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UniProtKB - P21673 (SAT1_HUMAN)

Entry version 201 (07 Apr 2021)
Sequence version 1 (01 May 1991)
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Protein

Diamine acetyltransferase 1

Gene

SAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N1-acetylspermine > putrescine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine (PubMed:16455797, PubMed:17516632).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 8.7 sec(-1) with spermidine as substrate (PubMed:15283699). kcat is 5 sec(-1) with spermine as substrate (PubMed:15283699).1 Publication
  1. KM=3.8 µM for acetyl-coenzyme A1 Publication
  2. KM=5.7 µM for spermine1 Publication
  3. KM=3.7 µM for spermine1 Publication
  4. KM=22 µM for spermidine1 Publication
  5. KM=58 µM for spermidine1 Publication

    pH dependencei

    Optimum pH is 8.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine degradation

    This protein is involved in step 1 of the subpathway that synthesizes N-acetylputrescine from putrescine.2 Publications
    Proteins known to be involved in this subpathway in this organism are:
    1. Diamine acetyltransferase 1 (SAT1), Diamine acetyltransferase 1, Diamine acetyltransferase 1 (SAT1), Diamine acetyltransferase 1 (AILE3)
    This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetylputrescine from putrescine, the pathway putrescine degradation and in Amine and polyamine degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92Substrate; via carbonyl oxygen1 Publication1
    Binding sitei152Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS05339-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.3.1.57, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P21673

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-351200, Interconversion of polyamines

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P21673

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00188;UER00363

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Diamine acetyltransferase 1Curated (EC:2.3.1.573 Publications)
    Alternative name(s):
    Polyamine N-acetyltransferase 1Curated
    Putrescine acetyltransferase1 Publication
    Spermidine/spermine N(1)-acetyltransferase 12 Publications
    Short name:
    SSAT2 Publications
    Short name:
    SSAT-1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SAT1Imported
    Synonyms:SAT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:10540, SAT1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		313020, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P21673

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000130066.16

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Overexpression of SAT1 and the consequent putrescine accumulation might play a role in the pathogenesis of keratosis follicularis spinulosa decalvans.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi140Y → F: Reduces activity by 95%. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		6303

    MalaCards human disease database

    More...    MalaCardsi    		SAT1

    Open Targets

    More...    OpenTargetsi    		ENSG00000130066

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		2340, Keratosis follicularis spinulosa decalvans

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA162402389

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P21673, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4286

    Drug and drug target database

    More...    DrugBanki    		DB04633, N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
    DB00127, Spermine

    DrugCentral

    More...    DrugCentrali    		P21673

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		SAT1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		114322

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745911 – 171Diamine acetyltransferase 1Add BLAST171

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P21673

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P21673

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P21673

    PeptideAtlas

    More...    PeptideAtlasi    		P21673

    PRoteomics IDEntifications database

    More...    PRIDEi    		P21673

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		53885

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P21673

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P21673

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000130066, Expressed in palpebral conjunctiva and 239 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P21673, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P21673, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000130066, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details
    P21673
    With#Exp.IntAct
    ABHD15 [Q6UXT9]3EBI-711613,EBI-2824666
    APP [P05067]3EBI-711613,EBI-77613
    BHLHA9 [Q7RTU4]3EBI-711613,EBI-17508719
    C19orf25 [Q9UFG5]3EBI-711613,EBI-741214
    CASP7 [P55210]6EBI-711613,EBI-523958
    CCDC148 [Q8NFR7]5EBI-711613,EBI-2349862
    CCHCR1 - isoform 3 [Q8TD31-3]6EBI-711613,EBI-10175300
    CDC42EP1 - isoform 2 [Q00587-2]3EBI-711613,EBI-11027409
    COX6C [P09669]3EBI-711613,EBI-715040
    DDX39A [O00148]3EBI-711613,EBI-348253
    DIPK1B [Q5VUD6]6EBI-711613,EBI-721274
    DMRT3 [Q9NQL9]6EBI-711613,EBI-9679045
    EIF3D [O15371]3EBI-711613,EBI-353818
    FAM156A [Q8NDB6]3EBI-711613,EBI-749727
    FAM228A [Q86W67]3EBI-711613,EBI-12958227
    FAM86C1P - isoform 2 [Q9NVL1-2]3EBI-711613,EBI-12845222
    FH [P07954]3EBI-711613,EBI-1050358
    GAS2L2 [Q8NHY3]3EBI-711613,EBI-7960826
    HOXB9 [P17482]6EBI-711613,EBI-745290
    KCNA4 [P22459]4EBI-711613,EBI-631235
    KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-711613,EBI-9089060
    LHX3 - isoform B [Q9UBR4-2]5EBI-711613,EBI-12039345
    LNX1 [Q8TBB1]8EBI-711613,EBI-739832
    LYRM7 [Q5U5X0]3EBI-711613,EBI-13943106
    MEOX2 [Q6FHY5]3EBI-711613,EBI-16439278
    MRPL12 [P52815]3EBI-711613,EBI-358272
    MTA1 [Q13330]3EBI-711613,EBI-714236
    MYPOP [Q86VE0]3EBI-711613,EBI-2858213
    NIF3L1 [Q9GZT8]5EBI-711613,EBI-740897
    NTAQ1 [Q96HA8]3EBI-711613,EBI-741158
    PSMA1 [P25786]3EBI-711613,EBI-359352
    RBM17 [Q96I25]13EBI-711613,EBI-740272
    REL [Q04864]3EBI-711613,EBI-307352
    RPP25 [Q9BUL9]8EBI-711613,EBI-366570
    itself4EBI-711613,EBI-711613
    SAT2 [Q96F10]5EBI-711613,EBI-748746
    SNAI2 [O43623]3EBI-711613,EBI-9876238
    TACO1 [Q9BSH4]4EBI-711613,EBI-747797
    TCF25 [Q9BQ70]11EBI-711613,EBI-745182
    TEAD4 [Q15561]3EBI-711613,EBI-747736
    TEX43 [Q6ZNM6]3EBI-711613,EBI-18115728
    TLE5 - isoform 2 [Q08117-2]3EBI-711613,EBI-11741437
    TNNI1 [P19237]3EBI-711613,EBI-746692
    TXN2 [Q99757]3EBI-711613,EBI-2932492
    USHBP1 [Q8N6Y0]3EBI-711613,EBI-739895

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		112210, 98 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-36801N

    Protein interaction database and analysis system

    More...    IntActi    		P21673, 93 interactors

    Molecular INTeraction database

    More...    MINTi    		P21673

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000368572

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P21673

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P21673, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1171
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P21673

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P21673

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 171N-acetyltransferasePROSITE-ProRule annotationAdd BLAST168

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 28Substrate binding1 Publication2
    Regioni94 – 96Acetyl-CoA binding1 Publication3
    Regioni102 – 107Acetyl-CoA binding1 Publication6
    Regioni126 – 128Substrate binding1 Publication3
    Regioni133 – 136Acetyl-CoA binding1 Publication4
    Regioni140 – 143Acetyl-CoA binding1 Publication4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acetyltransferase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3216, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00950000183121

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_013985_41_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P21673

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		EDFYVMA

    Database of Orthologous Groups

    More...    OrthoDBi    		1228251at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P21673

    TreeFam database of animal gene trees

    More...    TreeFami    		TF319736

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR016181, Acyl_CoA_acyltransferase
    IPR000182, GNAT_dom
    IPR032957, SAT1

    The PANTHER Classification System

    More...    PANTHERi    		PTHR10545:SF36, PTHR10545:SF36, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00583, Acetyltransf_1, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF55729, SSF55729, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51186, GNAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P21673-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP 
            60         70         80         90        100
    FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY 
           110        120        130        140        150
    RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS 
           160        170 
    EEGWRLFKID KEYLLKMATE E
    Length:171
    Mass (Da):20,024
    Last modified:May 1, 1991 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A0578B88CD72F09
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PD37E9PD37_HUMAN
    Diamine acetyltransferase 1
    SAT1
    		143Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A6NJE6A6NJE6_HUMAN
    Diamine acetyltransferase 1
    SAT1
    		150Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A6NM56A6NM56_HUMAN
    Diamine acetyltransferase 1
    SAT1
    		120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26K → E in CAA78509 (PubMed:1417826).Curated1
    Sequence conflicti26K → E in AAA98854 (PubMed:8573111).Curated1
    Sequence conflicti69H → G AA sequence (PubMed:2241897).Curated1
    Sequence conflicti84W → P AA sequence (PubMed:2241897).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M77693 mRNA Translation: AAA60573.1
    M55580 mRNA Translation: AAA63260.1
    Z14136 Genomic DNA Translation: CAA78509.1
    U40369 Genomic DNA Translation: AAA98854.1
    BT006825 mRNA Translation: AAP35471.1
    CR450294 mRNA Translation: CAG29290.1
    AK312162 mRNA Translation: BAG35096.1
    CH471074 Genomic DNA Translation: EAW99000.1
    BC002503 mRNA Translation: AAH02503.1
    BC008424 mRNA Translation: AAH08424.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS14207.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JH0783

    NCBI Reference Sequences

    More...    RefSeqi    		NP_002961.1, NM_002970.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000379270; ENSP00000368572; ENSG00000130066

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		6303

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:6303

    UCSC genome browser

    More...    UCSCi    		uc004dau.5, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M77693 mRNA Translation: AAA60573.1
    M55580 mRNA Translation: AAA63260.1
    Z14136 Genomic DNA Translation: CAA78509.1
    U40369 Genomic DNA Translation: AAA98854.1
    BT006825 mRNA Translation: AAP35471.1
    CR450294 mRNA Translation: CAG29290.1
    AK312162 mRNA Translation: BAG35096.1
    CH471074 Genomic DNA Translation: EAW99000.1
    BC002503 mRNA Translation: AAH02503.1
    BC008424 mRNA Translation: AAH08424.1
    CCDSiCCDS14207.1
    PIRiJH0783
    RefSeqiNP_002961.1, NM_002970.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2B3UX-ray1.85A/B1-171[»]
    2B3VX-ray1.95A1-171[»]
    2B4BX-ray2.00A/B1-171[»]
    2B4DX-ray2.00A/B1-171[»]
    2B58X-ray1.95A1-171[»]
    2B5GX-ray1.70A/B1-171[»]
    2F5IX-ray2.30A/B1-171[»]
    2FXFX-ray2.00A/B2-171[»]
    2G3TX-ray1.80A/B1-171[»]
    2JEVX-ray2.30A/B1-171[»]
    SMRiP21673
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi112210, 98 interactors
    DIPiDIP-36801N
    IntActiP21673, 93 interactors
    MINTiP21673
    STRINGi9606.ENSP00000368572

    Chemistry databases

    BindingDBiP21673
    ChEMBLiCHEMBL4286
    DrugBankiDB04633, N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
    DB00127, Spermine
    DrugCentraliP21673

    PTM databases

    iPTMnetiP21673
    PhosphoSitePlusiP21673

    Genetic variation databases

    BioMutaiSAT1
    DMDMi114322

    Proteomic databases

    EPDiP21673
    MassIVEiP21673
    PaxDbiP21673
    PeptideAtlasiP21673
    PRIDEiP21673
    ProteomicsDBi53885

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		24525, 253 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		6303

    Genome annotation databases

    EnsembliENST00000379270; ENSP00000368572; ENSG00000130066
    GeneIDi6303
    KEGGihsa:6303
    UCSCiuc004dau.5, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		6303
    DisGeNETi6303

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		SAT1
    HGNCiHGNC:10540, SAT1
    HPAiENSG00000130066, Low tissue specificity
    MalaCardsiSAT1
    MIMi313020, gene
    neXtProtiNX_P21673
    OpenTargetsiENSG00000130066
    Orphaneti2340, Keratosis follicularis spinulosa decalvans
    PharmGKBiPA162402389
    VEuPathDBiHostDB:ENSG00000130066.16

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3216, Eukaryota
    GeneTreeiENSGT00950000183121
    HOGENOMiCLU_013985_41_1_1
    InParanoidiP21673
    OMAiEDFYVMA
    OrthoDBi1228251at2759
    PhylomeDBiP21673
    TreeFamiTF319736

    Enzyme and pathway databases

    UniPathwayiUPA00188;UER00363
    BioCyciMetaCyc:HS05339-MONOMER
    BRENDAi2.3.1.57, 2681
    PathwayCommonsiP21673
    ReactomeiR-HSA-351200, Interconversion of polyamines
    SIGNORiP21673

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		6303, 6 hits in 628 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		SAT1, human
    EvolutionaryTraceiP21673

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		SAT1_(gene)

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		6303
    PharosiP21673, Tbio

    Protein Ontology

    More...    PROi    		PR:P21673
    RNActiP21673, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000130066, Expressed in palpebral conjunctiva and 239 other tissues
    ExpressionAtlasiP21673, baseline and differential
    GenevisibleiP21673, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016181, Acyl_CoA_acyltransferase
    IPR000182, GNAT_dom
    IPR032957, SAT1
    PANTHERiPTHR10545:SF36, PTHR10545:SF36, 1 hit
    PfamiView protein in Pfam
    PF00583, Acetyltransf_1, 1 hit
    SUPFAMiSSF55729, SSF55729, 1 hit
    PROSITEiView protein in PROSITE
    PS51186, GNAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAT1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21673
    Secondary accession number(s): Q6ICU9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: April 7, 2021
    This is version 201 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
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