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Entry version 189 (13 Feb 2019)
Sequence version 3 (09 Feb 2010)
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Protein

fMet-Leu-Phe receptor

Gene

FPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).4 Publications4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • G protein-coupled receptor binding Source: UniProtKB
  • N-formyl peptide receptor activity Source: MGI
  • RAGE receptor binding Source: Ensembl
  • scavenger receptor binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21462

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21462

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FPR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171051.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3826 FPR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136537 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 285ExtracellularSequence analysisAdd BLAST19
Transmembranei286 – 305Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini306 – 350CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2357

MalaCards human disease database

More...
MalaCardsi
FPR1

Open Targets

More...
OpenTargetsi
ENSG00000171051

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
447740 Susceptibility to localized juvenile periodontitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28244

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3359

Drug and drug target database

More...
DrugBanki
DB00716 Nedocromil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
222

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FPR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
288558848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694441 – 350fMet-Leu-Phe receptorAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi98 ↔ 176PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei328PhosphoserineSequence analysis1
Modified residuei329PhosphothreonineSequence analysis1
Modified residuei331PhosphothreonineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1
Modified residuei334PhosphothreonineSequence analysis1
Modified residuei336PhosphothreonineSequence analysis1
Modified residuei338PhosphoserineSequence analysis1
Modified residuei339PhosphothreonineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; which is necessary for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21462

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21462

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21462

PeptideAtlas

More...
PeptideAtlasi
P21462

PRoteomics IDEntifications database

More...
PRIDEi
P21462

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53872

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21462

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neutrophils.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171051 Expressed in 175 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21462 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21462 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046550
HPA061744

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108640, 4 interactors

Protein interaction database and analysis system

More...
IntActi
P21462, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302707

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21462

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21462

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II0H Eukaryota
ENOG410YB48 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107927

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21462

KEGG Orthology (KO)

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KOi
K04172

Identification of Orthologs from Complete Genome Data

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OMAi
GHWPFGW

Database of Orthologous Groups

More...
OrthoDBi
646662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21462

TreeFam database of animal gene trees

More...
TreeFami
TF330976

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027345 Formyl_pep_1_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR24225 PTHR24225, 1 hit
PTHR24225:SF15 PTHR24225:SF15, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P21462-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF
110 120 130 140 150
VFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW
160 170 180 190 200
VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV
210 220 230 240 250
RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF
260 270 280 290 300
FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML
310 320 330 340 350
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK
Length:350
Mass (Da):38,446
Last modified:February 9, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06651DF820B1CBD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R315M0R315_HUMAN
fMet-Leu-Phe receptor
FPR1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZT0M0QZT0_HUMAN
fMet-Leu-Phe receptor
FPR1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti238R → P in AAA36362 (PubMed:2161213).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05591511I → T1 PublicationCorresponds to variant dbSNP:rs5030878EnsemblClinVar.1
Natural variantiVAR_003476101V → L2 PublicationsCorresponds to variant dbSNP:rs2070745EnsemblClinVar.1
Natural variantiVAR_055916190R → W. Corresponds to variant dbSNP:rs5030880Ensembl.1
Natural variantiVAR_003477192N → K2 PublicationsCorresponds to variant dbSNP:rs1042229EnsemblClinVar.1
Natural variantiVAR_003478346E → A3 PublicationsCorresponds to variant dbSNP:rs867228EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37128 mRNA Translation: AAA36362.1
M60626 mRNA Translation: AAA35846.1
M60627 mRNA Translation: AAA35847.1
L10820 Genomic DNA Translation: AAA16863.1
AY301273 Genomic DNA Translation: AAP58403.1
BT007429 mRNA Translation: AAP36097.1
AC018755 Genomic DNA Translation: AAF87842.1
BC005315 mRNA Translation: AAH05315.1
S49810 mRNA Translation: AAD14906.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12839.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2014 A42009

NCBI Reference Sequences

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RefSeqi
NP_001180235.1, NM_001193306.1
NP_002020.1, NM_002029.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.753

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304748; ENSP00000302707; ENSG00000171051
ENST00000595042; ENSP00000471493; ENSG00000171051

Database of genes from NCBI RefSeq genomes

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GeneIDi
2357

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2357

UCSC genome browser

More...
UCSCi
uc002pxq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37128 mRNA Translation: AAA36362.1
M60626 mRNA Translation: AAA35846.1
M60627 mRNA Translation: AAA35847.1
L10820 Genomic DNA Translation: AAA16863.1
AY301273 Genomic DNA Translation: AAP58403.1
BT007429 mRNA Translation: AAP36097.1
AC018755 Genomic DNA Translation: AAF87842.1
BC005315 mRNA Translation: AAH05315.1
S49810 mRNA Translation: AAD14906.1
CCDSiCCDS12839.1
PIRiJC2014 A42009
RefSeqiNP_001180235.1, NM_001193306.1
NP_002020.1, NM_002029.3
UniGeneiHs.753

3D structure databases

ProteinModelPortaliP21462
SMRiP21462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108640, 4 interactors
IntActiP21462, 4 interactors
STRINGi9606.ENSP00000302707

Chemistry databases

BindingDBiP21462
ChEMBLiCHEMBL3359
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi222

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP21462
PhosphoSitePlusiP21462

Polymorphism and mutation databases

BioMutaiFPR1
DMDMi288558848

Proteomic databases

EPDiP21462
jPOSTiP21462
PaxDbiP21462
PeptideAtlasiP21462
PRIDEiP21462
ProteomicsDBi53872

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2357
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304748; ENSP00000302707; ENSG00000171051
ENST00000595042; ENSP00000471493; ENSG00000171051
GeneIDi2357
KEGGihsa:2357
UCSCiuc002pxq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2357
DisGeNETi2357
EuPathDBiHostDB:ENSG00000171051.8

GeneCards: human genes, protein and diseases

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GeneCardsi
FPR1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0015389
HIX0174408
HGNCiHGNC:3826 FPR1
HPAiHPA046550
HPA061744
MalaCardsiFPR1
MIMi136537 gene
neXtProtiNX_P21462
OpenTargetsiENSG00000171051
Orphaneti447740 Susceptibility to localized juvenile periodontitis
PharmGKBiPA28244

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00940000153365
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiP21462
KOiK04172
OMAiGHWPFGW
OrthoDBi646662at2759
PhylomeDBiP21462
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP21462
SIGNORiP21462

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Formyl_peptide_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2357

Protein Ontology

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PROi
PR:P21462

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171051 Expressed in 175 organ(s), highest expression level in blood
ExpressionAtlasiP21462 baseline and differential
GenevisibleiP21462 HS

Family and domain databases

InterProiView protein in InterPro
IPR027345 Formyl_pep_1_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF15 PTHR24225:SF15, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFPR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21462
Secondary accession number(s): Q14939
, Q7Z6A4, Q86U52, Q9NS48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 9, 2010
Last modified: February 13, 2019
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
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