UniProtKB - P21515 (ACPH_ECOLI)
Protein
Acyl carrier protein phosphodiesterase
Gene
acpH
Organism
Escherichia coli (strain K12)
Status
Functioni
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation1 Publication
Catalytic activityi
- EC:3.1.4.14UniRule annotation1 Publication
GO - Molecular functioni
- [acyl-carrier-protein] phosphodiesterase activity Source: EcoCyc
GO - Biological processi
- fatty acid biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Hydrolase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11095-MONOMER ECOL316407:JW0394-MONOMER MetaCyc:EG11095-MONOMER |
BRENDAi | 3.1.4.14 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)Short name: ACP phosphodiesteraseUniRule annotation |
Gene namesi | Name:acpHUniRule annotation Synonyms:yajB Ordered Locus Names:b0404, JW0394 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168605 | 1 – 193 | Acyl carrier protein phosphodiesteraseAdd BLAST | 193 |
Proteomic databases
PaxDbi | P21515 |
PRIDEi | P21515 |
Interactioni
Protein-protein interaction databases
BioGridi | 4261717, 13 interactors |
IntActi | P21515, 2 interactors |
STRINGi | 511145.b0404 |
Family & Domainsi
Sequence similaritiesi
Belongs to the AcpH family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108ZYK Bacteria COG3124 LUCA |
HOGENOMi | HOG000275880 |
InParanoidi | P21515 |
KOi | K08682 |
PhylomeDBi | P21515 |
Family and domain databases
HAMAPi | MF_01950 AcpH, 1 hit |
InterProi | View protein in InterPro IPR007431 ACP_PD IPR023491 ACP_phosphodiesterase_gpbac |
PANTHERi | PTHR38764 PTHR38764, 1 hit |
Pfami | View protein in Pfam PF04336 ACP_PD, 1 hit |
PIRSFi | PIRSF011489 DUF479, 1 hit |
i Sequence
Sequence statusi: Complete.
P21515-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV
60 70 80 90 100
LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
110 120 130 140 150
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
160 170 180 190
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASR KAL
Sequence cautioni
The sequence AAA16113 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37702 Genomic DNA Translation: AAA16113.1 Frameshift. U82664 Genomic DNA Translation: AAB40160.1 U00096 Genomic DNA Translation: AAC73507.1 AP009048 Genomic DNA Translation: BAE76184.1 |
PIRi | D64769 |
RefSeqi | NP_414938.1, NC_000913.3 WP_001009885.1, NZ_SSZK01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC73507; AAC73507; b0404 BAE76184; BAE76184; BAE76184 |
GeneIDi | 949132 |
KEGGi | ecj:JW0394 eco:b0404 |
PATRICi | fig|511145.12.peg.420 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37702 Genomic DNA Translation: AAA16113.1 Frameshift. U82664 Genomic DNA Translation: AAB40160.1 U00096 Genomic DNA Translation: AAC73507.1 AP009048 Genomic DNA Translation: BAE76184.1 |
PIRi | D64769 |
RefSeqi | NP_414938.1, NC_000913.3 WP_001009885.1, NZ_SSZK01000009.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 4261717, 13 interactors |
IntActi | P21515, 2 interactors |
STRINGi | 511145.b0404 |
Proteomic databases
PaxDbi | P21515 |
PRIDEi | P21515 |
Genome annotation databases
EnsemblBacteriai | AAC73507; AAC73507; b0404 BAE76184; BAE76184; BAE76184 |
GeneIDi | 949132 |
KEGGi | ecj:JW0394 eco:b0404 |
PATRICi | fig|511145.12.peg.420 |
Organism-specific databases
EchoBASEi | EB1087 |
Phylogenomic databases
eggNOGi | ENOG4108ZYK Bacteria COG3124 LUCA |
HOGENOMi | HOG000275880 |
InParanoidi | P21515 |
KOi | K08682 |
PhylomeDBi | P21515 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11095-MONOMER ECOL316407:JW0394-MONOMER MetaCyc:EG11095-MONOMER |
BRENDAi | 3.1.4.14 2026 |
Miscellaneous databases
PROi | PR:P21515 |
Family and domain databases
HAMAPi | MF_01950 AcpH, 1 hit |
InterProi | View protein in InterPro IPR007431 ACP_PD IPR023491 ACP_phosphodiesterase_gpbac |
PANTHERi | PTHR38764 PTHR38764, 1 hit |
Pfami | View protein in Pfam PF04336 ACP_PD, 1 hit |
PIRSFi | PIRSF011489 DUF479, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACPH_ECOLI | |
Accessioni | P21515Primary (citable) accession number: P21515 Secondary accession number(s): P46123, P77369, Q2MC22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | November 1, 1997 | |
Last modified: | November 13, 2019 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene