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Protein

Tumor necrosis factor alpha-induced protein 3

Gene

TNFAIP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.12 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei100By similarity1
Active sitei103Nucleophile1 Publication1
Active sitei256Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri381 – 416A20-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri472 – 507A20-type 2PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri515 – 548A20-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri601 – 636A20-type 4PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri651 – 686A20-type 5PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri710 – 745A20-type 6PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri756 – 790A20-type 7PROSITE-ProRule annotationAdd BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • K63-linked polyubiquitin modification-dependent protein binding Source: GO_Central
  • kinase binding Source: Ensembl
  • Lys63-specific deubiquitinase activity Source: Reactome
  • protease binding Source: BHF-UCL
  • protein self-association Source: BHF-UCL
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
  • thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase
Biological processApoptosis, Inflammatory response, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P21580

SIGNOR Signaling Network Open Resource

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SIGNORi
P21580

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C64.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 3 (EC:2.3.2.-, EC:3.4.19.125 Publications)
Short name:
TNF alpha-induced protein 3
Alternative name(s):
OTU domain-containing protein 7C
Putative DNA-binding protein A20
Zinc finger protein A20
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFAIP3
Synonyms:OTUD7C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000118503.14

Human Gene Nomenclature Database

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HGNCi
HGNC:11896 TNFAIP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
191163 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21580

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoinflammatory syndrome, familial, Behcet-like (AISBL)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, autoinflammatory disorder with early onset, characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. Additional variable features include skin rash, uveitis, and polyarthritis.
See also OMIM:616744
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076302243C → Y in AISBL; increases inflammatory cytokine secretion; increases NF-kappaB signaling. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi70D → A: Minor effect on 'Lys-48' deubiquitinase activity. Strongly reduced 'Lys-63' deubiquitinase activity. 2 Publications1
Mutagenesisi97T → A: Minor effect on 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi100D → A: Strongly reduced deubiquitinase activity. 1 Publication1
Mutagenesisi103C → A: Loss of deubiquitinase activity. 4 Publications1
Mutagenesisi103C → S: Loss of 'Lys-63' deubiquitinating activity. Down-regulation of TNF-induced NF-kappa-B activity less effective. 4 Publications1
Mutagenesisi106H → A: Reduces deubiquitinase activity. 1 Publication1
Mutagenesisi157L → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi159Y → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi190S → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi192E → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi224F → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi227L → A: Strongly reduced 'Lys-48' deubiquitinase activity. 1 Publication1
Mutagenesisi256H → A: Loss of deubiquitinase activity. 2 Publications1
Mutagenesisi521C → A: No effect on ubiquitin ligase activity; when associated with A-524. 1 Publication1
Mutagenesisi524C → A: No effect on ubiquitin ligase activity; when associated with A-521. 1 Publication1
Mutagenesisi562R → A: Abolishes interactionj with YWHAZ AND YWHAH; no effect on inhibitory activity of TNF-induced NF-kappa-B activation. 1 Publication1
Mutagenesisi565S → A: Abolishes interactionj with YWHAZ AND YWHAH; no effect on inhibitory activity of TNF-induced NF-kappa-B activation. 1 Publication1
Mutagenesisi614Y → A: Impairs ubiquitination activity. Loss of down-regulation of NF-kappa-B activity; when associated with A-615 or R-626. 1 Publication1
Mutagenesisi615F → A: Impairs ubiquitination activity. Loss of down-regulation of NF-kappa-B activity; when associated with A-614. 1 Publication1
Mutagenesisi624C → A: Marked attenuation of ubiquitin ligase activity and inhibition of RIPK1 degradation; when associated with A-627. 1 Publication1
Mutagenesisi626L → R: Impairs ubiquitination activity. Loss of down-regulation of NF-kappa-B activity; when associated with A-614. 1 Publication1
Mutagenesisi627C → A: Marked attenuation of ubiquitin ligase activity and inhibition of RIPK1 degradation; when associated with A-624. 1 Publication1
Mutagenesisi770 – 771FG → AA: Impairs polyubiquitin binding, abolishes inhibition of IKK activation. 1 Publication2
Mutagenesisi779C → A: Impairs polyubiquitin binding, abolishes inhibition of IKK activation; when associated with A-782. 1 Publication1
Mutagenesisi782C → A: Impairs polyubiquitin binding, abolishes inhibition of IKK activation; when associated with A-779. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7128

MalaCards human disease database

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MalaCardsi
TNFAIP3
MIMi616744 phenotype

Open Targets

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OpenTargetsi
ENSG00000118503

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
476102 Hereditary pediatric Behcet-like disease
536 NON RARE IN EUROPE: Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36593

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TNFAIP3

Domain mapping of disease mutations (DMDM)

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DMDMi
112894

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001887912 – 790Tumor necrosis factor alpha-induced protein 3Add BLAST789
ChainiPRO_00004181272 – 439A20p50Add BLAST438
ChainiPRO_0000418128440 – 790A20p37Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei439 – 440Cleavage; by MALT12

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P21580

MaxQB - The MaxQuant DataBase

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MaxQBi
P21580

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P21580

PeptideAtlas

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PeptideAtlasi
P21580

PRoteomics IDEntifications database

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PRIDEi
P21580

ProteomicsDB human proteome resource

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ProteomicsDBi
53879

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P21580

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P21580

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000118503 Expressed in 211 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

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CleanExi
HS_TNFAIP3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21580 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21580 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA002116
HPA067479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112983, 94 interactors

Database of interacting proteins

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DIPi
DIP-33804N

Protein interaction database and analysis system

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IntActi
P21580, 63 interactors

Molecular INTeraction database

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MINTi
P21580

STRING: functional protein association networks

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STRINGi
9606.ENSP00000237289

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P21580

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21580

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P21580

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 263OTUPROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 300TRAF-bindingAdd BLAST243
Regioni157 – 159Interaction with ubiquitinCurated3
Regioni190 – 192Interaction with ubiquitinCurated3
Regioni224 – 227Interaction with ubiquitinCurated4
Regioni369 – 775Interaction with TNIP1By similarityAdd BLAST407
Regioni386 – 453Interaction with RIPK11 PublicationAdd BLAST68
Regioni605 – 655Required for proteosomal degradation of UBE2N and UBE2D3, TRAF6 deubiquitination, and TAX1BP1 interaction with UBE2NBy similarityAdd BLAST51
Regioni606 – 790Sufficient for inhibitory activity of TNF-induced NF-kappa-B activityBy similarityAdd BLAST185
Regioni697 – 790Required for lysosomal localization and for TRAF2 lysosomal degradationAdd BLAST94

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin.1 Publication
The OTU domain mediates the deubiquitinase activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C64 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri381 – 416A20-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri472 – 507A20-type 2PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri515 – 548A20-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri601 – 636A20-type 4PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri651 – 686A20-type 5PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri710 – 745A20-type 6PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri756 – 790A20-type 7PROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQZK Eukaryota
ENOG41117NJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158448

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000133004

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG059260

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21580

KEGG Orthology (KO)

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KOi
K11859

Identification of Orthologs from Complete Genome Data

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OMAi
QRFHEAK

Database of Orthologous Groups

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OrthoDBi
EOG091G01QE

Database for complete collections of gene phylogenies

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PhylomeDBi
P21580

TreeFam database of animal gene trees

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TreeFami
TF323312

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033478 A20
IPR003323 OTU_dom
IPR002653 Znf_A20

The PANTHER Classification System

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PANTHERi
PTHR13367:SF3 PTHR13367:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02338 OTU, 1 hit
PF01754 zf-A20, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00259 ZnF_A20, 7 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50802 OTU, 1 hit
PS51036 ZF_A20, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P21580-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM
60 70 80 90 100
FRTCQFCPQF REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD
110 120 130 140 150
GNCLMHATSQ YMWGVQDTDL VLRKALFSTL KETDTRNFKF RWQLESLKSQ
160 170 180 190 200
EFVETGLCYD TRNWNDEWDN LIKMASTDTP MARSGLQYNS LEEIHIFVLC
210 220 230 240 250
NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA QECYRYPIVL
260 270 280 290 300
GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE
310 320 330 340 350
KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ
360 370 380 390 400
HEYKKWQENS EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT
410 420 430 440 450
QPLCHECSER RQKNQNKLPK LNSKPGPEGL PGMALGASRG EAYEPLAWNP
460 470 480 490 500
EESTGGPHSA PPTAPSPFLF SETTAMKCRS PGCPFTLNVQ HNGFCERCHN
510 520 530 540 550
ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF KRTTAEASSS
560 570 580 590 600
LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD
610 620 630 640 650
RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR
660 670 680 690 700
FQNTIPCLGR ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ
710 720 730 740 750
RRDVPRTTQS TSRPKCARAS CKNILACRSE ELCMECQHPN QRMGPGAHRG
760 770 780 790
EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN ECFQFKQMYG
Length:790
Mass (Da):89,614
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i320AEA97F58D4491
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3TTY5D3TTY5_HUMAN
Truncated tumor necrosis factor alp...
TNFAIP3
669Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1N1A0A087X1N1_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXL5A0A087WXL5_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
470Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU80A0A087WU80_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VXQ8Q5VXQ8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVN3A0A087WVN3_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VXQ9Q5VXQ9_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VXR0Q5VXR0_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP3
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020447125A → V1 PublicationCorresponds to variant dbSNP:rs5029941EnsemblClinVar.1
Natural variantiVAR_022143127F → C1 PublicationCorresponds to variant dbSNP:rs2230926EnsemblClinVar.1
Natural variantiVAR_076302243C → Y in AISBL; increases inflammatory cytokine secretion; increases NF-kappaB signaling. 1 Publication1
Natural variantiVAR_029319766A → P1 PublicationCorresponds to variant dbSNP:rs5029957Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M59465 mRNA Translation: AAA51550.1
AK312862 mRNA Translation: BAG35714.1
AY248754 Genomic DNA Translation: AAO61093.1
AL357060 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47925.1
CH471051 Genomic DNA Translation: EAW47926.1
BC113871 mRNA Translation: AAI13872.1
BC114480 mRNA Translation: AAI14481.1
AL157444 mRNA Translation: CAB75664.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5187.1

Protein sequence database of the Protein Information Resource

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PIRi
A35797

NCBI Reference Sequences

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RefSeqi
NP_001257436.1, NM_001270507.1
NP_001257437.1, NM_001270508.1
NP_006281.1, NM_006290.3
XP_005267176.1, XM_005267119.1
XP_011534397.1, XM_011536095.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.211600

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000237289; ENSP00000237289; ENSG00000118503
ENST00000612899; ENSP00000481570; ENSG00000118503

Database of genes from NCBI RefSeq genomes

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GeneIDi
7128

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7128

UCSC genome browser

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UCSCi
uc003qhr.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59465 mRNA Translation: AAA51550.1
AK312862 mRNA Translation: BAG35714.1
AY248754 Genomic DNA Translation: AAO61093.1
AL357060 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47925.1
CH471051 Genomic DNA Translation: EAW47926.1
BC113871 mRNA Translation: AAI13872.1
BC114480 mRNA Translation: AAI14481.1
AL157444 mRNA Translation: CAB75664.1
CCDSiCCDS5187.1
PIRiA35797
RefSeqiNP_001257436.1, NM_001270507.1
NP_001257437.1, NM_001270508.1
NP_006281.1, NM_006290.3
XP_005267176.1, XM_005267119.1
XP_011534397.1, XM_011536095.1
UniGeneiHs.211600

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQENMR-A597-631[»]
2EQFNMR-A758-790[»]
2EQGNMR-A381-416[»]
2VFJX-ray3.20A/B/C/D1-366[»]
3DKBX-ray2.50A/B/C/D/E/F1-370[»]
3OJ3X-ray2.50I/J/K/L/M/N/O/P592-635[»]
3OJ4X-ray3.40C/F592-635[»]
3VUWX-ray1.95E/F/G757-789[»]
3VUXX-ray1.70E/F/G757-790[»]
3VUYX-ray1.98D/E/F757-790[»]
3ZJDX-ray1.87A/B1-366[»]
3ZJEX-ray1.84A/B1-366[»]
3ZJFX-ray2.20A/B1-366[»]
3ZJGX-ray1.92A/B1-366[»]
5LRXX-ray2.85A/C/E/F1-366[»]
5V3BX-ray3.00A/B/C/D/E/F1-366[»]
5V3PX-ray2.50A/B/C/D/E/F1-366[»]
ProteinModelPortaliP21580
SMRiP21580
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112983, 94 interactors
DIPiDIP-33804N
IntActiP21580, 63 interactors
MINTiP21580
STRINGi9606.ENSP00000237289

Protein family/group databases

MEROPSiC64.003

PTM databases

iPTMnetiP21580
PhosphoSitePlusiP21580

Polymorphism and mutation databases

BioMutaiTNFAIP3
DMDMi112894

Proteomic databases

EPDiP21580
MaxQBiP21580
PaxDbiP21580
PeptideAtlasiP21580
PRIDEiP21580
ProteomicsDBi53879

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237289; ENSP00000237289; ENSG00000118503
ENST00000612899; ENSP00000481570; ENSG00000118503
GeneIDi7128
KEGGihsa:7128
UCSCiuc003qhr.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7128
DisGeNETi7128
EuPathDBiHostDB:ENSG00000118503.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TNFAIP3
HGNCiHGNC:11896 TNFAIP3
HPAiHPA002116
HPA067479
MalaCardsiTNFAIP3
MIMi191163 gene
616744 phenotype
neXtProtiNX_P21580
OpenTargetsiENSG00000118503
Orphaneti476102 Hereditary pediatric Behcet-like disease
536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBiPA36593

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQZK Eukaryota
ENOG41117NJ LUCA
GeneTreeiENSGT00940000158448
HOGENOMiHOG000133004
HOVERGENiHBG059260
InParanoidiP21580
KOiK11859
OMAiQRFHEAK
OrthoDBiEOG091G01QE
PhylomeDBiP21580
TreeFamiTF323312

Enzyme and pathway databases

ReactomeiR-HSA-168638 NOD1/2 Signaling Pathway
R-HSA-5357786 TNFR1-induced proapoptotic signaling
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
SignaLinkiP21580
SIGNORiP21580

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNFAIP3 human
EvolutionaryTraceiP21580

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNFAIP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7128

Protein Ontology

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PROi
PR:P21580

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118503 Expressed in 211 organ(s), highest expression level in bone marrow
CleanExiHS_TNFAIP3
ExpressionAtlasiP21580 baseline and differential
GenevisibleiP21580 HS

Family and domain databases

InterProiView protein in InterPro
IPR033478 A20
IPR003323 OTU_dom
IPR002653 Znf_A20
PANTHERiPTHR13367:SF3 PTHR13367:SF3, 1 hit
PfamiView protein in Pfam
PF02338 OTU, 1 hit
PF01754 zf-A20, 4 hits
SMARTiView protein in SMART
SM00259 ZnF_A20, 7 hits
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit
PS51036 ZF_A20, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNAP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21580
Secondary accession number(s): B2R767
, E1P588, Q2HIX9, Q5VXQ7, Q9NSR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: December 5, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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