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Entry version 194 (12 Aug 2020)
Sequence version 2 (10 Jun 2008)
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Protein

Dynamin-1

Gene

Dnm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).By similarity

Caution

Absence of tyrosine and threonine phosphorylation is demonstrated in PubMed:17376771. However, tyrosine and threonine phosphorylation may still occur in different experimental conditions.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 45GTPSequence analysis8
Nucleotide bindingi136 – 140GTPSequence analysis5
Nucleotide bindingi205 – 208GTPSequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.5.5, 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-190873, Gap junction degradation
R-RNO-196025, Formation of annular gap junctions
R-RNO-2132295, MHC class II antigen presentation
R-RNO-437239, Recycling pathway of L1
R-RNO-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin-1 (EC:3.6.5.5)
Alternative name(s):
B-dynamin
D100
Dynamin, brain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnm1
Synonyms:Dnm
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
71096, Dnm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075191

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065651 – 864Dynamin-1Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80PhosphotyrosineBy similarity1
Modified residuei1253'-nitrotyrosine; alternateBy similarity1
Modified residuei125Phosphotyrosine; alternateBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei347PhosphoserineCombined sources1 Publication1
Modified residuei354PhosphotyrosineBy similarity1
Modified residuei512Phosphoserine1 Publication1
Modified residuei774Phosphoserine1 Publication1
Modified residuei778Phosphoserine1 Publication1
Modified residuei796Omega-N-methylarginineBy similarity1
Modified residuei822Phosphoserine1 Publication1
Modified residuei851PhosphoserineCombined sources1 Publication1
Modified residuei857PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated by CDK5 in nerve terminals and dephosphorylated by calcineurin when synaptic vesicle endocytosis (SVE) is stimulated by depolarization-dependent calcium influx.2 Publications

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21575

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21575

PRoteomics IDEntifications database

More...
PRIDEi
P21575

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0004:P21575

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21575

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21575

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain-specific (peripheral sensory neurons).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in neurons after maturation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000033835, Expressed in frontal cortex and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21575, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAV1 and SH3GLB1.

Interacts with SNX9.

Interacts with SNX33 (via SH3 domain) (By similarity).

Interacts with PHOCN.

Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds SH3GL1, SH3GL2 and SH3GL3.

Interacts with MYO1E (via SH3 domain).

Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity).

Interacts with DIAPH1 (By similarity).

Interacts with AMPH, BIN1 AND SYNJ1 (PubMed:9341169).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
250837, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P21575

Database of interacting proteins

More...
DIPi
DIP-30978N

Protein interaction database and analysis system

More...
IntActi
P21575, 17 interactors

Molecular INTeraction database

More...
MINTi
P21575

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047444

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21575

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21575

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P21575

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini519 – 625PHPROSITE-ProRule annotationAdd BLAST107
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi753 – 851Pro-richAdd BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0446, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008964_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21575

KEGG Orthology (KO)

More...
KOi
K01528

Identification of Orthologs from Complete Genome Data

More...
OMAi
XVMLLID

Database of Orthologous Groups

More...
OrthoDBi
264244at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21575

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08771, DLP_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027741, DNM1
IPR000375, Dynamin_central
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00195, DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P21575-1) [UniParc]FASTAAdd to basket
Also known as: aa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVNSTTEY AEFLHCKGKK FTDFEEVRLE
110 120 130 140 150
IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP
160 170 180 190 200
DIEFQIRDML MQFVTKENCL ILAVSPANSD LANSDALKIA KEVDPQGQRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VDEYKNFRPD DPARKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
IDTYELSGGA RINRIFHERF PFELVKMEFD EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDLAFE ATVKKQVQKL KEPSIKCVDM VVSELTSTIR KCSEKLQQYP
460 470 480 490 500
RLREEMERIV TTHIREREGR TKEQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSNQMNKKK TSGNQDEILV IRKGWLTINN IGIMKGGSKE YWFVLTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLSVDNL KLRDVEKGFM SSKHIFALFN TEQRNVYKDY
610 620 630 640 650
RQLELACETQ EEVDSWKASF LRAGVYPERV GDKEKASETE ENGSDSFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKEFIFSE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQRRDEMLR MYHALKEALS IIGDINTTTV
760 770 780 790 800
STPMPPPVDD SWLQVQSVPA GRRSPTSSPT PQRRAPAVPP ARPGSRGPAP
810 820 830 840 850
GPPPAGSALG GAPPVPSRPG ASPDPFGPPP QVPSRPNRAP PGVPSRSGQA
860
SPSRPESPRP PFDL
Length:864
Mass (Da):97,295
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02EC9B533CC2EC83
GO
Isoform 2 (identifier: P21575-2) [UniParc]FASTAAdd to basket
Also known as: ab

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Localized to numerous punctate spots of various sizes distributed along the plasma membrane and throughout the cytoplasm.Curated
Show »
Length:851
Mass (Da):95,927
Checksum:i5D9294C5D1015A88
GO
Isoform 3 (identifier: P21575-3) [UniParc]FASTAAdd to basket
Also known as: ac

The sequence of this isoform differs from the canonical sequence as follows:
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,376
Checksum:iA36766D15D5AC466
GO
Isoform 4 (identifier: P21575-4) [UniParc]FASTAAdd to basket
Also known as: ad

The sequence of this isoform differs from the canonical sequence as follows:
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

Show »
Length:856
Mass (Da):96,270
Checksum:i727CC965C3929D99
GO
Isoform 5 (identifier: P21575-5) [UniParc]FASTAAdd to basket
Also known as: ba

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK

Show »
Length:864
Mass (Da):97,424
Checksum:i4E27474E413CCEE7
GO
Isoform 6 (identifier: P21575-6) [UniParc]FASTAAdd to basket
Also known as: bb

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → RITISDP

Note: Diffuse cytoplasmic distribution with some localization to the Golgi apparatus.Curated
Show »
Length:851
Mass (Da):96,057
Checksum:i5FE0938290E39F51
GO
Isoform 7 (identifier: P21575-7) [UniParc]FASTAAdd to basket
Also known as: bc

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     766-814: QSVPAGRRSP...AGSALGGAPP → AHVQPHAAAP...PRALQAGGFP
     815-864: Missing.

Show »
Length:814
Mass (Da):92,505
Checksum:i686364B0BFE8865C
GO
Isoform 8 (identifier: P21575-8) [UniParc]FASTAAdd to basket
Also known as: bd

The sequence of this isoform differs from the canonical sequence as follows:
     407-444: LAFEATVKKQ...LTSTIRKCSE → MAFETIVKKQ...LISTVRQCTK
     845-864: SRSGQASPSRPESPRPPFDL → SQPIGSGKSVPS

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Length:856
Mass (Da):96,399
Checksum:i1A01F8B610A0EF9E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034033407 – 444LAFEA…RKCSE → MAFETIVKKQVKKIREPCLK CVDMVISELISTVRQCTK in isoform 5, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST38
Alternative sequenceiVSP_034034766 – 814QSVPA…GGAPP → AHVQPHAAAPSPRRAPSPAR VAGPCSWASACWIRPGGGSP RALQAGGFP in isoform 3 and isoform 7. CuratedAdd BLAST49
Alternative sequenceiVSP_034035815 – 864Missing in isoform 3 and isoform 7. CuratedAdd BLAST50
Alternative sequenceiVSP_034037845 – 864SRSGQ…PPFDL → RITISDP in isoform 2 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_034036845 – 864SRSGQ…PPFDL → SQPIGSGKSVPS in isoform 4 and isoform 8. CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X54531 mRNA Translation: CAA38397.1
CO398357 mRNA No translation available.
CB583951 mRNA No translation available.
CB708564 mRNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
S11508

NCBI Reference Sequences

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RefSeqi
NP_542420.1, NM_080689.4 [P21575-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000047921; ENSRNOP00000041582; ENSRNOG00000033835 [P21575-1]
ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835 [P21575-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
140694

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:140694

UCSC genome browser

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UCSCi
RGD:71096, rat [P21575-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54531 mRNA Translation: CAA38397.1
CO398357 mRNA No translation available.
CB583951 mRNA No translation available.
CB708564 mRNA No translation available.
PIRiS11508
RefSeqiNP_542420.1, NM_080689.4 [P21575-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AKAX-ray1.90B6-304[»]
3ZVRX-ray3.10A1-752[»]
SMRiP21575
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi250837, 27 interactors
CORUMiP21575
DIPiDIP-30978N
IntActiP21575, 17 interactors
MINTiP21575
STRINGi10116.ENSRNOP00000047444

Chemistry databases

BindingDBiP21575
ChEMBLiCHEMBL1075191

PTM databases

iPTMnetiP21575
PhosphoSitePlusiP21575

2D gel databases

World-2DPAGEi0004:P21575

Proteomic databases

jPOSTiP21575
PaxDbiP21575
PRIDEiP21575

Genome annotation databases

EnsembliENSRNOT00000047921; ENSRNOP00000041582; ENSRNOG00000033835 [P21575-1]
ENSRNOT00000064039; ENSRNOP00000060845; ENSRNOG00000033835 [P21575-2]
GeneIDi140694
KEGGirno:140694
UCSCiRGD:71096, rat [P21575-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1759
RGDi71096, Dnm1

Phylogenomic databases

eggNOGiKOG0446, Eukaryota
GeneTreeiENSGT00940000155214
HOGENOMiCLU_008964_1_0_1
InParanoidiP21575
KOiK01528
OMAiXVMLLID
OrthoDBi264244at2759
PhylomeDBiP21575

Enzyme and pathway databases

BRENDAi3.6.5.5, 5301
ReactomeiR-RNO-190873, Gap junction degradation
R-RNO-196025, Formation of annular gap junctions
R-RNO-2132295, MHC class II antigen presentation
R-RNO-437239, Recycling pathway of L1
R-RNO-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

EvolutionaryTraceiP21575

Protein Ontology

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PROi
PR:P21575

Gene expression databases

BgeeiENSRNOG00000033835, Expressed in frontal cortex and 22 other tissues
GenevisibleiP21575, RN

Family and domain databases

CDDicd08771, DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027741, DNM1
IPR000375, Dynamin_central
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00195, DYNAMIN
SMARTiView protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYN1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21575
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 10, 2008
Last modified: August 12, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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