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Protein

Tryptophan 2,3-dioxygenase

Gene

Tdo2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 1 heme group per subunit.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Indoleamine 2,3-dioxygenase 2 (Ido2), Tryptophan 2,3-dioxygenase (Tdo2)
  2. Kynurenine formamidase (Afmid)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144SubstrateUniRule annotation1
Metal bindingi328Iron (heme axial ligand)UniRule annotation1
Binding sitei342SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processTryptophan catabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.11 5301
ReactomeiR-RNO-71240 Tryptophan catabolism
UniPathwayi
UPA00333;UER00453

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Short name:
TOUniRule annotation
Short name:
TRPOUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:Tdo2UniRule annotation
Synonyms:Tdo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi68370 Tdo2

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724011 – 406Tryptophan 2,3-dioxygenaseAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21643
PRIDEiP21643

PTM databases

iPTMnetiP21643
PhosphoSitePlusiP21643

Expressioni

Tissue specificityi

Liver.

Inductioni

By dexamethasone.1 Publication

Gene expression databases

BgeeiENSRNOG00000011612 Expressed in 4 organ(s), highest expression level in liver
GenevisibleiP21643 RN

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015732

Chemistry databases

BindingDBiP21643

Structurei

3D structure databases

ProteinModelPortaliP21643
SMRiP21643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 76Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3906 Eukaryota
COG3483 LUCA
GeneTreeiENSGT00390000008593
HOGENOMiHOG000221584
HOVERGENiHBG003043
InParanoidiP21643
KOiK00453
OMAiYWDLYQL
OrthoDBiEOG091G080K
PhylomeDBiP21643
TreeFamiTF105827

Family and domain databases

HAMAPiMF_01972 T23O, 1 hit
InterProiView protein in InterPro
IPR037217 Trp/Indoleamine_2_3_dOase-like
IPR004981 Trp_2_3_dOase
PANTHERiPTHR10138 PTHR10138, 1 hit
PfamiView protein in Pfam
PF03301 Trp_dioxygenase, 1 hit
SUPFAMiSSF140959 SSF140959, 2 hits

Sequencei

Sequence statusi: Complete.

P21643-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGCPFSGNS VGYTLKNLSM EDNEEDGAQT GVNRASKGGL IYGDYLQLEK
60 70 80 90 100
ILNAQELQSE IKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG
110 120 130 140 150
HVRDERNMLK VMTRMHRVVV IFKLLVQQFS VLETMTALDF NDFREYLSPA
160 170 180 190 200
SGFQSLQFRL LENKIGVLQS LRVPYNRKHY RDNFEGDYNE LLLKSEQEQT
210 220 230 240 250
LLQLVEAWLE RTPGLEPHGF NFWGKFEKNI LKGLEEEFLK IQAKKDSEEK
260 270 280 290 300
EEQMAEFRKQ KEVLLCLFDE KRHDYLLSKG ERRLSYRALQ GALMIYFYRE
310 320 330 340 350
EPRFQVPFQL LTSLMDIDTL MTKWRYNHVC MVHRMLGSKA GTGGSSGYYY
360 370 380 390 400
LRSTVSDRYK VFVDLFNLSS YLVPRHWIPK MNPIIHKFLY TAEYSDSSYF

SSDESD
Length:406
Mass (Da):47,857
Last modified:May 1, 1991 - v1
Checksum:i9C45973BEE3BF93A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207Missing in X60833 (PubMed:1511007).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55167 mRNA Translation: AAA63503.1
BC089802 mRNA Translation: AAH89802.1
X05145 Genomic DNA Translation: CAA28794.1
X01849 Genomic DNA Translation: CAA25974.1
X60833 Genomic DNA No translation available.
PIRiA35484
RefSeqiNP_071798.1, NM_022403.2
UniGeneiRn.1029

Genome annotation databases

EnsembliENSRNOT00000015732; ENSRNOP00000015732; ENSRNOG00000011612
GeneIDi64206
KEGGirno:64206
UCSCiRGD:68370 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55167 mRNA Translation: AAA63503.1
BC089802 mRNA Translation: AAH89802.1
X05145 Genomic DNA Translation: CAA28794.1
X01849 Genomic DNA Translation: CAA25974.1
X60833 Genomic DNA No translation available.
PIRiA35484
RefSeqiNP_071798.1, NM_022403.2
UniGeneiRn.1029

3D structure databases

ProteinModelPortaliP21643
SMRiP21643
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015732

Chemistry databases

BindingDBiP21643
ChEMBLiCHEMBL2686

PTM databases

iPTMnetiP21643
PhosphoSitePlusiP21643

Proteomic databases

PaxDbiP21643
PRIDEiP21643

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015732; ENSRNOP00000015732; ENSRNOG00000011612
GeneIDi64206
KEGGirno:64206
UCSCiRGD:68370 rat

Organism-specific databases

CTDi6999
RGDi68370 Tdo2

Phylogenomic databases

eggNOGiKOG3906 Eukaryota
COG3483 LUCA
GeneTreeiENSGT00390000008593
HOGENOMiHOG000221584
HOVERGENiHBG003043
InParanoidiP21643
KOiK00453
OMAiYWDLYQL
OrthoDBiEOG091G080K
PhylomeDBiP21643
TreeFamiTF105827

Enzyme and pathway databases

UniPathwayi
UPA00333;UER00453

BRENDAi1.13.11.11 5301
ReactomeiR-RNO-71240 Tryptophan catabolism

Miscellaneous databases

PROiPR:P21643

Gene expression databases

BgeeiENSRNOG00000011612 Expressed in 4 organ(s), highest expression level in liver
GenevisibleiP21643 RN

Family and domain databases

HAMAPiMF_01972 T23O, 1 hit
InterProiView protein in InterPro
IPR037217 Trp/Indoleamine_2_3_dOase-like
IPR004981 Trp_2_3_dOase
PANTHERiPTHR10138 PTHR10138, 1 hit
PfamiView protein in Pfam
PF03301 Trp_dioxygenase, 1 hit
SUPFAMiSSF140959 SSF140959, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiT23O_RAT
AccessioniPrimary (citable) accession number: P21643
Secondary accession number(s): Q5EBC2, Q6LBW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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