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Protein

Protein Wnt-2

Gene

Wnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Functions as upstream regulator of FGF10 expression (PubMed:19686689). Plays an important role in embryonic lung development (PubMed:19686689). May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (PubMed:20018874).Curated1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Alternative name(s):
INT-1-related protein1 Publication
Short name:
IRP
Gene namesi
Name:Wnt2
Synonyms:Irp, Wnt-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98954 Wnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Nearly complete perinatal lethality within minutes after birth, due to lung hypoplasia (PubMed:19686689). About 4% survive for more than 30 days (PubMed:19686689). Combined disruption of Wnt2 and Wnt2b leads to lung agenesis and loss of trachea development (PubMed:19686689). In contrast, development of liver, stomach, intestine, pancreas and kidneys appears grossly normal (PubMed:19686689).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004141126 – 360Protein Wnt-2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 87By similarity
Disulfide bondi127 ↔ 135By similarity
Disulfide bondi137 ↔ 157By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP21552
PaxDbiP21552
PRIDEiP21552

PTM databases

iPTMnetiP21552
PhosphoSitePlusiP21552

Expressioni

Tissue specificityi

In embryos in the developing allantois, pericardium heart, and ventral-lateral mesoderm; in adults in lung, brain, heart and placenta.

Developmental stagei

Detected in ventral mesencephalon from 10.5 to 15.5 dpc; expression levels decrease moderately, but steadily during this period (PubMed:20018874). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut from 9.0 to 10.5 dpc (PubMed:19686689). Detected in the developing mesenchyme with higher levels surrounding the distal regions of the branching airways from 12.5 to 18.5 dpc (PubMed:19686689).2 Publications

Gene expression databases

BgeeiENSMUSG00000010797 Expressed in 142 organ(s), highest expression level in lung
CleanExiMM_WNT2
GenevisibleiP21552 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204572, 1 interactor
STRINGi10090.ENSMUSP00000010941

Chemistry databases

BindingDBiP21552

Structurei

3D structure databases

ProteinModelPortaliP21552
SMRiP21552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiP21552
KOiK00182
OMAiHTCKPHK
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVPLGGIWL WLPLLLTWLT PEVSSSWWYM RATGGSSRVM CDNVPGLVSR
60 70 80 90 100
QRQLCHRHPD VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV
110 120 130 140 150
LLRSSRESAF VYAISSAGVV FAITRACSQG ELKSCSCDPK KKGSAKDSKG
160 170 180 190 200
TFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR
210 220 230 240 250
FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG
260 270 280 290 300
TGFTVANKRF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG
310 320 330 340 350
MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA
360
PKSADWATPT
Length:360
Mass (Da):40,482
Last modified:July 27, 2011 - v2
Checksum:i5E37644D3815EEAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232D → E no nucleotide entry (PubMed:2693041).Curated1
Sequence conflicti232D → E no nucleotide entry (PubMed:2279700).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012093 mRNA Translation: BAB28025.1
CH466533 Genomic DNA Translation: EDL13868.1
BC026373 mRNA Translation: AAH26373.1
CCDSiCCDS19928.1
PIRiB36470
RefSeqiNP_076142.3, NM_023653.5
UniGeneiMm.33653

Genome annotation databases

EnsembliENSMUST00000010941; ENSMUSP00000010941; ENSMUSG00000010797
GeneIDi22413
KEGGimmu:22413
UCSCiuc009bag.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWNT2_MOUSE
AccessioniPrimary (citable) accession number: P21552
Secondary accession number(s): Q9CZW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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