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UniProtKB - P21675 (TAF1_HUMAN)

Entry version 231 (25 May 2022)
Sequence version 2 (01 May 1992)
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Protein

Transcription initiation factor TFIID subunit 1

Gene

TAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).

TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).

The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).

TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473).

TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473).

Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415).

Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659).

Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659).

Possesses DNA-binding activity (PubMed:25412659).

Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607).

Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).

11 Publications

Miscellaneous

Isoforms including the downstream (d) exons are preferentially expressed in brain, and may play a role in the regulation of genes involved in dopamine processing and transport.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autophosphorylates on Ser residues (PubMed:8625415). Inhibited by retinoblastoma tumor suppressor protein, RB1 (PubMed:9858607). Binding to TAF7 or CIITA inhibits the histone acetyltransferase activity (PubMed:11592977, PubMed:22711989).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1195 – 1273HMG box; involved in promoter bindingCombined sourcesAdd BLAST79

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Host-virus interaction, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.48, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P21675

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P21675

SIGNOR Signaling Network Open Resource

More...SIGNORi		P21675

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.3.1.481 Publication, EC:2.7.11.1)
Alternative name(s):
Cell cycle gene 1 protein
TBP-associated factor 250 kDa
Short name:
p250
Transcription initiation factor TFIID 250 kDa subunit
Short name:
TAF(II)250
Short name:
TAFII-250
Short name:
TAFII250
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF1
Synonyms:BA2R, CCG1, CCGS, TAF2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11535, TAF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		313650, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P21675

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147133

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 3, torsion, X-linked (DYT3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. It has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.
Related information in OMIM
Intellectual developmental disorder, X-linked, syndromic 33 (MRXS33)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, delayed speech and language, and characteristic facial features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076394575P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl.1
Natural variantiVAR_076395786C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl.1
Natural variantiVAR_076396955D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl.1
Natural variantiVAR_0763971225R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl.1
Natural variantiVAR_0763981316I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl.1
Natural variantiVAR_0763991431R → H in MRXS33; unknown pathological significance. 1 Publication1
Natural variantiVAR_0764001496N → H in MRXS33; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi137S → A: No decrease in kinase activity. 1 Publication1
Mutagenesisi145D → A: Reduces kinase activity; when associated with A-147; A-149; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi147D → A: Reduces kinase activity; when associated with A-145; A-149; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi149E → A: Reduces kinase activity; when associated with A-145; A-147; A-150; A-152 and A-154. 1 Publication1
Mutagenesisi150D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-152 and A-154. 1 Publication1
Mutagenesisi152D → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-154. 1 Publication1
Mutagenesisi154K → A: Reduces kinase activity; when associated with A-145; A-147; A-149; A-150 and A-152. 1 Publication1
Mutagenesisi305C → A: Reduces kinase activity; when associated with A-307; A-308; A-309 and A-310. 1 Publication1
Mutagenesisi307S → A: Reduces kinase activity; when associated with A-305; A-308; A-309 and A-310. 1 Publication1
Mutagenesisi308D → A: Reduces kinase activity; when associated with A-305; A-307; A-309 and A-310. 1 Publication1
Mutagenesisi309D → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-310. 1 Publication1
Mutagenesisi310E → A: Reduces kinase activity; when associated with A-305; A-307; A-308 and A-309. 1 Publication1
Mutagenesisi721E → Q: 25% decrease in histone acetylation. 1 Publication1
Mutagenesisi827 – 829Missing : Dramatic decrease in histone acetylation. 1 Publication3

Keywords - Diseasei

Disease variant, Dystonia, Mental retardation, Parkinsonism

Organism-specific databases

DisGeNET

More...DisGeNETi		6872

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TAF1

MalaCards human disease database

More...MalaCardsi		TAF1
MIMi300966, phenotype
314250, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		53351, X-linked dystonia-parkinsonism
480907, X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36310

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P21675, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3217390

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2231

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		115942

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112151 – 1872Transcription initiation factor TFIID subunit 1Add BLAST1872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei137Phosphoserine; by autocatalysis1 Publication1
Modified residuei307Phosphoserine; by autocatalysisCombined sources1 Publication1
Modified residuei544N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki562Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1669PhosphoserineBy similarity1
Modified residuei1672PhosphoserineBy similarity1
Modified residuei1778PhosphoserineBy similarity1
Modified residuei1781PhosphoserineBy similarity1
Modified residuei1799PhosphoserineBy similarity1
Modified residuei1826PhosphoserineCombined sources1
Isoform 3 (identifier: P21675-3)
Modified residuei1697PhosphoserineCombined sources1
Isoform 4 (identifier: P21675-4)
Modified residuei1700PhosphoserineCombined sources1
Isoform 2a (identifier: P21675-5)
Modified residuei1700PhosphoserineCombined sources1
Isoform 2g (identifier: P21675-9)
Modified residuei1702PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase II in vitro.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P21675

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P21675

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P21675

MaxQB - The MaxQuant DataBase

More...MaxQBi		P21675

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P21675

PeptideAtlas

More...PeptideAtlasi		P21675

PRoteomics IDEntifications database

More...PRIDEi		P21675

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3401
53886 [P21675-1]
53887 [P21675-2]
53888 [P21675-3]
53889 [P21675-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P21675, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P21675

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P21675

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147133, Expressed in sural nerve and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P21675, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P21675, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147133, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:7680771, PubMed:33795473).

Interacts with TAF7; the interaction is direct (PubMed:25412659, PubMed:11592977). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53 (PubMed:15053879).

Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846).

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). RB1 interacts with the N-terminal domain of TAF1 (PubMed:9858607).

Interacts with ASF1A and ASF1B (PubMed:10759893, PubMed:12093919, PubMed:12842904).

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (PubMed:22464331).

12 Publications

(Microbial infection) Interacts with SV40 Large T antigen.

1 Publication

(Microbial infection) Interacts with herpes simplex virus 1 ICP4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112735, 220 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P21675

Database of interacting proteins

More...DIPi		DIP-147N

Protein interaction database and analysis system

More...IntActi		P21675, 55 interactors

Molecular INTeraction database

More...MINTi		P21675

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000406549

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P21675

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P21675, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P21675

Small Angle Scattering Biological Data Bank

More...SASBDBi		P21675

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P21675

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P21675

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 414Protein kinase 1Add BLAST414
Domaini1397 – 1467Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1425 – 1872Protein kinase 2Add BLAST448
Domaini1520 – 1590Bromo 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 204DisorderedSequence analysisAdd BLAST56
Regioni513 – 536DisorderedSequence analysisAdd BLAST24
Regioni517 – 976Histone acetyltransferase (HAT)Add BLAST460
Regioni969 – 988DisorderedSequence analysisAdd BLAST20
Regioni1107 – 1127DisorderedSequence analysisAdd BLAST21
Regioni1137 – 1156DisorderedSequence analysisAdd BLAST20
Regioni1233 – 1257DisorderedSequence analysisAdd BLAST25
Regioni1342 – 1629Interaction with ASF1A and ASF1B1 PublicationAdd BLAST288
Regioni1630 – 1655DisorderedSequence analysisAdd BLAST26
Regioni1675 – 1872DisorderedSequence analysisAdd BLAST198

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1351 – 1358Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi178 – 197Polar residuesSequence analysisAdd BLAST20
Compositional biasi1717 – 1733Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1737 – 1751Polar residuesSequence analysisAdd BLAST15
Compositional biasi1803 – 1822Polar residuesSequence analysisAdd BLAST20
Compositional biasi1848 – 1872Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). The second domain also recognizes and binds histones that are butyrylated and crotonylated (PubMed:26365797).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0008, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000572_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P21675

Database of Orthologous Groups

More...OrthoDBi		103411at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P21675

TreeFam database of animal gene trees

More...TreeFami		TF313573

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1100.10, 1 hit
1.20.920.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00545

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR040240, TAF1
IPR011177, TAF1_animal
IPR022591, TAF1_HAT_dom
IPR009067, TAF_II_230-bd
IPR036741, TAFII-230_TBP-bd_sf
IPR041670, Znf-CCHC_6

The PANTHER Classification System

More...PANTHERi		PTHR13900, PTHR13900, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439, Bromodomain, 2 hits
PF12157, DUF3591, 1 hit
PF09247, TBP-binding, 1 hit
PF15288, zf-CCHC_6, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003047, TAF1_animal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297, BROMO, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47055, SSF47055, 1 hit
SSF47370, SSF47370, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: the TAF1/DYT3 multiple transcript system is composed of 38 evolutionary conserved exons plus 5 downstream exons referred to as exons d1-d5 that are primate-specific. Multiple highly polymorphic variants can be generated by splicing exons d3 and d4 to various combinations of exons 1-37.

This entry has 12 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21675-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGCDLLLR TAATITAAAI MSDTDSDEDS AGGGPFSLAG FLFGNINGAG 
        60         70         80         90        100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELTGT DGALVNDEGW 
       110        120        130        140        150
VRSTEDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHSDYD EDDYDADCED 
       160        170        180        190        200
IDCKLMPPPP PPPGPMKKDK DQDSITGEKV DFSSSSDSES EMGPQEATQA 
       210        220        230        240        250
ESEDGKLTLP LAGIMQHDAT KLLPSVTELF PEFRPGKVLR FLRLFGPGKN 
       260        270        280        290        300
VPSVWRSARR KRKKKHRELI QEEQIQEVEC SVESEVSQKS LWNYDYAPPP 
       310        320        330        340        350
PPEQCLSDDE ITMMAPVESK FSQSTGDIDK VTDTKPRVAE WRYGPARLWY 
       360        370        380        390        400
DMLGVPEDGS GFDYGFKLRK TEHEPVIKSR MIEEFRKLEE NNGTDLLADE 
       410        420        430        440        450
NFLMVTQLHW EDDIIWDGED VKHKGTKPQR ASLAGWLPSS MTRNAMAYNV 
       460        470        480        490        500
QQGFAATLDD DKPWYSIFPI DNEDLVYGRW EDNIIWDAQA MPRLLEPPVL 
       510        520        530        540        550
TLDPNDENLI LEIPDEKEEA TSNSPSKESK KESSLKKSRI LLGKTGVIKE 
       560        570        580        590        600
EPQQNMSQPE VKDPWNLSND EYYYPKQQGL RGTFGGNIIQ HSIPAVELRQ 
       610        620        630        640        650
PFFPTHMGPI KLRQFHRPPL KKYSFGALSQ PGPHSVQPLL KHIKKKAKMR 
       660        670        680        690        700
EQERQASGGG EMFFMRTPQD LTGKDGDLIL AEYSEENGPL MMQVGMATKI 
       710        720        730        740        750
KNYYKRKPGK DPGAPDCKYG ETVYCHTSPF LGSLHPGQLL QAFENNLFRA 
       760        770        780        790        800
PIYLHKMPET DFLIIRTRQG YYIRELVDIF VVGQQCPLFE VPGPNSKRAN 
       810        820        830        840        850
THIRDFLQVF IYRLFWKSKD RPRRIRMEDI KKAFPSHSES SIRKRLKLCA 
       860        870        880        890        900
DFKRTGMDSN WWVLKSDFRL PTEEEIRAMV SPEQCCAYYS MIAAEQRLKD 
       910        920        930        940        950
AGYGEKSFFA PEEENEEDFQ MKIDDEVRTA PWNTTRAFIA AMKGKCLLEV 
       960        970        980        990       1000
TGVADPTGCG EGFSYVKIPN KPTQQKDDKE PQPVKKTVTG TDADLRRLSL 
      1010       1020       1030       1040       1050
KNAKQLLRKF GVPEEEIKKL SRWEVIDVVR TMSTEQARSG EGPMSKFARG 
      1060       1070       1080       1090       1100
SRFSVAEHQE RYKEECQRIF DLQNKVLSST EVLSTDTDSS SAEDSDFEEM 
      1110       1120       1130       1140       1150
GKNIENMLQN KKTSSQLSRE REEQERKELQ RMLLAAGSAA SGNNHRDDDT 
      1160       1170       1180       1190       1200
ASVTSLNSSA TGRCLKIYRT FRDEEGKEYV RCETVRKPAV IDAYVRIRTT 
      1210       1220       1230       1240       1250
KDEEFIRKFA LFDEQHREEM RKERRRIQEQ LRRLKRNQEK EKLKGPPEKK 
      1260       1270       1280       1290       1300
PKKMKERPDL KLKCGACGAI GHMRTNKFCP LYYQTNAPPS NPVAMTEEQE 
      1310       1320       1330       1340       1350
EELEKTVIHN DNEELIKVEG TKIVLGKQLI ESADEVRRKS LVLKFPKQQL 
      1360       1370       1380       1390       1400
PPKKKRRVGT TVHCDYLNRP HKSIHRRRTD PMVTLSSILE SIINDMRDLP 
      1410       1420       1430       1440       1450
NTYPFHTPVN AKVVKDYYKI ITRPMDLQTL RENVRKRLYP SREEFREHLE 
      1460       1470       1480       1490       1500
LIVKNSATYN GPKHSLTQIS QSMLDLCDEK LKEKEDKLAR LEKAINPLLD 
      1510       1520       1530       1540       1550
DDDQVAFSFI LDNIVTQKMM AVPDSWPFHH PVNKKFVPDY YKVIVNPMDL 
      1560       1570       1580       1590       1600
ETIRKNISKH KYQSRESFLD DVNLILANSV KYNGPESQYT KTAQEIVNVC 
      1610       1620       1630       1640       1650
YQTLTEYDEH LTQLEKDICT AKEAALEEAE LESLDPMTPG PYTPQPPDLY 
      1660       1670       1680       1690       1700
DTNTSLSMSR DASVFQDESN MSVLDIPSAT PEKQVTQEGE DGDGDLADEE 
      1710       1720       1730       1740       1750
EGTVQQPQAS VLYEDLLMSE GEDDEEDAGS DEEGDNPFSA IQLSESGSDS 
      1760       1770       1780       1790       1800
DVGSGGIRPK QPRMLQENTR MDMENEESMM SYEGDGGEAS HGLEDSNISY 
      1810       1820       1830       1840       1850
GSYEEPDPKS NTQDTSFSSI GGYEVSEEEE DEEEEEQRSG PSVLSQVHLS 
      1860       1870 
EDEEDSEDFH SIAGDSDLDS DE
Length:1,872
Mass (Da):212,677
Last modified:May 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93BE3D181A72ABEB
GO
Isoform 2 (identifier: P21675-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: G → GVSENGEGIILPSIIAPSSLAS

Show »
Length:1,893
Mass (Da):214,714
Checksum:iAE148C222B418BB4
GO
Isoform 3 (identifier: P21675-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1686: Missing.
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,832
Mass (Da):208,364
Checksum:i6C51A0F5885FF667
GO
Isoform 4 (identifier: P21675-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP

Show »
Length:1,906
Mass (Da):216,451
Checksum:i8880885A3D444515
GO
Isoform 2a (identifier: P21675-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,835
Mass (Da):208,693
Checksum:i4EF338B27B304C13
GO
Isoform 2c (identifier: P21675-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,801
Mass (Da):204,919
Checksum:i245D4080FB804D6D
GO
Isoform 2d (identifier: P21675-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1645-1645: Q → QAK
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,803
Mass (Da):205,118
Checksum:i1B90B7A234BDB92C
GO
Isoform 2e (identifier: P21675-8) [UniParc]FASTAAdd to basket
Also known as: 2F

The sequence of this isoform differs from the canonical sequence as follows:
     1585-1592: PESQYTKT → YMCTTCRT
     1593-1872: Missing.

Show »
Length:1,592
Mass (Da):182,054
Checksum:i72C8271DD47EE24D
GO
Isoform 2g (identifier: P21675-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1645-1645: Q → QAK
     1687-1687: Q → QMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAP
     1799-1872: SYGSYEEPDP...AGDSDLDSDE → RYQ

Show »
Length:1,837
Mass (Da):208,892
Checksum:i5165FAF620722AD3
GO
Isoform 2h (identifier: P21675-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1525-1528: SWPF → IITK
     1529-1872: Missing.

Show »
Length:1,528
Mass (Da):174,433
Checksum:i75267CFDD8211DD6
GO
Isoform 2i (identifier: P21675-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1525-1540: SWPFHHPVNKKFVPDY → VSCLCAKYFLAISSPS
     1541-1872: Missing.

Show »
Length:1,540
Mass (Da):175,648
Checksum:i4DC37D3B71D7AA10
GO
Isoform N-TAF1 (identifier: P21675-12) [UniParc]FASTAAdd to basket
Also known as: TA14-391

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: G → GVSENGEGIILPSIIAPSSLAS
     1645-1645: Q → QAK

Note: Only detected in brain, highest expression in the caudate nucleus.Curated
Show »
Length:1,895
Mass (Da):214,913
Checksum:i68B48D4582D8A090
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A804HIC2A0A804HIC2_HUMAN
Transcription initiation factor TFI...
TAF1
1,907Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HK58A0A804HK58_HUMAN
Transcription initiation factor TFI...
TAF1
1,877Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HIY8A0A804HIY8_HUMAN
Transcription initiation factor TFI...
TAF1
1,598Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY98H7BY98_HUMAN
Transcription initiation factor TFI...
TAF1
458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2K9H7C2K9_HUMAN
Transcription initiation factor TFI...
TAF1
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9L7H0Y9L7_HUMAN
Transcription initiation factor TFI...
TAF1
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HHS0A0A804HHS0_HUMAN
Transcription initiation factor TFI...
TAF1
840Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HLH3A0A804HLH3_HUMAN
Transcription initiation factor TFI...
TAF1
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HJ48A0A804HJ48_HUMAN
Transcription initiation factor TFI...
TAF1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HJ34A0A804HJ34_HUMAN
Transcription initiation factor TFI...
TAF1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020678269L → V2 PublicationsCorresponds to variant dbSNP:rs28382158Ensembl.1
Natural variantiVAR_041930297A → G1 PublicationCorresponds to variant dbSNP:rs35317750Ensembl.1
Natural variantiVAR_041931453G → D in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_077838472N → D Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200177996Ensembl.1
Natural variantiVAR_076394575P → S in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321630Ensembl.1
Natural variantiVAR_041932651E → K in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041933691M → I in a lung bronchoalveolar carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_076395786C → R in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321628Ensembl.1
Natural variantiVAR_076396955D → H in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321631Ensembl.1
Natural variantiVAR_0778391169R → C Found in a patient with X-linked intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1569301036Ensembl.1
Natural variantiVAR_0763971225R → W in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321629Ensembl.1
Natural variantiVAR_0763981316I → T in MRXS33. 1 PublicationCorresponds to variant dbSNP:rs864321627Ensembl.1
Natural variantiVAR_0484331383V → I. Corresponds to variant dbSNP:rs7050748Ensembl.1
Natural variantiVAR_0763991431R → H in MRXS33; unknown pathological significance. 1 Publication1
Natural variantiVAR_0764001496N → H in MRXS33; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012362177G → GVSENGEGIILPSIIAPSSL AS in isoform 2 and isoform N-TAF1. 1 Publication1
Alternative sequenceiVSP_0533761525 – 1540SWPFH…FVPDY → VSCLCAKYFLAISSPS in isoform 2i. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0533751525 – 1528SWPF → IITK in isoform 2h. 1 Publication4
Alternative sequenceiVSP_0533771529 – 1872Missing in isoform 2h. 1 PublicationAdd BLAST344
Alternative sequenceiVSP_0533781541 – 1872Missing in isoform 2i. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0533791585 – 1592PESQYTKT → YMCTTCRT in isoform 2e. 2 Publications8
Alternative sequenceiVSP_0533801593 – 1872Missing in isoform 2e. 2 PublicationsAdd BLAST280
Alternative sequenceiVSP_0533811645Q → QAK in isoform 2d, isoform 2g and isoform N-TAF1. 3 Publications1
Alternative sequenceiVSP_0533821684 – 1686Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0533831687Q → QMRQGRGRLGEEDSDVDIEG YDDEEEDGKPKTPAP in isoform 2g, isoform 2a, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_0533841799 – 1872SYGSY…LDSDE → RYQ in isoform 2g, isoform 2a, isoform 2c, isoform 2d and isoform 3. 2 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D90359 mRNA Translation: BAA14374.1
X07024 mRNA Translation: CAA30073.1 Sequence problems.
AB300418 mRNA Translation: BAG15901.1
AY623109 Genomic DNA Translation: AAT38105.1
AL590762 Genomic DNA No translation available.
AL590763 Genomic DNA No translation available.
AB209316 mRNA Translation: BAD92553.1
AJ549247 mRNA Translation: CAD70490.1
AJ549248 mRNA Translation: CAD70491.3
AJ549249 mRNA Translation: CAD70492.2
AJ549250 mRNA Translation: CAD70493.3
AJ555148 mRNA Translation: CAD87527.2
AJ555149 mRNA Translation: CAD87528.2
AM711892 mRNA Translation: CAM98555.1
AM711893 mRNA Translation: CAM98556.1
AM711894 mRNA Translation: CAM98557.1
AM711895 mRNA Translation: CAM98558.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40262

NCBI Reference Sequences

More...RefSeqi		NP_001273003.1, NM_001286074.1
NP_004597.2, NM_004606.4
NP_620278.1, NM_138923.3
XP_005262354.1, XM_005262297.4 [P21675-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276072.9; ENSP00000276072.5; ENSG00000147133.17
ENST00000373790.9; ENSP00000362895.5; ENSG00000147133.17
ENST00000423759.6; ENSP00000406549.2; ENSG00000147133.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6872

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6872

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000423759.6; ENSP00000406549.2; NM_004606.5; NP_004597.3

UCSC genome browser

More...UCSCi		uc004dzt.6, human [P21675-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90359 mRNA Translation: BAA14374.1
X07024 mRNA Translation: CAA30073.1 Sequence problems.
AB300418 mRNA Translation: BAG15901.1
AY623109 Genomic DNA Translation: AAT38105.1
AL590762 Genomic DNA No translation available.
AL590763 Genomic DNA No translation available.
AB209316 mRNA Translation: BAD92553.1
AJ549247 mRNA Translation: CAD70490.1
AJ549248 mRNA Translation: CAD70491.3
AJ549249 mRNA Translation: CAD70492.2
AJ549250 mRNA Translation: CAD70493.3
AJ555148 mRNA Translation: CAD87527.2
AJ555149 mRNA Translation: CAD87528.2
AM711892 mRNA Translation: CAM98555.1
AM711893 mRNA Translation: CAM98556.1
AM711894 mRNA Translation: CAM98557.1
AM711895 mRNA Translation: CAM98558.1
PIRiA40262
RefSeqiNP_001273003.1, NM_001286074.1
NP_004597.2, NM_004606.4
NP_620278.1, NM_138923.3
XP_005262354.1, XM_005262297.4 [P21675-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQFX-ray2.10A1359-1638[»]
3AADX-ray3.30A1342-1629[»]
3UV4X-ray1.89A/B1501-1635[»]
3UV5X-ray2.03A1373-1635[»]
4RGWX-ray2.30A579-1215[»]
4YYMX-ray1.50A/B1497-1638[»]
4YYNX-ray1.85A/B1497-1638[»]
5FURelectron microscopy8.50G1-1872[»]
5I1QX-ray1.50A1497-1638[»]
5I29X-ray1.21A1497-1638[»]
5MG2X-ray1.75A1501-1635[»]
6BQDX-ray2.14A/B1501-1630[»]
6FICX-ray2.18T1359-1638[»]
6MZDelectron microscopy9.80A21-1872[»]
6MZLelectron microscopy23.00A1-1872[»]
6MZMelectron microscopy7.50A588-1083[»]
6P38X-ray2.80A1501-1635[»]
6P39X-ray2.94A1500-1635[»]
6P3AX-ray2.99A/B1501-1635[»]
7EDXelectron microscopy4.50A1-1872[»]
7EG7electron microscopy6.20A1-1872[»]
7EG8electron microscopy7.40A1-1872[»]
7EG9electron microscopy3.70A1-1872[»]
7EGAelectron microscopy4.10A1-1872[»]
7EGBelectron microscopy3.30A1-1872[»]
7EGCelectron microscopy3.90A1-1872[»]
7EGDelectron microscopy6.75A1-1872[»]
7EGEelectron microscopy9.00A1-1872[»]
7EGHelectron microscopy3.04A1-1872[»]
7EGIelectron microscopy9.82A1-1872[»]
7EGJelectron microscopy8.64A1-1872[»]
7ENAelectron microscopy4.07DA1-1872[»]
7ENCelectron microscopy4.13DA1-1872[»]
7JJGX-ray1.60A1501-1635[»]
7JJHX-ray2.10A1373-1635[»]
7JSPX-ray1.70A1501-1635[»]
7JTCX-ray2.05A1501-1635[»]
7K03X-ray1.60A1373-1635[»]
7K0DX-ray2.20A1373-1635[»]
7K0UX-ray2.52A/B1501-1635[»]
7K1PX-ray2.45A1501-1635[»]
7K27X-ray1.50A1373-1635[»]
7K3OX-ray1.70A/B1501-1635[»]
7K42X-ray1.70A/B1501-1635[»]
7K6FX-ray1.86A1373-1635[»]
7L6XX-ray2.75A1373-1635[»]
7LB0X-ray2.33A1373-1635[»]
7LB1X-ray1.35A1373-1635[»]
7LB2X-ray1.70A1373-1635[»]
7LB3X-ray1.90A1501-1635[»]
7N42X-ray1.90A1373-1635[»]
7P4SX-ray2.17A1501-1635[»]
7T2IX-ray1.89A1373-1635[»]
7T36X-ray1.65A1373-1635[»]
AlphaFoldDBiP21675
SASBDBiP21675
SMRiP21675
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112735, 220 interactors
ComplexPortaliCPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CORUMiP21675
DIPiDIP-147N
IntActiP21675, 55 interactors
MINTiP21675
STRINGi9606.ENSP00000406549

Chemistry databases

BindingDBiP21675
ChEMBLiCHEMBL3217390
GuidetoPHARMACOLOGYi2231

PTM databases

GlyGeniP21675, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP21675
PhosphoSitePlusiP21675

Genetic variation databases

BioMutaiTAF1
DMDMi115942

Proteomic databases

EPDiP21675
jPOSTiP21675
MassIVEiP21675
MaxQBiP21675
PaxDbiP21675
PeptideAtlasiP21675
PRIDEiP21675
ProteomicsDBi3401
53886 [P21675-1]
53887 [P21675-2]
53888 [P21675-3]
53889 [P21675-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P21675, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		346, 290 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		6872

Genome annotation databases

EnsembliENST00000276072.9; ENSP00000276072.5; ENSG00000147133.17
ENST00000373790.9; ENSP00000362895.5; ENSG00000147133.17
ENST00000423759.6; ENSP00000406549.2; ENSG00000147133.17
GeneIDi6872
KEGGihsa:6872
MANE-SelectiENST00000423759.6; ENSP00000406549.2; NM_004606.5; NP_004597.3
UCSCiuc004dzt.6, human [P21675-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6872
DisGeNETi6872

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAF1
GeneReviewsiTAF1
HGNCiHGNC:11535, TAF1
HPAiENSG00000147133, Low tissue specificity
MalaCardsiTAF1
MIMi300966, phenotype
313650, gene
314250, phenotype
neXtProtiNX_P21675
Orphaneti53351, X-linked dystonia-parkinsonism
480907, X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome
PharmGKBiPA36310
VEuPathDBiHostDB:ENSG00000147133

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0008, Eukaryota
HOGENOMiCLU_000572_3_0_1
InParanoidiP21675
OrthoDBi103411at2759
PhylomeDBiP21675
TreeFamiTF313573

Enzyme and pathway databases

BRENDAi2.3.1.48, 2681
PathwayCommonsiP21675
ReactomeiR-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
SignaLinkiP21675
SIGNORiP21675

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6872, 329 hits in 737 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TAF1, human
EvolutionaryTraceiP21675

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6872
PharosiP21675, Tchem

Protein Ontology

More...PROi		PR:P21675
RNActiP21675, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147133, Expressed in sural nerve and 226 other tissues
ExpressionAtlasiP21675, baseline and differential
GenevisibleiP21675, HS

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
IDEALiIID00545
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR040240, TAF1
IPR011177, TAF1_animal
IPR022591, TAF1_HAT_dom
IPR009067, TAF_II_230-bd
IPR036741, TAFII-230_TBP-bd_sf
IPR041670, Znf-CCHC_6
PANTHERiPTHR13900, PTHR13900, 1 hit
PfamiView protein in Pfam
PF00439, Bromodomain, 2 hits
PF12157, DUF3591, 1 hit
PF09247, TBP-binding, 1 hit
PF15288, zf-CCHC_6, 1 hit
PIRSFiPIRSF003047, TAF1_animal, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SUPFAMiSSF47055, SSF47055, 1 hit
SSF47370, SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21675
Secondary accession number(s): A5CVC8
, A5CVC9, A5CVD0, A5CVD1, B1Q2X3, Q59FZ3, Q6IUZ1, Q70Q86, Q70Q87, Q70T00, Q70T01, Q70T02, Q70T03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1992
Last modified: May 25, 2022
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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