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Protein

Serine--pyruvate aminotransferase

Gene

AGXT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei360Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS10525-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.6.1.44 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-9033241 Peroxisomal protein import

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine--pyruvate aminotransferase (EC:2.6.1.51)
Short name:
SPT
Alternative name(s):
Alanine--glyoxylate aminotransferase (EC:2.6.1.44)
Short name:
AGT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGXT
Synonyms:AGT1, SPAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000172482.4

Human Gene Nomenclature Database

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HGNCi
HGNC:341 AGXT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604285 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P21549

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperoxaluria primary 1 (HP1)24 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and progressive tissue accumulation of insoluble calcium oxalate. Affected individuals are at risk for nephrolithiasis, nephrocalcinosis and early onset end-stage renal disease.
See also OMIM:259900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07458236R → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177157EnsemblClinVar.1
Natural variantiVAR_07458341G → E in HP1; loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177168EnsemblClinVar.1
Natural variantiVAR_00058841G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of protein stability; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; partial mitochondrial mistargeting; intraperoxisomal protein aggregation seen. 7 PublicationsCorresponds to variant dbSNP:rs121908523EnsemblClinVar.1
Natural variantiVAR_01096941G → V in HP1; reduced alanine--glyoxylate aminotransferase activity; no loss of dimerization; no effect on protein stability. 3 PublicationsCorresponds to variant dbSNP:rs180177168EnsemblClinVar.1
Natural variantiVAR_07458447G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in protein misfolding; decreased alanine--glyoxylate aminotransferase activity; reduced expression levels; reduced pyridoxal phosphate binding; reduced dimerization; reduced thermostability; increased propensity to aggregation; increased susceptibility to proteolytic degradation within the N-terminal region; mitochondrial mistargeting; exposure to pyridoxine can rescue the functionality by partially preventing aggregation and degradation and by redirecting all the protein to the peroxisome. 1 PublicationCorresponds to variant dbSNP:rs180177173EnsemblClinVar.1
Natural variantiVAR_00887882G → E in HP1; abolishes alanine--glyoxylate aminotransferase activity by interfering with pyridoxal phosphate binding. 3 PublicationsCorresponds to variant dbSNP:rs121908522EnsemblClinVar.1
Natural variantiVAR_06054882G → R in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177185EnsemblClinVar.1
Natural variantiVAR_01097095E → EE in HP1. 2 Publications1
Natural variantiVAR_060549108W → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability. 3 PublicationsCorresponds to variant dbSNP:rs180177197EnsemblClinVar.1
Natural variantiVAR_060550112A → D in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability; causes protein aggregation. 2 PublicationsCorresponds to variant dbSNP:rs796052061EnsemblClinVar.1
Natural variantiVAR_010971116G → R in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177207EnsemblClinVar.1
Natural variantiVAR_060551139Missing in HP1. 1 Publication1
Natural variantiVAR_074585150L → P in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177222EnsemblClinVar.1
Natural variantiVAR_000589152F → I in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in protein destabilization; decreased alanine--glyoxylate aminotransferase activity; no loss of dimerization; mitochondrial mistargeting. 6 PublicationsCorresponds to variant dbSNP:rs121908524EnsemblClinVar.1
Natural variantiVAR_060552153L → V in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177223EnsemblClinVar.1
Natural variantiVAR_010972156G → R in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability. 7 PublicationsCorresponds to variant dbSNP:rs121908530EnsemblClinVar.1
Natural variantiVAR_060553158S → L in HP1; loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs180177225EnsemblClinVar.1
Natural variantiVAR_074586161G → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; reduced peroxisomal localization. 2 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_060554161G → R in HP1; loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; loss of dimerization. 3 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_074587161G → S in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; reduced peroxisomal localization. 2 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_074588166L → P in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177230EnsemblClinVar.1
Natural variantiVAR_000590170G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in mitochondrial mistargeting; slight decrease in alanine--glyoxylate aminotransferase activity; loss of dimerization; partial loss of protein stability but protein stability increases in the presence of pyridoxal phosphate; causes protein aggregation. 7 PublicationsCorresponds to variant dbSNP:rs121908529EnsemblClinVar.1
Natural variantiVAR_060555173C → Y in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability; causes protein aggregation. 3 PublicationsCorresponds to variant dbSNP:rs180177231EnsemblClinVar.1
Natural variantiVAR_010973183D → N in HP1; loss of alanine--glyoxylate aminotransferase activity; no loss of dimerization; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177236EnsemblClinVar.1
Natural variantiVAR_000591187S → F in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization but improved dimerization in the presence of pyridoxal phosphate; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177238EnsemblClinVar.1
Natural variantiVAR_060556190G → R in HP1. 4 PublicationsCorresponds to variant dbSNP:rs180177239EnsemblClinVar.1
Natural variantiVAR_060557195M → R in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177244EnsemblClinVar.1
Natural variantiVAR_060558201D → E in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177246EnsemblClinVar.1
Natural variantiVAR_074589202I → N in HP1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536352238EnsemblClinVar.1
Natural variantiVAR_000592205S → P in HP1; loss of alanine--glyoxylate aminotransferase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121908520EnsemblClinVar.1
Natural variantiVAR_060559218S → L in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177253EnsemblClinVar.1
Natural variantiVAR_008879233R → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 3 PublicationsCorresponds to variant dbSNP:rs121908526EnsemblClinVar.1
Natural variantiVAR_008880233R → H in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121908527EnsemblClinVar.1
Natural variantiVAR_060560233R → L in HP1. 1 PublicationCorresponds to variant dbSNP:rs121908527EnsemblClinVar.1
Natural variantiVAR_060561243D → H in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177258EnsemblClinVar.1
Natural variantiVAR_008881244I → T in HP1; prevalent mutation in the Canary islands; when associated with L-11 and M-340 on the minor AGXT allele; results in protein misfolding; decreased alanine--glyoxylate aminotransferase activity; no loss of dimerization; partial mitochondrial mistargeting. 9 PublicationsCorresponds to variant dbSNP:rs121908525EnsemblClinVar.1
Natural variantiVAR_060562253C → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs180177264EnsemblClinVar.1
Natural variantiVAR_060563279I → M in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177277EnsemblClinVar.1
Natural variantiVAR_060566287S → T in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177289EnsemblClinVar.1
Natural variantiVAR_060567289R → C in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177290EnsemblClinVar.1
Natural variantiVAR_060568296Missing in HP1. 1 Publication1
Natural variantiVAR_060569298L → P in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177293EnsemblClinVar.1
Natural variantiVAR_060571336V → D in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177155EnsemblClinVar.1
Natural variantiVAR_060572350G → D in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177156EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi209K → R: Affects pyridoxal phosphate binding; loss of alanine--glyoxylate aminotransferase activity. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
189

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
AGXT

MalaCards human disease database

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MalaCardsi
AGXT
MIMi259900 phenotype

Open Targets

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OpenTargetsi
ENSG00000172482

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
93598 Primary hyperoxaluria type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24633

Chemistry databases

Drug and drug target database

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DrugBanki
DB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
DB02079 Aminooxyacetic acid
DB00145 Glycine
DB00160 L-Alanine
DB00133 L-Serine
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AGXT

Domain mapping of disease mutations (DMDM)

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DMDMi
134855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001502371 – 392Serine--pyruvate aminotransferaseAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphothreonineCombined sources1
Modified residuei209N6-(pyridoxal phosphate)lysine1
Modified residuei225N6-acetyllysine; alternateBy similarity1
Modified residuei225N6-succinyllysine; alternateBy similarity1
Modified residuei234N6-acetyllysineBy similarity1
Modified residuei312N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P21549

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P21549

PeptideAtlas

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PeptideAtlasi
P21549

PRoteomics IDEntifications database

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PRIDEi
P21549

ProteomicsDB human proteome resource

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ProteomicsDBi
53874

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P21549

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P21549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172482 Expressed in 89 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

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CleanExi
HS_AGXT

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21549 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA035370
HPA035371

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106694, 4 interactors

Database of interacting proteins

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DIPi
DIP-59650N

Protein interaction database and analysis system

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IntActi
P21549, 38 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000302620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0CX-ray2.50A1-392[»]
1J04X-ray2.60A1-392[»]
2YOBX-ray1.90A/B1-388[»]
3R9AX-ray2.35A/C1-392[»]
4CBRX-ray2.30A1-392[»]
4CBSX-ray2.30A1-392[»]
4I8AX-ray2.90A/B/C/D1-392[»]
4KXKX-ray2.90A/C1-392[»]
4KYOX-ray2.20A/C1-392[»]
5F9SX-ray1.70A/B6-391[»]
5HHYX-ray1.70A/B6-391[»]
5LUCX-ray1.80A/B/E/G/M/N/S/T1-392[»]
5OFYX-ray2.80A1-392[»]
5OG0X-ray2.50A1-392[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P21549

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P21549

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P21549

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2862 Eukaryota
COG0075 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000171815

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006907

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21549

KEGG Orthology (KO)

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KOi
K00830

Identification of Orthologs from Complete Genome Data

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OMAi
WGCDDKP

Database of Orthologous Groups

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OrthoDBi
984738at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P21549

TreeFam database of animal gene trees

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TreeFami
TF313234

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR024169 SP_NH2Trfase/AEP_transaminase

Pfam protein domain database

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Pfami
View protein in Pfam
PF00266 Aminotran_5, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000524 SPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53383 SSF53383, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21549-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASHKLLVTP PKALLKPLSI PNQLLLGPGP SNLPPRIMAA GGLQMIGSMS
60 70 80 90 100
KDMYQIMDEI KEGIQYVFQT RNPLTLVISG SGHCALEAAL VNVLEPGDSF
110 120 130 140 150
LVGANGIWGQ RAVDIGERIG ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL
160 170 180 190 200
LFLTHGESST GVLQPLDGFG ELCHRYKCLL LVDSVASLGG TPLYMDRQGI
210 220 230 240 250
DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF YLDIKWLANF
260 270 280 290 300
WGCDDQPRMY HHTIPVISLY SLRESLALIA EQGLENSWRQ HREAAAYLHG
310 320 330 340 350
RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVI DHFDIEIMGG
360 370 380 390
LGPSTGKVLR IGLLGCNATR ENVDRVTEAL RAALQHCPKK KL
Length:392
Mass (Da):43,010
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2987DDE85B2470B4
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphism at position 11 acts synergistically with different mutations in AGXT producing specific enzymic phenotypes in HP1 patients. The combined presence of Leu-11 and Met-340 polymorphisms defines the minor AGXT allele, whereas their absence defines the major allele. The minor allele has frequencies of 20% in normal European and North American populations, and 50% in HP1 patients.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0605479T → N Polymorphism; no loss of alanine--glyoxylate aminotransferase activity. 3 PublicationsCorresponds to variant dbSNP:rs115014558EnsemblClinVar.1
Natural variantiVAR_00058711P → L Common polymorphism; reduction of specific alanine--glyoxylate aminotransferase activity in vitro; causes mitochondrial mistargeting when associated with R-170. 2 PublicationsCorresponds to variant dbSNP:rs34116584EnsemblClinVar.1
Natural variantiVAR_04823622N → S. Corresponds to variant dbSNP:rs34885252EnsemblClinVar.1
Natural variantiVAR_07458236R → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177157EnsemblClinVar.1
Natural variantiVAR_07458341G → E in HP1; loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177168EnsemblClinVar.1
Natural variantiVAR_00058841G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of protein stability; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; partial mitochondrial mistargeting; intraperoxisomal protein aggregation seen. 7 PublicationsCorresponds to variant dbSNP:rs121908523EnsemblClinVar.1
Natural variantiVAR_01096941G → V in HP1; reduced alanine--glyoxylate aminotransferase activity; no loss of dimerization; no effect on protein stability. 3 PublicationsCorresponds to variant dbSNP:rs180177168EnsemblClinVar.1
Natural variantiVAR_07458447G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in protein misfolding; decreased alanine--glyoxylate aminotransferase activity; reduced expression levels; reduced pyridoxal phosphate binding; reduced dimerization; reduced thermostability; increased propensity to aggregation; increased susceptibility to proteolytic degradation within the N-terminal region; mitochondrial mistargeting; exposure to pyridoxine can rescue the functionality by partially preventing aggregation and degradation and by redirecting all the protein to the peroxisome. 1 PublicationCorresponds to variant dbSNP:rs180177173EnsemblClinVar.1
Natural variantiVAR_00887882G → E in HP1; abolishes alanine--glyoxylate aminotransferase activity by interfering with pyridoxal phosphate binding. 3 PublicationsCorresponds to variant dbSNP:rs121908522EnsemblClinVar.1
Natural variantiVAR_06054882G → R in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177185EnsemblClinVar.1
Natural variantiVAR_01097095E → EE in HP1. 2 Publications1
Natural variantiVAR_060549108W → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability. 3 PublicationsCorresponds to variant dbSNP:rs180177197EnsemblClinVar.1
Natural variantiVAR_060550112A → D in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability; causes protein aggregation. 2 PublicationsCorresponds to variant dbSNP:rs796052061EnsemblClinVar.1
Natural variantiVAR_010971116G → R in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177207EnsemblClinVar.1
Natural variantiVAR_060551139Missing in HP1. 1 Publication1
Natural variantiVAR_074585150L → P in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177222EnsemblClinVar.1
Natural variantiVAR_000589152F → I in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in protein destabilization; decreased alanine--glyoxylate aminotransferase activity; no loss of dimerization; mitochondrial mistargeting. 6 PublicationsCorresponds to variant dbSNP:rs121908524EnsemblClinVar.1
Natural variantiVAR_060552153L → V in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177223EnsemblClinVar.1
Natural variantiVAR_010972156G → R in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability. 7 PublicationsCorresponds to variant dbSNP:rs121908530EnsemblClinVar.1
Natural variantiVAR_060553158S → L in HP1; loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs180177225EnsemblClinVar.1
Natural variantiVAR_074586161G → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; reduced peroxisomal localization. 2 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_060554161G → R in HP1; loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; loss of dimerization. 3 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_074587161G → S in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity; reduced expression levels; decreased protein stability; protein aggregation seen in the cytosol with a decreased aggregation propensity in the presence of pyridoxal phosphate; reduced peroxisomal localization. 2 PublicationsCorresponds to variant dbSNP:rs180177227EnsemblClinVar.1
Natural variantiVAR_074588166L → P in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 1 PublicationCorresponds to variant dbSNP:rs180177230EnsemblClinVar.1
Natural variantiVAR_000590170G → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in mitochondrial mistargeting; slight decrease in alanine--glyoxylate aminotransferase activity; loss of dimerization; partial loss of protein stability but protein stability increases in the presence of pyridoxal phosphate; causes protein aggregation. 7 PublicationsCorresponds to variant dbSNP:rs121908529EnsemblClinVar.1
Natural variantiVAR_060555173C → Y in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; decreased protein stability; causes protein aggregation. 3 PublicationsCorresponds to variant dbSNP:rs180177231EnsemblClinVar.1
Natural variantiVAR_010973183D → N in HP1; loss of alanine--glyoxylate aminotransferase activity; no loss of dimerization; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177236EnsemblClinVar.1
Natural variantiVAR_000591187S → F in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization but improved dimerization in the presence of pyridoxal phosphate; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177238EnsemblClinVar.1
Natural variantiVAR_060556190G → R in HP1. 4 PublicationsCorresponds to variant dbSNP:rs180177239EnsemblClinVar.1
Natural variantiVAR_060557195M → R in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177244EnsemblClinVar.1
Natural variantiVAR_060558201D → E in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177246EnsemblClinVar.1
Natural variantiVAR_074589202I → N in HP1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536352238EnsemblClinVar.1
Natural variantiVAR_000592205S → P in HP1; loss of alanine--glyoxylate aminotransferase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs121908520EnsemblClinVar.1
Natural variantiVAR_060559218S → L in HP1; loss of alanine--glyoxylate aminotransferase activity; loss of dimerization; no effect on protein stability. 2 PublicationsCorresponds to variant dbSNP:rs180177253EnsemblClinVar.1
Natural variantiVAR_008879233R → C in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 3 PublicationsCorresponds to variant dbSNP:rs121908526EnsemblClinVar.1
Natural variantiVAR_008880233R → H in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs121908527EnsemblClinVar.1
Natural variantiVAR_060560233R → L in HP1. 1 PublicationCorresponds to variant dbSNP:rs121908527EnsemblClinVar.1
Natural variantiVAR_060561243D → H in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177258EnsemblClinVar.1
Natural variantiVAR_008881244I → T in HP1; prevalent mutation in the Canary islands; when associated with L-11 and M-340 on the minor AGXT allele; results in protein misfolding; decreased alanine--glyoxylate aminotransferase activity; no loss of dimerization; partial mitochondrial mistargeting. 9 PublicationsCorresponds to variant dbSNP:rs121908525EnsemblClinVar.1
Natural variantiVAR_060562253C → R in HP1; when associated with L-11 and M-340 on the minor AGXT allele; results in loss of alanine--glyoxylate aminotransferase activity. 2 PublicationsCorresponds to variant dbSNP:rs180177264EnsemblClinVar.1
Natural variantiVAR_060563279I → M in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177277EnsemblClinVar.1
Natural variantiVAR_060564279I → T1 PublicationCorresponds to variant dbSNP:rs140992177EnsemblClinVar.1
Natural variantiVAR_060565280A → V1 PublicationCorresponds to variant dbSNP:rs73106685EnsemblClinVar.1
Natural variantiVAR_060566287S → T in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177289EnsemblClinVar.1
Natural variantiVAR_060567289R → C in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177290EnsemblClinVar.1
Natural variantiVAR_048237295A → T. Corresponds to variant dbSNP:rs13408961EnsemblClinVar.1
Natural variantiVAR_060568296Missing in HP1. 1 Publication1
Natural variantiVAR_060569298L → P in HP1. 2 PublicationsCorresponds to variant dbSNP:rs180177293EnsemblClinVar.1
Natural variantiVAR_060570326V → I1 PublicationCorresponds to variant dbSNP:rs115057148EnsemblClinVar.1
Natural variantiVAR_060571336V → D in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177155EnsemblClinVar.1
Natural variantiVAR_000593340I → M Common polymorphism; associated with hyperoxaluria. 1 PublicationCorresponds to variant dbSNP:rs4426527EnsemblClinVar.1
Natural variantiVAR_060572350G → D in HP1. 1 PublicationCorresponds to variant dbSNP:rs180177156EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X56092 mRNA Translation: CAA39572.1
X53414 mRNA Translation: CAA37493.1
D13368 mRNA Translation: BAA02632.1
M61763 Genomic DNA Translation: AAA51680.1
AK292754 mRNA Translation: BAF85443.1
AC104809 Genomic DNA Translation: AAY24168.1
CH471063 Genomic DNA Translation: EAW71222.1
BC132819 mRNA Translation: AAI32820.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2543.1

Protein sequence database of the Protein Information Resource

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PIRi
I39419 XNHUSP

NCBI Reference Sequences

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RefSeqi
NP_000021.1, NM_000030.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.144567

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307503; ENSP00000302620; ENSG00000172482

Database of genes from NCBI RefSeq genomes

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GeneIDi
189

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:189

UCSC genome browser

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UCSCi
uc002waa.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56092 mRNA Translation: CAA39572.1
X53414 mRNA Translation: CAA37493.1
D13368 mRNA Translation: BAA02632.1
M61763 Genomic DNA Translation: AAA51680.1
AK292754 mRNA Translation: BAF85443.1
AC104809 Genomic DNA Translation: AAY24168.1
CH471063 Genomic DNA Translation: EAW71222.1
BC132819 mRNA Translation: AAI32820.1
CCDSiCCDS2543.1
PIRiI39419 XNHUSP
RefSeqiNP_000021.1, NM_000030.2
UniGeneiHs.144567

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0CX-ray2.50A1-392[»]
1J04X-ray2.60A1-392[»]
2YOBX-ray1.90A/B1-388[»]
3R9AX-ray2.35A/C1-392[»]
4CBRX-ray2.30A1-392[»]
4CBSX-ray2.30A1-392[»]
4I8AX-ray2.90A/B/C/D1-392[»]
4KXKX-ray2.90A/C1-392[»]
4KYOX-ray2.20A/C1-392[»]
5F9SX-ray1.70A/B6-391[»]
5HHYX-ray1.70A/B6-391[»]
5LUCX-ray1.80A/B/E/G/M/N/S/T1-392[»]
5OFYX-ray2.80A1-392[»]
5OG0X-ray2.50A1-392[»]
ProteinModelPortaliP21549
SMRiP21549
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106694, 4 interactors
DIPiDIP-59650N
IntActiP21549, 38 interactors
STRINGi9606.ENSP00000302620

Chemistry databases

DrugBankiDB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
DB02079 Aminooxyacetic acid
DB00145 Glycine
DB00160 L-Alanine
DB00133 L-Serine
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetiP21549
PhosphoSitePlusiP21549

Polymorphism and mutation databases

BioMutaiAGXT
DMDMi134855

Proteomic databases

MaxQBiP21549
PaxDbiP21549
PeptideAtlasiP21549
PRIDEiP21549
ProteomicsDBi53874

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307503; ENSP00000302620; ENSG00000172482
GeneIDi189
KEGGihsa:189
UCSCiuc002waa.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
189
DisGeNETi189
EuPathDBiHostDB:ENSG00000172482.4

GeneCards: human genes, protein and diseases

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GeneCardsi
AGXT
GeneReviewsiAGXT
HGNCiHGNC:341 AGXT
HPAiHPA035370
HPA035371
MalaCardsiAGXT
MIMi259900 phenotype
604285 gene
neXtProtiNX_P21549
OpenTargetsiENSG00000172482
Orphaneti93598 Primary hyperoxaluria type 1
PharmGKBiPA24633

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2862 Eukaryota
COG0075 LUCA
GeneTreeiENSGT00940000153241
HOGENOMiHOG000171815
HOVERGENiHBG006907
InParanoidiP21549
KOiK00830
OMAiWGCDDKP
OrthoDBi984738at2759
PhylomeDBiP21549
TreeFamiTF313234

Enzyme and pathway databases

BioCyciMetaCyc:HS10525-MONOMER
BRENDAi2.6.1.44 2681
ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

EvolutionaryTraceiP21549

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AGXT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
189

Protein Ontology

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PROi
PR:P21549

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172482 Expressed in 89 organ(s), highest expression level in right lobe of liver
CleanExiHS_AGXT
GenevisibleiP21549 HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR024169 SP_NH2Trfase/AEP_transaminase
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000524 SPT, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPYA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21549
Secondary accession number(s): Q53QU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: January 16, 2019
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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