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UniProtKB - P21530 (POLG_CSFVB)

Protein

Genome polyprotein

Gene
N/A
Organism
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane.By similarity
P7 forms a leader sequence to properly orient NS2 in the membrane.By similarity
Uncleaved NS2-3 is required for production of infectious virus.By similarity
NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.PROSITE-ProRule annotation
NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.By similarity
NS4A is a cofactor for the NS3 protease activity.By similarity
RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.PROSITE-ProRule annotation

Catalytic activityi

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
NTP + H2O = NDP + phosphate.
ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei22For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei49For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei69For N-terminal protease activityPROSITE-ProRule annotation1
Active sitei1447For cysteine protease NS2 activityPROSITE-ProRule annotation1
Active sitei1461For cysteine protease NS2 activityPROSITE-ProRule annotation1
Active sitei1512For cysteine protease NS2 activityPROSITE-ProRule annotation1
Active sitei1658Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1695Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1
Active sitei1752Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHelicase, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Thiol protease, Transferase, Viral ion channel
Biological processActivation of host autophagy by virus, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Ion transport, Transport, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replication, Virus entry into host cell
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS31.001

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 13 chains:
N-terminal protease (EC:3.4.22.-)
Short name:
N-pro
Alternative name(s):
Autoprotease p20
Capsid protein C
E(rns) glycoprotein
Alternative name(s):
gp44/48
Envelope glycoprotein E1
Alternative name(s):
gp33
Envelope glycoprotein E2
Alternative name(s):
gp55
p7
Non-structural protein 2-3
Short name:
NS2-3
Cysteine protease NS2 (EC:3.4.22.-)
Alternative name(s):
Non-structural protein 2
Serine protease NS3 (EC:3.4.21.113, EC:3.6.1.15, EC:3.6.4.13)
Alternative name(s):
Non-structural protein 3
Non-structural protein 4A
Short name:
NS4A
Non-structural protein 4B
Short name:
NS4B
Non-structural protein 5A
Short name:
NS5A
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
NS5B
OrganismiClassical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
Taxonomic identifieri11098 [NCBI]
Taxonomic lineageiViruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Pestivirus ›
Virus hostiSus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008569 Componenti: Genome

Subcellular locationi

E(rns) glycoprotein :
Envelope glycoprotein E2 :
Cysteine protease NS2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1140 – 1164HelicalPROSITE-ProRule annotationAdd BLAST25
Transmembranei1189 – 1209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1217 – 1237HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1247 – 1267HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1281 – 1301HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1360 – 1380HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1568 – 1588HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000380621 – 168N-terminal proteaseBy similarityAdd BLAST168
ChainiPRO_0000038063169 – 267Capsid protein CBy similarityAdd BLAST99
ChainiPRO_0000038064268 – 494E(rns) glycoproteinBy similarityAdd BLAST227
ChainiPRO_0000038065495 – 656Envelope glycoprotein E1By similarityAdd BLAST162
ChainiPRO_0000038066657 – 1062Envelope glycoprotein E2By similarityAdd BLAST406
ChainiPRO_00000380671063 – 1132p7By similarityAdd BLAST70
ChainiPRO_00000380681133 – 2272Non-structural protein 2-3By similarityAdd BLAST1140
ChainiPRO_00003493621133 – 1589Cysteine protease NS2PROSITE-ProRule annotationAdd BLAST457
ChainiPRO_00000380691590 – 2272Serine protease NS3By similarityAdd BLAST683
ChainiPRO_00000380702273 – 2336Non-structural protein 4ABy similarityAdd BLAST64
ChainiPRO_00000380712337 – 2683Non-structural protein 4BBy similarityAdd BLAST347
ChainiPRO_00000380722684 – 3180Non-structural protein 5ABy similarityAdd BLAST497
ChainiPRO_00000380733181 – 3898RNA-directed RNA polymeraseBy similarityAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi594N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi805N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi874N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi918N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi949N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1713N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2134N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2217N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2419N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2494N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2787N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2815N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi2891N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3103N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3211N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3316N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3689N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3698N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi3794N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Post-translational modificationi

The E(rns) glycoprotein is heavily glycosylated.By similarity
The viral RNA of pestiviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing resulting in the production of at least eleven individual proteins. The N-terminal protease cleaves itself from the nascent polyprotein autocatalytically and thereby generates the N-terminus of the adjacent viral capsid protein C.
Cleavage between E2 and p7 is partial.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168 – 169Cleavage; by autolysisBy similarity2
Sitei267 – 268Cleavage; by host signal peptidaseBy similarity2
Sitei494 – 495CleavageBy similarity2
Sitei656 – 657Cleavage; by host signal peptidaseBy similarity2
Sitei1062 – 1063Cleavage; by host signal peptidase; partialBy similarity2
Sitei1132 – 1133Cleavage; by host signal peptidaseBy similarity2
Sitei1589 – 1590Cleavage; partial; by cysteine protease NS2By similarity2
Sitei2272 – 2273Cleavage; by serine protease NS3By similarity2
Sitei2336 – 2337Cleavage; by serine protease NS3By similarity2
Sitei2683 – 2684Cleavage; by serine protease NS3By similarity2
Sitei3180 – 3181Cleavage; by serine protease NS3By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21530

Expressioni

Inductioni

Translated cap independently from an internal ribosome entry site (IRES).1 Publication

Interactioni

Subunit structurei

The E(rns) glycoprotein is found as a homodimer; disulfide-linked. The E1 and E2 envelope glycoproteins form disulfide-linked homodimers as well as heterodimers.By similarity

Protein-protein interaction databases

IntActiP21530, 62 interactors

Structurei

3D structure databases

ProteinModelPortaliP21530
SMRiP21530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 168Peptidase C53Add BLAST168
Domaini1441 – 1589Peptidase C74PROSITE-ProRule annotationAdd BLAST149
Domaini1590 – 1763Peptidase S31PROSITE-ProRule annotationAdd BLAST174
Domaini1802 – 1960Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST159
Domaini1978 – 2179Helicase C-terminalPROSITE-ProRule annotationAdd BLAST202
Domaini3519 – 3642RdRp catalyticPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Belongs to the pestivirus polyprotein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001OO

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR021824 Capsid-C_pestivirus
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR022120 NS2
IPR030399 NS2_C74
IPR027417 P-loop_NTPase
IPR008751 Peptidase_C53
IPR032521 Pestivirus_E2
IPR000280 Pestivirus_NS3_S31
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
IPR036430 RNase_T2-like_sf
IPR033130 RNase_T2_His_AS_2
PfamiView protein in Pfam
PF11889 DUF3409, 1 hit
PF07652 Flavi_DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF05550 Peptidase_C53, 1 hit
PF12387 Peptidase_C74, 1 hit
PF05578 Peptidase_S31, 1 hit
PF16329 Pestivirus_E2, 1 hit
PF00998 RdRP_3, 1 hit
PRINTSiPR00729 CDVENDOPTASE
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55895 SSF55895, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51692 PESTIVIRUS_NS2_PRO, 1 hit
PS51535 PESTIVIRUS_NS3PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS00531 RNASE_T2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21530-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELNHFELLY KTNKQKPMGV EEPVYDVTGR PLFGDPSEVH PQSTLKLPHD 
        60         70         80         90        100
RGRGNIKTTL KNLPRRGDCR SGNHLGPVSG IYVKPGPVFY QDYMGPVYHR 
       110        120        130        140        150
APLEFFDEAQ FCEVTKRIGR VTGSDGKLYH IYVCIDGCIL LKLAKRGEPR 
       160        170        180        190        200
TLKWIRNLTD CPLWVTSCSD DGASASKEKK PDRINKGKLK IAPKEHEKDS 
       210        220        230        240        250
RTKPPDATIV VEGVKYQVKK KGKVKGKNTQ DGLYHNKNKP PESRKKLEKA 
       260        270        280        290        300
LLAWAVIAIM LYQPVAAENI TQWNLRDNGT NGIQHAMYLR GVSRSLHGIW 
       310        320        330        340        350
PEKICKGVPT YLATDTELRE IQGMMVASEG TNYTCCKLQR HEWNKHGWCN 
       360        370        380        390        400
WYNIDPWIQL MNRTQANLAE GPPSKECAVT CRYDKNADIN VVTQARNRPT 
       410        420        430        440        450
TLTGCKKGTN FSFAGTVIEG PCNFNVSVED ILYGDHECGS LLQDTALYLV 
       460        470        480        490        500
DGMTNTIERA RQGAARVTSW LGRQLRIAGK RLEGRSKTWF GAYALSPYCN 
       510        520        530        540        550
VTTKIGYIWY TNNCTPACLP KNTKIIGPGK FDTNAEDGKI LHEMGGHLSE 
       560        570        580        590        600
FLLLSLVVLS DFAPETASAL YLILHYVIPQ SHEEPEGCDT NQLNLTVELR 
       610        620        630        640        650
TEDVIPSSVW NVGKYVCVRP DWWPYETKVA LLFEEAGQVV KLALRALRDL 
       660        670        680        690        700
TRVWNSASTT AFLICLIKVL RGQVVQGVIW LLLVTGAQGR LACKEDHRYA 
       710        720        730        740        750
ISTTNEIGLH GAEGLTTTWK EYNHNLQLDD GTVKAICMAG SFKVTALNVV 
       760        770        780        790        800
SRRYLASLHK DALPTSVTFE LLFDGTSPLT EEMGDDFGFG LCPYDTSPVV 
       810        820        830        840        850
KGKYNTTLLN GSAFYLVCPI GWTGVIECTA VSPTTLRTEV VKTFRREKPF 
       860        870        880        890        900
PYRRDCVTTT VENEDLFYCK WGGNWTCVKG EPVTYTGGPV KQCRWCGFDF 
       910        920        930        940        950
NEPDGLPHYP IGKCILANET GYRIVDSTDC NRDGVVISTE GSHECLIGNT 
       960        970        980        990       1000
TVKVHALDER LGPMPCRPKE IVSSAGPVRK TSCTFNYAKT LRNRYYEPRD 
      1010       1020       1030       1040       1050
SYFQQYMLKG EYQYWFDLDV TDRHSDYFAE FIVLVVVALL GGRYVLWLIV 
      1060       1070       1080       1090       1100
TYIVLTEQLA AGLQLGQGEV VLIGNLITHT DIEVVVYFLL LYLVMRDEPI 
      1110       1120       1130       1140       1150
KKWILLLFHA MTNNPVKTIT VALLMVSGVA KGGKIDGGWQ RLPETNFDIQ 
      1160       1170       1180       1190       1200
LALTVIVVAV MLLAKKDPTT VPLVITVATL RTAKITNGLS TDLAIATVST 
      1210       1220       1230       1240       1250
ALLTWTYISD YYKYKTLLQY LISTVTGIFL IRVLKGVGEL DLHTPTLPSY 
      1260       1270       1280       1290       1300
RPLFFILVYL ISTAVVTRWN LDIAGLLLQC VPTLLMVFTM WADILTLILI 
      1310       1320       1330       1340       1350
LPTYELTKLY YLKEVKIGAE RGWLWKTNFK RVNDIYEVDQ AGEGVYLFPS 
      1360       1370       1380       1390       1400
KQKTGTITGT MLPLIKAILI SCISNKWQFI YLLYLIFEVS YYLHKKIIDE 
      1410       1420       1430       1440       1450
IAGGTNFISR LVAALIEANW AFDNEEVRGL KKFFLLSSRV KELIIKHKVR 
      1460       1470       1480       1490       1500
NEVMVHWFGD EEVYGMPKLV GLVKAATLSK NKHCILCTVC ENREWRGETC 
      1510       1520       1530       1540       1550
PKCGRFGPPV TCGMTLADFE EKHYKRIFFR EDQSEGPVRE EYAGYLQYRA 
      1560       1570       1580       1590       1600
RGQLFLRNLP VLATKVKMLL VGNLGTEVGD LEHLGWVLRG PAVCKKVTEH 
      1610       1620       1630       1640       1650
EKCTTSIMDK LTAFFGVMPR GTTPRAPVRF PTSLLKIRRG LETGWAYTHQ 
      1660       1670       1680       1690       1700
GGISSVDHVT CGKDLLVCDT MGRTRVVCQS NNKMTDESEY GVKTDSGCPE 
      1710       1720       1730       1740       1750
GARCYVFNRE AVNISGTKGA MVHLQKTGGE FTCVTASGTP AFFDLKNLKG 
      1760       1770       1780       1790       1800
WSGLPIFEAS SGRVVGRVKV GKNEDSKPTK LMSGIQTVSK STTDLTEMVK 
      1810       1820       1830       1840       1850
KITTMNRGEF RQITLATGAG KTTELPRSVI EEIGRHKRVL VLIPLRAAAE 
      1860       1870       1880       1890       1900
SVYQYMRQKH PSIAFNLRIG EMKEGDMATG ITYASYGYFC QMPQPKLRAA 
      1910       1920       1930       1940       1950
MVEYSFIFLD EYHCSTPEQL AIMGKIHRFS ENLRVVAMTA TPAGTVTTTG 
      1960       1970       1980       1990       2000
QKHPIEEYIA PEVMKGEDLG PEYLDIAGLK IPVEEMKSNM LVFVPTRNMA 
      2010       2020       2030       2040       2050
VETAKKLKAK GYNSGYYYSG EDPSNLRVVT SQSPYVVVAT NAIESGVTLP 
      2060       2070       2080       2090       2100
DLDVVVDTGL KCEKRIRLSP KMPFIVTGLK RMAVTIGEQA QRRGRVGRVK 
      2110       2120       2130       2140       2150
PGRYYRSQET PVGSKDYHYD LLQAQRYGIE DGINITKSFR EMNYDWSLYE 
      2160       2170       2180       2190       2200
EDSLMITQLE ILNNLLISEE LPMAVKNIMA RTDHPEPIQL AYNSYETQVP 
      2210       2220       2230       2240       2250
VLFPKIKNGE VTDSYDNYTF LNARKLGDDV PPYVYATEDE DLAVELLGLD 
      2260       2270       2280       2290       2300
WPDPGNQGTV EAGRALKQVV GLSTAENALL VALFGYVGYQ ALSKRHIPVV 
      2310       2320       2330       2340       2350
TDIYSIEDHR LEDTTHLQYA PNAIKTEGKE TELKELAQGD VQRCMEAMTN 
      2360       2370       2380       2390       2400
YARDGIQFMK SQALKVKETP TYKETMDTVA DYVKKFMEAL ADSKEDIIKY 
      2410       2420       2430       2440       2450
GLWGTHTALY KSIGARLGNE TAFATLVVKW LAFGGESIAD HVKQAATDLV 
      2460       2470       2480       2490       2500
VYYIINRPQF PGDTETQQEG RKFVASLLVS ALATYTYKSW NYNNLSKIVE 
      2510       2520       2530       2540       2550
PALATLPYAA TALKLFAPTR LESVVILSTA IYKTYLSIRR GKSDGLLGTG 
      2560       2570       2580       2590       2600
VSAAMEIMSQ NPVSVGIAVM LGVGAVAAHN AIEASEQKRT LLMKVFVKNF 
      2610       2620       2630       2640       2650
LDQAATDELV KESPEKIIMA LFEAVQTVGN PLRLVYHVYG VFYKGWEAKE 
      2660       2670       2680       2690       2700
LAQRTAGRNL FTLIMFEAVE LLGVDSEGKI RQLSSNYILE LLYKFRDSIK 
      2710       2720       2730       2740       2750
SSVRQMAISW APAPFSCDWT PTDDRIGLPQ DNFLRVETKC PCGYKMKAVK 
      2760       2770       2780       2790       2800
NCAGELRLLE EEGSFLCRNK FGRGSRNYRV TKYYDDNLSE IKPVIRMEGH 
      2810       2820       2830       2840       2850
VELYYKGATI KLDFNNSKTI LATDKWEVDH STLVRVLKRH TGAGYCGAYL 
      2860       2870       2880       2890       2900
GEKPNHKHLI ERDCATITKD KVCFLKMKRG CAFTYDLSLH NLTRLIELVH 
      2910       2920       2930       2940       2950
KNNLEDKEIP AVTVTTWLAY TFVNEDIGTI KPAFGEKITP EMQEEITLQP 
      2960       2970       2980       2990       3000
AVLVDATDVT VTVVGETPTM TTGETPTTFT SSGPDPKGQQ VLKLGVGEGQ 
      3010       3020       3030       3040       3050
YPGTNPQRAS LHEAIQSADE RPSVLILGSD KATSNRVKTV KNVKVYRGRD 
      3060       3070       3080       3090       3100
PLEVRDMMRR GKILVIALSR VDNALLKFVD YKGTFLTRET LEALSLGRPK 
      3110       3120       3130       3140       3150
KKNITKAEAQ WLLRLEDQME ELPDWFAAGE PIFLEANIKH DRYHLVGDIA 
      3160       3170       3180       3190       3200
TIKEKAKQLG ATDSTKISKE VGAKVYSMKL SNWVMQEENK QSNLTPLFEE 
      3210       3220       3230       3240       3250
LLQQCPPGGQ NKTAHMVSAY QLAQGNWMPT SCHVFMGTIS ARRTKTHPYE 
      3260       3270       3280       3290       3300
AYVKLRELVE EHKMKTLCPG SSLRNDNEWV IGKIKYQGNL RTKHMLNPGK 
      3310       3320       3330       3340       3350
VAEQLHREGH RHNVYNKTIG SVMTATGIRL EKLPVVRAQT DTTNFHQAIR 
      3360       3370       3380       3390       3400
DKIDKEENLQ TPGLHKKLME VFNALKRPEL ESSYDAVEWE ELERGINRKG 
      3410       3420       3430       3440       3450
AAGFFERKNI GEILDSEKIK VEEIIDNLKK GRNIKYYETA IPKNEKRDVN 
      3460       3470       3480       3490       3500
DDWTAGDFVD EKKPRVIQYP EAKTRLAITK VMYKWVKQKP VVIPGYEGKT 
      3510       3520       3530       3540       3550
PLFQIFDKVK KEWDQFQNPV AVSFDTKAWD TQVTTNDLEL IKDIQKYYFK 
      3560       3570       3580       3590       3600
KKWHKFIDTL TMHMSEVPVI TADGEVYIRK GQRGSGQPDT SAGNSMLNVL 
      3610       3620       3630       3640       3650
TMVYAFCEAT GVPYKSFDRV AKIHVCGDDG FLITERALGE KFASKGVQIL 
      3660       3670       3680       3690       3700
YEAGKPQKIT EGDKMKVAYQ FADIEFCSHT PIQVRWSDNT SSYMPGRNTT 
      3710       3720       3730       3740       3750
TILAKMATRL DSSGERGTIA YEKAVAFSFL LMYSWNPLIR RICLLVLSTE 
      3760       3770       3780       3790       3800
LQVKPGKSTT YYYEGDPISA YKEVIGHNLF DLKRTSFEKL AKLNLSMSVL 
      3810       3820       3830       3840       3850
GAWTRHTSKR LLQDCVNMGV KEGNWLVNAD RLVSSKTGNR YVPGEGHTLQ 
      3860       3870       3880       3890 
GRHYEELALA RKQINSFQGT DRYNLGPIVN MVLRRLRVMM MTLIGRGV
Length:3,898
Mass (Da):438,430
Last modified:May 1, 1991 - v1
Checksum:iEC6EB207A09D59FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31768 Genomic RNA Translation: AAA43843.1
PIRiA35317 GNWVHB

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31768 Genomic RNA Translation: AAA43843.1
PIRiA35317 GNWVHB

3D structure databases

ProteinModelPortaliP21530
SMRiP21530
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21530, 62 interactors

Protein family/group databases

MEROPSiS31.001

Proteomic databases

PRIDEiP21530

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090001OO

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR021824 Capsid-C_pestivirus
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR022120 NS2
IPR030399 NS2_C74
IPR027417 P-loop_NTPase
IPR008751 Peptidase_C53
IPR032521 Pestivirus_E2
IPR000280 Pestivirus_NS3_S31
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
IPR036430 RNase_T2-like_sf
IPR033130 RNase_T2_His_AS_2
PfamiView protein in Pfam
PF11889 DUF3409, 1 hit
PF07652 Flavi_DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF05550 Peptidase_C53, 1 hit
PF12387 Peptidase_C74, 1 hit
PF05578 Peptidase_S31, 1 hit
PF16329 Pestivirus_E2, 1 hit
PF00998 RdRP_3, 1 hit
PRINTSiPR00729 CDVENDOPTASE
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF55895 SSF55895, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51692 PESTIVIRUS_NS2_PRO, 1 hit
PS51535 PESTIVIRUS_NS3PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS00531 RNASE_T2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOLG_CSFVB
AccessioniPrimary (citable) accession number: P21530
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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