DIT2

Functionⁱ

Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	435	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

heme binding Source: InterPro
iron ion binding Source: InterPro
monooxygenase activity Source: UniProtKB-KW
oxidoreductase activity
Source: SGD
Inferred from sequence or structural similarityⁱ
- 8183942
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ascospore wall assembly
Source: SGD
Inferred from direct assayⁱ
- 8183942

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Sporulation
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29946-MONOMER

BioCycⁱ

YEAST:G3O-29946-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450-DIT2 (EC:1.14.14.-) Alternative name(s): Cytochrome P450 56
Gene namesⁱ	Name:DIT2 Synonyms:CYP56 Ordered Locus Names:YDR402C ORF Names:D9509.20
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR402C
Saccharomyces Genome Database More...SGDⁱ	S000002810 DIT2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000052042	1 – 489	Cytochrome P450-DIT2Add BLAST		489

Proteomic databases

PaxDbⁱ	P21595
PRIDEⁱ	P21595

Expressionⁱ

Developmental stageⁱ

Sporulation.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	32462, 137 interactors
STRINGⁱ	4932.YDR402C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P21595
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144447
HOGENOMⁱ	HOG000160758
InParanoidⁱ	P21595
KEGG Orthology (KO) More...KOⁱ	K00493
OMAⁱ	SVFRIWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1BL6

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P21595-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELLKLLCLI LFLTLSYVAF AIIVPPLNFP KNIPTIPFYV VFLPVIFPID 
        60         70         80         90        100
QTELYDLYIR ESMEKYGAVK FFFGSRWNIL VSRSEYLAQI FKDEDTFAKS 
       110        120        130        140        150
GNQKKIPYSA LAAYTGDNVI SAYGAVWRNY RNAVTNGLQH FDDAPIFKNA 
       160        170        180        190        200
KILCTLIKNR LLEGQTSIPM GPLSQRMALD NISQVALGFD FGALTHEKNA 
       210        220        230        240        250
FHEHLIRIKK QIFHPFFLTF PFLDVLPIPS RKKAFKDVVS FRELLVKRVQ 
       260        270        280        290        300
DELVNNYKFE QTTFAASDLI RAHNNEIIDY KQLTDNIVII LVAGHENPQL 
       310        320        330        340        350
LFNSSLYLLA KYSNEWQEKL RKEVNGITDP KGLADLPLLN AFLFEVVRMY 
       360        370        380        390        400
PPLSTIINRC TTKTCKLGAE IVIPKGVYVG YNNFGTSHDP KTWGTTADDF 
       410        420        430        440        450
KPERWGSDIE TIRKNWRMAK NRCAVTGFHG GRRACLGEKL ALTEMRISLA 
       460        470        480 
EMLKQFRWSL DPEWEEKLTP AGPLCPLNLK LKFNENIME

Length:489

Mass (Da):56,071

Last modified:October 1, 1996 - v2

Checksum:ⁱ9A301276DDBEB18F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	445	M → I in CAA39246 (PubMed:2249774).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55713 Genomic DNA Translation: CAA39246.1 U32274 Genomic DNA Translation: AAB64842.1 BK006938 Genomic DNA Translation: DAA12244.1
PIRⁱ	B36395
NCBI Reference Sequences More...RefSeqⁱ	NP_010690.1, NM_001180710.1

Genome annotation databases

EnsemblFungiⁱ	YDR402C; YDR402C; YDR402C
GeneIDⁱ	852011
KEGGⁱ	sce:YDR402C

Protein	Similar proteins		Species	Score	Length
P21595	Dit2p		YEASC		489
Dit2p		YEASZ		489

Protein	Similar proteins		Species	Score	Length
P21595	Dit2p		YEASC		489
Dit2p		YEASZ		489
Cytochrome P450-DIT2		YEAS1		489
DIT2p N-formyltyrosine oxidase		Saccharomyces sp. 'boulardii'		489
YDR402Cp-like protein		YEAS6		489
+5

Protein	Similar proteins		Species	Score	Length
P21595	Dit2p		YEASC		489
Dit2p		YEASZ		489
K7_Dit2p		YEASK		489
Cytochrome P450-DIT2		YEAS1		489
DIT2p N-formyltyrosine oxidase		Saccharomyces sp. 'boulardii'		489
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55713 Genomic DNA Translation: CAA39246.1 U32274 Genomic DNA Translation: AAB64842.1 BK006938 Genomic DNA Translation: DAA12244.1
PIRⁱ	B36395
NCBI Reference Sequences More...RefSeqⁱ	NP_010690.1, NM_001180710.1

3D structure databases

ProteinModelPortalⁱ	P21595
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32462, 137 interactors
STRINGⁱ	4932.YDR402C

Proteomic databases

PaxDbⁱ	P21595
PRIDEⁱ	P21595

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDR402C; YDR402C; YDR402C
GeneIDⁱ	852011
KEGGⁱ	sce:YDR402C

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR402C
Saccharomyces Genome Database More...SGDⁱ	S000002810 DIT2

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144447
HOGENOMⁱ	HOG000160758
InParanoidⁱ	P21595
KEGG Orthology (KO) More...KOⁱ	K00493
OMAⁱ	SVFRIWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1BL6

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29946-MONOMER

BioCycⁱ

YEAST:G3O-29946-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P21595

PROⁱ

PR:P21595

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP56_YEAST
Accessionⁱ	P21595Primary (citable) accession number: P21595 Secondary accession number(s): D6VT34
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	October 1, 1996
	Last modified:	March 28, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P21595 (CP56_YEAST)

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Cytochrome P450-DIT2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ