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UniProtKB - P21576 (VPS1_YEAST)
Protein
Vacuolar protein sorting-associated protein 1
Gene
VPS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Essential for protein sorting in meiotic cell division of S.cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein.
1 PublicationMiscellaneous
Present with 5960 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 43 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 178 – 182 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 247 – 250 | GTPSequence analysis | 4 |
GO - Molecular functioni
- GTPase activity Source: SGD
- GTP binding Source: UniProtKB-KW
- microtubule binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: SGD
- cell division Source: UniProtKB-KW
- endocytosis Source: SGD
- lipid tube assembly Source: SGD
- meiotic cell cycle Source: UniProtKB-KW
- peroxisome fission Source: SGD
- peroxisome organization Source: SGD
- protein retention in Golgi apparatus Source: SGD
- protein targeting to vacuole Source: SGD
- vacuolar transport Source: SGD
Keywordsi
Molecular function | Motor protein |
Biological process | Cell cycle, Cell division, Meiosis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-169911, Regulation of Apoptosis R-SCE-196025, Formation of annular gap junctions R-SCE-75153, Apoptotic execution phase |
Protein family/group databases
TCDBi | 9.A.63.1.1, the retromer-dependent vacuolar protein sorting (r-vps) family |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 1 |
Gene namesi | Name:VPS1 Synonyms:LAM1, SPO15 Ordered Locus Names:YKR001C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001709, VPS1 |
VEuPathDBi | FungiDB:YKR001C |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- actin cortical patch Source: SGD
- microtubule Source: GO_Central
Cytosol
- cytosol Source: SGD
Endosome
- late endosome Source: SGD
Mitochondrion
- mitochondrial outer membrane Source: SGD
- mitochondrion Source: SGD
Peroxisome
- peroxisome Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206588 | 1 – 704 | Vacuolar protein sorting-associated protein 1Add BLAST | 704 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 579 | PhosphoserineCombined sources | 1 | |
Modified residuei | 599 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P21576 |
PaxDbi | P21576 |
PRIDEi | P21576 |
TopDownProteomicsi | P21576 |
PTM databases
iPTMneti | P21576 |
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 34133, 531 interactors |
DIPi | DIP-6290N |
IntActi | P21576, 60 interactors |
MINTi | P21576 |
STRINGi | 4932.YKR001C |
Miscellaneous databases
RNActi | P21576, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 336 | Dynamin-type GPROSITE-ProRule annotationAdd BLAST | 311 | |
Domaini | 618 – 704 | GEDPROSITE-ProRule annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 43 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 62 – 64 | G2 motifPROSITE-ProRule annotation | 3 | |
Regioni | 76 – 122 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 178 – 181 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 247 – 250 | G4 motifPROSITE-ProRule annotation | 4 | |
Regioni | 277 – 280 | G5 motifPROSITE-ProRule annotation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 94 – 122 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
HOGENOMi | CLU_008964_5_2_1 |
InParanoidi | P21576 |
OMAi | IPGQKFH |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
i Sequence
Sequence statusi: Complete.
P21576-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV
60 70 80 90 100
GRDFLPRGTG IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD
110 120 130 140 150
KKKDESGKHQ NEGQSEDNKE EWGEFLHLPG KKFYNFDEIR KEIVKETDKV
160 170 180 190 200
TGANSGISSV PINLRIYSPH VLTLTLVDLP GLTKVPVGDQ PPDIERQIKD
210 220 230 240 250
MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT RTIGVLTKVD
260 270 280 290 300
LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF
310 320 330 340 350
FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ
360 370 380 390 400
NELINLGPET MDSASSVVLS MITDFSNEYA GILDGEAKEL SSQELSGGAR
410 420 430 440 450
ISYVFHETFK NGVDSLDPFD QIKDSDIRTI MYNSSGSAPS LFVGTEAFEV
460 470 480 490 500
LVKQQIRRFE EPSLRLVTLV FDELVRMLKQ IISQPKYSRY PALREAISNQ
510 520 530 540 550
FIQFLKDATI PTNEFVVDII KAEQTYINTA HPDLLKGSQA MVMVEEKLHP
560 570 580 590 600
RQVAVDPKTG KPLPTQPSSS KAPVMEEKSG FFGGFFSTKN KKKLAALESP
610 620 630 640 650
PPVLKATGQM TERETMETEV IKLLISSYFS IVKRTIADII PKALMLKLIV
660 670 680 690 700
KSKTDIQKVL LEKLYGKQDI EELTKENDIT IQRRKECKKM VEILRNASQI
VSSV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | T → N in AAA35216 (PubMed:2112425).Curated | 1 | |
Sequence conflicti | 111 | N → E in AAA35216 (PubMed:2112425).Curated | 1 | |
Sequence conflicti | 141 | K → Q in CAA38214 (PubMed:1825352).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54316 Genomic DNA Translation: CAA38214.1 M33315 Genomic DNA Translation: AAA35216.1 X65124 Genomic DNA Translation: CAA46251.1 Z28226 Genomic DNA Translation: CAA82071.1 BK006944 Genomic DNA Translation: DAA09157.1 |
PIRi | S25820 |
RefSeqi | NP_012926.1, NM_001179791.1 |
Genome annotation databases
EnsemblFungii | YKR001C_mRNA; YKR001C; YKR001C |
GeneIDi | 853870 |
KEGGi | sce:YKR001C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54316 Genomic DNA Translation: CAA38214.1 M33315 Genomic DNA Translation: AAA35216.1 X65124 Genomic DNA Translation: CAA46251.1 Z28226 Genomic DNA Translation: CAA82071.1 BK006944 Genomic DNA Translation: DAA09157.1 |
PIRi | S25820 |
RefSeqi | NP_012926.1, NM_001179791.1 |
3D structure databases
SMRi | P21576 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34133, 531 interactors |
DIPi | DIP-6290N |
IntActi | P21576, 60 interactors |
MINTi | P21576 |
STRINGi | 4932.YKR001C |
Protein family/group databases
TCDBi | 9.A.63.1.1, the retromer-dependent vacuolar protein sorting (r-vps) family |
PTM databases
iPTMneti | P21576 |
Proteomic databases
MaxQBi | P21576 |
PaxDbi | P21576 |
PRIDEi | P21576 |
TopDownProteomicsi | P21576 |
Genome annotation databases
EnsemblFungii | YKR001C_mRNA; YKR001C; YKR001C |
GeneIDi | 853870 |
KEGGi | sce:YKR001C |
Organism-specific databases
SGDi | S000001709, VPS1 |
VEuPathDBi | FungiDB:YKR001C |
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
HOGENOMi | CLU_008964_5_2_1 |
InParanoidi | P21576 |
OMAi | IPGQKFH |
Enzyme and pathway databases
Reactomei | R-SCE-169911, Regulation of Apoptosis R-SCE-196025, Formation of annular gap junctions R-SCE-75153, Apoptotic execution phase |
Miscellaneous databases
PROi | PR:P21576 |
RNActi | P21576, protein |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS1_YEAST | |
Accessioni | P21576Primary (citable) accession number: P21576 Secondary accession number(s): D6VXT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families