VPS1

Functionⁱ

Essential for protein sorting in meiotic cell division of Saccharomyces cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein.1 Publication

Miscellaneous

Present with 5960 molecules/cell in log phase SD medium.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	36 – 43	GTPSequence analysis	8
Nucleotide bindingⁱ	178 – 182	GTPSequence analysis	5
Nucleotide bindingⁱ	247 – 250	GTPSequence analysis	4

GO - Molecular functionⁱ

GTPase activity
Source: SGD
Inferred from direct assayⁱ
- 8299420
GTP binding Source: UniProtKB-KW
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: SGD
Inferred from mutant phenotypeⁱ
- 15265985
cell division Source: UniProtKB-KW
dynamin family protein polymerization involved in mitochondrial fission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
endocytosis
Source: SGD
Inferred from mutant phenotypeⁱ
- 20841380
lipid tube assembly
Source: SGD
Inferred from direct assayⁱ
- 20841380
meiotic cell cycle Source: UniProtKB-KW
membrane fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrial fission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peroxisome fission
Source: SGD
Inferred from mutant phenotypeⁱ
- 18445678
peroxisome organization
Source: SGD
Inferred from direct assayⁱ
- 12707309
protein retention in Golgi apparatus
Source: SGD
Inferred from mutant phenotypeⁱ
- 8649377
protein targeting to vacuole
Source: SGD
Inferred from mutant phenotypeⁱ
- 8299420
vacuolar transport
Source: SGD
Inferred from mutant phenotypeⁱ
- 8299420

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Biological process	Cell cycle, Cell division, Meiosis
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31979-MONOMER
Reactomeⁱ	R-SCE-1169408 ISG15 antiviral mechanism R-SCE-75153 Apoptotic execution phase

Protein family/group databases

TCDBⁱ	9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

TCDBⁱ

9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 1
Gene namesⁱ	Name:VPS1 Synonyms:LAM1, SPO15 Ordered Locus Names:YKR001C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000001709 VPS1

SGDⁱ

S000001709 VPS1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206588	1 – 704	Vacuolar protein sorting-associated protein 1Add BLAST		704

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	579	PhosphoserineCombined sources		1
Modified residueⁱ	599	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P21576
PaxDbⁱ	P21576
PRIDEⁱ	P21576
TopDownProteomicsⁱ	P21576

PTM databases

iPTMnetⁱ	P21576

iPTMnetⁱ

P21576

Interactionⁱ

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	34133, 501 interactors
Database of interacting proteins More...DIPⁱ	DIP-6290N
IntActⁱ	P21576, 60 interactors
Molecular INTeraction database More...MINTⁱ	P21576
STRINGⁱ	4932.YKR001C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P21576
SMRⁱ	P21576
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 336	Dynamin-type GPROSITE-ProRule annotationAdd BLAST		311
Domainⁱ	618 – 704	GEDPROSITE-ProRule annotationAdd BLAST		87

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	36 – 43	G1 motifPROSITE-ProRule annotation	8
Regionⁱ	62 – 64	G2 motifPROSITE-ProRule annotation	3
Regionⁱ	178 – 181	G3 motifPROSITE-ProRule annotation	4
Regionⁱ	247 – 250	G4 motifPROSITE-ProRule annotation	4
Regionⁱ	277 – 280	G5 motifPROSITE-ProRule annotation	4

Sequence similaritiesⁱ

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119213
HOGENOMⁱ	HOG000161068
InParanoidⁱ	P21576
KEGG Orthology (KO) More...KOⁱ	K17065
OMAⁱ	FTTVGVQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C16PN

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08771 DLP_1, 1 hit
InterProⁱ	View protein in InterPro IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P21576-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV 
        60         70         80         90        100
GRDFLPRGTG IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD 
       110        120        130        140        150
KKKDESGKHQ NEGQSEDNKE EWGEFLHLPG KKFYNFDEIR KEIVKETDKV 
       160        170        180        190        200
TGANSGISSV PINLRIYSPH VLTLTLVDLP GLTKVPVGDQ PPDIERQIKD 
       210        220        230        240        250
MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT RTIGVLTKVD 
       260        270        280        290        300
LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF 
       310        320        330        340        350
FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ 
       360        370        380        390        400
NELINLGPET MDSASSVVLS MITDFSNEYA GILDGEAKEL SSQELSGGAR 
       410        420        430        440        450
ISYVFHETFK NGVDSLDPFD QIKDSDIRTI MYNSSGSAPS LFVGTEAFEV 
       460        470        480        490        500
LVKQQIRRFE EPSLRLVTLV FDELVRMLKQ IISQPKYSRY PALREAISNQ 
       510        520        530        540        550
FIQFLKDATI PTNEFVVDII KAEQTYINTA HPDLLKGSQA MVMVEEKLHP 
       560        570        580        590        600
RQVAVDPKTG KPLPTQPSSS KAPVMEEKSG FFGGFFSTKN KKKLAALESP 
       610        620        630        640        650
PPVLKATGQM TERETMETEV IKLLISSYFS IVKRTIADII PKALMLKLIV 
       660        670        680        690        700
KSKTDIQKVL LEKLYGKQDI EELTKENDIT IQRRKECKKM VEILRNASQI 

VSSV

Length:704

Mass (Da):78,737

Last modified:July 1, 1993 - v2

Checksum:ⁱD9AB527C04B3A977

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	33	T → N in AAA35216 (PubMed:2112425).Curated	1
Sequence conflictⁱ	111	N → E in AAA35216 (PubMed:2112425).Curated	1
Sequence conflictⁱ	141	K → Q in CAA38214 (PubMed:1825352).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54316 Genomic DNA Translation: CAA38214.1 M33315 Genomic DNA Translation: AAA35216.1 X65124 Genomic DNA Translation: CAA46251.1 Z28226 Genomic DNA Translation: CAA82071.1 BK006944 Genomic DNA Translation: DAA09157.1
PIRⁱ	S25820
NCBI Reference Sequences More...RefSeqⁱ	NP_012926.1, NM_001179791.1

Genome annotation databases

EnsemblFungiⁱ	YKR001C; YKR001C; YKR001C
GeneIDⁱ	853870
KEGGⁱ	sce:YKR001C

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21576	VPS1p Dynamin-like GTPase required for vacuolar sorting		Saccharomyces sp. 'boulardii'		704	UniRef100_P21576
Vps1p		YEASC		704
YKR001Cp-like protein		YEAS6		704
Vps1p		YEAS2		704
Vacuolar sorting protein		YEAS7		704

Protein	Similar proteins		Species	Score	Length	Source
P21576	VPS1p Dynamin-like GTPase required for vacuolar sorting		Saccharomyces sp. 'boulardii'		704	UniRef90_P21576
Vps1p		YEASC		704
YKR001Cp-like protein		YEAS6		704
Vps1p		YEAS2		704
Vacuolar sorting protein		YEAS7		704
+13

Protein	Similar proteins		Species	Score	Length	Source
P21576	Vacuolar protein sorting-associated protein 1		SCHPO		678	UniRef50_P21576
VPS1p Dynamin-like GTPase required for vacuolar sorting		Saccharomyces sp. 'boulardii'		704
Vps1p		YEASC		704
YKR001Cp-like protein		YEAS6		704
Vps1p		YEAS2		704
+304

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54316 Genomic DNA Translation: CAA38214.1 M33315 Genomic DNA Translation: AAA35216.1 X65124 Genomic DNA Translation: CAA46251.1 Z28226 Genomic DNA Translation: CAA82071.1 BK006944 Genomic DNA Translation: DAA09157.1
PIRⁱ	S25820
RefSeqⁱ	NP_012926.1, NM_001179791.1

3D structure databases

ProteinModelPortalⁱ	P21576
SMRⁱ	P21576
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	34133, 501 interactors
DIPⁱ	DIP-6290N
IntActⁱ	P21576, 60 interactors
MINTⁱ	P21576
STRINGⁱ	4932.YKR001C

Protein family/group databases

TCDBⁱ	9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

TCDBⁱ

9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

PTM databases

iPTMnetⁱ	P21576

iPTMnetⁱ

P21576

Proteomic databases

MaxQBⁱ	P21576
PaxDbⁱ	P21576
PRIDEⁱ	P21576
TopDownProteomicsⁱ	P21576

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YKR001C; YKR001C; YKR001C
GeneIDⁱ	853870
KEGGⁱ	sce:YKR001C

Organism-specific databases

SGDⁱ	S000001709 VPS1

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119213
HOGENOMⁱ	HOG000161068
InParanoidⁱ	P21576
KOⁱ	K17065
OMAⁱ	FTTVGVQ
OrthoDBⁱ	EOG092C16PN

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31979-MONOMER
Reactomeⁱ	R-SCE-1169408 ISG15 antiviral mechanism R-SCE-75153 Apoptotic execution phase

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P21576

PROⁱ

PR:P21576

Family and domain databases

CDDⁱ	cd08771 DLP_1, 1 hit
InterProⁱ	View protein in InterPro IPR000375 Dynamin_central IPR001401 Dynamin_GTPase IPR019762 Dynamin_GTPase_CS IPR022812 Dynamin_SF IPR030381 G_DYNAMIN_dom IPR003130 GED IPR020850 GED_dom IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11566 PTHR11566, 1 hit
Pfamⁱ	View protein in Pfam PF01031 Dynamin_M, 1 hit PF00350 Dynamin_N, 1 hit PF02212 GED, 1 hit
PRINTSⁱ	PR00195 DYNAMIN
SMARTⁱ	View protein in SMART SM00053 DYNc, 1 hit SM00302 GED, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00410 G_DYNAMIN_1, 1 hit PS51718 G_DYNAMIN_2, 1 hit PS51388 GED, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS1_YEAST
Accessionⁱ	P21576Primary (citable) accession number: P21576 Secondary accession number(s): D6VXT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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UniProtKB - P21576 (VPS1_YEAST)

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Vacuolar protein sorting-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Endosome

Mitochondrion

Peroxisome

Vacuole

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ