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Entry version 205 (25 May 2022)
Sequence version 1 (01 May 1991)
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Protein

Diamine acetyltransferase 1

Gene

SAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632).

Substrate specificity: norspermidine = spermidine >> spermine > N1-acetylspermine > putrescine (PubMed:17516632).

This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797).

Also involved in the regulation of polyamine transport out of cells (PubMed:16455797).

Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine (PubMed:16455797, PubMed:17516632).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 8.7 sec(-1) with spermidine as substrate (PubMed:15283699). kcat is 5 sec(-1) with spermine as substrate (PubMed:15283699).1 Publication
  1. KM=3.8 µM for acetyl-coenzyme A1 Publication
  2. KM=5.7 µM for spermine1 Publication
  3. KM=3.7 µM for spermine1 Publication
  4. KM=22 µM for spermidine1 Publication
  5. KM=58 µM for spermidine1 Publication

pH dependencei

Optimum pH is 8.0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes N-acetylputrescine from putrescine.2 Publications This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetylputrescine from putrescine, the pathway putrescine degradation and in Amine and polyamine degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei92Substrate; via carbonyl oxygen1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Proton donorBy similarity1
Binding sitei152Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.57, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P21673

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-351200, Interconversion of polyamines

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P21673

SIGNOR Signaling Network Open Resource

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SIGNORi
P21673

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00188;UER00363

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diamine acetyltransferase 1Curated (EC:2.3.1.573 Publications)
Alternative name(s):
Polyamine N-acetyltransferase 1Curated
Putrescine acetyltransferase1 Publication
Spermidine/spermine N(1)-acetyltransferase 12 Publications
Short name:
SSAT2 Publications
Short name:
SSAT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAT1Imported
Synonyms:SAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10540, SAT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
313020, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P21673

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000130066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Overexpression of SAT1 and the consequent putrescine accumulation might play a role in the pathogenesis of keratosis follicularis spinulosa decalvans.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi140Y → F: Reduces activity by 95%. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6303

MalaCards human disease database

More...
MalaCardsi
SAT1

Open Targets

More...
OpenTargetsi
ENSG00000130066

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2340, Keratosis follicularis spinulosa decalvans

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402389

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21673, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4286

Drug and drug target database

More...
DrugBanki
DB04633, N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
DB00127, Spermine

DrugCentral

More...
DrugCentrali
P21673

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745911 – 171Diamine acetyltransferase 1Add BLAST171

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21673

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P21673

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21673

PeptideAtlas

More...
PeptideAtlasi
P21673

PRoteomics IDEntifications database

More...
PRIDEi
P21673

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53885

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21673

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21673

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130066, Expressed in palpebral conjunctiva and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21673, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21673, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130066, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P21673
With#Exp.IntAct
ABHD15 [Q6UXT9]3EBI-711613,EBI-2824666
APP [P05067]3EBI-711613,EBI-77613
BHLHA9 [Q7RTU4]3EBI-711613,EBI-17508719
C19orf25 [Q9UFG5]3EBI-711613,EBI-741214
CASP7 [P55210]6EBI-711613,EBI-523958
CCDC148 [Q8NFR7]5EBI-711613,EBI-2349862
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-711613,EBI-10175300
CDC42EP1 - isoform 2 [Q00587-2]3EBI-711613,EBI-11027409
COX6C [P09669]3EBI-711613,EBI-715040
DDX39A [O00148]3EBI-711613,EBI-348253
DIPK1B [Q5VUD6]6EBI-711613,EBI-721274
DMRT3 [Q9NQL9]6EBI-711613,EBI-9679045
EIF3D [O15371]3EBI-711613,EBI-353818
FAM156A [Q8NDB6]3EBI-711613,EBI-749727
FAM228A [Q86W67]3EBI-711613,EBI-12958227
FAM86C1P - isoform 2 [Q9NVL1-2]3EBI-711613,EBI-12845222
FH [P07954]3EBI-711613,EBI-1050358
GAS2L2 [Q8NHY3]3EBI-711613,EBI-7960826
HOXB9 [P17482]6EBI-711613,EBI-745290
KCNA4 [P22459]4EBI-711613,EBI-631235
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-711613,EBI-9089060
LHX3 - isoform B [Q9UBR4-2]5EBI-711613,EBI-12039345
LNX1 [Q8TBB1]8EBI-711613,EBI-739832
LYRM7 [Q5U5X0]3EBI-711613,EBI-13943106
MEOX2 [Q6FHY5]3EBI-711613,EBI-16439278
MRPL12 [P52815]3EBI-711613,EBI-358272
MTA1 [Q13330]3EBI-711613,EBI-714236
MYPOP [Q86VE0]3EBI-711613,EBI-2858213
NIF3L1 [Q9GZT8]5EBI-711613,EBI-740897
NTAQ1 [Q96HA8]3EBI-711613,EBI-741158
PSMA1 [P25786]3EBI-711613,EBI-359352
RBM17 [Q96I25]13EBI-711613,EBI-740272
REL [Q04864]3EBI-711613,EBI-307352
RPP25 [Q9BUL9]8EBI-711613,EBI-366570
itself4EBI-711613,EBI-711613
SAT2 [Q96F10]5EBI-711613,EBI-748746
SNAI2 [O43623]3EBI-711613,EBI-9876238
TACO1 [Q9BSH4]4EBI-711613,EBI-747797
TCF25 [Q9BQ70]11EBI-711613,EBI-745182
TEAD4 [Q15561]3EBI-711613,EBI-747736
TEX43 [Q6ZNM6]3EBI-711613,EBI-18115728
TLE5 - isoform 2 [Q08117-2]3EBI-711613,EBI-11741437
TNNI1 [P19237]3EBI-711613,EBI-746692
TXN2 [Q99757]3EBI-711613,EBI-2932492
USHBP1 [Q8N6Y0]3EBI-711613,EBI-739895

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112210, 103 interactors

Database of interacting proteins

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DIPi
DIP-36801N

Protein interaction database and analysis system

More...
IntActi
P21673, 93 interactors

Molecular INTeraction database

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MINTi
P21673

STRING: functional protein association networks

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STRINGi
9606.ENSP00000368572

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21673

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21673, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

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AlphaFoldDBi
P21673

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21673

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21673

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 171N-acetyltransferasePROSITE-ProRule annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 28Substrate binding1 Publication2
Regioni94 – 96Acetyl-CoA binding1 Publication3
Regioni102 – 107Acetyl-CoA binding1 Publication6
Regioni126 – 128Substrate binding1 Publication3
Regioni133 – 136Acetyl-CoA binding1 Publication4
Regioni140 – 143Acetyl-CoA binding1 Publication4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3216, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183121

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_013985_41_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21673

Identification of Orthologs from Complete Genome Data

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OMAi
AVERQCG

Database of Orthologous Groups

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OrthoDBi
1228251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21673

TreeFam database of animal gene trees

More...
TreeFami
TF319736

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000182, GNAT_dom
IPR032957, SAT1

The PANTHER Classification System

More...
PANTHERi
PTHR10545:SF36, PTHR10545:SF36, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00583, Acetyltransf_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55729, SSF55729, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51186, GNAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P21673-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP
60 70 80 90 100
FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY
110 120 130 140 150
RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS
160 170
EEGWRLFKID KEYLLKMATE E
Length:171
Mass (Da):20,024
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A0578B88CD72F09
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PD37E9PD37_HUMAN
Diamine acetyltransferase 1
SAT1
143Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q2TM25Q2TM25_HUMAN
Diamine acetyltransferase 1
SAT1 SAT
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26K → E in CAA78509 (PubMed:1417826).Curated1
Sequence conflicti26K → E in AAA98854 (PubMed:8573111).Curated1
Sequence conflicti69H → G AA sequence (PubMed:2241897).Curated1
Sequence conflicti84W → P AA sequence (PubMed:2241897).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M77693 mRNA Translation: AAA60573.1
M55580 mRNA Translation: AAA63260.1
Z14136 Genomic DNA Translation: CAA78509.1
U40369 Genomic DNA Translation: AAA98854.1
BT006825 mRNA Translation: AAP35471.1
CR450294 mRNA Translation: CAG29290.1
AK312162 mRNA Translation: BAG35096.1
CH471074 Genomic DNA Translation: EAW99000.1
BC002503 mRNA Translation: AAH02503.1
BC008424 mRNA Translation: AAH08424.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14207.1

Protein sequence database of the Protein Information Resource

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PIRi
JH0783

NCBI Reference Sequences

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RefSeqi
NP_002961.1, NM_002970.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000379270.5; ENSP00000368572.4; ENSG00000130066.17

Database of genes from NCBI RefSeq genomes

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GeneIDi
6303

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6303

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000379270.5; ENSP00000368572.4; NM_002970.4; NP_002961.1

UCSC genome browser

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UCSCi
uc004dau.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77693 mRNA Translation: AAA60573.1
M55580 mRNA Translation: AAA63260.1
Z14136 Genomic DNA Translation: CAA78509.1
U40369 Genomic DNA Translation: AAA98854.1
BT006825 mRNA Translation: AAP35471.1
CR450294 mRNA Translation: CAG29290.1
AK312162 mRNA Translation: BAG35096.1
CH471074 Genomic DNA Translation: EAW99000.1
BC002503 mRNA Translation: AAH02503.1
BC008424 mRNA Translation: AAH08424.1
CCDSiCCDS14207.1
PIRiJH0783
RefSeqiNP_002961.1, NM_002970.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B3UX-ray1.85A/B1-171[»]
2B3VX-ray1.95A1-171[»]
2B4BX-ray2.00A/B1-171[»]
2B4DX-ray2.00A/B1-171[»]
2B58X-ray1.95A1-171[»]
2B5GX-ray1.70A/B1-171[»]
2F5IX-ray2.30A/B1-171[»]
2FXFX-ray2.00A/B2-171[»]
2G3TX-ray1.80A/B1-171[»]
2JEVX-ray2.30A/B1-171[»]
AlphaFoldDBiP21673
SMRiP21673
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112210, 103 interactors
DIPiDIP-36801N
IntActiP21673, 93 interactors
MINTiP21673
STRINGi9606.ENSP00000368572

Chemistry databases

BindingDBiP21673
ChEMBLiCHEMBL4286
DrugBankiDB04633, N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
DB00127, Spermine
DrugCentraliP21673

PTM databases

iPTMnetiP21673
PhosphoSitePlusiP21673

Genetic variation databases

BioMutaiSAT1
DMDMi114322

Proteomic databases

EPDiP21673
MassIVEiP21673
PaxDbiP21673
PeptideAtlasiP21673
PRIDEiP21673
ProteomicsDBi53885

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24525, 258 antibodies from 22 providers

The DNASU plasmid repository

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DNASUi
6303

Genome annotation databases

EnsembliENST00000379270.5; ENSP00000368572.4; ENSG00000130066.17
GeneIDi6303
KEGGihsa:6303
MANE-SelectiENST00000379270.5; ENSP00000368572.4; NM_002970.4; NP_002961.1
UCSCiuc004dau.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6303
DisGeNETi6303

GeneCards: human genes, protein and diseases

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GeneCardsi
SAT1
HGNCiHGNC:10540, SAT1
HPAiENSG00000130066, Low tissue specificity
MalaCardsiSAT1
MIMi313020, gene
neXtProtiNX_P21673
OpenTargetsiENSG00000130066
Orphaneti2340, Keratosis follicularis spinulosa decalvans
PharmGKBiPA162402389
VEuPathDBiHostDB:ENSG00000130066

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3216, Eukaryota
GeneTreeiENSGT00950000183121
HOGENOMiCLU_013985_41_1_1
InParanoidiP21673
OMAiAVERQCG
OrthoDBi1228251at2759
PhylomeDBiP21673
TreeFamiTF319736

Enzyme and pathway databases

UniPathwayiUPA00188;UER00363
BRENDAi2.3.1.57, 2681
PathwayCommonsiP21673
ReactomeiR-HSA-351200, Interconversion of polyamines
SignaLinkiP21673
SIGNORiP21673

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6303, 15 hits in 712 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SAT1, human
EvolutionaryTraceiP21673

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SAT1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6303
PharosiP21673, Tbio

Protein Ontology

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PROi
PR:P21673
RNActiP21673, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130066, Expressed in palpebral conjunctiva and 240 other tissues
ExpressionAtlasiP21673, baseline and differential
GenevisibleiP21673, HS

Family and domain databases

InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000182, GNAT_dom
IPR032957, SAT1
PANTHERiPTHR10545:SF36, PTHR10545:SF36, 1 hit
PfamiView protein in Pfam
PF00583, Acetyltransf_1, 1 hit
SUPFAMiSSF55729, SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186, GNAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21673
Secondary accession number(s): Q6ICU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 25, 2022
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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