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Protein

Vacuolar protein sorting-associated protein 1

Gene

VPS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for protein sorting in meiotic cell division of Saccharomyces cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein.1 Publication

Miscellaneous

Present with 5960 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43GTPSequence analysis8
Nucleotide bindingi178 – 182GTPSequence analysis5
Nucleotide bindingi247 – 250GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Meiosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31979-MONOMER
ReactomeiR-SCE-1169408 ISG15 antiviral mechanism
R-SCE-75153 Apoptotic execution phase

Protein family/group databases

TCDBi9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 1
Gene namesi
Name:VPS1
Synonyms:LAM1, SPO15
Ordered Locus Names:YKR001C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

SGDiS000001709 VPS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065881 – 704Vacuolar protein sorting-associated protein 1Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei579PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21576
PaxDbiP21576
PRIDEiP21576
TopDownProteomicsiP21576

PTM databases

iPTMnetiP21576

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34133, 501 interactors
DIPiDIP-6290N
IntActiP21576, 60 interactors
MINTiP21576
STRINGi4932.YKR001C

Structurei

3D structure databases

ProteinModelPortaliP21576
SMRiP21576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 336Dynamin-type GPROSITE-ProRule annotationAdd BLAST311
Domaini618 – 704GEDPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 43G1 motifPROSITE-ProRule annotation8
Regioni62 – 64G2 motifPROSITE-ProRule annotation3
Regioni178 – 181G3 motifPROSITE-ProRule annotation4
Regioni247 – 250G4 motifPROSITE-ProRule annotation4
Regioni277 – 280G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119213
HOGENOMiHOG000161068
InParanoidiP21576
KOiK17065
OMAiFTTVGVQ
OrthoDBiEOG092C16PN

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

P21576-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV
60 70 80 90 100
GRDFLPRGTG IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD
110 120 130 140 150
KKKDESGKHQ NEGQSEDNKE EWGEFLHLPG KKFYNFDEIR KEIVKETDKV
160 170 180 190 200
TGANSGISSV PINLRIYSPH VLTLTLVDLP GLTKVPVGDQ PPDIERQIKD
210 220 230 240 250
MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT RTIGVLTKVD
260 270 280 290 300
LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF
310 320 330 340 350
FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ
360 370 380 390 400
NELINLGPET MDSASSVVLS MITDFSNEYA GILDGEAKEL SSQELSGGAR
410 420 430 440 450
ISYVFHETFK NGVDSLDPFD QIKDSDIRTI MYNSSGSAPS LFVGTEAFEV
460 470 480 490 500
LVKQQIRRFE EPSLRLVTLV FDELVRMLKQ IISQPKYSRY PALREAISNQ
510 520 530 540 550
FIQFLKDATI PTNEFVVDII KAEQTYINTA HPDLLKGSQA MVMVEEKLHP
560 570 580 590 600
RQVAVDPKTG KPLPTQPSSS KAPVMEEKSG FFGGFFSTKN KKKLAALESP
610 620 630 640 650
PPVLKATGQM TERETMETEV IKLLISSYFS IVKRTIADII PKALMLKLIV
660 670 680 690 700
KSKTDIQKVL LEKLYGKQDI EELTKENDIT IQRRKECKKM VEILRNASQI

VSSV
Length:704
Mass (Da):78,737
Last modified:July 1, 1993 - v2
Checksum:iD9AB527C04B3A977
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33T → N in AAA35216 (PubMed:2112425).Curated1
Sequence conflicti111N → E in AAA35216 (PubMed:2112425).Curated1
Sequence conflicti141K → Q in CAA38214 (PubMed:1825352).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54316 Genomic DNA Translation: CAA38214.1
M33315 Genomic DNA Translation: AAA35216.1
X65124 Genomic DNA Translation: CAA46251.1
Z28226 Genomic DNA Translation: CAA82071.1
BK006944 Genomic DNA Translation: DAA09157.1
PIRiS25820
RefSeqiNP_012926.1, NM_001179791.1

Genome annotation databases

EnsemblFungiiYKR001C; YKR001C; YKR001C
GeneIDi853870
KEGGisce:YKR001C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54316 Genomic DNA Translation: CAA38214.1
M33315 Genomic DNA Translation: AAA35216.1
X65124 Genomic DNA Translation: CAA46251.1
Z28226 Genomic DNA Translation: CAA82071.1
BK006944 Genomic DNA Translation: DAA09157.1
PIRiS25820
RefSeqiNP_012926.1, NM_001179791.1

3D structure databases

ProteinModelPortaliP21576
SMRiP21576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34133, 501 interactors
DIPiDIP-6290N
IntActiP21576, 60 interactors
MINTiP21576
STRINGi4932.YKR001C

Protein family/group databases

TCDBi9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

PTM databases

iPTMnetiP21576

Proteomic databases

MaxQBiP21576
PaxDbiP21576
PRIDEiP21576
TopDownProteomicsiP21576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR001C; YKR001C; YKR001C
GeneIDi853870
KEGGisce:YKR001C

Organism-specific databases

SGDiS000001709 VPS1

Phylogenomic databases

GeneTreeiENSGT00760000119213
HOGENOMiHOG000161068
InParanoidiP21576
KOiK17065
OMAiFTTVGVQ
OrthoDBiEOG092C16PN

Enzyme and pathway databases

BioCyciYEAST:G3O-31979-MONOMER
ReactomeiR-SCE-1169408 ISG15 antiviral mechanism
R-SCE-75153 Apoptotic execution phase

Miscellaneous databases

PROiPR:P21576

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS1_YEAST
AccessioniPrimary (citable) accession number: P21576
Secondary accession number(s): D6VXT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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Main funding by: National Institutes of Health

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