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UniProtKB - P21675 (TAF1_HUMAN)

Protein

Transcription initiation factor TFIID subunit 1

Gene

TAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).10 Publications

Miscellaneous

Isoforms including the downstream (d) exons are preferentially expressed in brain, and may play a role in the regulation of genes involved in dopamine processing and transport.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Cofactori

Mg2+

Activity regulationi

Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1195 – 1273HMG boxAdd BLAST79

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionAcyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Host-virus interaction, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORiP21675

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.3.1.481 Publication, EC:2.7.11.1)
Alternative name(s):
Cell cycle gene 1 protein
TBP-associated factor 250 kDa
Short name:
p250
Transcription initiation factor TFIID 250 kDa subunit
Short name:
TAF(II)250
Short name:
TAFII-250
Short name:
TAFII250
Gene namesi
Name:TAF1
Synonyms:BA2R, CCG1, CCGS, TAF2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147133.15
HGNCiHGNC:11535 TAF1
MIMi313650 gene
neXtProtiNX_P21675

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Dystonia 3, torsion, X-linked (DYT3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.
See also OMIM:314250
Mental retardation, X-linked, syndromic, 33 (MRXS33)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, delayed speech and language, and characteristic facial features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:300966
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076394575P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl.1
Natural variantiVAR_076395786C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl.1
Natural variantiVAR_076396955D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl.1
Natural variantiVAR_0763971225R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl.1
Natural variantiVAR_0763981316I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl.1
Natural variantiVAR_0763991431R → H in MRXS33; unknown pathological significance. 1 Publication1
Natural variantiVAR_0764001496N → H in MRXS33; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi137S → A: No decrease in kinase activity. 1 Publication1
Mutagenesisi145D → A: Reduces kinase activity; when associated with A-147; A-149; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi147D → A: Reduces kinase activity; when associated with A-145; A-149; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi149E → A: Reduces kinase activity; when associated with A-145; A-147; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi150D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-152 and A-154. 1 Publication1
Mutagenesisi152D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-154. 1 Publication1
Mutagenesisi154K → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-152. 1 Publication1
Mutagenesisi305C → A: Reduces kinase activity; when associated with A-307; A-308; A-309 and A-310. 1 Publication1
Mutagenesisi307S → A: Reduces kinase activity; when associated with A-305; A-308; A-309 and A-310. 1 Publication1
Mutagenesisi308D → A: Reduces kinase activity; when associated with A-305; A-307; A-309 and A-310. 1 Publication1
Mutagenesisi309D → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-310. 1 Publication1
Mutagenesisi310E → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-309. 1 Publication1
Mutagenesisi721E → Q: 25% decrease in histone acetylation. 1 Publication1
Mutagenesisi827 – 829Missing : Dramatic decrease in histone acetylation. 1 Publication3

Keywords - Diseasei

Disease mutation, Dystonia, Mental retardation, Parkinsonism

Organism-specific databases

DisGeNETi6872
GeneReviewsiTAF1
MalaCardsiTAF1
MIMi300966 phenotype
314250 phenotype
OpenTargetsiENSG00000147133
Orphaneti53351 X-linked dystonia-parkinsonism
PharmGKBiPA36310

Chemistry databases

ChEMBLiCHEMBL3217390
GuidetoPHARMACOLOGYi2231

Polymorphism and mutation databases

BioMutaiTAF1
DMDMi115942

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112151 – 1872Transcription initiation factor TFIID subunit 1Add BLAST1872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Phosphoserine; by autocatalysis1 Publication1
Modified residuei307Phosphoserine; by autocatalysisCombined sources1 Publication1
Modified residuei544N6-acetyllysineBy similarity1
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki562Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1669PhosphoserineBy similarity1
Modified residuei1672PhosphoserineBy similarity1
Modified residuei1778PhosphoserineBy similarity1
Modified residuei1781PhosphoserineBy similarity1
Modified residuei1799PhosphoserineBy similarity1
Modified residuei1826PhosphoserineCombined sources1
Isoform 3 (identifier: P21675-3)
Modified residuei1697PhosphoserineCombined sources1
Isoform 4 (identifier: P21675-4)
Modified residuei1700PhosphoserineCombined sources1
Isoform 2a (identifier: P21675-5)
Modified residuei1700PhosphoserineCombined sources1
Isoform 2g (identifier: P21675-9)
Modified residuei1702PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by casein kinase II in vitro.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP21675
MaxQBiP21675
PaxDbiP21675
PeptideAtlasiP21675
PRIDEiP21675
ProteomicsDBi53886
53887 [P21675-2]
53888 [P21675-3]
53889 [P21675-4]

PTM databases

iPTMnetiP21675
PhosphoSitePlusiP21675

Expressioni

Gene expression databases

BgeeiENSG00000147133 Expressed in 212 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP21675 baseline and differential
GenevisibleiP21675 HS

Organism-specific databases

HPAiCAB016283
HPA001075

Interactioni

Subunit structurei

TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors (PubMed:7680771). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53 (PubMed:15053879). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846). Interacts with TAF7; the interaction is direct (PubMed:25412659). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B (PubMed:10759893, PubMed:12093919, PubMed:12842904). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (PubMed:22464331).10 Publications
(Microbial infection) Interacts with SV40 Large T antigen.1 Publication
(Microbial infection) Interacts with herpes simplex virus 1 ICP4.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112735, 77 interactors
ComplexPortaliCPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiP21675
DIPiDIP-147N
IntActiP21675, 40 interactors
MINTiP21675
STRINGi9606.ENSP00000276072

Chemistry databases

BindingDBiP21675

Structurei

Secondary structure

11872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21675
SMRiP21675
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21675

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 414Protein kinase 1Add BLAST414
Domaini1397 – 1467Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1425 – 1872Protein kinase 2Add BLAST448
Domaini1520 – 1590Bromo 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni517 – 976Histone acetyltransferase (HAT)Add BLAST460
Regioni1342 – 1629Interaction with ASF1A and ASF1B1 PublicationAdd BLAST288

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1351 – 1358Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 165Pro-rich9
Compositional biasi1627 – 1872Asp/Glu-rich (acidic tail)Add BLAST246

Domaini

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). The second domain also recognizes and binds histones that are butyrylated and crotonylated (PubMed:26365797).2 Publications

Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00910000144099
HOGENOMiHOG000020066
HOVERGENiHBG050223
InParanoidiP21675
KOiK03125
OMAiRSFHRPP
OrthoDBiEOG091G00MO
PhylomeDBiP21675
TreeFamiTF313573

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

Sequences (12+)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket
Note: the TAF1/DYT3 multiple transcript system is composed of 38 evolutionary conserved exons plus 5 downstream exons referred to as exons d1-d5 that are primate-specific. Multiple highly polymorphic variants can be generated by splicing exons d3 and d4 to various combinations of exons 1-37.

This entry has 12 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21675-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGCDLLLR TAATITAAAI MSDTDSDEDS AGGGPFSLAG FLFGNINGAG 
        60         70         80         90        100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELTGT DGALVNDEGW 
       110        120        130        140        150
VRSTEDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHSDYD EDDYDADCED 
       160        170        180        190        200
IDCKLMPPPP PPPGPMKKDK DQDSITGEKV DFSSSSDSES EMGPQEATQA 
       210        220        230        240        250
ESEDGKLTLP LAGIMQHDAT KLLPSVTELF PEFRPGKVLR FLRLFGPGKN 
       260        270        280        290        300
VPSVWRSARR KRKKKHRELI QEEQIQEVEC SVESEVSQKS LWNYDYAPPP 
       310        320        330        340        350
PPEQCLSDDE ITMMAPVESK FSQSTGDIDK VTDTKPRVAE WRYGPARLWY 
       360        370        380        390        400
DMLGVPEDGS GFDYGFKLRK TEHEPVIKSR MIEEFRKLEE NNGTDLLADE 
       410        420        430        440        450
NFLMVTQLHW EDDIIWDGED VKHKGTKPQR ASLAGWLPSS MTRNAMAYNV 
       460        470        480        490        500
QQGFAATLDD DKPWYSIFPI DNEDLVYGRW EDNIIWDAQA MPRLLEPPVL 
       510        520        530        540        550
TLDPNDENLI LEIPDEKEEA TSNSPSKESK KESSLKKSRI LLGKTGVIKE 
       560        570        580        590        600
EPQQNMSQPE VKDPWNLSND EYYYPKQQGL RGTFGGNIIQ HSIPAVELRQ 
       610        620        630        640        650
PFFPTHMGPI KLRQFHRPPL KKYSFGALSQ PGPHSVQPLL KHIKKKAKMR 
       660        670        680        690        700
EQERQASGGG EMFFMRTPQD LTGKDGDLIL AEYSEENGPL MMQVGMATKI 
       710        720        730        740        750
KNYYKRKPGK DPGAPDCKYG ETVYCHTSPF LGSLHPGQLL QAFENNLFRA 
       760        770        780        790        800
PIYLHKMPET DFLIIRTRQG YYIRELVDIF VVGQQCPLFE VPGPNSKRAN 
       810        820        830        840        850
THIRDFLQVF IYRLFWKSKD RPRRIRMEDI KKAFPSHSES SIRKRLKLCA 
       860        870        880        890        900
DFKRTGMDSN WWVLKSDFRL PTEEEIRAMV SPEQCCAYYS MIAAEQRLKD 
       910        920        930        940        950
AGYGEKSFFA PEEENEEDFQ MKIDDEVRTA PWNTTRAFIA AMKGKCLLEV 
       960        970        980        990       1000
TGVADPTGCG EGFSYVKIPN KPTQQKDDKE PQPVKKTVTG TDADLRRLSL 
      1010       1020       1030       1040       1050
KNAKQLLRKF GVPEEEIKKL SRWEVIDVVR TMSTEQARSG EGPMSKFARG 
      1060       1070       1080       1090       1100
SRFSVAEHQE RYKEECQRIF DLQNKVLSST EVLSTDTDSS SAEDSDFEEM 
      1110       1120       1130       1140       1150
GKNIENMLQN KKTSSQLSRE REEQERKELQ RMLLAAGSAA SGNNHRDDDT 
      1160       1170       1180       1190       1200
ASVTSLNSSA TGRCLKIYRT FRDEEGKEYV RCETVRKPAV IDAYVRIRTT 
      1210       1220       1230       1240       1250
KDEEFIRKFA LFDEQHREEM RKERRRIQEQ LRRLKRNQEK EKLKGPPEKK 
      1260       1270       1280       1290       1300
PKKMKERPDL KLKCGACGAI GHMRTNKFCP LYYQTNAPPS NPVAMTEEQE 
      1310       1320       1330       1340       1350
EELEKTVIHN DNEELIKVEG TKIVLGKQLI ESADEVRRKS LVLKFPKQQL 
      1360       1370       1380       1390       1400
PPKKKRRVGT TVHCDYLNRP HKSIHRRRTD PMVTLSSILE SIINDMRDLP 
      1410       1420       1430       1440       1450
NTYPFHTPVN AKVVKDYYKI ITRPMDLQTL RENVRKRLYP SREEFREHLE 
      1460       1470       1480       1490       1500
LIVKNSATYN GPKHSLTQIS QSMLDLCDEK LKEKEDKLAR LEKAINPLLD 
      1510       1520       1530       1540       1550
DDDQVAFSFI LDNIVTQKMM AVPDSWPFHH PVNKKFVPDY YKVIVNPMDL 
      1560       1570       1580       1590       1600
ETIRKNISKH KYQSRESFLD DVNLILANSV KYNGPESQYT KTAQEIVNVC 
      1610       1620       1630       1640       1650
YQTLTEYDEH LTQLEKDICT AKEAALEEAE LESLDPMTPG PYTPQPPDLY 
      1660       1670       1680       1690       1700
DTNTSLSMSR DASVFQDESN MSVLDIPSAT PEKQVTQEGE DGDGDLADEE 
      1710       1720       1730       1740       1750
EGTVQQPQAS VLYEDLLMSE GEDDEEDAGS DEEGDNPFSA IQLSESGSDS 
      1760       1770       1780       1790       1800
DVGSGGIRPK QPRMLQENTR MDMENEESMM SYEGDGGEAS HGLEDSNISY 
      1810       1820       1830       1840       1850
GSYEEPDPKS NTQDTSFSSI GGYEVSEEEE DEEEEEQRSG PSVLSQVHLS 
      1860       1870 
EDEEDSEDFH SIAGDSDLDS DE
Length:1,872
Mass (Da):212,677
Last modified:May 1, 1992 - v2
Checksum:i93BE3D181A72ABEB
GO
Isoform 2 (identifier: P21675-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: G → GVSENGEGIILPSIIAPSSLAS

Show »
Length:1,893
Mass (Da):214,714
Checksum:iAE148C222B418BB4
GO
Isoform 3 (identifier: P21675-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1686: Missing.
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,832
Mass (Da):208,364
Checksum:i6C51A0F5885FF667
GO
Isoform 4 (identifier: P21675-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP

Show »
Length:1,906
Mass (Da):216,451
Checksum:i8880885A3D444515
GO
Isoform 2a (identifier: P21675-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,835
Mass (Da):208,693
Checksum:i4EF338B27B304C13
GO
Isoform 2c (identifier: P21675-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,801
Mass (Da):204,919
Checksum:i245D4080FB804D6D
GO
Isoform 2d (identifier: P21675-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1645-1645: Q → QAK
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,803
Mass (Da):205,118
Checksum:i1B90B7A234BDB92C
GO
Isoform 2e (identifier: P21675-8) [UniParc]FASTAAdd to basket
Also known as: 2F

The sequence of this isoform differs from the canonical sequence as follows:
     1585-1592: PESQYTKT → YMCTTCRT
     1593-1872: Missing.

Show »
Length:1,592
Mass (Da):182,054
Checksum:i72C8271DD47EE24D
GO
Isoform 2g (identifier: P21675-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1645-1645: Q → QAK
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,837
Mass (Da):208,892
Checksum:i5165FAF620722AD3
GO
Isoform 2h (identifier: P21675-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1525-1528: SWPF → IITK
     1529-1872: Missing.

Show »
Length:1,528
Mass (Da):174,433
Checksum:i75267CFDD8211DD6
GO
Isoform 2i (identifier: P21675-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1525-1540: SWPFHHPVNKKFVPDY → VSCLCAKYFLAISSPS
     1541-1872: Missing.

Show »
Length:1,540
Mass (Da):175,648
Checksum:i4DC37D3B71D7AA10
GO
Isoform N-TAF1 (identifier: P21675-12) [UniParc]FASTAAdd to basket
Also known as: TA14-391

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: G → GVSENGEGIILPSIIAPSSLAS
     1645-1645: Q → QAK

Note: Only detected in brain, highest expression in the caudate nucleus.
Show »
Length:1,895
Mass (Da):214,913
Checksum:i68B48D4582D8A090
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY98H7BY98_HUMAN
Transcription initiation factor TFI...
TAF1
458Annotation score:
H7C2K9H7C2K9_HUMAN
Transcription initiation factor TFI...
TAF1
490Annotation score:
H0Y9L7H0Y9L7_HUMAN
Transcription initiation factor TFI...
TAF1
279Annotation score:
H0Y8N6H0Y8N6_HUMAN
Transcription initiation factor TFI...
TAF1
150Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020678269L → V2 PublicationsCorresponds to variant dbSNP:rs28382158Ensembl.1
Natural variantiVAR_041930297A → G1 PublicationCorresponds to variant dbSNP:rs35317750Ensembl.1
Natural variantiVAR_041931453G → D in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_077838472N → D Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200177996Ensembl.1
Natural variantiVAR_076394575P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl.1
Natural variantiVAR_041932651E → K in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041933691M → I in a lung bronchoalveolar carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_076395786C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl.1
Natural variantiVAR_076396955D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl.1
Natural variantiVAR_0778391169R → C Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 Publication1
Natural variantiVAR_0763971225R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl.1
Natural variantiVAR_0763981316I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl.1
Natural variantiVAR_0484331383V → I. Corresponds to variant dbSNP:rs7050748Ensembl.1
Natural variantiVAR_0763991431R → H in MRXS33; unknown pathological significance. 1 Publication1
Natural variantiVAR_0764001496N → H in MRXS33; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012362177G → GVSENGEGIILPSIIAPSSL AS in isoform 2 and isoform N-TAF1. 1 Publication1
Alternative sequenceiVSP_0533761525 – 1540SWPFH…FVPDY → VSCLCAKYFLAISSPS in isoform 2i. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0533751525 – 1528SWPF → IITK in isoform 2h. 1 Publication4
Alternative sequenceiVSP_0533771529 – 1872Missing in isoform 2h. 1 PublicationAdd BLAST344
Alternative sequenceiVSP_0533781541 – 1872Missing in isoform 2i. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0533791585 – 1592PESQYTKT → YMCTTCRT in isoform 2e. 2 Publications8
Alternative sequenceiVSP_0533801593 – 1872Missing in isoform 2e. 2 PublicationsAdd BLAST280
Alternative sequenceiVSP_0533811645Q → QAK in isoform 2d, isoform 2g and isoform N-TAF1. 3 Publications1
Alternative sequenceiVSP_0533821684 – 1686Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0533831687Q → QMRQGRGRLGEEDSDVDIEG YDDEEEDGKPKTPAP in isoform 2g, isoform 2a, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_0533841799 – 1872SYGSY…LDSDE → RYQ in isoform 2g, isoform 2a, isoform 2c, isoform 2d and isoform 3. 2 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90359 mRNA Translation: BAA14374.1
X07024 mRNA Translation: CAA30073.1 Sequence problems.
AB300418 mRNA Translation: BAG15901.1
AY623109 Genomic DNA Translation: AAT38105.1
AL590762 Genomic DNA No translation available.
AL590763 Genomic DNA No translation available.
AB209316 mRNA Translation: BAD92553.1
AJ549247 mRNA Translation: CAD70490.1
AJ549248 mRNA Translation: CAD70491.3
AJ549249 mRNA Translation: CAD70492.2
AJ549250 mRNA Translation: CAD70493.3
AJ555148 mRNA Translation: CAD87527.2
AJ555149 mRNA Translation: CAD87528.2
AM711892 mRNA Translation: CAM98555.1
AM711893 mRNA Translation: CAM98556.1
AM711894 mRNA Translation: CAM98557.1
AM711895 mRNA Translation: CAM98558.1
CCDSiCCDS14412.1 [P21675-2]
CCDS35325.1 [P21675-1]
CCDS69783.1 [P21675-12]
PIRiA40262
RefSeqiNP_001273003.1, NM_001286074.1 [P21675-12]
NP_004597.2, NM_004606.4 [P21675-2]
NP_620278.1, NM_138923.3 [P21675-1]
XP_005262354.1, XM_005262297.4 [P21675-4]
UniGeneiHs.158560

Genome annotation databases

EnsembliENST00000276072; ENSP00000276072; ENSG00000147133 [P21675-2]
ENST00000373790; ENSP00000362895; ENSG00000147133 [P21675-1]
ENST00000423759; ENSP00000406549; ENSG00000147133 [P21675-12]
GeneIDi6872
KEGGihsa:6872
UCSCiuc004dzt.6 human [P21675-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90359 mRNA Translation: BAA14374.1
X07024 mRNA Translation: CAA30073.1 Sequence problems.
AB300418 mRNA Translation: BAG15901.1
AY623109 Genomic DNA Translation: AAT38105.1
AL590762 Genomic DNA No translation available.
AL590763 Genomic DNA No translation available.
AB209316 mRNA Translation: BAD92553.1
AJ549247 mRNA Translation: CAD70490.1
AJ549248 mRNA Translation: CAD70491.3
AJ549249 mRNA Translation: CAD70492.2
AJ549250 mRNA Translation: CAD70493.3
AJ555148 mRNA Translation: CAD87527.2
AJ555149 mRNA Translation: CAD87528.2
AM711892 mRNA Translation: CAM98555.1
AM711893 mRNA Translation: CAM98556.1
AM711894 mRNA Translation: CAM98557.1
AM711895 mRNA Translation: CAM98558.1
CCDSiCCDS14412.1 [P21675-2]
CCDS35325.1 [P21675-1]
CCDS69783.1 [P21675-12]
PIRiA40262
RefSeqiNP_001273003.1, NM_001286074.1 [P21675-12]
NP_004597.2, NM_004606.4 [P21675-2]
NP_620278.1, NM_138923.3 [P21675-1]
XP_005262354.1, XM_005262297.4 [P21675-4]
UniGeneiHs.158560

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQFX-ray2.10A1359-1638[»]
3AADX-ray3.30A1342-1629[»]
3UV4X-ray1.89A/B1501-1635[»]
3UV5X-ray2.03A1373-1635[»]
4RGWX-ray2.30A579-1215[»]
4YYMX-ray1.50A/B1497-1638[»]
4YYNX-ray1.85A/B1497-1638[»]
5FURelectron microscopy8.50G1-1872[»]
5I1QX-ray1.50A1497-1638[»]
5I29X-ray1.21A1497-1638[»]
5MG2X-ray1.75A1501-1635[»]
6FICX-ray2.18T1359-1638[»]
ProteinModelPortaliP21675
SMRiP21675
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112735, 77 interactors
ComplexPortaliCPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiP21675
DIPiDIP-147N
IntActiP21675, 40 interactors
MINTiP21675
STRINGi9606.ENSP00000276072

Chemistry databases

BindingDBiP21675
ChEMBLiCHEMBL3217390
GuidetoPHARMACOLOGYi2231

PTM databases

iPTMnetiP21675
PhosphoSitePlusiP21675

Polymorphism and mutation databases

BioMutaiTAF1
DMDMi115942

Proteomic databases

EPDiP21675
MaxQBiP21675
PaxDbiP21675
PeptideAtlasiP21675
PRIDEiP21675
ProteomicsDBi53886
53887 [P21675-2]
53888 [P21675-3]
53889 [P21675-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276072; ENSP00000276072; ENSG00000147133 [P21675-2]
ENST00000373790; ENSP00000362895; ENSG00000147133 [P21675-1]
ENST00000423759; ENSP00000406549; ENSG00000147133 [P21675-12]
GeneIDi6872
KEGGihsa:6872
UCSCiuc004dzt.6 human [P21675-1]

Organism-specific databases

CTDi6872
DisGeNETi6872
EuPathDBiHostDB:ENSG00000147133.15
GeneCardsiTAF1
GeneReviewsiTAF1
HGNCiHGNC:11535 TAF1
HPAiCAB016283
HPA001075
MalaCardsiTAF1
MIMi300966 phenotype
313650 gene
314250 phenotype
neXtProtiNX_P21675
OpenTargetsiENSG00000147133
Orphaneti53351 X-linked dystonia-parkinsonism
PharmGKBiPA36310
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00910000144099
HOGENOMiHOG000020066
HOVERGENiHBG050223
InParanoidiP21675
KOiK03125
OMAiRSFHRPP
OrthoDBiEOG091G00MO
PhylomeDBiP21675
TreeFamiTF313573

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORiP21675

Miscellaneous databases

ChiTaRSiTAF1 human
EvolutionaryTraceiP21675
GeneWikiiTAF1
GenomeRNAii6872
PROiPR:P21675
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147133 Expressed in 212 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP21675 baseline and differential
GenevisibleiP21675 HS

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1_HUMAN
AccessioniPrimary (citable) accession number: P21675
Secondary accession number(s): A5CVC8
, A5CVC9, A5CVD0, A5CVD1, B1Q2X3, Q59FZ3, Q6IUZ1, Q70Q86, Q70Q87, Q70T00, Q70T01, Q70T02, Q70T03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 207 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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