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Entry version 169 (02 Dec 2020)
Sequence version 3 (24 Oct 2003)
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Protein

Protein scabrous

Gene

sca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Notch signaling pathway

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21520

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein scabrous
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sca
ORF Names:CG17579
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003326, sca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 51Sequence analysisAdd BLAST51
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000910852 – 799Protein scabrousAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi542 ↔ 568PROSITE-ProRule annotation
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi618N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi687 ↔ 700PROSITE-ProRule annotation
Glycosylationi744N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Possesses five pairs of dibasic residues that may be the target of proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003326, Expressed in embryo and 31 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21520, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
62183, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P21520, 2 interactors

Molecular INTeraction database

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MINTi
P21520

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086969

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21520

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini533 – 737Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST205

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi200 – 343Gln-richAdd BLAST144

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2579, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021665_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21520

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTDCAAN

Database of Orthologous Groups

More...
OrthoDBi
497548at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21520

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00087, FReD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR020837, Fibrinogen_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00147, Fibrinogen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00186, FBG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P21520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDWQTFPDL QKKKVSRDHL NCPATMAGSN VLWPILLAVV LLQISVAFVS
60 70 80 90 100
GAASGGVVLS DVNNMLRDAK VVTSEKPVVH SKQETEAPES SVELLRFVDD
110 120 130 140 150
DEDSEDISSI ERQDGRTMES KKMADQVRLL TKQLNALMLR RREDYEMLEH
160 170 180 190 200
NLRKSLRLTT NANSVDADMR SELNQLREEL AALRSSQSGN KERLTVEWLQ
210 220 230 240 250
QTISEIRKQL VDLQRTASNV AQDVQQRSST FEDLATIRSD YQQLKLDLAA
260 270 280 290 300
QRERQQQTEV YVQELREEML QQEQDFQHAL VKLQQRTRKD GSSASVEEES
310 320 330 340 350
GSQEANQEQT GLETTADHKR RHCRFQSEQI HQLQLAQRNL RRQVNGLRFH
360 370 380 390 400
HIDERVRSIE VEQHRIANAN FNLSSQIASL DKLHTSMLEL LEDVEGLQTK
410 420 430 440 450
MDKSIPELRH EISKLEFANA QITSEQSLIR EEGTNAARSL QAMAVSVSVL
460 470 480 490 500
QEEREGMRKL SANVDQLRTN VDRLQSLVND EMKNKLTHLN KPHKRPHHQN
510 520 530 540 550
VQAQMPQDDS PIDSVLAETL VSELENVETQ YEAIINKLPH DCSEVHTQTD
560 570 580 590 600
GLHLIAPAGQ RHPLMTHCTA DGWTTVQRRF DGSADFNRSW ADYAQGFGAP
610 620 630 640 650
GGEFWIGNEQ LHHLTLDNCS RLQVQMQDIY DNVWVAEYKR FYISSRADGY
660 670 680 690 700
RLHIAEYSGN ASDALNYQQG MQFSAIDDDR DISQTHCAAN YEGGWWFSHC
710 720 730 740 750
QHANLNGRYN LGLTWFDAAR NEWIAVKSSR MLVKRLPAVE CQANASASGA
760 770 780 790
FVSVSGSAAD AAPSSGATTT TTTATAAPAT VTTPKTNNSV VQFVAAGQA
Length:799
Mass (Da):90,119
Last modified:October 24, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87E1B4D60D4F5C29
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA28880 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti301G → C in AAA28880 (PubMed:2175046).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60065 Genomic DNA Translation: AAA28880.1 Different initiation.
AE013599 Genomic DNA Translation: AAF58455.2
AY129456 mRNA Translation: AAM76198.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39832

NCBI Reference Sequences

More...
RefSeqi
NP_476710.2, NM_057362.3
NP_725230.2, NM_165951.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087855; FBpp0086968; FBgn0003326
FBtr0087856; FBpp0086969; FBgn0003326

Database of genes from NCBI RefSeq genomes

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GeneIDi
36411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17579

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60065 Genomic DNA Translation: AAA28880.1 Different initiation.
AE013599 Genomic DNA Translation: AAF58455.2
AY129456 mRNA Translation: AAM76198.1
PIRiA39832
RefSeqiNP_476710.2, NM_057362.3
NP_725230.2, NM_165951.2

3D structure databases

SMRiP21520
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62183, 13 interactors
IntActiP21520, 2 interactors
MINTiP21520
STRINGi7227.FBpp0086969

Proteomic databases

PaxDbiP21520

Genome annotation databases

EnsemblMetazoaiFBtr0087855; FBpp0086968; FBgn0003326
FBtr0087856; FBpp0086969; FBgn0003326
GeneIDi36411
KEGGidme:Dmel_CG17579

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36411
FlyBaseiFBgn0003326, sca

Phylogenomic databases

eggNOGiKOG2579, Eukaryota
HOGENOMiCLU_021665_0_0_1
InParanoidiP21520
OMAiTTDCAAN
OrthoDBi497548at2759
PhylomeDBiP21520

Enzyme and pathway databases

SignaLinkiP21520

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36411, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36411

Protein Ontology

More...
PROi
PR:P21520

Gene expression databases

BgeeiFBgn0003326, Expressed in embryo and 31 other tissues
GenevisibleiP21520, DM

Family and domain databases

CDDicd00087, FReD, 1 hit
InterProiView protein in InterPro
IPR036056, Fibrinogen-like_C
IPR002181, Fibrinogen_a/b/g_C_dom
IPR020837, Fibrinogen_CS
PfamiView protein in Pfam
PF00147, Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186, FBG, 1 hit
SUPFAMiSSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21520
Secondary accession number(s): Q0E998, Q8MQI8, Q9V6G9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 24, 2003
Last modified: December 2, 2020
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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