SAT1

Functionⁱ

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N₁-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N₁- and N₈-acetylspermidine), spermine, N₁-acetylspermidine and N₈-acetylspermidine.2 Publications

Catalytic activityⁱ

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.2 Publications

Kineticsⁱ

pH dependenceⁱ

Optimum pH is 8.0.1 Publication

Pathwayⁱ: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes N-acetylputrescine from putrescine.
Proteins known to be involved in this subpathway in this organism are:

Diamine acetyltransferase 2 (SAT2), Diamine acetyltransferase 1 (SAT1)

This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetylputrescine from putrescine, the pathway putrescine degradation and in Amine and polyamine degradation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	92	Substrate; via carbonyl oxygen1 Publication		1
Binding siteⁱ	152	Substrate1 Publication		1

GO - Molecular functionⁱ

diamine N-acetyltransferase activity Source: GO_Central
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
spermidine binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: UniProtKB
Inferred from expression patternⁱ
- 11866539
polyamine biosynthetic process Source: Reactome
putrescine catabolic process Source: UniProtKB-UniPathway
regulation of cell proliferation Source: Ensembl
spermidine acetylation Source: GO_Central
spermine catabolic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05339-MONOMER
BRENDAⁱ	2.3.1.57 2681
Reactomeⁱ	R-HSA-351200 Interconversion of polyamines
SIGNORⁱ	P21673
UniPathwayⁱ	UPA00188;UER00363

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Diamine acetyltransferase 1 (EC:2.3.1.572 Publications) Alternative name(s): Polyamine N-acetyltransferase 1 Putrescine acetyltransferase Spermidine/spermine N(1)-acetyltransferase 1 Short name: SSAT Short name: SSAT-1
Gene namesⁱ	Name:SAT1 Synonyms:SAT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130066.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10540 SAT1
MIMⁱ	313020 gene
neXtProtⁱ	NX_P21673

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Keratosis follicularis spinulosa decalvans X-linked (KFSDX)2 Publications

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	140	Y → F: Reduces activity by 95%. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6303
MalaCards human disease database More...MalaCardsⁱ	SAT1
MIMⁱ	308800 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000130066
Orphanetⁱ	2340 Keratosis follicularis spinulosa decalvans
PharmGKBⁱ	PA162402389

Chemistry databases

ChEMBLⁱ	CHEMBL4286
Drug and drug target database More...DrugBankⁱ	DB00127 Spermine

Polymorphism and mutation databases

BioMutaⁱ	SAT1
DMDMⁱ	114322

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074591	1 – 171	Diamine acetyltransferase 1Add BLAST		171

Proteomic databases

EPDⁱ	P21673
PaxDbⁱ	P21673
PeptideAtlas More...PeptideAtlasⁱ	P21673
PRIDEⁱ	P21673
ProteomicsDBⁱ	53885

PTM databases

iPTMnetⁱ	P21673
PhosphoSitePlusⁱ	P21673

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130066 Expressed in 228 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_SAT1
ExpressionAtlasⁱ	P21673 baseline and differential
Genevisibleⁱ	P21673 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB047343 CAB069914 HPA055312

HPAⁱ

CAB047343
CAB069914
HPA055312

Interactionⁱ

Subunit structureⁱ

Homodimer.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-711613,EBI-711613
C19orf25	Q9UFG5	3	EBI-711613,EBI-741214
CASP7	P55210	5	EBI-711613,EBI-523958
CCDC148	Q8NFR7	5	EBI-711613,EBI-2349862
CCHCR1	Q8TD31-3	7	EBI-711613,EBI-10175300
DDX39A	O00148	3	EBI-711613,EBI-348253
DMRT3	Q9NQL9	5	EBI-711613,EBI-9679045
EIF3D	O15371	3	EBI-711613,EBI-353818
FAM156A	Q8NDB6	3	EBI-711613,EBI-749727
FAM69B	Q5VUD6	5	EBI-711613,EBI-721274
HOXB9	P17482	6	EBI-711613,EBI-745290
KCNA4	P22459	3	EBI-711613,EBI-631235
LNX1	Q8TBB1	8	EBI-711613,EBI-739832
MTA1	Q13330	3	EBI-711613,EBI-714236
NIF3L1	Q9GZT8	4	EBI-711613,EBI-740897
RBM17	Q96I25	9	EBI-711613,EBI-740272
REL	Q04864	3	EBI-711613,EBI-307352
RPP25	Q9BUL9	4	EBI-711613,EBI-366570
SAT2	Q96F10	3	EBI-711613,EBI-748746
SNAI2	O43623	3	EBI-711613,EBI-9876238
TACO1	Q9BSH4	3	EBI-711613,EBI-747797
TCF25	Q9BQ70	9	EBI-711613,EBI-745182

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112210, 73 interactors
Database of interacting proteins More...DIPⁱ	DIP-36801N
IntActⁱ	P21673, 88 interactors
Molecular INTeraction database More...MINTⁱ	P21673
STRINGⁱ	9606.ENSP00000368572

Chemistry databases

BindingDBⁱ

P21673

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 8	Combined sources	4
Helixⁱ	11 – 13	Combined sources	3
Helixⁱ	14 – 25	Combined sources	12
Beta strandⁱ	28 – 30	Combined sources	3
Helixⁱ	31 – 33	Combined sources	3
Helixⁱ	38 – 45	Combined sources	8
Beta strandⁱ	46 – 49	Combined sources	4
Beta strandⁱ	53 – 58	Combined sources	6
Helixⁱ	61 – 63	Combined sources	3
Beta strandⁱ	71 – 82	Combined sources	12
Turnⁱ	83 – 85	Combined sources	3
Beta strandⁱ	86 – 96	Combined sources	11
Helixⁱ	98 – 100	Combined sources	3
Beta strandⁱ	102 – 104	Combined sources	3
Helixⁱ	105 – 120	Combined sources	16
Beta strandⁱ	123 – 130	Combined sources	8
Helixⁱ	134 – 141	Combined sources	8
Turnⁱ	142 – 144	Combined sources	3
Helixⁱ	148 – 152	Combined sources	5
Beta strandⁱ	154 – 160	Combined sources	7
Helixⁱ	161 – 168	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P21673
SMRⁱ	P21673
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P21673

EvolutionaryTraceⁱ

P21673

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 171	N-acetyltransferasePROSITE-ProRule annotationAdd BLAST		168

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	27 – 28	Substrate binding1 Publication	2
Regionⁱ	94 – 96	Acetyl-CoA binding1 Publication	3
Regionⁱ	102 – 107	Acetyl-CoA binding1 Publication	6
Regionⁱ	126 – 128	Substrate binding1 Publication	3
Regionⁱ	133 – 136	Acetyl-CoA binding1 Publication	4
Regionⁱ	140 – 143	Acetyl-CoA binding1 Publication	4

Sequence similaritiesⁱ

Belongs to the acetyltransferase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3216 Eukaryota COG0454 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039972
HOGENOMⁱ	HOG000078521
HOVERGENⁱ	HBG063175
InParanoidⁱ	P21673
KEGG Orthology (KO) More...KOⁱ	K00657
OMAⁱ	VKCRCSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UNU
PhylomeDBⁱ	P21673
TreeFamⁱ	TF319736

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom IPR032957 SAT1
PANTHERⁱ	PTHR10545:SF36 PTHR10545:SF36, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P21673-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP 
        60         70         80         90        100
FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY 
       110        120        130        140        150
RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS 
       160        170 
EEGWRLFKID KEYLLKMATE E

Length:171

Mass (Da):20,024

Last modified:May 1, 1991 - v1

Checksum:ⁱ6A0578B88CD72F09

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6NM56	A6NM56_HUMAN	Diamine acetyltransferase 1 Diamine acetyltransferase 1	SAT1	120	Annotation score:
E9PD37	E9PD37_HUMAN	Diamine acetyltransferase 1 Diamine acetyltransferase 1	SAT1	143	Annotation score:
A6NJE6	A6NJE6_HUMAN	Diamine acetyltransferase 1 Diamine acetyltransferase 1	SAT1	150	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	K → E in CAA78509 (PubMed:1417826).Curated	1
Sequence conflictⁱ	26	K → E in AAA98854 (PubMed:8573111).Curated	1
Sequence conflictⁱ	69	H → G AA sequence (PubMed:2241897).Curated	1
Sequence conflictⁱ	84	W → P AA sequence (PubMed:2241897).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77693 mRNA Translation: AAA60573.1 M55580 mRNA Translation: AAA63260.1 Z14136 Genomic DNA Translation: CAA78509.1 U40369 Genomic DNA Translation: AAA98854.1 BT006825 mRNA Translation: AAP35471.1 CR450294 mRNA Translation: CAG29290.1 AK312162 mRNA Translation: BAG35096.1 CH471074 Genomic DNA Translation: EAW99000.1 BC002503 mRNA Translation: AAH02503.1 BC008424 mRNA Translation: AAH08424.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14207.1
PIRⁱ	JH0783
NCBI Reference Sequences More...RefSeqⁱ	NP_002961.1, NM_002970.3
UniGeneⁱ	Hs.28491

Genome annotation databases

Ensemblⁱ	ENST00000379270; ENSP00000368572; ENSG00000130066
GeneIDⁱ	6303
KEGGⁱ	hsa:6303
UCSC genome browser More...UCSCⁱ	uc004dau.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21673	SAT1 isoform 1		PANTR		171	UniRef100_P21673
Uncharacterized protein		PANPA		171
Spermidine/spermine N1-acetyltransferase 1		GORGO		171
UPI000065CA50		HUMAN		179
UPI0000697617		HUMAN		170

Protein	Similar proteins		Species	Score	Length	Source
P21673	Diamine acetyltransferase 1		BOVIN		171	UniRef90_P21673
Diamine acetyltransferase 1		CRIGR		171
Diamine acetyltransferase 1		MESAU		171
Diamine acetyltransferase 1	)	MOUSE		171
Diamine acetyltransferase 1		MUSSA		171
+110

Protein	Similar proteins		Species	Score	Length	Source
P21673	Diamine acetyltransferase 1		PIG		171	UniRef50_P21673
Diamine acetyltransferase 1		BOVIN		171
Diamine acetyltransferase 1		MUSSA		171
Diamine acetyltransferase 1	)	MOUSE		171
Diamine acetyltransferase 1		CRIGR		171
+248

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77693 mRNA Translation: AAA60573.1 M55580 mRNA Translation: AAA63260.1 Z14136 Genomic DNA Translation: CAA78509.1 U40369 Genomic DNA Translation: AAA98854.1 BT006825 mRNA Translation: AAP35471.1 CR450294 mRNA Translation: CAG29290.1 AK312162 mRNA Translation: BAG35096.1 CH471074 Genomic DNA Translation: EAW99000.1 BC002503 mRNA Translation: AAH02503.1 BC008424 mRNA Translation: AAH08424.1
CCDSⁱ	CCDS14207.1
PIRⁱ	JH0783
RefSeqⁱ	NP_002961.1, NM_002970.3
UniGeneⁱ	Hs.28491

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2B3U	X-ray	1.85	A/B	1-171	[»]
	2B3V	X-ray	1.95	A	1-171	[»]
	2B4B	X-ray	2.00	A/B	1-171	[»]
	2B4D	X-ray	2.00	A/B	1-171	[»]
	2B58	X-ray	1.95	A	1-171	[»]
	2B5G	X-ray	1.70	A/B	1-171	[»]
	2F5I	X-ray	2.30	A/B	1-171	[»]
	2FXF	X-ray	2.00	A/B	2-171	[»]
	2G3T	X-ray	1.80	A/B	1-171	[»]
	2JEV	X-ray	2.30	A/B	1-171	[»]
ProteinModelPortalⁱ	P21673
SMRⁱ	P21673
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112210, 73 interactors
DIPⁱ	DIP-36801N
IntActⁱ	P21673, 88 interactors
MINTⁱ	P21673
STRINGⁱ	9606.ENSP00000368572

Chemistry databases

BindingDBⁱ	P21673
ChEMBLⁱ	CHEMBL4286
DrugBankⁱ	DB00127 Spermine

PTM databases

iPTMnetⁱ	P21673
PhosphoSitePlusⁱ	P21673

Polymorphism and mutation databases

BioMutaⁱ	SAT1
DMDMⁱ	114322

Proteomic databases

EPDⁱ	P21673
PaxDbⁱ	P21673
PeptideAtlasⁱ	P21673
PRIDEⁱ	P21673
ProteomicsDBⁱ	53885

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6303
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379270; ENSP00000368572; ENSG00000130066
GeneIDⁱ	6303
KEGGⁱ	hsa:6303
UCSCⁱ	uc004dau.5 human

Organism-specific databases

CTDⁱ	6303
DisGeNETⁱ	6303
EuPathDBⁱ	HostDB:ENSG00000130066.16
GeneCardsⁱ	SAT1
H-InvDBⁱ	HIX0176797
HGNCⁱ	HGNC:10540 SAT1
HPAⁱ	CAB047343 CAB069914 HPA055312
MalaCardsⁱ	SAT1
MIMⁱ	308800 phenotype 313020 gene
neXtProtⁱ	NX_P21673
OpenTargetsⁱ	ENSG00000130066
Orphanetⁱ	2340 Keratosis follicularis spinulosa decalvans
PharmGKBⁱ	PA162402389
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3216 Eukaryota COG0454 LUCA
GeneTreeⁱ	ENSGT00440000039972
HOGENOMⁱ	HOG000078521
HOVERGENⁱ	HBG063175
InParanoidⁱ	P21673
KOⁱ	K00657
OMAⁱ	VKCRCSS
OrthoDBⁱ	EOG091G0UNU
PhylomeDBⁱ	P21673
TreeFamⁱ	TF319736

Enzyme and pathway databases

UniPathwayⁱ	UPA00188;UER00363
BioCycⁱ	MetaCyc:HS05339-MONOMER
BRENDAⁱ	2.3.1.57 2681
Reactomeⁱ	R-HSA-351200 Interconversion of polyamines
SIGNORⁱ	P21673

Miscellaneous databases

ChiTaRSⁱ	SAT1 human
EvolutionaryTraceⁱ	P21673
GeneWikiⁱ	SAT1_(gene)
GenomeRNAiⁱ	6303
Protein Ontology More...PROⁱ	PR:P21673
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130066 Expressed in 228 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_SAT1
ExpressionAtlasⁱ	P21673 baseline and differential
Genevisibleⁱ	P21673 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom IPR032957 SAT1
PANTHERⁱ	PTHR10545:SF36 PTHR10545:SF36, 1 hit
Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SAT1_HUMAN
Accessionⁱ	P21673Primary (citable) accession number: P21673 Secondary accession number(s): Q6ICU9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	May 1, 1991
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P21673 (SAT1_HUMAN)

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Diamine acetyltransferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

pH dependencei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine degradation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

pH dependenceⁱ

Pathwayⁱ: putrescine degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ