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Entry version 159 (29 Sep 2021)
Sequence version 1 (01 May 1991)
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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

COX10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • farnesyltranstransferase activity Source: GO_Central
  • protoheme IX farnesyltransferase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.141, 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-189451, Heme biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrial (EC:2.5.1.-)
Alternative name(s):
Heme O synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX10
Ordered Locus Names:YPL172C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006093, COX10

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPL172C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei141 – 165HelicalSequence analysisAdd BLAST25
Transmembranei180 – 198HelicalSequence analysisAdd BLAST19
Transmembranei221 – 239HelicalSequence analysisAdd BLAST19
Transmembranei250 – 268HelicalSequence analysisAdd BLAST19
Transmembranei338 – 356HelicalSequence analysisAdd BLAST19
Transmembranei369 – 386HelicalSequence analysisAdd BLAST18
Transmembranei429 – 453HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003592531 – 462Protoheme IX farnesyltransferase, mitochondrialAdd BLAST432

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21592

PRoteomics IDEntifications database

More...
PRIDEi
P21592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36011, 430 interactors

Database of interacting proteins

More...
DIPi
DIP-3982N

STRING: functional protein association networks

More...
STRINGi
4932.YPL172C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21592, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1380, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153771

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029631_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21592

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSICSYA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13957, PT_UbiA_Cox10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006369, Protohaem_IX_farnesylTrfase
IPR016315, Protohaem_IX_farnesylTrfase_mt
IPR000537, UbiA_prenyltransferase
IPR030470, UbiA_prenylTrfase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR43448, PTHR43448, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01040, UbiA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001773, COX10, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01473, cyoE_ctaB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00943, UBIA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P21592-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH
60 70 80 90 100
GGKQQHINTA PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG
110 120 130 140 150
SEATTDASTQ LPFNVKLVDP MVRKSKRPSH AISEGLNMKT LKKKVIMPYL
160 170 180 190 200
QLTKPRLTIL VMLSAICSYA LSPYPASVNE LLCLTVGTTL CSGSANAINM
210 220 230 240 250
GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV SILYFGVNPT
260 270 280 290 300
VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH
310 320 330 340 350
PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL
360 370 380 390 400
RYSILMFPLC FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS
410 420 430 440 450
AKTLKDNVKF NKGLSVANIY ARKTFMASVL HLPAILILAI IHKKGRWDWI
460
YPGEAKRPQE RF
Length:462
Mass (Da):52,148
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8535C6D1BE2674F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55566 Genomic DNA Translation: AAA34509.1
Z73528 Genomic DNA Translation: CAA97879.1
L29279 Genomic DNA Translation: AAA64523.1
BK006949 Genomic DNA Translation: DAA11262.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37812, COBY10

NCBI Reference Sequences

More...
RefSeqi
NP_015153.1, NM_001183986.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL172C_mRNA; YPL172C; YPL172C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL172C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55566 Genomic DNA Translation: AAA34509.1
Z73528 Genomic DNA Translation: CAA97879.1
L29279 Genomic DNA Translation: AAA64523.1
BK006949 Genomic DNA Translation: DAA11262.1
PIRiA37812, COBY10
RefSeqiNP_015153.1, NM_001183986.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi36011, 430 interactors
DIPiDIP-3982N
STRINGi4932.YPL172C

Proteomic databases

PaxDbiP21592
PRIDEiP21592

Genome annotation databases

EnsemblFungiiYPL172C_mRNA; YPL172C; YPL172C
GeneIDi855931
KEGGisce:YPL172C

Organism-specific databases

SGDiS000006093, COX10
VEuPathDBiFungiDB:YPL172C

Phylogenomic databases

eggNOGiKOG1380, Eukaryota
GeneTreeiENSGT00940000153771
HOGENOMiCLU_029631_2_1_1
InParanoidiP21592
OMAiSSICSYA

Enzyme and pathway databases

BRENDAi2.5.1.141, 984
ReactomeiR-SCE-189451, Heme biosynthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21592
RNActiP21592, protein

Family and domain databases

CDDicd13957, PT_UbiA_Cox10, 1 hit
InterProiView protein in InterPro
IPR006369, Protohaem_IX_farnesylTrfase
IPR016315, Protohaem_IX_farnesylTrfase_mt
IPR000537, UbiA_prenyltransferase
IPR030470, UbiA_prenylTrfase_CS
PANTHERiPTHR43448, PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040, UbiA, 1 hit
PIRSFiPIRSF001773, COX10, 1 hit
TIGRFAMsiTIGR01473, cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943, UBIA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX10_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21592
Secondary accession number(s): D6W3J6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 29, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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