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Protein

Homing endonuclease I-DmoI

Gene
N/A
Organism
Desulfurococcus mobilis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endonuclease involved in intron homing. Recognizes a recognizes up to 20 bp of DNA in the 23S rRNA gene intron. It has a slow turnover rate and cuts the coding strand with a slight preference over the non-coding strand.

Temperature dependencei

Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211
Active sitei1171

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processIntron homing
LigandMagnesium

Protein family/group databases

REBASEi2542 I-DmoI

Names & Taxonomyi

Protein namesi
Recommended name:
Homing endonuclease I-DmoI (EC:3.1.-.-)
OrganismiDesulfurococcus mobilis
Taxonomic identifieri2275 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001927911 – 194Homing endonuclease I-DmoIAdd BLAST194

Proteomic databases

PRIDEiP21505

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21505
SMRiP21505
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21505

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 147DOD-type homing endonucleasePROSITE-ProRule annotationAdd BLAST134

Family and domain databases

Gene3Di3.10.28.10, 1 hit
InterProiView protein in InterPro
IPR027434 Homing_endonucl
IPR006142 INTEIN
IPR004042 Intein_endonuc
IPR004860 LAGLIDADG_2
PfamiView protein in Pfam
PF14528 LAGLIDADG_3, 2 hits
PRINTSiPR00379 INTEIN
SUPFAMiSSF55608 SSF55608, 2 hits
PROSITEiView protein in PROSITE
PS50819 INTEIN_ENDONUCLEASE, 1 hit

Sequencei

Sequence statusi: Complete.

P21505-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHNNENVSGI SAYLLGLIIG DGGLYKLKYK GNRSEYRVVI TQKSENLIKQ
60 70 80 90 100
HIAPLMQFLI DELNVKSKIQ IVKGDTRYEL RVSSKKLYYY FANMLERIRL
110 120 130 140 150
FNMREQIAFI KGLYVAEGDK TLKRLRIWNK NKALLEIVSR WLNNLGVRNT
160 170 180 190
IHLDDHRHGV YVLNISLRDR IKFVHTILSS HLNPLPPERA GGYT
Length:194
Mass (Da):22,609
Last modified:May 1, 1991 - v1
Checksum:i99ED3354907F35A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03263 Genomic DNA Translation: CAA27018.1
PIRiA31224

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03263 Genomic DNA Translation: CAA27018.1
PIRiA31224

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B24X-ray2.20A1-188[»]
1MOWX-ray2.40A/D/G/J-[»]
2VS7X-ray2.05A/D/G2-188[»]
2VS8X-ray2.10A/F/K2-188[»]
4D6NX-ray2.35A/F/K2-188[»]
4D6OX-ray2.20A/D/G2-188[»]
4UN7X-ray2.70A/D/G2-188[»]
4UN8X-ray2.60A/D/G2-188[»]
4UN9X-ray2.73A/D/G2-188[»]
4UNAX-ray2.30A/D/G2-188[»]
4UNBX-ray2.55A/D/G2-188[»]
4UNCX-ray2.30A/D/G2-188[»]
4UT0X-ray2.40A/F/K2-188[»]
5A0WX-ray2.20A/D/G2-188[»]
5AK9X-ray2.60A/E/J2-188[»]
5AKFX-ray2.45A/E/I2-188[»]
5AKMX-ray2.40A/F/K2-188[»]
5AKNX-ray2.75A/F/K2-188[»]
5O6GX-ray2.75A/D/G2-188[»]
5O6IX-ray2.25A/F/K2-188[»]
ProteinModelPortaliP21505
SMRiP21505
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi2542 I-DmoI

Proteomic databases

PRIDEiP21505

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP21505

Family and domain databases

Gene3Di3.10.28.10, 1 hit
InterProiView protein in InterPro
IPR027434 Homing_endonucl
IPR006142 INTEIN
IPR004042 Intein_endonuc
IPR004860 LAGLIDADG_2
PfamiView protein in Pfam
PF14528 LAGLIDADG_3, 2 hits
PRINTSiPR00379 INTEIN
SUPFAMiSSF55608 SSF55608, 2 hits
PROSITEiView protein in PROSITE
PS50819 INTEIN_ENDONUCLEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDMO1_DESMO
AccessioniPrimary (citable) accession number: P21505
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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