UniProtKB - P21595 (CP56_YEAST)
Protein
Cytochrome P450-DIT2
Gene
DIT2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 435 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- NADPH dehydrogenase activity Source: SGD
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
GO - Biological processi
- ascospore wall assembly Source: SGD
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Sporulation |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DIT2 Synonyms:CYP56 Ordered Locus Names:YDR402C ORF Names:D9509.20 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YDR402C |
SGDi | S000002810, DIT2 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052042 | 1 – 489 | Cytochrome P450-DIT2Add BLAST | 489 |
Proteomic databases
PaxDbi | P21595 |
Expressioni
Developmental stagei
Sporulation.
Interactioni
Protein-protein interaction databases
BioGRIDi | 32462, 168 interactors |
STRINGi | 4932.YDR402C |
Miscellaneous databases
RNActi | P21595, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000167749 |
HOGENOMi | CLU_031576_0_0_1 |
InParanoidi | P21595 |
OMAi | FGSRWNI |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
P21595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELLKLLCLI LFLTLSYVAF AIIVPPLNFP KNIPTIPFYV VFLPVIFPID
60 70 80 90 100
QTELYDLYIR ESMEKYGAVK FFFGSRWNIL VSRSEYLAQI FKDEDTFAKS
110 120 130 140 150
GNQKKIPYSA LAAYTGDNVI SAYGAVWRNY RNAVTNGLQH FDDAPIFKNA
160 170 180 190 200
KILCTLIKNR LLEGQTSIPM GPLSQRMALD NISQVALGFD FGALTHEKNA
210 220 230 240 250
FHEHLIRIKK QIFHPFFLTF PFLDVLPIPS RKKAFKDVVS FRELLVKRVQ
260 270 280 290 300
DELVNNYKFE QTTFAASDLI RAHNNEIIDY KQLTDNIVII LVAGHENPQL
310 320 330 340 350
LFNSSLYLLA KYSNEWQEKL RKEVNGITDP KGLADLPLLN AFLFEVVRMY
360 370 380 390 400
PPLSTIINRC TTKTCKLGAE IVIPKGVYVG YNNFGTSHDP KTWGTTADDF
410 420 430 440 450
KPERWGSDIE TIRKNWRMAK NRCAVTGFHG GRRACLGEKL ALTEMRISLA
460 470 480
EMLKQFRWSL DPEWEEKLTP AGPLCPLNLK LKFNENIME
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 445 | M → I in CAA39246 (PubMed:2249774).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55713 Genomic DNA Translation: CAA39246.1 U32274 Genomic DNA Translation: AAB64842.1 BK006938 Genomic DNA Translation: DAA12244.1 |
PIRi | B36395 |
RefSeqi | NP_010690.1, NM_001180710.1 |
Genome annotation databases
EnsemblFungii | YDR402C_mRNA; YDR402C; YDR402C |
GeneIDi | 852011 |
KEGGi | sce:YDR402C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55713 Genomic DNA Translation: CAA39246.1 U32274 Genomic DNA Translation: AAB64842.1 BK006938 Genomic DNA Translation: DAA12244.1 |
PIRi | B36395 |
RefSeqi | NP_010690.1, NM_001180710.1 |
3D structure databases
SMRi | P21595 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32462, 168 interactors |
STRINGi | 4932.YDR402C |
Proteomic databases
PaxDbi | P21595 |
Genome annotation databases
EnsemblFungii | YDR402C_mRNA; YDR402C; YDR402C |
GeneIDi | 852011 |
KEGGi | sce:YDR402C |
Organism-specific databases
EuPathDBi | FungiDB:YDR402C |
SGDi | S000002810, DIT2 |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00940000167749 |
HOGENOMi | CLU_031576_0_0_1 |
InParanoidi | P21595 |
OMAi | FGSRWNI |
Miscellaneous databases
PROi | PR:P21595 |
RNActi | P21595, protein |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP56_YEAST | |
Accessioni | P21595Primary (citable) accession number: P21595 Secondary accession number(s): D6VT34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names