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UniProtKB - P21589 (5NTD_HUMAN)

Entry version 212 (02 Dec 2020)
Sequence version 1 (01 May 1991)
Previous versions | rss
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Protein

5'-nucleotidase

Gene

NT5E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi36Zinc 1Combined sources1 Publication1
Metal bindingi38Zinc 1Combined sources1 Publication1
Metal bindingi85Zinc 1Combined sources1 Publication1
Metal bindingi85Zinc 2Combined sources1 Publication1
Metal bindingi117Zinc 2Combined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei118Transition state stabilizer1 Publication1
Sitei121Transition state stabilizer1 Publication1
Metal bindingi220Zinc 2Combined sources1 Publication1
Metal bindingi243Zinc 2Combined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei245SubstrateCombined sources1 Publication1
Binding sitei354SubstrateCombined sources1 Publication1
Binding sitei390SubstrateCombined sources1 Publication1
Binding sitei395SubstrateCombined sources1 Publication1
Binding sitei417SubstrateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05981-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P21589

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196807, Nicotinate metabolism
R-HSA-73621, Pyrimidine catabolism
R-HSA-74259, Purine catabolism
R-HSA-9660826, Purinergic signaling in leishmaniasis infection

SIGNOR Signaling Network Open Resource

More...SIGNORi		P21589

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Alternative name(s):
Ecto-5'-nucleotidase
CD_antigen: CD73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NT5E
Synonyms:NT5, NTE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000135318.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:8021, NT5E

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		129190, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P21589

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Calcification of joints and arteries (CALJA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065185358C → Y in CALJA; absence from the plasma-membrane; exhibits no catalytic AMPase activity. 2 PublicationsCorresponds to variant dbSNP:rs387906620EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		4907

MalaCards human disease database

More...MalaCardsi		NT5E
MIMi211800, phenotype

Open Targets

More...OpenTargetsi		ENSG00000135318

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		289601, Hereditary arterial and articular multiple calcification syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31804

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P21589, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5957

Drug and drug target database

More...DrugBanki		DB00987, Cytarabine
DB00806, Pentoxifylline

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1232

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NT5E

Domain mapping of disease mutations (DMDM)

More...DMDMi		112825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000001527 – 5495'-nucleotidase1 PublicationAdd BLAST523
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000000016550 – 574Removed in mature formAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 57Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi333N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi353 ↔ 358Combined sources1 Publication
Disulfide bondi365 ↔ 387Combined sources1 Publication
Glycosylationi403N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi476 ↔ 479Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi549GPI-anchor amidated serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-552

Encyclopedia of Proteome Dynamics

More...EPDi		P21589

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P21589

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P21589

MaxQB - The MaxQuant DataBase

More...MaxQBi		P21589

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P21589

PeptideAtlas

More...PeptideAtlasi		P21589

PRoteomics IDEntifications database

More...PRIDEi		P21589

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53883 [P21589-1]
53884 [P21589-2]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		NT5E

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P21589, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P21589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P21589

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P21589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135318, Expressed in stromal cell of endometrium and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P21589, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P21589, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135318, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110962, 61 interactors

Database of interacting proteins

More...DIPi		DIP-59992N

Protein interaction database and analysis system

More...IntActi		P21589, 41 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000257770

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P21589

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P21589, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P21589

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni500 – 506Substrate bindingCombined sources1 Publication7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4419, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063775

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005854_7_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		NYDCDSP

Database of Orthologous Groups

More...OrthoDBi		900867at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P21589

TreeFam database of animal gene trees

More...TreeFami		TF323589

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.21.10, 1 hit
3.90.780.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008334, 5'-Nucleotdase_C
IPR036907, 5'-Nucleotdase_C_sf
IPR006146, 5'-Nucleotdase_CS
IPR006179, 5_nucleotidase/apyrase
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like

The PANTHER Classification System

More...PANTHERi		PTHR11575, PTHR11575, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02872, 5_nucleotid_C, 1 hit
PF00149, Metallophos, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01607, APYRASEFAMLY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55816, SSF55816, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00785, 5_NUCLEOTIDASE_1, 1 hit
PS00786, 5_NUCLEOTIDASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P21589-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK 
        60         70         80         90        100
CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE 
       110        120        130        140        150
VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL 
       160        170        180        190        200
ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL 
       210        220        230        240        250
QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT 
       260        270        280        290        300
GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV 
       310        320        330        340        350
ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS 
       360        370        380        390        400
QSCRFRECNM GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE 
       410        420        430        440        450
RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL 
       460        470        480        490        500
QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF 
       510        520        530        540        550
LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST 
       560        570 
GSHCHGSFSL IFLSLWAVIF VLYQ
Length:574
Mass (Da):63,368
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA99AF170AB7EAECE
GO
Isoform 2 (identifier: P21589-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-453: Missing.

Show »
Length:524
Mass (Da):57,949
Checksum:i98A11D22CFC7C610
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96B60Q96B60_HUMAN
Ecto-5'-nucleotidase
NT5E hCG_401111
264Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7R7H0Y7R7_HUMAN
5'-nucleotidase
NT5E
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3X5H0Y3X5_HUMAN
5'-nucleotidase
NT5E
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065185358C → Y in CALJA; absence from the plasma-membrane; exhibits no catalytic AMPase activity. 2 PublicationsCorresponds to variant dbSNP:rs387906620EnsemblClinVar.1
Natural variantiVAR_022091376T → A1 PublicationCorresponds to variant dbSNP:rs2229523Ensembl.1
Natural variantiVAR_048103379M → T. Corresponds to variant dbSNP:rs2229524Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043076404 – 453Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X55740 mRNA Translation: CAA39271.1
AK075008 mRNA Translation: BAG52050.1
AL135903 Genomic DNA No translation available.
AL589666 Genomic DNA No translation available.
U21730 Genomic DNA Translation: AAA96950.1
AF069067 Genomic DNA Translation: AAC98672.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5002.1 [P21589-1]
CCDS56439.1 [P21589-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S11032

NCBI Reference Sequences

More...RefSeqi		NP_001191742.1, NM_001204813.1 [P21589-2]
NP_002517.1, NM_002526.3 [P21589-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000257770; ENSP00000257770; ENSG00000135318 [P21589-1]
ENST00000369651; ENSP00000358665; ENSG00000135318 [P21589-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4907

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4907

UCSC genome browser

More...UCSCi		uc003pko.5, human [P21589-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55740 mRNA Translation: CAA39271.1
AK075008 mRNA Translation: BAG52050.1
AL135903 Genomic DNA No translation available.
AL589666 Genomic DNA No translation available.
U21730 Genomic DNA Translation: AAA96950.1
AF069067 Genomic DNA Translation: AAC98672.1
CCDSiCCDS5002.1 [P21589-1]
CCDS56439.1 [P21589-2]
PIRiS11032
RefSeqiNP_001191742.1, NM_001204813.1 [P21589-2]
NP_002517.1, NM_002526.3 [P21589-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H1SX-ray2.20A/B27-549[»]
4H1YX-ray1.58P27-549[»]
4H2BX-ray1.70A27-549[»]
4H2FX-ray1.85A27-549[»]
4H2GX-ray1.55A27-549[»]
4H2IX-ray2.00A27-549[»]
6HXWX-ray2.78A/B27-553[»]
6S7FX-ray2.05A27-549[»]
6S7HX-ray1.85A27-549[»]
6TVEX-ray1.05P27-549[»]
6TVGX-ray1.48A27-549[»]
6TVXX-ray2.60A27-549[»]
6TW0X-ray2.50A27-549[»]
6TWAX-ray2.00A27-549[»]
6TWFX-ray2.50A27-549[»]
6XUEX-ray1.94A/B27-549[»]
6XUGX-ray2.09A/B27-549[»]
6XUQX-ray1.97A27-549[»]
6Z9BX-ray2.17A27-549[»]
SMRiP21589
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110962, 61 interactors
DIPiDIP-59992N
IntActiP21589, 41 interactors
STRINGi9606.ENSP00000257770

Chemistry databases

BindingDBiP21589
ChEMBLiCHEMBL5957
DrugBankiDB00987, Cytarabine
DB00806, Pentoxifylline
GuidetoPHARMACOLOGYi1232

PTM databases

DEPODiNT5E
GlyGeniP21589, 4 sites
iPTMnetiP21589
PhosphoSitePlusiP21589
SwissPalmiP21589

Polymorphism and mutation databases

BioMutaiNT5E
DMDMi112825

Proteomic databases

CPTACiCPTAC-552
EPDiP21589
jPOSTiP21589
MassIVEiP21589
MaxQBiP21589
PaxDbiP21589
PeptideAtlasiP21589
PRIDEiP21589
ProteomicsDBi53883 [P21589-1]
53884 [P21589-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P21589, 24 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3007, 1234 antibodies

The DNASU plasmid repository

More...DNASUi		4907

Genome annotation databases

EnsembliENST00000257770; ENSP00000257770; ENSG00000135318 [P21589-1]
ENST00000369651; ENSP00000358665; ENSG00000135318 [P21589-2]
GeneIDi4907
KEGGihsa:4907
UCSCiuc003pko.5, human [P21589-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4907
DisGeNETi4907
EuPathDBiHostDB:ENSG00000135318.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		NT5E
HGNCiHGNC:8021, NT5E
HPAiENSG00000135318, Low tissue specificity
MalaCardsiNT5E
MIMi129190, gene
211800, phenotype
neXtProtiNX_P21589
OpenTargetsiENSG00000135318
Orphaneti289601, Hereditary arterial and articular multiple calcification syndrome
PharmGKBiPA31804

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4419, Eukaryota
GeneTreeiENSGT00530000063775
HOGENOMiCLU_005854_7_1_1
OMAiNYDCDSP
OrthoDBi900867at2759
PhylomeDBiP21589
TreeFamiTF323589

Enzyme and pathway databases

BioCyciMetaCyc:HS05981-MONOMER
PathwayCommonsiP21589
ReactomeiR-HSA-196807, Nicotinate metabolism
R-HSA-73621, Pyrimidine catabolism
R-HSA-74259, Purine catabolism
R-HSA-9660826, Purinergic signaling in leishmaniasis infection
SIGNORiP21589

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4907, 2 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NT5E, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NT5E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4907
PharosiP21589, Tchem

Protein Ontology

More...PROi		PR:P21589
RNActiP21589, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135318, Expressed in stromal cell of endometrium and 232 other tissues
ExpressionAtlasiP21589, baseline and differential
GenevisibleiP21589, HS

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334, 5'-Nucleotdase_C
IPR036907, 5'-Nucleotdase_C_sf
IPR006146, 5'-Nucleotdase_CS
IPR006179, 5_nucleotidase/apyrase
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
PANTHERiPTHR11575, PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872, 5_nucleotid_C, 1 hit
PF00149, Metallophos, 1 hit
PRINTSiPR01607, APYRASEFAMLY
SUPFAMiSSF55816, SSF55816, 1 hit
PROSITEiView protein in PROSITE
PS00785, 5_NUCLEOTIDASE_1, 1 hit
PS00786, 5_NUCLEOTIDASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5NTD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21589
Secondary accession number(s): B3KQI8, O75520, Q5W116
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: December 2, 2020
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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