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Entry version 158 (29 Sep 2021)
Sequence version 5 (23 Jan 2007)
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Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane
R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72689, Formation of a pool of free 40S subunits
R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Neoplasm-related protein C140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpl6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
619826, Rpl6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001710122 – 29860S ribosomal protein L6Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104N6-succinyllysineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei217N6-succinyllysineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21533

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21533

PRoteomics IDEntifications database

More...
PRIDEi
P21533

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21533

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21533

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21533

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000025936, Expressed in spleen and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21533, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (By similarity). May bind IPO9 with low affinity (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
250640, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P21533, 9 interactors

Molecular INTeraction database

More...
MINTi
P21533

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000051135

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21533

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi40 – 54Basic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1694, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003682

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_066767_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21533

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERHQISE

Database of Orthologous Groups

More...
OrthoDBi
1227453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21533

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13156, KOW_RPL6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000915, 60S_ribosomal_L6E
IPR041997, KOW_RPL6
IPR014722, Rib_L2_dom2
IPR005568, Ribosomal_L6_N
IPR008991, Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10715, PTHR10715, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01159, Ribosomal_L6e, 1 hit
PF03868, Ribosomal_L6e_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104, SSF50104, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01170, RIBOSOMAL_L6E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P21533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEKAEKPD KKEQKPAAKK AGGDATAPRA LPAGAVKKSS SKAKKLRKSK
60 70 80 90 100
PHCSRNPVLV RGIGRYSRSA MYSRKALYKR KYSAAKTKVE KKKKKEKVLA
110 120 130 140 150
TVTKTVGGDK NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRRL
160 170 180 190 200
RSSITPGTVL IILTGRHRGK RVVFLKQLGS GLLLVTGPLA LNRVPLRRTH
210 220 230 240 250
QKFVIATSTK VDISKVKIPK HLTDAYFKKK PLRKPRHQEG EIFDTEKEKY
260 270 280 290
EITEQRKADQ KAVDSQILPK IKAVPQLQGY LRSQFSLTNG MYPHKLVF
Length:298
Mass (Da):33,562
Last modified:January 23, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC92724D0F998503C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31 – 35LPAGA → GAWC in CAA60588 (PubMed:8828793).Curated5
Sequence conflicti184L → P in AAB30818 (PubMed:8185817).Curated1
Sequence conflicti191 – 220LNRVP…VKIPK → STEFLCVGHTRSLSSPPLQK LISARLKFQ in AAB30818 (PubMed:8185817).CuratedAdd BLAST30
Sequence conflicti264 – 279DSQIL…PQLQG → TRRFCQRSKLSPSSRA in AAB30818 (PubMed:8185817).CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X87107 mRNA Translation: CAA60588.1
BC078761 mRNA Translation: AAH78761.1
BC097295 mRNA Translation: AAH97295.1
S71021 mRNA Translation: AAB30818.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S11416
T50782

NCBI Reference Sequences

More...
RefSeqi
NP_446423.2, NM_053971.3
XP_006249440.1, XM_006249378.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000034951; ENSRNOP00000038065; ENSRNOG00000025936

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:117042

UCSC genome browser

More...
UCSCi
RGD:619826, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87107 mRNA Translation: CAA60588.1
BC078761 mRNA Translation: AAH78761.1
BC097295 mRNA Translation: AAH97295.1
S71021 mRNA Translation: AAB30818.2
PIRiS11416
T50782
RefSeqiNP_446423.2, NM_053971.3
XP_006249440.1, XM_006249378.3

3D structure databases

SMRiP21533
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi250640, 4 interactors
IntActiP21533, 9 interactors
MINTiP21533
STRINGi10116.ENSRNOP00000051135

PTM databases

iPTMnetiP21533
PhosphoSitePlusiP21533
SwissPalmiP21533

Proteomic databases

jPOSTiP21533
PaxDbiP21533
PRIDEiP21533

Genome annotation databases

EnsembliENSRNOT00000034951; ENSRNOP00000038065; ENSRNOG00000025936
GeneIDi117042
KEGGirno:117042
UCSCiRGD:619826, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6128
RGDi619826, Rpl6

Phylogenomic databases

eggNOGiKOG1694, Eukaryota
GeneTreeiENSGT00390000003682
HOGENOMiCLU_066767_0_0_1
InParanoidiP21533
OMAiERHQISE
OrthoDBi1227453at2759
PhylomeDBiP21533

Enzyme and pathway databases

ReactomeiR-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane
R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72689, Formation of a pool of free 40S subunits
R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21533

Gene expression databases

BgeeiENSRNOG00000025936, Expressed in spleen and 20 other tissues
GenevisibleiP21533, RN

Family and domain databases

CDDicd13156, KOW_RPL6, 1 hit
Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR000915, 60S_ribosomal_L6E
IPR041997, KOW_RPL6
IPR014722, Rib_L2_dom2
IPR005568, Ribosomal_L6_N
IPR008991, Translation_prot_SH3-like_sf
PANTHERiPTHR10715, PTHR10715, 1 hit
PfamiView protein in Pfam
PF01159, Ribosomal_L6e, 1 hit
PF03868, Ribosomal_L6e_N, 1 hit
SUPFAMiSSF50104, SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01170, RIBOSOMAL_L6E, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21533
Secondary accession number(s): Q4QRA9, Q64624, Q68G26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 158 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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