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Protein

Vitamin D-binding protein

Gene

Gc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.By similarity

GO - Molecular functioni

GO - Biological processi

  • vitamin D metabolic process Source: MGI

Keywordsi

Molecular functionActin-binding
Biological processTransport
LigandVitamin D

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D-binding protein
Short name:
DBP
Short name:
VDB
Alternative name(s):
Gc-globulin
Group-specific component
Gene namesi
Name:Gc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95669 Gc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 162 PublicationsAdd BLAST16
ChainiPRO_000000110317 – 476Vitamin D-binding proteinAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 75PROSITE-ProRule annotation
Disulfide bondi74 ↔ 83PROSITE-ProRule annotation
Disulfide bondi96 ↔ 112PROSITE-ProRule annotation
Disulfide bondi111 ↔ 122PROSITE-ProRule annotation
Disulfide bondi145 ↔ 190PROSITE-ProRule annotation
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
Disulfide bondi220 ↔ 266PROSITE-ProRule annotation
Disulfide bondi265 ↔ 273PROSITE-ProRule annotation
Disulfide bondi286 ↔ 300PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi299 ↔ 311PROSITE-ProRule annotation
Disulfide bondi335 ↔ 376PROSITE-ProRule annotation
Disulfide bondi375 ↔ 384PROSITE-ProRule annotation
Disulfide bondi407 ↔ 453PROSITE-ProRule annotation
Modified residuei434PhosphoserineBy similarity1
Disulfide bondi452 ↔ 462PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP21614
PaxDbiP21614
PeptideAtlasiP21614
PRIDEiP21614

2D gel databases

REPRODUCTION-2DPAGEiP21614

PTM databases

iPTMnetiP21614
PhosphoSitePlusiP21614
SwissPalmiP21614

Expressioni

Gene expression databases

BgeeiENSMUSG00000035540 Expressed in 71 organ(s), highest expression level in left lobe of liver
CleanExiMM_GC
ExpressionAtlasiP21614 baseline and differential
GenevisibleiP21614 MM

Interactioni

Subunit structurei

Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes (By similarity). Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3 (PubMed:10052453).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199850, 1 interactor
IntActiP21614, 5 interactors
MINTiP21614
STRINGi10090.ENSMUSP00000046636

Structurei

3D structure databases

ProteinModelPortaliP21614
SMRiP21614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 208Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini209 – 394Albumin 2PROSITE-ProRule annotationAdd BLAST186
Domaini395 – 476Albumin 3PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410II89 Eukaryota
ENOG4111PH6 LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000140946
HOVERGENiHBG009729
InParanoidiP21614
KOiK12258
OMAiNSPPLYC
OrthoDBiEOG091G059U
PhylomeDBiP21614
TreeFamiTF335561

Family and domain databases

CDDicd00015 ALBUMIN, 1 hit
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
IPR000213 VitD-bd
IPR015247 VitD-bind_III
PANTHERiPTHR11385 PTHR11385, 1 hit
PTHR11385:SF11 PTHR11385:SF11, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 2 hits
PF09164 VitD-bind_III, 1 hit
PRINTSiPR00802 SERUMALBUMIN
PR00804 VITAMNDBNDNG
SMARTiView protein in SMART
SM00103 ALBUMIN, 2 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 1 hit
PS51438 ALBUMIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21614-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRVLVLLLA LAFGHALERG RDYEKDKVCN ELAMLGKEDF RSLSLILYSR
60 70 80 90 100
KFSSSTFEQV NQLVKEVVSL TEECCAEGAD PTCYDTRTSE LSVKSCESDA
110 120 130 140 150
PFPVHPGTPE CCTKEGLERK LCMAALSHQP QEFPTYVEPT NDEICEAFRR
160 170 180 190 200
DPKGFADQFL YEYSSNYGQA PLPLLVAYTK NYLSMVGSCC TSANPTVCFV
210 220 230 240 250
KERLQMKHLS LLTTMSNRVC SQYAAYGKEK SRLSHLIKLA QKVPTANLEN
260 270 280 290 300
VLPLAEDFTE ILSRCCESTS EDCMASELPE HTIKICQNLS KKNSKFEECC
310 320 330 340 350
QENTPMNIFM CTYFMPAAEP LQLPAIKLPT GKDLCGQSTT QAMDQYTFEL
360 370 380 390 400
SRRTQVPEVF LSKVLEPTLK TLRECCDTQD SVACFSTQSP LLKRQLTSFI
410 420 430 440 450
EKGQEMCADY SENTFTEYKK KLAERLRTKT PNTSPAELKD MVEKHSDFAS
460 470
KCCSINSPPL YCSSQIDAEM IDTLQS
Length:476
Mass (Da):53,600
Last modified:October 10, 2003 - v2
Checksum:i633B0CE183CD43FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGM6A0A0G2JGM6_MOUSE
Vitamin D-binding protein
Gc
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247N → K in BAB27297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010965 mRNA Translation: BAB27297.1
BC010762 mRNA Translation: AAH10762.1
BC051395 mRNA Translation: AAH51395.2
M55413 mRNA Translation: AAA37669.1
CCDSiCCDS19407.1
PIRiA35327
RefSeqiNP_032122.1, NM_008096.2
UniGeneiMm.196595

Genome annotation databases

EnsembliENSMUST00000049209; ENSMUSP00000046636; ENSMUSG00000035540
GeneIDi14473
KEGGimmu:14473
UCSCiuc008yam.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010965 mRNA Translation: BAB27297.1
BC010762 mRNA Translation: AAH10762.1
BC051395 mRNA Translation: AAH51395.2
M55413 mRNA Translation: AAA37669.1
CCDSiCCDS19407.1
PIRiA35327
RefSeqiNP_032122.1, NM_008096.2
UniGeneiMm.196595

3D structure databases

ProteinModelPortaliP21614
SMRiP21614
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199850, 1 interactor
IntActiP21614, 5 interactors
MINTiP21614
STRINGi10090.ENSMUSP00000046636

PTM databases

iPTMnetiP21614
PhosphoSitePlusiP21614
SwissPalmiP21614

2D gel databases

REPRODUCTION-2DPAGEiP21614

Proteomic databases

MaxQBiP21614
PaxDbiP21614
PeptideAtlasiP21614
PRIDEiP21614

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049209; ENSMUSP00000046636; ENSMUSG00000035540
GeneIDi14473
KEGGimmu:14473
UCSCiuc008yam.2 mouse

Organism-specific databases

CTDi2638
MGIiMGI:95669 Gc

Phylogenomic databases

eggNOGiENOG410II89 Eukaryota
ENOG4111PH6 LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000140946
HOVERGENiHBG009729
InParanoidiP21614
KOiK12258
OMAiNSPPLYC
OrthoDBiEOG091G059U
PhylomeDBiP21614
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism

Miscellaneous databases

ChiTaRSiGc mouse
PROiPR:P21614
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035540 Expressed in 71 organ(s), highest expression level in left lobe of liver
CleanExiMM_GC
ExpressionAtlasiP21614 baseline and differential
GenevisibleiP21614 MM

Family and domain databases

CDDicd00015 ALBUMIN, 1 hit
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
IPR000213 VitD-bd
IPR015247 VitD-bind_III
PANTHERiPTHR11385 PTHR11385, 1 hit
PTHR11385:SF11 PTHR11385:SF11, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 2 hits
PF09164 VitD-bind_III, 1 hit
PRINTSiPR00802 SERUMALBUMIN
PR00804 VITAMNDBNDNG
SMARTiView protein in SMART
SM00103 ALBUMIN, 2 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 1 hit
PS51438 ALBUMIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVTDB_MOUSE
AccessioniPrimary (citable) accession number: P21614
Secondary accession number(s): Q7TS97, Q91XG1, Q9CY31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 10, 2003
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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