UniProtKB - P21548 (GBRG2_CHICK)
Gamma-aminobutyric acid receptor subunit gamma-2
GABRG2
Functioni
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity).
Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).
Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
By similarityMiscellaneous
Activity regulationi
GO - Molecular functioni
- chloride channel activity Source: UniProtKB
- GABA-A receptor activity Source: UniProtKB
- GABA-gated chloride ion channel activity Source: GO_Central
- inhibitory extracellular ligand-gated ion channel activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: GO_Central
GO - Biological processi
- adult behavior Source: Ensembl
- cellular response to histamine Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: UniProtKB
- gamma-aminobutyric acid signaling pathway Source: GO_Central
- inhibitory synapse assembly Source: UniProtKB
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- post-embryonic development Source: Ensembl
- regulation of membrane potential Source: GO_Central
- regulation of postsynaptic membrane potential Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit gamma-2Alternative name(s): GABA(A) receptor subunit gamma-2 |
Gene namesi | Name:GABRG2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity; Multi-pass membrane protein Sequence analysis
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- dendrite membrane Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- axon Source: Ensembl
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: UniProtKB
- GABA-ergic synapse Source: Ensembl
- neuron projection Source: GO_Central
- postsynapse Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 39 – 272 | ExtracellularCuratedAdd BLAST | 234 | |
Transmembranei | 273 – 295 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 299 – 321 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 333 – 355 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 356 – 450 | CytoplasmicCuratedAdd BLAST | 95 | |
Transmembranei | 451 – 474 | HelicalCuratedAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 38 | Sequence analysisAdd BLAST | 38 | |
ChainiPRO_0000000480 | 39 – 474 | Gamma-aminobutyric acid receptor subunit gamma-2Add BLAST | 436 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 189 ↔ 203 | By similarity | ||
Glycosylationi | 246 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P21548 |
PTM databases
iPTMneti | P21548 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000001706, Expressed in brain and 2 other tissues |
Interactioni
Subunit structurei
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
By similarityProtein-protein interaction databases
STRINGi | 9031.ENSGALP00000034151 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 376 – 383 | Insertion, similar to human gamma-2 sequence which is proposed to be caused by alternative splicing | 8 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156685 |
HOGENOMi | CLU_010920_2_0_1 |
InParanoidi | P21548 |
OMAi | PMDVHSC |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P21548 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005439, GABBAg2_rcpt IPR005437, GABRG-1/4 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA PR01622, GABAARGAMMA2 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTPSNPTRLG STALLNPAFS LKMMVWALVF LSLIQCSTQK GDDDYEDYTS
60 70 80 90 100
NKTWVLTPKV HESDVTLILN GLLEGYDNKL RPDIGVKPTV IHTDMYVNSI
110 120 130 140 150
GPVNAINMEY TIDIFFAQTW YDRRLKFNST IKVLRLNSNM VGKIWIPDTF
160 170 180 190 200
FRNSKKADAH WITTPNRMLR IWNDGRVLYT LRLTIDAECQ LQLHNFPMDA
210 220 230 240 250
HSCPLEFSSY GYPREEIIYQ WKRSSVEVGD TRSWRLYQFS FTGLRNTTEV
260 270 280 290 300
VKTTSGDYVV MSVYFNLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV
310 320 330 340 350
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV
360 370 380 390 400
EYGTLHYFVS NRKPSKDKDK KKKNPLLRMF SFKAPTIDIR PRSATIQMNN
410 420 430 440 450
ATHLQERDEE YGYECLDGKD CASFFCCFED CRTGAWRHGR IHIRIAKMDS
460 470
YARIFFPTAF CLFNLVYWVS YLYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54944 mRNA Translation: CAA38704.1 |
PIRi | S13086 |
RefSeqi | NP_990676.1, NM_205345.2 |
Genome annotation databases
Ensembli | ENSGALT00000065912; ENSGALP00000053851; ENSGALG00000038042 |
GeneIDi | 396289 |
KEGGi | gga:396289 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54944 mRNA Translation: CAA38704.1 |
PIRi | S13086 |
RefSeqi | NP_990676.1, NM_205345.2 |
3D structure databases
AlphaFoldDBi | P21548 |
SMRi | P21548 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000034151 |
PTM databases
iPTMneti | P21548 |
Proteomic databases
PaxDbi | P21548 |
Genome annotation databases
Ensembli | ENSGALT00000065912; ENSGALP00000053851; ENSGALG00000038042 |
GeneIDi | 396289 |
KEGGi | gga:396289 |
Organism-specific databases
CTDi | 2566 |
Phylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156685 |
HOGENOMi | CLU_010920_2_0_1 |
InParanoidi | P21548 |
OMAi | PMDVHSC |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P21548 |
Miscellaneous databases
PROi | PR:P21548 |
Gene expression databases
Bgeei | ENSGALG00000001706, Expressed in brain and 2 other tissues |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005439, GABBAg2_rcpt IPR005437, GABRG-1/4 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA PR01622, GABAARGAMMA2 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRG2_CHICK | |
Accessioni | P21548Primary (citable) accession number: P21548 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families