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Entry version 200 (07 Oct 2020)
Sequence version 2 (02 Sep 2008)
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Protein

Sphingosine 1-phosphate receptor 1

Gene

S1PR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAngiogenesis, Chemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P21453

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21453

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21453

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.2.1, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 1
Short name:
S1P receptor 1
Short name:
S1P1
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 1
Sphingosine 1-phosphate receptor Edg-1
Short name:
S1P receptor Edg-1
CD_antigen: CD363
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S1PR1
Synonyms:CHEDG1, EDG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170989.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3165, S1PR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601974, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21453

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 46Extracellular1 PublicationAdd BLAST46
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 68Helical; Name=1Add BLAST22
Topological domaini69 – 82Cytoplasmic1 PublicationAdd BLAST14
Transmembranei83 – 104Helical; Name=2Add BLAST22
Topological domaini105 – 116Extracellular1 PublicationAdd BLAST12
Transmembranei117 – 138Helical; Name=3Add BLAST22
Topological domaini139 – 160Cytoplasmic1 PublicationAdd BLAST22
Transmembranei161 – 182Helical; Name=4Add BLAST22
Topological domaini183 – 196Extracellular1 PublicationAdd BLAST14
Transmembranei197 – 224Helical; Name=5Add BLAST28
Topological domaini225 – 257Cytoplasmic1 PublicationAdd BLAST33
Transmembranei258 – 278Helical; Name=6Add BLAST21
Topological domaini279 – 289Extracellular1 PublicationAdd BLAST11
Transmembranei290 – 310Helical; Name=7Add BLAST21
Topological domaini311 – 382Cytoplasmic1 PublicationAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120R → A: Drastically reduced affinity for sphingosine 1-phosphate. 1 Publication1
Mutagenesisi121E → A: Drastically reduced affinity for sphingosine 1-phosphate. 1 Publication1
Mutagenesisi121E → Q: Slight activation of the receptor at maximal ligand concentration. 1 Publication1
Mutagenesisi210F → L: Impairs sphingosine 1-phosphate binding and signaling. 1 Publication1
Mutagenesisi236T → A: Acts as a dominant negative GPCR and inhibits S1P-induced Rac activation, chemotaxis, and angiogenesis. 1 Publication1
Mutagenesisi265F → L: Impairs sphingosine 1-phosphate binding and signaling. 1 Publication1
Mutagenesisi269W → F or L: Impairs sphingosine 1-phosphate binding and signaling. 1 Publication1
Mutagenesisi292R → A or V: Drastically reduced affinity for sphingosine 1-phosphate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1901

Open Targets

More...
OpenTargetsi
ENSG00000170989

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402344

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21453, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4333

Drug and drug target database

More...
DrugBanki
DB09105, Asfotase alfa
DB08868, Fingolimod
DB12612, Ozanimod
DB12371, Siponimod

DrugCentral

More...
DrugCentrali
P21453

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
275

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
S1PR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205371820

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694121 – 382Sphingosine 1-phosphate receptor 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi30N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi184 ↔ 191PROSITE-ProRule annotation1 Publication
Modified residuei236Phosphothreonine; by PKB/AKT11 Publication1
Disulfide bondi282 ↔ 287PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi328S-palmitoyl cysteineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei353PhosphoserineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.2 Publications

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21453

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21453

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P21453

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21453

PeptideAtlas

More...
PeptideAtlasi
P21453

PRoteomics IDEntifications database

More...
PRIDEi
P21453

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53871

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P21453, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21453

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21453

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21453

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170989, Expressed in right lung and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21453, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21453, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170989, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAI1 and GNAI3.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108225, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P21453

Database of interacting proteins

More...
DIPi
DIP-60427N

Protein interaction database and analysis system

More...
IntActi
P21453, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305416

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P21453, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21453

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 121Sphingosine 1-phosphate binding2
Regioni265 – 269Sphingosine 1-phosphate binding5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSFG, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00970000193365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047979_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21453

KEGG Orthology (KO)

More...
KOi
K04288

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFIACWA

Database of Orthologous Groups

More...
OrthoDBi
981486at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21453

TreeFam database of animal gene trees

More...
TreeFami
TF330052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000987, EDG1_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004061, S1P_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR22750:SF16, PTHR22750:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237, GPCRRHODOPSN
PR01523, S1PRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21453-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV
60 70 80 90 100
VFILICCFII LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA
110 120 130 140 150
NLLLSGATTY KLTPAQWFLR EGSMFVALSA SVFSLLAIAI ERYITMLKMK
160 170 180 190 200
LHNGSNNFRL FLLISACWVI SLILGGLPIM GWNCISALSS CSTVLPLYHK
210 220 230 240 250
HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN ISKASRSSEK
260 270 280 290 300
SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA
310 320 330 340 350
VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF
360 370 380
SRSKSDNSSH PQKDEGDNPE TIMSSGNVNS SS
Length:382
Mass (Da):42,811
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CCE8685A5E1BAD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IUD4A0A3B3IUD4_HUMAN
Sphingosine 1-phosphate receptor 1
S1PR1
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250 – 252KSL → NV in AAA52336 (PubMed:2160972).Curated3
Sequence conflicti250 – 252KSL → NV in AAC51905 (PubMed:9409733).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04615815S → L. Corresponds to variant dbSNP:rs4987250Ensembl.1
Natural variantiVAR_046159115A → T. Corresponds to variant dbSNP:rs11542632Ensembl.1
Natural variantiVAR_046160332P → R. Corresponds to variant dbSNP:rs7549921Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M31210 mRNA Translation: AAA52336.1
AF022137 mRNA Translation: AAC51905.1
AF233365 mRNA Translation: AAF43420.1
AK312493 mRNA Translation: BAG35395.1
CR541786 mRNA Translation: CAG46585.1
CR542269 mRNA Translation: CAG47065.1
AL109741 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72927.1
CH471097 Genomic DNA Translation: EAW72928.1
BC018650 mRNA Translation: AAH18650.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS777.1

Protein sequence database of the Protein Information Resource

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PIRi
A35300

NCBI Reference Sequences

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RefSeqi
NP_001307659.1, NM_001320730.1
NP_001391.2, NM_001400.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000305352; ENSP00000305416; ENSG00000170989
ENST00000475289; ENSP00000498038; ENSG00000170989
ENST00000648480; ENSP00000497478; ENSG00000170989
ENST00000649383; ENSP00000497175; ENSG00000170989

Database of genes from NCBI RefSeq genomes

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GeneIDi
1901

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1901

UCSC genome browser

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UCSCi
uc001dud.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31210 mRNA Translation: AAA52336.1
AF022137 mRNA Translation: AAC51905.1
AF233365 mRNA Translation: AAF43420.1
AK312493 mRNA Translation: BAG35395.1
CR541786 mRNA Translation: CAG46585.1
CR542269 mRNA Translation: CAG47065.1
AL109741 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72927.1
CH471097 Genomic DNA Translation: EAW72928.1
BC018650 mRNA Translation: AAH18650.1
CCDSiCCDS777.1
PIRiA35300
RefSeqiNP_001307659.1, NM_001320730.1
NP_001391.2, NM_001400.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V2WX-ray3.35A2-231[»]
A244-326[»]
3V2YX-ray2.80A2-231[»]
A244-326[»]
SMRiP21453
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108225, 30 interactors
CORUMiP21453
DIPiDIP-60427N
IntActiP21453, 23 interactors
STRINGi9606.ENSP00000305416

Chemistry databases

BindingDBiP21453
ChEMBLiCHEMBL4333
DrugBankiDB09105, Asfotase alfa
DB08868, Fingolimod
DB12612, Ozanimod
DB12371, Siponimod
DrugCentraliP21453
GuidetoPHARMACOLOGYi275

Protein family/group databases

TCDBi9.A.14.2.1, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

GlyGeniP21453, 2 sites
iPTMnetiP21453
PhosphoSitePlusiP21453
SwissPalmiP21453

Polymorphism and mutation databases

BioMutaiS1PR1
DMDMi205371820

Proteomic databases

EPDiP21453
jPOSTiP21453
MassIVEiP21453
PaxDbiP21453
PeptideAtlasiP21453
PRIDEiP21453
ProteomicsDBi53871

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4111, 731 antibodies

The DNASU plasmid repository

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DNASUi
1901

Genome annotation databases

EnsembliENST00000305352; ENSP00000305416; ENSG00000170989
ENST00000475289; ENSP00000498038; ENSG00000170989
ENST00000648480; ENSP00000497478; ENSG00000170989
ENST00000649383; ENSP00000497175; ENSG00000170989
GeneIDi1901
KEGGihsa:1901
UCSCiuc001dud.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1901
DisGeNETi1901
EuPathDBiHostDB:ENSG00000170989.8

GeneCards: human genes, protein and diseases

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GeneCardsi
S1PR1
HGNCiHGNC:3165, S1PR1
HPAiENSG00000170989, Tissue enhanced (blood)
MIMi601974, gene
neXtProtiNX_P21453
OpenTargetsiENSG00000170989
PharmGKBiPA162402344

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSFG, Eukaryota
GeneTreeiENSGT00970000193365
HOGENOMiCLU_047979_1_0_1
InParanoidiP21453
KOiK04288
OMAiCFIACWA
OrthoDBi981486at2759
PhylomeDBiP21453
TreeFamiTF330052

Enzyme and pathway databases

PathwayCommonsiP21453
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiP21453
SIGNORiP21453

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1901, 4 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
S1PR1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
S1PR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1901
PharosiP21453, Tclin

Protein Ontology

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PROi
PR:P21453
RNActiP21453, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170989, Expressed in right lung and 200 other tissues
ExpressionAtlasiP21453, baseline and differential
GenevisibleiP21453, HS

Family and domain databases

InterProiView protein in InterPro
IPR000987, EDG1_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004061, S1P_rcpt
PANTHERiPTHR22750:SF16, PTHR22750:SF16, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01523, S1PRECEPTOR
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS1PR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21453
Secondary accession number(s): D3DT66, Q9BYY4, Q9NYN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: September 2, 2008
Last modified: October 7, 2020
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  8. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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