEAS HGLEDSNISY
1810 1820 1830 1840 1850
GSYEEPDPKS NTQDTSFSSI GGYEVSEEEE DEEEEEQRSG PSVLSQVHLS
1860 1870
EDEEDSEDFH SIAGDSDLDS DE
The sequence of this isoform differs from the canonical sequence as follows:
1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ
The sequence of this isoform differs from the canonical sequence as follows:
1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ
The sequence of this isoform differs from the canonical sequence as follows:
1645-1645: Q → QAK
1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ
The sequence of this isoform differs from the canonical sequence as follows:
1585-1592: PESQYTKT → YMCTTCRT
1593-1872: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1645-1645: Q → QAK
1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ
The sequence of this isoform differs from the canonical sequence as follows:
1525-1528: SWPF → IITK
1529-1872: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1525-1540: SWPFHHPVNKKFVPDY → VSCLCAKYFLAISSPS
1541-1872: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
177-177: G → GVSENGEGIILPSIIAPSSLAS
1645-1645: Q → QAK
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A804HIC2 | A0A804HIC2_HUMAN | Transcription initiation factor TFI... | TAF1 | 1,907 | Annotation score: | ||
A0A804HK58 | A0A804HK58_HUMAN | Transcription initiation factor TFI... | TAF1 | 1,877 | Annotation score: | ||
A0A804HIY8 | A0A804HIY8_HUMAN | Transcription initiation factor TFI... | TAF1 | 1,598 | Annotation score: | ||
H7BY98 | H7BY98_HUMAN | Transcription initiation factor TFI... | TAF1 | 458 | Annotation score: | ||
H7C2K9 | H7C2K9_HUMAN | Transcription initiation factor TFI... | TAF1 | 456 | Annotation score: | ||
H0Y9L7 | H0Y9L7_HUMAN | Transcription initiation factor TFI... | TAF1 | 341 | Annotation score: | ||
A0A804HHS0 | A0A804HHS0_HUMAN | Transcription initiation factor TFI... | TAF1 | 840 | Annotation score: | ||
A0A804HLH3 | A0A804HLH3_HUMAN | Transcription initiation factor TFI... | TAF1 | 336 | Annotation score: | ||
A0A804HJ48 | A0A804HJ48_HUMAN | Transcription initiation factor TFI... | TAF1 | 73 | Annotation score: | ||
A0A804HJ34 | A0A804HJ34_HUMAN | Transcription initiation factor TFI... | TAF1 | 183 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020678 | 269 | L → V2 PublicationsCorresponds to variant dbSNP:rs28382158Ensembl. | 1 | |
Natural variantiVAR_041930 | 297 | A → G1 PublicationCorresponds to variant dbSNP:rs35317750Ensembl. | 1 | |
Natural variantiVAR_041931 | 453 | G → D in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_077838 | 472 | N → D Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200177996Ensembl. | 1 | |
Natural variantiVAR_076394 | 575 | P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl. | 1 | |
Natural variantiVAR_041932 | 651 | E → K in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041933 | 691 | M → I in a lung bronchoalveolar carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_076395 | 786 | C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl. | 1 | |
Natural variantiVAR_076396 | 955 | D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl. | 1 | |
Natural variantiVAR_077839 | 1169 | R → C Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1569301036Ensembl. | 1 | |
Natural variantiVAR_076397 | 1225 | R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl. | 1 | |
Natural variantiVAR_076398 | 1316 | I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl. | 1 | |
Natural variantiVAR_048433 | 1383 | V → I. Corresponds to variant dbSNP:rs7050748Ensembl. | 1 | |
Natural variantiVAR_076399 | 1431 | R → H in MRXS33; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_076400 | 1496 | N → H in MRXS33; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012362 | 177 | G → GVSENGEGIILPSIIAPSSL AS in isoform 2 and isoform N-TAF1. 1 Publication | 1 | |
Alternative sequenceiVSP_053376 | 1525 – 1540 | SWPFH…FVPDY → VSCLCAKYFLAISSPS in isoform 2i. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_053375 | 1525 – 1528 | SWPF → IITK in isoform 2h. 1 Publication | 4 | |
Alternative sequenceiVSP_053377 | 1529 – 1872 | Missing in isoform 2h. 1 PublicationAdd BLAST | 344 | |
Alternative sequenceiVSP_053378 | 1541 – 1872 | Missing in isoform 2i. 1 PublicationAdd BLAST | 332 | |
Alternative sequenceiVSP_053379 | 1585 – 1592 | PESQYTKT → YMCTTCRT in isoform 2e. 2 Publications | 8 | |
Alternative sequenceiVSP_053380 | 1593 – 1872 | Missing in isoform 2e. 2 PublicationsAdd BLAST | 280 | |
Alternative sequenceiVSP_053381 | 1645 | Q → QAK in isoform 2d, isoform 2g and isoform N-TAF1. 3 Publications | 1 | |
Alternative sequenceiVSP_053382 | 1684 – 1686 | Missing in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_053383 | 1687 | Q → QMRQGRGRLGEEDSDVDIEG YDDEEEDGKPKTPAP in isoform 2g, isoform 2a, isoform 3 and isoform 4. 3 Publications | 1 | |
Alternative sequenceiVSP_053384 | 1799 – 1872 | SYGSY…LDSDE → RYQ in isoform 2g, isoform 2a, isoform 2c, isoform 2d and isoform 3. 2 PublicationsAdd BLAST | 74 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90359 mRNA Translation: BAA14374.1 X07024 mRNA Translation: CAA30073.1 Sequence problems. AB300418 mRNA Translation: BAG15901.1 AY623109 Genomic DNA Translation: AAT38105.1 AL590762 Genomic DNA No translation available. AL590763 Genomic DNA No translation available. AB209316 mRNA Translation: BAD92553.1 AJ549247 mRNA Translation: CAD70490.1 AJ549248 mRNA Translation: CAD70491.3 AJ549249 mRNA Translation: CAD70492.2 AJ549250 mRNA Translation: CAD70493.3 AJ555148 mRNA Translation: CAD87527.2 AJ555149 mRNA Translation: CAD87528.2 AM711892 mRNA Translation: CAM98555.1 AM711893 mRNA Translation: CAM98556.1 AM711894 mRNA Translation: CAM98557.1 AM711895 mRNA Translation: CAM98558.1 |
PIRi | A40262 |
RefSeqi | NP_001273003.1, NM_001286074.1 NP_004597.2, NM_004606.4 NP_620278.1, NM_138923.3 XP_005262354.1, XM_005262297.4 [P21675-4] |
Genome annotation databases
Ensembli | ENST00000276072.9; ENSP00000276072.5; ENSG00000147133.17 ENST00000373790.9; ENSP00000362895.5; ENSG00000147133.17 ENST00000423759.6; ENSP00000406549.2; ENSG00000147133.17 |
GeneIDi | 6872 |
KEGGi | hsa:6872 |
MANE-Selecti | ENST00000423759.6; ENSP00000406549.2; NM_004606.5; NP_004597.3 |
UCSCi | uc004dzt.6, human [P21675-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90359 mRNA Translation: BAA14374.1 X07024 mRNA Translation: CAA30073.1 Sequence problems. AB300418 mRNA Translation: BAG15901.1 AY623109 Genomic DNA Translation: AAT38105.1 AL590762 Genomic DNA No translation available. AL590763 Genomic DNA No translation available. AB209316 mRNA Translation: BAD92553.1 AJ549247 mRNA Translation: CAD70490.1 AJ549248 mRNA Translation: CAD70491.3 AJ549249 mRNA Translation: CAD70492.2 AJ549250 mRNA Translation: CAD70493.3 AJ555148 mRNA Translation: CAD87527.2 AJ555149 mRNA Translation: CAD87528.2 AM711892 mRNA Translation: CAM98555.1 AM711893 mRNA Translation: CAM98556.1 AM711894 mRNA Translation: CAM98557.1 AM711895 mRNA Translation: CAM98558.1 |
PIRi | A40262 |
RefSeqi | NP_001273003.1, NM_001286074.1 NP_004597.2, NM_004606.4 NP_620278.1, NM_138923.3 XP_005262354.1, XM_005262297.4 [P21675-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EQF | X-ray | 2.10 | A | 1359-1638 | [»] | |
3AAD | X-ray | 3.30 | A | 1342-1629 | [»] | |
3UV4 | X-ray | 1.89 | A/B | 1501-1635 | [»] | |
3UV5 | X-ray | 2.03 | A | 1373-1635 | [»] | |
4RGW | X-ray | 2.30 | A | 579-1215 | [»] | |
4YYM | X-ray | 1.50 | A/B | 1497-1638 | [»] | |
4YYN | X-ray | 1.85 | A/B | 1497-1638 | [»] | |
5FUR | electron microscopy | 8.50 | G | 1-1872 | [»] | |
5I1Q | X-ray | 1.50 | A | 1497-1638 | [»] | |
5I29 | X-ray | 1.21 | A | 1497-1638 | [»] | |
5MG2 | X-ray | 1.75 | A | 1501-1635 | [»] | |
6BQD | X-ray | 2.14 | A/B | 1501-1630 | [»] | |
6FIC | X-ray | 2.18 | T | 1359-1638 | [»] | |
6MZD | electron microscopy | 9.80 | A | 21-1872 | [»] | |
6MZL | electron microscopy | 23.00 | A | 1-1872 | [»] | |
6MZM | electron microscopy | 7.50 | A | 588-1083 | [»] | |
6P38 | X-ray | 2.80 | A | 1501-1635 | [»] | |
6P39 | X-ray | 2.94 | A | 1500-1635 | [»] | |
6P3A | X-ray | 2.99 | A/B | 1501-1635 | [»] | |
7EDX | electron microscopy | 4.50 | A | 1-1872 | [»] | |
7EG7 | electron microscopy | 6.20 | A | 1-1872 | [»] | |
7EG8 | electron microscopy | 7.40 | A | 1-1872 | [»] | |
7EG9 | electron microscopy | 3.70 | A | 1-1872 | [»] | |
7EGA | electron microscopy | 4.10 | A | 1-1872 | [»] | |
7EGB | electron microscopy | 3.30 | A | 1-1872 | [»] | |
7EGC | electron microscopy | 3.90 | A | 1-1872 | [»] | |
7EGD | electron microscopy | 6.75 | A | 1-1872 | [»] | |
7EGE | electron microscopy | 9.00 | A | 1-1872 | [»] | |
7EGH | electron microscopy | 3.04 | A | 1-1872 | [»] | |
7EGI | electron microscopy | 9.82 | A | 1-1872 | [»] | |
7EGJ | electron microscopy | 8.64 | A | 1-1872 | [»] | |
7ENA | electron microscopy | 4.07 | DA | 1-1872 | [»] | |
7ENC | electron microscopy | 4.13 | DA | 1-1872 | [»] | |
7JJG | X-ray | 1.60 | A | 1501-1635 | [»] | |
7JJH | X-ray | 2.10 | A | 1373-1635 | [»] | |
7JSP | X-ray | 1.70 | A | 1501-1635 | [»] | |
7JTC | X-ray | 2.05 | A | 1501-1635 | [»] | |
7K03 | X-ray | 1.60 | A | 1373-1635 | [»] | |
7K0D | X-ray | 2.20 | A | 1373-1635 | [»] | |
7K0U | X-ray | 2.52 | A/B | 1501-1635 | [»] | |
7K1P | X-ray | 2.45 | A | 1501-1635 | [»] | |
7K27 | X-ray | 1.50 | A | 1373-1635 | [»] | |
7K3O | X-ray | 1.70 | A/B | 1501-1635 | [»] | |
7K42 | X-ray | 1.70 | A/B | 1501-1635 | [»] | |
7K6F | X-ray | 1.86 | A | 1373-1635 | [»] | |
7L6X | X-ray | 2.75 | A | 1373-1635 | [»] | |
7LB0 | X-ray | 2.33 | A | 1373-1635 | [»] | |
7LB1 | X-ray | 1.35 | A | 1373-1635 | [»] | |
7LB2 | X-ray | 1.70 | A | 1373-1635 | [»] | |
7LB3 | X-ray | 1.90 | A | 1501-1635 | [»] | |
7N42 | X-ray | 1.90 | A | 1373-1635 | [»] | |
7P4S | X-ray | 2.17 | A | 1501-1635 | [»] | |
7T2I | X-ray | 1.89 | A | 1373-1635 | [»] | |
7T36 | X-ray | 1.65 | A | 1373-1635 | [»] | |
AlphaFoldDBi | P21675 | |||||
SASBDBi | P21675 | |||||
SMRi | P21675 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112735, 220 interactors |
ComplexPortali | CPX-915, General transcription factor complex TFIID CPX-930, General transcription factor complex TFIID, TAF4B variant |
CORUMi | P21675 |
DIPi | DIP-147N |
IntActi | P21675, 55 interactors |
MINTi | P21675 |
STRINGi | 9606.ENSP00000406549 |
Chemistry databases
BindingDBi | P21675 |
ChEMBLi | CHEMBL3217390 |
GuidetoPHARMACOLOGYi | 2231 |
PTM databases
GlyGeni | P21675, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P21675 |
PhosphoSitePlusi | P21675 |
Genetic variation databases
BioMutai | TAF1 |
DMDMi | 115942 |
Proteomic databases
EPDi | P21675 |
jPOSTi | P21675 |
MassIVEi | P21675 |
MaxQBi | P21675 |
PaxDbi | P21675 |
PeptideAtlasi | P21675 |
PRIDEi | P21675 |
ProteomicsDBi | 3401 53886 [P21675-1] 53887 [P21675-2] 53888 [P21675-3] 53889 [P21675-4] |
Protocols and materials databases
ABCDi | P21675, 1 sequenced antibody |
Antibodypediai | 346, 290 antibodies from 37 providers |
DNASUi | 6872 |
Genome annotation databases
Ensembli | ENST00000276072.9; ENSP00000276072.5; ENSG00000147133.17 ENST00000373790.9; ENSP00000362895.5; ENSG00000147133.17 ENST00000423759.6; ENSP00000406549.2; ENSG00000147133.17 |
GeneIDi | 6872 |
KEGGi | hsa:6872 |
MANE-Selecti | ENST00000423759.6; ENSP00000406549.2; NM_004606.5; NP_004597.3 |
UCSCi | uc004dzt.6, human [P21675-1] |
Organism-specific databases
CTDi | 6872 |
DisGeNETi | 6872 |
GeneCardsi | TAF1 |
GeneReviewsi | TAF1 |
HGNCi | HGNC:11535, TAF1 |
HPAi | ENSG00000147133, Low tissue specificity |
MalaCardsi | TAF1 |
MIMi | 300966, phenotype 313650, gene 314250, phenotype |
neXtProti | NX_P21675 |
Orphaneti | 53351, X-linked dystonia-parkinsonism 480907, X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome |
PharmGKBi | PA36310 |
VEuPathDBi | HostDB:ENSG00000147133 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0008, Eukaryota |
HOGENOMi | CLU_000572_3_0_1 |
InParanoidi | P21675 |
OrthoDBi | 103411at2759 |
PhylomeDBi | P21675 |
TreeFami | TF313573 |
Enzyme and pathway databases
BRENDAi | 2.3.1.48, 2681 |
PathwayCommonsi | P21675 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | P21675 |
SIGNORi | P21675 |
Miscellaneous databases
BioGRID-ORCSi | 6872, 329 hits in 737 CRISPR screens |
ChiTaRSi | TAF1, human |
EvolutionaryTracei | P21675 |
GeneWikii | TAF1 |
GenomeRNAii | 6872 |
Pharosi | P21675, Tchem |
PROi | PR:P21675 |
RNActi | P21675, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147133, Expressed in sural nerve and 226 other tissues |
ExpressionAtlasi | P21675, baseline and differential |
Genevisiblei | P21675, HS |
Family and domain databases
Gene3Di | 1.10.1100.10, 1 hit 1.20.920.10, 2 hits |
IDEALi | IID00545 |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR022591, TAF1_HAT_dom IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR041670, Znf-CCHC_6 |
PANTHERi | PTHR13900, PTHR13900, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit |
PIRSFi | PIRSF003047, TAF1_animal, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF1_HUMAN | |
Accessioni | P21675Primary (citable) accession number: P21675 Secondary accession number(s): A5CVC8 Q70T03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families