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Entry version 186 (31 Jul 2019)
Sequence version 3 (14 May 2014)
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Protein

Synaptotagmin 1

Gene

Syt1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi222Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi223Calcium 1By similarity1
Metal bindingi223Calcium 2By similarity1
Metal bindingi229Calcium 1By similarity1
Metal bindingi282Calcium 1By similarity1
Metal bindingi282Calcium 2By similarity1
Metal bindingi283Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi284Calcium 1By similarity1
Metal bindingi284Calcium 2By similarity1
Metal bindingi284Calcium 3By similarity1
Metal bindingi287Calcium 3By similarity1
Metal bindingi288Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi290Calcium 2By similarity1
Metal bindingi290Calcium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-888590 GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin 1
Alternative name(s):
p65
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syt1
Synonyms:syt
ORF Names:CG3139
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004242 Syt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 107VesicularAdd BLAST107
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei108 – 134HelicalSequence analysisAdd BLAST27
Topological domaini135 – 474CytoplasmicAdd BLAST340

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001839861 – 474Synaptotagmin 1Add BLAST474

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21521

PRoteomics IDEntifications database

More...
PRIDEi
P21521

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004242 Expressed in 20 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21521 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21521 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homotrimer (Potential).

Identified in a complex with Syn and nwk (PubMed:29568072).

Interacts with StnA and StnB via its second C2 domain. This interaction may mediate its retrieval from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane.

Curated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59696, 14 interactors

Protein interaction database and analysis system

More...
IntActi
P21521, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21521

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 296C2 1PROSITE-ProRule annotationAdd BLAST91
Domaini339 – 430C2 2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 434Phospholipid bindingCuratedAdd BLAST249

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IT3Q Eukaryota
ENOG410Z15P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168041

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21521

KEGG Orthology (KO)

More...
KOi
K15290

Identification of Orthologs from Complete Genome Data

More...
OMAi
ETTHHSK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21521

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR015428 Synaptotagmin1

The PANTHER Classification System

More...
PANTHERi
PTHR10024:SF239 PTHR10024:SF239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P21521-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPNAKSETD AKPEAEPAPA SEPAADLESV DQKLEETHHS KFREVDRQEQ
60 70 80 90 100
EVLAEKAAEA ASQRIAQVES TTRSATTEAQ ESTTTAVPVI KKIEHVGEVV
110 120 130 140 150
TEVIAERTGL PTWGVVAIII LVFLVVFGII FFCVRRFLKK RRTKDGKGKK
160 170 180 190 200
GVDMKSVQLL GSAYKEKVQP DMEELTENAE EGDEEDKQSE QKLGRLNFKL
210 220 230 240 250
EYDFNSNSLA VTVIQAEELP ALDMGGTSDP YVKVYLLPDK KKKFETKVHR
260 270 280 290 300
KTLSPVFNET FTFKSLPYAD AMNKTLVFAI FDFDRFSKHD QIGEVKVPLC
310 320 330 340 350
TIDLAQTIEE WRDLVSVEGE GGQEKLGDIC FSLRYVPTAG KLTVVILEAK
360 370 380 390 400
NLKKMDVGGL SDPYVKIAIM QNGKRLKKKK TSIKKCTLNP YYNESFSFEV
410 420 430 440 450
PFEQIQKICL VVTVVDYDRI GTSEPIGRCI LGCMGTGTEL RHWSDMLASP
460 470
RRPIAQWHTL KDPEETDEIL KNMK
Length:474
Mass (Da):53,260
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76F3A34EEABE875B
GO
Isoform B (identifier: P21521-2) [UniParc]FASTAAdd to basket
Also known as: C, I

The sequence of this isoform differs from the canonical sequence as follows:
     168-169: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):53,033
Checksum:i40BB77BB9D468FCA
GO
Isoform E (identifier: P21521-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-325: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):53,003
Checksum:i4B1802A7171FABC5
GO
Isoform G (identifier: P21521-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-331: EKLGDICF → VVLREVNI
     332-474: Missing.

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):37,049
Checksum:i6547B3F12C9300C6
GO
Isoform F (identifier: P21521-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-170: QP → SV
     171-474: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,643
Checksum:iD7DE111600B3D9FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2J4C1X2J4C1_DROME
Synaptotagmin 1, isoform I
Syt1 D. Syt I, Dmel\CG3139, Droso1, DSypt, DSypt1
472Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2J979X2J979_DROME
Synaptotagmin 1, isoform H
Syt1 D. Syt I, Dmel\CG3139, Droso1, DSypt, DSypt1
473Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50109 differs from that shown. Intron retention.Curated
The sequence AAM50109 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26D → E in AAA28925 (PubMed:1840599).Curated1

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 367, 379, 383 and 405.2 Publications
Partially edited.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti367I → V in RNA edited version. 1
Natural varianti379K → R in RNA edited version. 1
Natural varianti383I → V in RNA edited version. 1
Natural varianti405I → M in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011862168 – 169Missing in isoform B. 1 Publication2
Alternative sequenceiVSP_054628169 – 170QP → SV in isoform F. Curated2
Alternative sequenceiVSP_054629171 – 474Missing in isoform F. CuratedAdd BLAST304
Alternative sequenceiVSP_054630324 – 331EKLGDICF → VVLREVNI in isoform G. Curated8
Alternative sequenceiVSP_054631324 – 325Missing in isoform E. Curated2
Alternative sequenceiVSP_054632332 – 474Missing in isoform G. CuratedAdd BLAST143

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55048 mRNA Translation: AAA28925.1
AE014134 Genomic DNA Translation: AAF51205.1
AE014134 Genomic DNA Translation: AAF51206.2
AE014134 Genomic DNA Translation: AAS64625.2
AE014134 Genomic DNA Translation: AAN10415.1
AE014134 Genomic DNA Translation: AGB92502.1
AE014134 Genomic DNA Translation: AGB92503.1
BT004498 mRNA Translation: AAO42662.1
AY119455 mRNA Translation: AAM50109.1 Sequence problems.

Protein sequence database of the Protein Information Resource

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PIRi
B39052 BMFFSY

NCBI Reference Sequences

More...
RefSeqi
NP_001259965.1, NM_001273036.1 [P21521-6]
NP_001259966.1, NM_001273037.1
NP_001285568.1, NM_001298639.1 [P21521-2]
NP_523460.2, NM_078736.3 [P21521-1]
NP_722838.1, NM_164501.2 [P21521-2]
NP_722839.1, NM_164502.2 [P21521-2]
NP_995619.2, NM_205897.2 [P21521-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077726; FBpp0077410; FBgn0004242 [P21521-1]
FBtr0077727; FBpp0077411; FBgn0004242 [P21521-2]
FBtr0077728; FBpp0077412; FBgn0004242 [P21521-2]
FBtr0332218; FBpp0304523; FBgn0004242 [P21521-4]
FBtr0332219; FBpp0304524; FBgn0004242 [P21521-6]
FBtr0332220; FBpp0304525; FBgn0004242 [P21521-5]
FBtr0345331; FBpp0311487; FBgn0004242 [P21521-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3139

UCSC genome browser

More...
UCSCi
CG3139-RC d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55048 mRNA Translation: AAA28925.1
AE014134 Genomic DNA Translation: AAF51205.1
AE014134 Genomic DNA Translation: AAF51206.2
AE014134 Genomic DNA Translation: AAS64625.2
AE014134 Genomic DNA Translation: AAN10415.1
AE014134 Genomic DNA Translation: AGB92502.1
AE014134 Genomic DNA Translation: AGB92503.1
BT004498 mRNA Translation: AAO42662.1
AY119455 mRNA Translation: AAM50109.1 Sequence problems.
PIRiB39052 BMFFSY
RefSeqiNP_001259965.1, NM_001273036.1 [P21521-6]
NP_001259966.1, NM_001273037.1
NP_001285568.1, NM_001298639.1 [P21521-2]
NP_523460.2, NM_078736.3 [P21521-1]
NP_722838.1, NM_164501.2 [P21521-2]
NP_722839.1, NM_164502.2 [P21521-2]
NP_995619.2, NM_205897.2 [P21521-4]

3D structure databases

SMRiP21521
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59696, 14 interactors
IntActiP21521, 3 interactors
STRINGi7227.FBpp0077410

Proteomic databases

PaxDbiP21521
PRIDEiP21521

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077726; FBpp0077410; FBgn0004242 [P21521-1]
FBtr0077727; FBpp0077411; FBgn0004242 [P21521-2]
FBtr0077728; FBpp0077412; FBgn0004242 [P21521-2]
FBtr0332218; FBpp0304523; FBgn0004242 [P21521-4]
FBtr0332219; FBpp0304524; FBgn0004242 [P21521-6]
FBtr0332220; FBpp0304525; FBgn0004242 [P21521-5]
FBtr0345331; FBpp0311487; FBgn0004242 [P21521-2]
GeneIDi33473
KEGGidme:Dmel_CG3139
UCSCiCG3139-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6857
FlyBaseiFBgn0004242 Syt1

Phylogenomic databases

eggNOGiENOG410IT3Q Eukaryota
ENOG410Z15P LUCA
GeneTreeiENSGT00940000168041
InParanoidiP21521
KOiK15290
OMAiETTHHSK
PhylomeDBiP21521

Enzyme and pathway databases

ReactomeiR-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33473

Protein Ontology

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PROi
PR:P21521

Gene expression databases

BgeeiFBgn0004242 Expressed in 20 organ(s), highest expression level in head
ExpressionAtlasiP21521 baseline and differential
GenevisibleiP21521 DM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR015428 Synaptotagmin1
PANTHERiPTHR10024:SF239 PTHR10024:SF239, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSY65_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21521
Secondary accession number(s): A4V023
, M9PB17, M9PE99, Q7KU16, Q86NN2, Q8MRR8, Q9VQG7, Q9VQG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 14, 2014
Last modified: July 31, 2019
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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