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Entry version 169 (02 Dec 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Ribonuclease R

Gene

rnr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (rRNAs, tRNAs and SsrA/tmRNA). In stationary phase, involved in the post-transcriptional regulation of ompA mRNA stability. Shortens RNA processively to di- and trinucleotides. In vitro, exhibits helicase activity, which is independent of its RNase activity. RNases 2 and R (rnb and this entry) contribute to rRNA degradation during starvation, while RNase R and PNPase (this entry and pnp) are the major contributors to quality control of rRNA during steady state growth (PubMed:21135037). Required for the expression of virulence genes in enteroinvasive strains of E.coli.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.1 Publication EC:3.1.13.1

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by the presence of a monovalent cation (PubMed:11948193). Highly unstable in exponential growth phase. This instability is due to the binding of SsrA/tmRNA and its associated protein SmpB to the C-terminal region of RNase R (PubMed:20688916). In contrast, RNase R becomes stabilized upon entry into stationary phase. The difference in stability between exponential and stationary phase is due to the acetylation of a single lysine residue (PubMed:21981926).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=26900 nmol/min/mg enzyme with Poly(A) as substrate1 Publication
    2. Vmax=4840 nmol/min/mg enzyme with 23S rRNA as substrate1 Publication
    3. Vmax=2750 nmol/min/mg enzyme with 16S rRNA as substrate1 Publication
    4. Vmax=290 nmol/min/mg enzyme with 5S rRNA as substrate1 Publication
    5. Vmax=350 nmol/min/mg enzyme with tRNA as substrate1 Publication

    pH dependencei

    Optimum pH is 7.5-9.5.1 Publication

    Temperature dependencei

    Optimum temperature is 50 degrees Celsius.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
    Biological processStress response, Virulence

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:EG11259-MONOMER
    MetaCyc:EG11259-MONOMER

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ribonuclease R (EC:3.1.13.1)
    Short name:
    RNase R
    Alternative name(s):
    Protein VacB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:rnr
    Synonyms:vacB, yjeC
    Ordered Locus Names:b4179, JW5741
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi272D → N: Loss of RNase activity, but exhibits helicase activity. 1 Publication1
    Mutagenesisi280D → N: Loss of RNase activity, but exhibits helicase activity. 1 Publication1
    Mutagenesisi544K → A: Lack of acetylation. Maintains protein's instability in exponential phase. Becomes unstable in stationary phase. 1 Publication1
    Mutagenesisi544K → R: Lack of acetylation. Stabilizes exponential phase RNase R. 1 Publication1
    Mutagenesisi764E → A: Becomes unstable in stationary phase; when associated with A-766. 1 Publication1
    Mutagenesisi766D → A: Becomes unstable in stationary phase; when associated with A-764. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001664022 – 813Ribonuclease RAdd BLAST812

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei544N6-acetyllysine; by PatZ2 Publications1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Acetylated at Lys-544 by PatZ during exponential growth phase. Acetylation alters RNase R structure and enhances binding of SsrA/tmRNA and SmpB, leading to instability and degradation of RNase R. Not acetylated and stable in stationary phase cells.3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P21499

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P21499

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P21499

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P21499

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Induced seven- to eightfold by cold shock. Induction is mainly a result of the stabilization of the rnr transcripts. Also induced at stationary phase.3 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4261892, 65 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-10733N

    Protein interaction database and analysis system

    More...
    IntActi
    P21499, 61 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4179

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P21499

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini644 – 725S1 motifAdd BLAST82

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0557, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_002333_7_0_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P21499

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P21499

    Family and domain databases

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01895, RNase_R, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011129, CSD
    IPR040476, CSD2
    IPR012340, NA-bd_OB-fold
    IPR013223, RNase_B_OB_dom
    IPR001900, RNase_II/R
    IPR022966, RNase_II/R_CS
    IPR004476, RNase_II/RNase_R
    IPR011805, RNase_R
    IPR013668, RNase_R_HTH_12
    IPR022967, S1_dom
    IPR003029, S1_domain

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17876, CSD2, 1 hit
    PF08461, HTH_12, 1 hit
    PF08206, OB_RNB, 1 hit
    PF00773, RNB, 1 hit
    PF00575, S1, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00357, CSP, 1 hit
    SM00955, RNB, 1 hit
    SM00316, S1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50249, SSF50249, 4 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00358, 3_prime_RNase, 1 hit
    TIGR02063, RNase_R, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01175, RIBONUCLEASE_II, 1 hit
    PS50126, S1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P21499-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSQDPFQERE AEKYANPIPS REFILEHLTK REKPASRDEL AVELHIEGEE
    60 70 80 90 100
    QLEGLRRRLR AMERDGQLVF TRRQCYALPE RLDLVKGTVI GHRDGYGFLR
    110 120 130 140 150
    VEGRKDDLYL SSEQMKTCIH GDQVLAQPLG ADRKGRREAR IVRVLVPKTS
    160 170 180 190 200
    QIVGRYFTEA GVGFVVPDDS RLSFDILIPP DQIMGARMGF VVVVELTQRP
    210 220 230 240 250
    TRRTKAVGKI VEVLGDNMGT GMAVDIALRT HEIPYIWPQA VEQQVAGLKE
    260 270 280 290 300
    EVPEEAKAGR VDLRDLPLVT IDGEDARDFD DAVYCEKKRG GGWRLWVAIA
    310 320 330 340 350
    DVSYYVRPST PLDREARNRG TSVYFPSQVI PMLPEVLSNG LCSLNPQVDR
    360 370 380 390 400
    LCMVCEMTVS SKGRLTGYKF YEAVMSSHAR LTYTKVWHIL QGDQDLREQY
    410 420 430 440 450
    APLVKHLEEL HNLYKVLDKA REERGGISFE SEEAKFIFNA ERRIERIEQT
    460 470 480 490 500
    QRNDAHKLIE ECMILANISA ARFVEKAKEP ALFRIHDKPS TEAITSFRSV
    510 520 530 540 550
    LAELGLELPG GNKPEPRDYA ELLESVADRP DAEMLQTMLL RSMKQAIYDP
    560 570 580 590 600
    ENRGHFGLAL QSYAHFTSPI RRYPDLTLHR AIKYLLAKEQ GHQGNTTETG
    610 620 630 640 650
    GYHYSMEEML QLGQHCSMAE RRADEATRDV ADWLKCDFML DQVGNVFKGV
    660 670 680 690 700
    ISSVTGFGFF VRLDDLFIDG LVHVSSLDND YYRFDQVGQR LMGESSGQTY
    710 720 730 740 750
    RLGDRVEVRV EAVNMDERKI DFSLISSERA PRNVGKTARE KAKKGDAGKK
    760 770 780 790 800
    GGKRRQVGKK VNFEPDSAFR GEKKTKPKAA KKDARKAKKP SAKTQKIAAA
    810
    TKAKRAAKKK VAE
    Length:813
    Mass (Da):92,109
    Last modified:February 1, 1995 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7516DF0A40D35594
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA97075 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U14003 Genomic DNA Translation: AAA97075.1 Different initiation.
    U00096 Genomic DNA Translation: AAC77136.2
    AP009048 Genomic DNA Translation: BAE78180.1
    J04199 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S56404

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418600.4, NC_000913.3
    WP_000076332.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC77136; AAC77136; b4179
    BAE78180; BAE78180; BAE78180

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948692

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW5741
    eco:b4179

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2522

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U14003 Genomic DNA Translation: AAA97075.1 Different initiation.
    U00096 Genomic DNA Translation: AAC77136.2
    AP009048 Genomic DNA Translation: BAE78180.1
    J04199 Genomic DNA No translation available.
    PIRiS56404
    RefSeqiNP_418600.4, NC_000913.3
    WP_000076332.1, NZ_LN832404.1

    3D structure databases

    SMRiP21499
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4261892, 65 interactors
    DIPiDIP-10733N
    IntActiP21499, 61 interactors
    STRINGi511145.b4179

    PTM databases

    iPTMnetiP21499

    Proteomic databases

    jPOSTiP21499
    PaxDbiP21499
    PRIDEiP21499

    Genome annotation databases

    EnsemblBacteriaiAAC77136; AAC77136; b4179
    BAE78180; BAE78180; BAE78180
    GeneIDi948692
    KEGGiecj:JW5741
    eco:b4179
    PATRICifig|1411691.4.peg.2522

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1239

    Phylogenomic databases

    eggNOGiCOG0557, Bacteria
    HOGENOMiCLU_002333_7_0_6
    InParanoidiP21499
    PhylomeDBiP21499

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11259-MONOMER
    MetaCyc:EG11259-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P21499

    Family and domain databases

    HAMAPiMF_01895, RNase_R, 1 hit
    InterProiView protein in InterPro
    IPR011129, CSD
    IPR040476, CSD2
    IPR012340, NA-bd_OB-fold
    IPR013223, RNase_B_OB_dom
    IPR001900, RNase_II/R
    IPR022966, RNase_II/R_CS
    IPR004476, RNase_II/RNase_R
    IPR011805, RNase_R
    IPR013668, RNase_R_HTH_12
    IPR022967, S1_dom
    IPR003029, S1_domain
    PfamiView protein in Pfam
    PF17876, CSD2, 1 hit
    PF08461, HTH_12, 1 hit
    PF08206, OB_RNB, 1 hit
    PF00773, RNB, 1 hit
    PF00575, S1, 1 hit
    SMARTiView protein in SMART
    SM00357, CSP, 1 hit
    SM00955, RNB, 1 hit
    SM00316, S1, 1 hit
    SUPFAMiSSF50249, SSF50249, 4 hits
    TIGRFAMsiTIGR00358, 3_prime_RNase, 1 hit
    TIGR02063, RNase_R, 1 hit
    PROSITEiView protein in PROSITE
    PS01175, RIBONUCLEASE_II, 1 hit
    PS50126, S1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNR_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21499
    Secondary accession number(s): P76800, Q2M6C6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: February 1, 1995
    Last modified: December 2, 2020
    This is version 169 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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