UniProtKB - P21530 (POLG_CSFVB)
Genome polyprotein
Functioni
Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.
By similarityPackages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Plays also a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
By similarityPlays a role in viral entry. Interacts with host RPSA that acts as a cellular attachment receptor for the virus. Possesses also intrinsic ribonuclease (RNase) activity that can inhibit the production of type I interferon and assist in the development of persistent infections.
By similarityPlays a role in cell attachment and subsequent fusion of viral and cellular membranes. Therefore, mediates together with envelope glycoprotein E2 the viral entry.
By similarityPlays a role in cell attachment and subsequent fusion of viral and cellular membranes. Therefore, mediates together with envelope glycoprotein E1 the viral entry.
By similarityPlays an essential role in the virus replication cycle by acting as a viroporin. Forms ion conductive pores, which alters the cell permeability allowing the transport of ions and other small molecules.
By similarityAutoprotease that associates with the host chaperone JIV and cleaves the NS2-3 protein between NS2 and NS3. Plays also a role in the formation of infectious particles.
By similarityPlays a role in the regulation of viral RNA replication.
By similarityMultifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and viral genome replication. The chymotrypsin-like serine protease activity utilizes NS4A as an essential cofactor and catalyzes the cleavage of the polyprotein leading to the release of NS4A, NS4B, NS5A, and NS5B. Plays a role in the inhibition of host NF-kappa-B activation by interacting with and inhibiting host TRAF6. Interacts with NS5B to enhance RNA-dependent RNA polymerase activity.
By similarityActs as a cofactor for the NS3 protease activity.
By similarityInduces a specific membrane alteration that serves as a scaffold for the virus replication complex (By similarity).
Antagonizes host cell apoptosis by interacting with host ferritin heavy chain. The ORF4 protein physically binds host FTH1/FHC, resulting in the reduction of FTH1 protein levels in host cells. Reduction of FTH1 concentration further inhibits the accumulation of reactive oxygen in host cells, leading to reduced apoptosis.
By similarityRegulates viral RNA replication by interacting with the 3'-untranslated region of viral RNA in a dose-dependent manner. At small concentrations promotes viral synthesis by interacting with the polymerase NS5B while at large concentrations, inhibits replication.
By similarityReplicates the viral (+) and (-) genome.
PROSITE-ProRule annotationCatalytic activityi
- Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites. EC:3.4.21.113
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 49 | For N-terminal protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 69 | For N-terminal protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1447 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1461 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1512 | For cysteine protease NS2 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1658 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1695 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1752 | Charge relay system; for serine protease NS3 activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- cysteine-type endopeptidase activity Source: InterPro
- ion channel activity Source: UniProtKB-KW
- ribonuclease T2 activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- serine-type endopeptidase activity Source: InterPro
- serine-type exopeptidase activity Source: InterPro
GO - Biological processi
- fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- pore formation by virus in membrane of host cell Source: UniProtKB-KW
- protein complex oligomerization Source: UniProtKB-KW
- regulation of intermediate filament polymerization Source: AgBase
- regulation of membrane tubulation Source: AgBase
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Source: UniProtKB-KW
- viral genome replication Source: AgBase
- viral protein processing Source: InterPro
- viral release from host cell Source: AgBase
- viral RNA genome replication Source: InterPro
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Protein family/group databases
MEROPSi | S31.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinCleaved into the following 13 chains: Alternative name(s): Autoprotease p20 Alternative name(s): gp44/48 Alternative name(s): gp33 Alternative name(s): gp55 Viroporin p7By similarity Alternative name(s): Non-structural protein 2 Serine protease NS3 (EC:3.4.21.113, EC:3.6.1.15, EC:3.6.4.13) Alternative name(s): Non-structural protein 3 Alternative name(s): NS5B |
Organismi | Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus) |
Taxonomic identifieri | 11098 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Flasuviricetes › Amarillovirales › Flaviviridae › Pestivirus › |
Virus hosti | Sus scrofa (Pig) [TaxID: 9823] |
Proteomesi |
|
Subcellular locationi
- Virion By similarity
- Host membrane ; Peripheral membrane protein
- Virion membrane ; Peripheral membrane protein Curated Note: The C-terminus membrane anchor of Erns represents an amphipathic helix embedded in plane into the membrane.By similarity
- Host cell surface By similarity
- Virion membrane By similarity
- Host membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
- Host cytoplasm By similarity
- Host cytoplasm By similarity
- Host cytoplasm By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1140 – 1164 | HelicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Transmembranei | 1189 – 1209 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1217 – 1237 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1247 – 1267 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1281 – 1301 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1360 – 1380 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1568 – 1588 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Host cytoplasm, Host membrane, Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000450894 | 1 – 3898 | Genome polyproteinAdd BLAST | 3898 | |
ChainiPRO_0000038062 | 1 – 168 | N-terminal proteaseBy similarityAdd BLAST | 168 | |
ChainiPRO_0000038063 | 169 – 267 | Capsid protein CBy similarityAdd BLAST | 99 | |
ChainiPRO_0000038064 | 268 – 494 | E(rns) glycoproteinBy similarityAdd BLAST | 227 | |
ChainiPRO_0000038065 | 495 – 656 | Envelope glycoprotein E1By similarityAdd BLAST | 162 | |
ChainiPRO_0000038066 | 657 – 1062 | Envelope glycoprotein E2By similarityAdd BLAST | 406 | |
ChainiPRO_0000038067 | 1063 – 1132 | Viroporin p7By similarityAdd BLAST | 70 | |
ChainiPRO_0000038068 | 1133 – 2272 | Non-structural protein 2-3By similarityAdd BLAST | 1140 | |
ChainiPRO_0000349362 | 1133 – 1589 | Cysteine protease NS2PROSITE-ProRule annotationAdd BLAST | 457 | |
ChainiPRO_0000038069 | 1590 – 2272 | Serine protease NS3By similarityAdd BLAST | 683 | |
ChainiPRO_0000038070 | 2273 – 2336 | Non-structural protein 4ABy similarityAdd BLAST | 64 | |
ChainiPRO_0000038071 | 2337 – 2683 | Non-structural protein 4BBy similarityAdd BLAST | 347 | |
ChainiPRO_0000038072 | 2684 – 3180 | Non-structural protein 5ABy similarityAdd BLAST | 497 | |
ChainiPRO_0000038073 | 3181 – 3898 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 718 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 157 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 278 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 332 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 410 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 425 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 500 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 594 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 805 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 810 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 874 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 918 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 949 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1713 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2134 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2217 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2419 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2494 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2787 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2815 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 2891 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3103 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3211 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3316 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3689 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3698 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 3794 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 168 – 169 | Cleavage; by autolysisPROSITE-ProRule annotation | 2 | |
Sitei | 267 – 268 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 494 – 495 | CleavageBy similarity | 2 | |
Sitei | 656 – 657 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 1062 – 1063 | Cleavage; by host signal peptidase; partialBy similarity | 2 | |
Sitei | 1132 – 1133 | Cleavage; by host signal peptidaseBy similarity | 2 | |
Sitei | 1589 – 1590 | Cleavage; partial; by cysteine protease NS2By similarity | 2 | |
Sitei | 2272 – 2273 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 2336 – 2337 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 2683 – 2684 | Cleavage; by serine protease NS3By similarity | 2 | |
Sitei | 3180 – 3181 | Cleavage; by serine protease NS3By similarity | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P21530 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity). Heterodimer with E1; disulfide-linked (By similarity).
By similarityHomodimer; disulfide-linked (By similarity). Heterodimer with E1; disulfide-linked (By similarity).
Interacts with host TRX2 (By similarity).
By similarityInteracts with host TRAF6; this interaction inhibits host NF-kappa-B pathway.
Interacts with NS5B; this interaction enhances RNA-dependent RNA polymerase activity.
Interacts with protein NS4A.
By similarityInteracts with host RAB5, this interaction facilitates the formation of NS4B-related complex.
Interacts with host FTH1; this interaction plays a positive role in viral anti-apoptosis.
By similarityInteracts with RNA-directed RNA polymerase.
Interacts with host RSAD2; this interaction inhibits viral replication.
By similarityInteracts with NS5A; this interaction promotes viral replication.
By similarityBinary interactionsi
N-terminal protease (PRO_0000038062)
With | #Exp. | IntAct |
---|---|---|
NFKBIA [P25963] from Homo sapiens. | 4 | EBI-12558622,EBI-307386 |
NFKBIA [Q08353] from Sus scrofa. | 4 | EBI-12558622,EBI-12558699 |
Capsid protein C (PRO_0000038063)
With | #Exp. | IntAct |
---|---|---|
IQGAP1 [K9IWF9] from Sus scrofa. | 3 | EBI-12515736,EBI-12515741 |
Protein-protein interaction databases
IntActi | P21530, 61 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 168 | Peptidase C53PROSITE-ProRule annotationAdd BLAST | 168 | |
Domaini | 1441 – 1589 | Peptidase C74PROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 1590 – 1763 | Peptidase S31PROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 1802 – 1960 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 159 | |
Domaini | 1978 – 2179 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 202 | |
Domaini | 3519 – 3642 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 242 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2968 – 2987 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.30.140.40, 1 hit 2.60.320.20, 1 hit 2.60.40.3000, 1 hit 2.60.40.4200, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 2 hits 3.90.730.10, 1 hit |
InterProi | View protein in InterPro IPR021824, Capsid-C_pestivirus IPR011492, DEAD_Flavivir IPR043502, DNA/RNA_pol_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR022120, NS2 IPR030399, NS2_C74 IPR027417, P-loop_NTPase IPR008751, Peptidase_C53 IPR042542, Peptidase_C53_interaction IPR032521, Pestivirus_E2 IPR042309, Pestivirus_E2_A IPR042310, Pestivirus_E2_B IPR042311, Pestivirus_E2_D IPR000280, Pestivirus_NS3_S31 IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV IPR036430, RNase_T2-like_sf IPR033130, RNase_T2_His_AS_2 |
Pfami | View protein in Pfam PF11889, DUF3409, 1 hit PF07652, Flavi_DEAD, 1 hit PF00271, Helicase_C, 1 hit PF05550, Peptidase_C53, 1 hit PF12387, Peptidase_C74, 1 hit PF05578, Peptidase_S31, 1 hit PF16329, Pestivirus_E2, 1 hit PF00998, RdRP_3, 1 hit |
PRINTSi | PR00729, CDVENDOPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55895, SSF55895, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51692, PESTIVIRUS_NS2_PRO, 1 hit PS51535, PESTIVIRUS_NS3PRO, 1 hit PS51876, PV_NPRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS00531, RNASE_T2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MELNHFELLY KTNKQKPMGV EEPVYDVTGR PLFGDPSEVH PQSTLKLPHD
60 70 80 90 100
RGRGNIKTTL KNLPRRGDCR SGNHLGPVSG IYVKPGPVFY QDYMGPVYHR
110 120 130 140 150
APLEFFDEAQ FCEVTKRIGR VTGSDGKLYH IYVCIDGCIL LKLAKRGEPR
160 170 180 190 200
TLKWIRNLTD CPLWVTSCSD DGASASKEKK PDRINKGKLK IAPKEHEKDS
210 220 230 240 250
RTKPPDATIV VEGVKYQVKK KGKVKGKNTQ DGLYHNKNKP PESRKKLEKA
260 270 280 290 300
LLAWAVIAIM LYQPVAAENI TQWNLRDNGT NGIQHAMYLR GVSRSLHGIW
310 320 330 340 350
PEKICKGVPT YLATDTELRE IQGMMVASEG TNYTCCKLQR HEWNKHGWCN
360 370 380 390 400
WYNIDPWIQL MNRTQANLAE GPPSKECAVT CRYDKNADIN VVTQARNRPT
410 420 430 440 450
TLTGCKKGTN FSFAGTVIEG PCNFNVSVED ILYGDHECGS LLQDTALYLV
460 470 480 490 500
DGMTNTIERA RQGAARVTSW LGRQLRIAGK RLEGRSKTWF GAYALSPYCN
510 520 530 540 550
VTTKIGYIWY TNNCTPACLP KNTKIIGPGK FDTNAEDGKI LHEMGGHLSE
560 570 580 590 600
FLLLSLVVLS DFAPETASAL YLILHYVIPQ SHEEPEGCDT NQLNLTVELR
610 620 630 640 650
TEDVIPSSVW NVGKYVCVRP DWWPYETKVA LLFEEAGQVV KLALRALRDL
660 670 680 690 700
TRVWNSASTT AFLICLIKVL RGQVVQGVIW LLLVTGAQGR LACKEDHRYA
710 720 730 740 750
ISTTNEIGLH GAEGLTTTWK EYNHNLQLDD GTVKAICMAG SFKVTALNVV
760 770 780 790 800
SRRYLASLHK DALPTSVTFE LLFDGTSPLT EEMGDDFGFG LCPYDTSPVV
810 820 830 840 850
KGKYNTTLLN GSAFYLVCPI GWTGVIECTA VSPTTLRTEV VKTFRREKPF
860 870 880 890 900
PYRRDCVTTT VENEDLFYCK WGGNWTCVKG EPVTYTGGPV KQCRWCGFDF
910 920 930 940 950
NEPDGLPHYP IGKCILANET GYRIVDSTDC NRDGVVISTE GSHECLIGNT
960 970 980 990 1000
TVKVHALDER LGPMPCRPKE IVSSAGPVRK TSCTFNYAKT LRNRYYEPRD
1010 1020 1030 1040 1050
SYFQQYMLKG EYQYWFDLDV TDRHSDYFAE FIVLVVVALL GGRYVLWLIV
1060 1070 1080 1090 1100
TYIVLTEQLA AGLQLGQGEV VLIGNLITHT DIEVVVYFLL LYLVMRDEPI
1110 1120 1130 1140 1150
KKWILLLFHA MTNNPVKTIT VALLMVSGVA KGGKIDGGWQ RLPETNFDIQ
1160 1170 1180 1190 1200
LALTVIVVAV MLLAKKDPTT VPLVITVATL RTAKITNGLS TDLAIATVST
1210 1220 1230 1240 1250
ALLTWTYISD YYKYKTLLQY LISTVTGIFL IRVLKGVGEL DLHTPTLPSY
1260 1270 1280 1290 1300
RPLFFILVYL ISTAVVTRWN LDIAGLLLQC VPTLLMVFTM WADILTLILI
1310 1320 1330 1340 1350
LPTYELTKLY YLKEVKIGAE RGWLWKTNFK RVNDIYEVDQ AGEGVYLFPS
1360 1370 1380 1390 1400
KQKTGTITGT MLPLIKAILI SCISNKWQFI YLLYLIFEVS YYLHKKIIDE
1410 1420 1430 1440 1450
IAGGTNFISR LVAALIEANW AFDNEEVRGL KKFFLLSSRV KELIIKHKVR
1460 1470 1480 1490 1500
NEVMVHWFGD EEVYGMPKLV GLVKAATLSK NKHCILCTVC ENREWRGETC
1510 1520 1530 1540 1550
PKCGRFGPPV TCGMTLADFE EKHYKRIFFR EDQSEGPVRE EYAGYLQYRA
1560 1570 1580 1590 1600
RGQLFLRNLP VLATKVKMLL VGNLGTEVGD LEHLGWVLRG PAVCKKVTEH
1610 1620 1630 1640 1650
EKCTTSIMDK LTAFFGVMPR GTTPRAPVRF PTSLLKIRRG LETGWAYTHQ
1660 1670 1680 1690 1700
GGISSVDHVT CGKDLLVCDT MGRTRVVCQS NNKMTDESEY GVKTDSGCPE
1710 1720 1730 1740 1750
GARCYVFNRE AVNISGTKGA MVHLQKTGGE FTCVTASGTP AFFDLKNLKG
1760 1770 1780 1790 1800
WSGLPIFEAS SGRVVGRVKV GKNEDSKPTK LMSGIQTVSK STTDLTEMVK
1810 1820 1830 1840 1850
KITTMNRGEF RQITLATGAG KTTELPRSVI EEIGRHKRVL VLIPLRAAAE
1860 1870 1880 1890 1900
SVYQYMRQKH PSIAFNLRIG EMKEGDMATG ITYASYGYFC QMPQPKLRAA
1910 1920 1930 1940 1950
MVEYSFIFLD EYHCSTPEQL AIMGKIHRFS ENLRVVAMTA TPAGTVTTTG
1960 1970 1980 1990 2000
QKHPIEEYIA PEVMKGEDLG PEYLDIAGLK IPVEEMKSNM LVFVPTRNMA
2010 2020 2030 2040 2050
VETAKKLKAK GYNSGYYYSG EDPSNLRVVT SQSPYVVVAT NAIESGVTLP
2060 2070 2080 2090 2100
DLDVVVDTGL KCEKRIRLSP KMPFIVTGLK RMAVTIGEQA QRRGRVGRVK
2110 2120 2130 2140 2150
PGRYYRSQET PVGSKDYHYD LLQAQRYGIE DGINITKSFR EMNYDWSLYE
2160 2170 2180 2190 2200
EDSLMITQLE ILNNLLISEE LPMAVKNIMA RTDHPEPIQL AYNSYETQVP
2210 2220 2230 2240 2250
VLFPKIKNGE VTDSYDNYTF LNARKLGDDV PPYVYATEDE DLAVELLGLD
2260 2270 2280 2290 2300
WPDPGNQGTV EAGRALKQVV GLSTAENALL VALFGYVGYQ ALSKRHIPVV
2310 2320 2330 2340 2350
TDIYSIEDHR LEDTTHLQYA PNAIKTEGKE TELKELAQGD VQRCMEAMTN
2360 2370 2380 2390 2400
YARDGIQFMK SQALKVKETP TYKETMDTVA DYVKKFMEAL ADSKEDIIKY
2410 2420 2430 2440 2450
GLWGTHTALY KSIGARLGNE TAFATLVVKW LAFGGESIAD HVKQAATDLV
2460 2470 2480 2490 2500
VYYIINRPQF PGDTETQQEG RKFVASLLVS ALATYTYKSW NYNNLSKIVE
2510 2520 2530 2540 2550
PALATLPYAA TALKLFAPTR LESVVILSTA IYKTYLSIRR GKSDGLLGTG
2560 2570 2580 2590 2600
VSAAMEIMSQ NPVSVGIAVM LGVGAVAAHN AIEASEQKRT LLMKVFVKNF
2610 2620 2630 2640 2650
LDQAATDELV KESPEKIIMA LFEAVQTVGN PLRLVYHVYG VFYKGWEAKE
2660 2670 2680 2690 2700
LAQRTAGRNL FTLIMFEAVE LLGVDSEGKI RQLSSNYILE LLYKFRDSIK
2710 2720 2730 2740 2750
SSVRQMAISW APAPFSCDWT PTDDRIGLPQ DNFLRVETKC PCGYKMKAVK
2760 2770 2780 2790 2800
NCAGELRLLE EEGSFLCRNK FGRGSRNYRV TKYYDDNLSE IKPVIRMEGH
2810 2820 2830 2840 2850
VELYYKGATI KLDFNNSKTI LATDKWEVDH STLVRVLKRH TGAGYCGAYL
2860 2870 2880 2890 2900
GEKPNHKHLI ERDCATITKD KVCFLKMKRG CAFTYDLSLH NLTRLIELVH
2910 2920 2930 2940 2950
KNNLEDKEIP AVTVTTWLAY TFVNEDIGTI KPAFGEKITP EMQEEITLQP
2960 2970 2980 2990 3000
AVLVDATDVT VTVVGETPTM TTGETPTTFT SSGPDPKGQQ VLKLGVGEGQ
3010 3020 3030 3040 3050
YPGTNPQRAS LHEAIQSADE RPSVLILGSD KATSNRVKTV KNVKVYRGRD
3060 3070 3080 3090 3100
PLEVRDMMRR GKILVIALSR VDNALLKFVD YKGTFLTRET LEALSLGRPK
3110 3120 3130 3140 3150
KKNITKAEAQ WLLRLEDQME ELPDWFAAGE PIFLEANIKH DRYHLVGDIA
3160 3170 3180 3190 3200
TIKEKAKQLG ATDSTKISKE VGAKVYSMKL SNWVMQEENK QSNLTPLFEE
3210 3220 3230 3240 3250
LLQQCPPGGQ NKTAHMVSAY QLAQGNWMPT SCHVFMGTIS ARRTKTHPYE
3260 3270 3280 3290 3300
AYVKLRELVE EHKMKTLCPG SSLRNDNEWV IGKIKYQGNL RTKHMLNPGK
3310 3320 3330 3340 3350
VAEQLHREGH RHNVYNKTIG SVMTATGIRL EKLPVVRAQT DTTNFHQAIR
3360 3370 3380 3390 3400
DKIDKEENLQ TPGLHKKLME VFNALKRPEL ESSYDAVEWE ELERGINRKG
3410 3420 3430 3440 3450
AAGFFERKNI GEILDSEKIK VEEIIDNLKK GRNIKYYETA IPKNEKRDVN
3460 3470 3480 3490 3500
DDWTAGDFVD EKKPRVIQYP EAKTRLAITK VMYKWVKQKP VVIPGYEGKT
3510 3520 3530 3540 3550
PLFQIFDKVK KEWDQFQNPV AVSFDTKAWD TQVTTNDLEL IKDIQKYYFK
3560 3570 3580 3590 3600
KKWHKFIDTL TMHMSEVPVI TADGEVYIRK GQRGSGQPDT SAGNSMLNVL
3610 3620 3630 3640 3650
TMVYAFCEAT GVPYKSFDRV AKIHVCGDDG FLITERALGE KFASKGVQIL
3660 3670 3680 3690 3700
YEAGKPQKIT EGDKMKVAYQ FADIEFCSHT PIQVRWSDNT SSYMPGRNTT
3710 3720 3730 3740 3750
TILAKMATRL DSSGERGTIA YEKAVAFSFL LMYSWNPLIR RICLLVLSTE
3760 3770 3780 3790 3800
LQVKPGKSTT YYYEGDPISA YKEVIGHNLF DLKRTSFEKL AKLNLSMSVL
3810 3820 3830 3840 3850
GAWTRHTSKR LLQDCVNMGV KEGNWLVNAD RLVSSKTGNR YVPGEGHTLQ
3860 3870 3880 3890
GRHYEELALA RKQINSFQGT DRYNLGPIVN MVLRRLRVMM MTLIGRGV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31768 Genomic RNA Translation: AAA43843.1 |
PIRi | A35317, GNWVHB |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31768 Genomic RNA Translation: AAA43843.1 |
PIRi | A35317, GNWVHB |
3D structure databases
SMRi | P21530 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P21530, 61 interactors |
Protein family/group databases
MEROPSi | S31.001 |
Proteomic databases
PRIDEi | P21530 |
Family and domain databases
Gene3Di | 2.30.140.40, 1 hit 2.60.320.20, 1 hit 2.60.40.3000, 1 hit 2.60.40.4200, 1 hit 3.30.70.270, 2 hits 3.40.50.300, 2 hits 3.90.730.10, 1 hit |
InterProi | View protein in InterPro IPR021824, Capsid-C_pestivirus IPR011492, DEAD_Flavivir IPR043502, DNA/RNA_pol_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR022120, NS2 IPR030399, NS2_C74 IPR027417, P-loop_NTPase IPR008751, Peptidase_C53 IPR042542, Peptidase_C53_interaction IPR032521, Pestivirus_E2 IPR042309, Pestivirus_E2_A IPR042310, Pestivirus_E2_B IPR042311, Pestivirus_E2_D IPR000280, Pestivirus_NS3_S31 IPR043128, Rev_trsase/Diguanyl_cyclase IPR007094, RNA-dir_pol_PSvirus IPR002166, RNA_pol_HCV IPR036430, RNase_T2-like_sf IPR033130, RNase_T2_His_AS_2 |
Pfami | View protein in Pfam PF11889, DUF3409, 1 hit PF07652, Flavi_DEAD, 1 hit PF00271, Helicase_C, 1 hit PF05550, Peptidase_C53, 1 hit PF12387, Peptidase_C74, 1 hit PF05578, Peptidase_S31, 1 hit PF16329, Pestivirus_E2, 1 hit PF00998, RdRP_3, 1 hit |
PRINTSi | PR00729, CDVENDOPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF55895, SSF55895, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51692, PESTIVIRUS_NS2_PRO, 1 hit PS51535, PESTIVIRUS_NS3PRO, 1 hit PS51876, PV_NPRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS00531, RNASE_T2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | POLG_CSFVB | |
Accessioni | P21530Primary (citable) accession number: P21530 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |