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Entry version 168 (11 Dec 2019)
Sequence version 3 (01 Feb 1995)
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Protein

Transcriptional activator protein DAL81

Gene

DAL81

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin.

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi150 – 179Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-31442-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator protein DAL81
Alternative name(s):
Regulatory protein UGA35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAL81
Synonyms:DURL, UGA35
Ordered Locus Names:YIR023W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YIR023W

Saccharomyces Genome Database

More...
SGDi
S000001462 DAL81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149471 – 970Transcriptional activator protein DAL81Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21657

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21657

PRoteomics IDEntifications database

More...
PRIDEi
P21657

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21657

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35014, 576 interactors

Database of interacting proteins

More...
DIPi
DIP-5733N

Protein interaction database and analysis system

More...
IntActi
P21657, 5 interactors

Molecular INTeraction database

More...
MINTi
P21657

STRING: functional protein association networks

More...
STRINGi
4932.YIR023W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21657 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 50Asn-richAdd BLAST27
Compositional biasi73 – 88Poly-GlnAdd BLAST16
Compositional biasi127 – 139Asn-richAdd BLAST13
Compositional biasi227 – 237Poly-GlnAdd BLAST11

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000094358

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21657

Identification of Orthologs from Complete Genome Data

More...
OMAi
WATSPGR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067 GAL4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701 SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21657-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPHQSPADN AASPTKSVKA TTKNSSTNNN VNSNNSNNNS NHDILNFNDN
60 70 80 90 100
YTTILQHLAN DHPNILREKG GSQQQQHQQQ QQQQQQQQQQ QQQQSLDTLL
110 120 130 140 150
HHYQSLLSKS DNAIAFDDNV SNSADHNGSN SNNNNNNNDI SSPGNLMGSC
160 170 180 190 200
NQCRLKKTKC NYFPDLGNCL ECETSRTKCT FSIAPNYLKR TSSGANNNMP
210 220 230 240 250
TSSNSKRMKN FEDYSNRLPS SMLYRHQQQQ QQQQQQQRIQ YPRSSFFVGP
260 270 280 290 300
ASVFDLNLTK HVRLDNVDQI QLSKTLSLRK VSPTAQFILQ DDFDTTLHSK
310 320 330 340 350
QEYEVDLVEN LVHPHGHLLV EIFFKLIHPF LPILHERVFL EKYSRSYREL
360 370 380 390 400
TAPLLASIYS LALQYWDFHP ALLGFPKPDV TAQLNNIALE TFYARVGRPK
410 420 430 440 450
LSIIQTGLLI LQCRSECHNN WVLCSSVVAL AEELGLGVEC NDWKLPKWEK
460 470 480 490 500
DLRKRLAWAV WLMDKWCALN EGRQSHLILG RNWMIKLLNF DDFPLNSPTI
510 520 530 540 550
LNSLQNDQSG SSPSSSNDVK NHQIAFGNLP IFNINPTLED FKNGTLMFQQ
560 570 580 590 600
MVSLSIILGE IMDTFYTQGS MTINKSIEQV LKLAKPLQLK LREWYHSLPK
610 620 630 640 650
NLSMSYATPQ KLNSNSTLTL AYFATEITLH RKIICALNPQ TPKELVQVCR
660 670 680 690 700
TAARTRLVAA IEFIRDLKNE HINAFWYNCS TGNLMLIGTF AALLYVTSAT
710 720 730 740 750
KEEAMIFRDY VRNYTWVLKI GSKYFDKLSN ALNNMHLLFA QIPGLLTDEP
760 770 780 790 800
VVVSPNSNIN SVNPQRSGVQ SQIPIQFNVG SPAMTEQGSP LNQWKNLPQE
810 820 830 840 850
ILQQLNSFPN GTTSTTTPVN PTSRQTQLES QGSPAINSAN NNSNNTPLPF
860 870 880 890 900
APNKSSKKTS QSSPNVTPSH MSRHPPSNTS SPRVNSSTNV NSNTQMNASP
910 920 930 940 950
LTSINETRQE SGDAADEKTA GRERTANEES STELKDDNPN SNQETSATGN
960 970
QTIKMNDDKN VTINTRETPL
Length:970
Mass (Da):109,174
Last modified:February 1, 1995 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FEBD271A18AFC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77 – 82Missing in AAA35192 (PubMed:1999281).Curated6
Sequence conflicti465K → R in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti497S → L in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti507D → G in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti760N → S in AAA35192 (PubMed:1999281).Curated1
Sequence conflicti785T → A in AAA34557 (PubMed:1990272).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63498 Genomic DNA Translation: AAA35192.1
M60415 Genomic DNA Translation: AAA34557.1
Z38061 Genomic DNA Translation: CAA86183.1
BK006942 Genomic DNA Translation: DAA08570.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S48485

NCBI Reference Sequences

More...
RefSeqi
NP_012289.3, NM_001179545.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIR023W_mRNA; YIR023W; YIR023W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIR023W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63498 Genomic DNA Translation: AAA35192.1
M60415 Genomic DNA Translation: AAA34557.1
Z38061 Genomic DNA Translation: CAA86183.1
BK006942 Genomic DNA Translation: DAA08570.1
PIRiS48485
RefSeqiNP_012289.3, NM_001179545.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi35014, 576 interactors
DIPiDIP-5733N
IntActiP21657, 5 interactors
MINTiP21657
STRINGi4932.YIR023W

PTM databases

iPTMnetiP21657

Proteomic databases

MaxQBiP21657
PaxDbiP21657
PRIDEiP21657

Genome annotation databases

EnsemblFungiiYIR023W_mRNA; YIR023W; YIR023W
GeneIDi854841
KEGGisce:YIR023W

Organism-specific databases

EuPathDBiFungiDB:YIR023W
SGDiS000001462 DAL81

Phylogenomic databases

HOGENOMiHOG000094358
InParanoidiP21657
OMAiWATSPGR

Enzyme and pathway databases

BioCyciYEAST:G3O-31442-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21657
RNActiP21657 protein

Family and domain databases

CDDicd00067 GAL4, 1 hit
InterProiView protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAL81_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21657
Secondary accession number(s): D6VVV4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1995
Last modified: December 11, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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