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Protein

Zinc finger protein 10

Gene

ZNF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 232C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 10
Alternative name(s):
Zinc finger protein KOX1
Gene namesi
Name:ZNF10
Synonyms:KOX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000256223.5
HGNCiHGNC:12879 ZNF10
MIMi194538 gene
neXtProtiNX_P21506

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7556
OpenTargetsiENSG00000256223
PharmGKBiPA37468

Polymorphism and mutation databases

BioMutaiZNF10
DMDMi55977778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473321 – 573Zinc finger protein 10Add BLAST573

Proteomic databases

MaxQBiP21506
PaxDbiP21506
PeptideAtlasiP21506
PRIDEiP21506
ProteomicsDBi53873

PTM databases

iPTMnetiP21506
PhosphoSitePlusiP21506

Expressioni

Gene expression databases

BgeeiENSG00000256223 Expressed in 185 organ(s), highest expression level in pituitary gland
CleanExiHS_ZNF10
ExpressionAtlasiP21506 baseline and differential
GenevisibleiP21506 HS

Organism-specific databases

HPAiHPA003204

Interactioni

Subunit structurei

Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).1 Publication

Protein-protein interaction databases

BioGridi113388, 7 interactors
IntActiP21506, 4 interactors
STRINGi9606.ENSP00000248211

Structurei

3D structure databases

ProteinModelPortaliP21506
SMRiP21506
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 232C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST27
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150907
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP21506
KOiK09228
OMAiVVHHRTH
OrthoDBiEOG091G02KC
PhylomeDBiP21506
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P21506-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL
60 70 80 90 100
VSLGYQLTKP DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR
110 120 130 140 150
SIFKDKQSCD IKMEGMARND LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV
160 170 180 190 200
AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV LREYFHKRDS HTKSLKHDLV
210 220 230 240 250
LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC PDNDNSLTHG
260 270 280 290 300
SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK
310 320 330 340 350
SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT
360 370 380 390 400
CNQCGKSFVH SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV
410 420 430 440 450
RVRPYECNEC GKSYSQRSHL VVHHRIHTGL KPFECKDCGK CFSRSSHLYS
460 470 480 490 500
HQRTHTGEKP YECHDCGKSF SQSSALIVHQ RIHTGEKPYE CCQCGKAFIR
510 520 530 540 550
KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT GEQFLTCNQC
560 570
GTALVNTSNL IGYQTNHIRE NAY
Length:573
Mass (Da):66,455
Last modified:November 23, 2004 - v3
Checksum:i5C850DBC8FF4A064
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD46F8WD46_HUMAN
Zinc finger protein 10
ZNF10
439Annotation score:
F5GZ75F5GZ75_HUMAN
Zinc finger protein 10
ZNF10
72Annotation score:
F5H311F5H311_HUMAN
Zinc finger protein 10
ZNF10
47Annotation score:
F5H0R3F5H0R3_HUMAN
Zinc finger protein 10
ZNF10
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 282Missing (PubMed:2288909).CuratedAdd BLAST134
Sequence conflicti374E → H in CAA36558 (PubMed:2288909).Curated1
Sequence conflicti514E → A in CAA36558 (PubMed:2288909).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052746227Q → R. Corresponds to variant dbSNP:rs11147259Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52332 mRNA Translation: CAA36558.1
AK314784 mRNA Translation: BAG37318.1
CH471218 Genomic DNA Translation: EAW54791.1
BC024182 mRNA Translation: AAH24182.1
CCDSiCCDS9283.1
PIRiS10397
RefSeqiNP_056209.2, NM_015394.4
UniGeneiHs.573983

Genome annotation databases

EnsembliENST00000248211; ENSP00000248211; ENSG00000256223
ENST00000426665; ENSP00000393814; ENSG00000256223
GeneIDi7556
KEGGihsa:7556
UCSCiuc001ulq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52332 mRNA Translation: CAA36558.1
AK314784 mRNA Translation: BAG37318.1
CH471218 Genomic DNA Translation: EAW54791.1
BC024182 mRNA Translation: AAH24182.1
CCDSiCCDS9283.1
PIRiS10397
RefSeqiNP_056209.2, NM_015394.4
UniGeneiHs.573983

3D structure databases

ProteinModelPortaliP21506
SMRiP21506
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113388, 7 interactors
IntActiP21506, 4 interactors
STRINGi9606.ENSP00000248211

PTM databases

iPTMnetiP21506
PhosphoSitePlusiP21506

Polymorphism and mutation databases

BioMutaiZNF10
DMDMi55977778

Proteomic databases

MaxQBiP21506
PaxDbiP21506
PeptideAtlasiP21506
PRIDEiP21506
ProteomicsDBi53873

Protocols and materials databases

DNASUi7556
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248211; ENSP00000248211; ENSG00000256223
ENST00000426665; ENSP00000393814; ENSG00000256223
GeneIDi7556
KEGGihsa:7556
UCSCiuc001ulq.4 human

Organism-specific databases

CTDi7556
DisGeNETi7556
EuPathDBiHostDB:ENSG00000256223.5
GeneCardsiZNF10
HGNCiHGNC:12879 ZNF10
HPAiHPA003204
MIMi194538 gene
neXtProtiNX_P21506
OpenTargetsiENSG00000256223
PharmGKBiPA37468
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150907
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP21506
KOiK09228
OMAiVVHHRTH
OrthoDBiEOG091G02KC
PhylomeDBiP21506
TreeFamiTF337898

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF10 human
GeneWikiiZNF10
GenomeRNAii7556
PROiPR:P21506
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256223 Expressed in 185 organ(s), highest expression level in pituitary gland
CleanExiHS_ZNF10
ExpressionAtlasiP21506 baseline and differential
GenevisibleiP21506 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF10_HUMAN
AccessioniPrimary (citable) accession number: P21506
Secondary accession number(s): B2RBS1, Q8TC91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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