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Protein

Fibroblast growth factor 6

Gene

Fgf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.By similarity

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cartilage condensation Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • myoblast differentiation Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:Fgf6
Synonyms:Fgf-6, Hstf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95520 Fgf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000896238 – 208Fibroblast growth factor 6Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 157Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21658
PRIDEiP21658

PTM databases

iPTMnetiP21658
PhosphoSitePlusiP21658

Expressioni

Tissue specificityi

Embryos, adult muscles and adult testis.

Gene expression databases

BgeeiENSMUSG00000000183 Expressed in 57 organ(s), highest expression level in tongue muscle
CleanExiMM_FGF6
GenevisibleiP21658 MM

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000187

Structurei

3D structure databases

ProteinModelPortaliP21658
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP21658
KOiK04358
OMAiFVYKGFY
OrthoDBiEOG091G0NAY
PhylomeDBiP21658
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028242 FGF6
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF25 PTHR11486:SF25, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
PPDGRISGTH EENPYSLLEI STVERGVVSL FGVKSALFIA MNSKGRLYTT
160 170 180 190 200
PSFHDECKFR ETLLPNNYNA YESDLYRGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,798
Last modified:November 1, 1995 - v2
Checksum:iBBF7B9301BB79A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92415 Genomic DNA Translation: AAA62260.1
M92416 mRNA Translation: AAA62261.1
X51552 Genomic DNA Translation: CAA35925.1
CCDSiCCDS20561.1
PIRiS14192
RefSeqiNP_034334.1, NM_010204.1
UniGeneiMm.3403

Genome annotation databases

EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183
GeneIDi14177
KEGGimmu:14177
UCSCiuc009dvo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92415 Genomic DNA Translation: AAA62260.1
M92416 mRNA Translation: AAA62261.1
X51552 Genomic DNA Translation: CAA35925.1
CCDSiCCDS20561.1
PIRiS14192
RefSeqiNP_034334.1, NM_010204.1
UniGeneiMm.3403

3D structure databases

ProteinModelPortaliP21658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000187

PTM databases

iPTMnetiP21658
PhosphoSitePlusiP21658

Proteomic databases

PaxDbiP21658
PRIDEiP21658

Protocols and materials databases

DNASUi14177
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183
GeneIDi14177
KEGGimmu:14177
UCSCiuc009dvo.1 mouse

Organism-specific databases

CTDi2251
MGIiMGI:95520 Fgf6

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP21658
KOiK04358
OMAiFVYKGFY
OrthoDBiEOG091G0NAY
PhylomeDBiP21658
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:P21658
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000183 Expressed in 57 organ(s), highest expression level in tongue muscle
CleanExiMM_FGF6
GenevisibleiP21658 MM

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028242 FGF6
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF25 PTHR11486:SF25, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF6_MOUSE
AccessioniPrimary (citable) accession number: P21658
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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