UniProtKB - P21515 (ACPH_ECOLI)
Protein
Acyl carrier protein phosphodiesterase
Gene
acpH
Organism
Escherichia coli (strain K12)
Status
Functioni
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation1 Publication
Catalytic activityi
- EC:3.1.4.14UniRule annotation1 Publication
GO - Molecular functioni
- [acyl-carrier-protein] phosphodiesterase activity Source: EcoCyc
GO - Biological processi
- fatty acid biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Hydrolase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11095-MONOMER MetaCyc:EG11095-MONOMER |
BRENDAi | 3.1.4.14, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)Short name: ACP phosphodiesteraseUniRule annotation |
Gene namesi | Name:acpHUniRule annotation Synonyms:yajB Ordered Locus Names:b0404, JW0394 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168605 | 1 – 193 | Acyl carrier protein phosphodiesteraseAdd BLAST | 193 |
Proteomic databases
jPOSTi | P21515 |
PaxDbi | P21515 |
PRIDEi | P21515 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261717, 13 interactors |
IntActi | P21515, 2 interactors |
STRINGi | 511145.b0404 |
Family & Domainsi
Sequence similaritiesi
Belongs to the AcpH family.UniRule annotation
Phylogenomic databases
eggNOGi | COG3124, Bacteria |
HOGENOMi | CLU_099370_1_0_6 |
InParanoidi | P21515 |
PhylomeDBi | P21515 |
Family and domain databases
HAMAPi | MF_01950, AcpH, 1 hit |
InterProi | View protein in InterPro IPR007431, ACP_PD IPR023491, ACP_phosphodiesterase_gpbac |
PANTHERi | PTHR38764, PTHR38764, 1 hit |
Pfami | View protein in Pfam PF04336, ACP_PD, 1 hit |
PIRSFi | PIRSF011489, DUF479, 1 hit |
i Sequence
Sequence statusi: Complete.
P21515-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV
60 70 80 90 100
LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
110 120 130 140 150
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
160 170 180 190
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASR KAL
Sequence cautioni
The sequence AAA16113 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37702 Genomic DNA Translation: AAA16113.1 Frameshift. U82664 Genomic DNA Translation: AAB40160.1 U00096 Genomic DNA Translation: AAC73507.1 AP009048 Genomic DNA Translation: BAE76184.1 |
PIRi | D64769 |
RefSeqi | NP_414938.1, NC_000913.3 WP_001009885.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73507; AAC73507; b0404 BAE76184; BAE76184; BAE76184 |
GeneIDi | 57731580 949132 |
KEGGi | ecj:JW0394 eco:b0404 |
PATRICi | fig|511145.12.peg.420 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37702 Genomic DNA Translation: AAA16113.1 Frameshift. U82664 Genomic DNA Translation: AAB40160.1 U00096 Genomic DNA Translation: AAC73507.1 AP009048 Genomic DNA Translation: BAE76184.1 |
PIRi | D64769 |
RefSeqi | NP_414938.1, NC_000913.3 WP_001009885.1, NZ_SSZK01000009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261717, 13 interactors |
IntActi | P21515, 2 interactors |
STRINGi | 511145.b0404 |
Proteomic databases
jPOSTi | P21515 |
PaxDbi | P21515 |
PRIDEi | P21515 |
Genome annotation databases
EnsemblBacteriai | AAC73507; AAC73507; b0404 BAE76184; BAE76184; BAE76184 |
GeneIDi | 57731580 949132 |
KEGGi | ecj:JW0394 eco:b0404 |
PATRICi | fig|511145.12.peg.420 |
Organism-specific databases
EchoBASEi | EB1087 |
Phylogenomic databases
eggNOGi | COG3124, Bacteria |
HOGENOMi | CLU_099370_1_0_6 |
InParanoidi | P21515 |
PhylomeDBi | P21515 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11095-MONOMER MetaCyc:EG11095-MONOMER |
BRENDAi | 3.1.4.14, 2026 |
Miscellaneous databases
PROi | PR:P21515 |
Family and domain databases
HAMAPi | MF_01950, AcpH, 1 hit |
InterProi | View protein in InterPro IPR007431, ACP_PD IPR023491, ACP_phosphodiesterase_gpbac |
PANTHERi | PTHR38764, PTHR38764, 1 hit |
Pfami | View protein in Pfam PF04336, ACP_PD, 1 hit |
PIRSFi | PIRSF011489, DUF479, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACPH_ECOLI | |
Accessioni | P21515Primary (citable) accession number: P21515 Secondary accession number(s): P46123, P77369, Q2MC22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families