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UniProtKB - P21556 (PTAFR_CAVPO)
Protein
Platelet-activating factor receptor
Gene
PTAFR
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- lipopolysaccharide binding Source: Ensembl
- lipopolysaccharide immune receptor activity Source: Ensembl
- phospholipid binding Source: Ensembl
- platelet activating factor receptor activity Source: Ensembl
GO - Biological processi
- chemotaxis Source: UniProtKB-KW
- inflammatory response Source: Ensembl
- inositol trisphosphate biosynthetic process Source: Ensembl
- phosphatidylinositol-mediated signaling Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-activating factor receptorShort name: PAF-R Short name: PAFr |
Gene namesi | Name:PTAFR |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 38 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 39 – 54 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 55 – 74 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 75 – 91 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 92 – 113 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 114 – 133 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 134 – 155 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 156 – 184 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 185 – 205 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 233 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 234 – 254 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 276 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 277 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 297 – 342 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070091 | 1 – 342 | Platelet-activating factor receptorAdd BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 90 ↔ 173 | PROSITE-ProRule annotation | ||
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Gene expression databases
Bgeei | ENSCPOG00000024245, Expressed in thyroid gland and 13 other tissues |
Interactioni
Subunit structurei
Interacts with ARRB1.
By similarityProtein-protein interaction databases
STRINGi | 10141.ENSCPOP00000015534 |
Chemistry databases
BindingDBi | P21556 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTQI, Eukaryota |
GeneTreei | ENSGT00980000198579 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P21556 |
OMAi | AIHVIIC |
OrthoDBi | 800525at2759 |
TreeFami | TF350009 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002282, PAF_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01153, PAFRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P21556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELNSSSRVD SEFRYTLFPI VYSIIFVLGI IANGYVLWVF ARLYPSKKLN
60 70 80 90 100
EIKIFMVNLT VADLLFLITL PLWIVYYSNQ GNWFLPKFLC NLAGCLFFIN
110 120 130 140 150
TYCSVAFLGV ITYNRFQAVK YPIKTAQATT RKRGIALSLV IWVAIVAAAS
160 170 180 190 200
YFLVMDSTNV VSNKAGSGNI TRCFEHYEKG SKPVLIIHIC IVLGFFIVFL
210 220 230 240 250
LILFCNLVII HTLLRQPVKQ QRNAEVRRRA LWMVCTVLAV FVICFVPHHM
260 270 280 290 300
VQLPWTLAEL GMWPSSNHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLSEKLNI MRSSQKCSRV TTDTGTEMAI PINHTPVNPI KN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56736 mRNA Translation: CAA40060.1 |
PIRi | S13638 |
RefSeqi | XP_005004316.1, XM_005004259.2 XP_013009648.1, XM_013154194.1 XP_013009649.1, XM_013154195.1 |
Genome annotation databases
Ensembli | ENSCPOT00000042353; ENSCPOP00000028935; ENSCPOG00000031748 |
GeneIDi | 100720710 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56736 mRNA Translation: CAA40060.1 |
PIRi | S13638 |
RefSeqi | XP_005004316.1, XM_005004259.2 XP_013009648.1, XM_013154194.1 XP_013009649.1, XM_013154195.1 |
3D structure databases
AlphaFoldDBi | P21556 |
SMRi | P21556 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000015534 |
Chemistry databases
BindingDBi | P21556 |
ChEMBLi | CHEMBL5136 |
DrugCentrali | P21556 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
ABCDi | P21556, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSCPOT00000042353; ENSCPOP00000028935; ENSCPOG00000031748 |
GeneIDi | 100720710 |
Organism-specific databases
CTDi | 5724 |
Phylogenomic databases
eggNOGi | ENOG502QTQI, Eukaryota |
GeneTreei | ENSGT00980000198579 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P21556 |
OMAi | AIHVIIC |
OrthoDBi | 800525at2759 |
TreeFami | TF350009 |
Miscellaneous databases
PROi | PR:P21556 |
Gene expression databases
Bgeei | ENSCPOG00000024245, Expressed in thyroid gland and 13 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002282, PAF_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01153, PAFRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTAFR_CAVPO | |
Accessioni | P21556Primary (citable) accession number: P21556 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families