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Protein

Cytochrome P450-DIT2

Gene

DIT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • ascospore wall assembly Source: SGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSporulation
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29946-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450-DIT2 (EC:1.14.14.-)
Alternative name(s):
Cytochrome P450 56
Gene namesi
Name:DIT2
Synonyms:CYP56
Ordered Locus Names:YDR402C
ORF Names:D9509.20
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR402C
SGDiS000002810 DIT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000520421 – 489Cytochrome P450-DIT2Add BLAST489

Proteomic databases

PaxDbiP21595
PRIDEiP21595

Expressioni

Developmental stagei

Sporulation.

Interactioni

Protein-protein interaction databases

BioGridi32462, 168 interactors
STRINGi4932.YDR402C

Structurei

3D structure databases

ProteinModelPortaliP21595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149317
HOGENOMiHOG000160758
InParanoidiP21595
KOiK00493
OMAiSVFRIWF
OrthoDBiEOG092C1BL6

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P21595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKLLCLI LFLTLSYVAF AIIVPPLNFP KNIPTIPFYV VFLPVIFPID
60 70 80 90 100
QTELYDLYIR ESMEKYGAVK FFFGSRWNIL VSRSEYLAQI FKDEDTFAKS
110 120 130 140 150
GNQKKIPYSA LAAYTGDNVI SAYGAVWRNY RNAVTNGLQH FDDAPIFKNA
160 170 180 190 200
KILCTLIKNR LLEGQTSIPM GPLSQRMALD NISQVALGFD FGALTHEKNA
210 220 230 240 250
FHEHLIRIKK QIFHPFFLTF PFLDVLPIPS RKKAFKDVVS FRELLVKRVQ
260 270 280 290 300
DELVNNYKFE QTTFAASDLI RAHNNEIIDY KQLTDNIVII LVAGHENPQL
310 320 330 340 350
LFNSSLYLLA KYSNEWQEKL RKEVNGITDP KGLADLPLLN AFLFEVVRMY
360 370 380 390 400
PPLSTIINRC TTKTCKLGAE IVIPKGVYVG YNNFGTSHDP KTWGTTADDF
410 420 430 440 450
KPERWGSDIE TIRKNWRMAK NRCAVTGFHG GRRACLGEKL ALTEMRISLA
460 470 480
EMLKQFRWSL DPEWEEKLTP AGPLCPLNLK LKFNENIME
Length:489
Mass (Da):56,071
Last modified:October 1, 1996 - v2
Checksum:i9A301276DDBEB18F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445M → I in CAA39246 (PubMed:2249774).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55713 Genomic DNA Translation: CAA39246.1
U32274 Genomic DNA Translation: AAB64842.1
BK006938 Genomic DNA Translation: DAA12244.1
PIRiB36395
RefSeqiNP_010690.1, NM_001180710.1

Genome annotation databases

EnsemblFungiiYDR402C; YDR402C; YDR402C
GeneIDi852011
KEGGisce:YDR402C

Similar proteinsi

Entry informationi

Entry nameiCP56_YEAST
AccessioniPrimary (citable) accession number: P21595
Secondary accession number(s): D6VT34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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