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Protein

Substance-K receptor

Gene

TACR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.1 Publication

GO - Molecular functioni

  • substance K receptor activity Source: GO_Central
  • tachykinin receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
SIGNORiP21452

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:TACR2
Synonyms:NK2R, NKNAR, TAC2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000075073.14
HGNCiHGNC:11527 TACR2
MIMi162321 gene
neXtProtiNX_P21452

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 56Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini57 – 69CytoplasmicSequence analysisAdd BLAST13
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 107ExtracellularSequence analysisAdd BLAST17
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 196ExtracellularSequence analysisAdd BLAST26
Transmembranei197 – 218Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini219 – 251CytoplasmicSequence analysisAdd BLAST33
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 290ExtracellularSequence analysisAdd BLAST18
Transmembranei291 – 310Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini311 – 398CytoplasmicSequence analysisAdd BLAST88

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6865
OpenTargetsiENSG00000075073
PharmGKBiPA36303

Chemistry databases

ChEMBLiCHEMBL2327
GuidetoPHARMACOLOGYi361

Polymorphism and mutation databases

BioMutaiTACR2
DMDMi229462950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698931 – 398Substance-K receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21452
PeptideAtlasiP21452
PRIDEiP21452
ProteomicsDBi53870

PTM databases

iPTMnetiP21452
PhosphoSitePlusiP21452

Expressioni

Gene expression databases

BgeeiENSG00000075073 Expressed in 104 organ(s), highest expression level in esophagus
CleanExiHS_TACR2
ExpressionAtlasiP21452 baseline and differential
GenevisibleiP21452 HS

Organism-specific databases

HPAiHPA076573

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655413,EBI-6655449

Protein-protein interaction databases

BioGridi112728, 3 interactors
ELMiP21452
IntActiP21452, 1 interactor
STRINGi9606.ENSP00000362403

Chemistry databases

BindingDBiP21452

Structurei

3D structure databases

ProteinModelPortaliP21452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219 Eukaryota
ENOG410XSC5 LUCA
GeneTreeiENSGT00930000150872
HOGENOMiHOG000013018
HOVERGENiHBG103412
InParanoidiP21452
KOiK04223
OMAiALHNDWY
OrthoDBiEOG091G0WYG
PhylomeDBiP21452
TreeFamiTF315303

Family and domain databases

CDDicd16004 7tmA_SKR_NK2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001681 Neurokn_rcpt
IPR000913 NK2_rcpt
PANTHERiPTHR43919:SF4 PTHR43919:SF4, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01025 NEUROKININ2R
PR00244 NEUROKININR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P21452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG
60 70 80 90 100
NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV
210 220 230 240 250
VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK
260 270 280 290 300
TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR
360 370 380 390
CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI
Length:398
Mass (Da):44,442
Last modified:May 5, 2009 - v3
Checksum:i20AD618EF74263A7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ80A0A087WZ80_HUMAN
Substance-K receptor
TACR2
362Annotation score:
A6NEW7A6NEW7_HUMAN
Substance-K receptor
TACR2
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38T → P in AAC31760 (PubMed:2173708).Curated1
Sequence conflicti38T → P in AAA60347 (PubMed:2173708).Curated1
Sequence conflicti40Y → V (PubMed:1659297).Curated1
Sequence conflicti264L → P in AAH96842 (PubMed:15489334).Curated1
Sequence conflicti293F → FF (PubMed:1848773).Curated1
Sequence conflicti340P → R in AAH96842 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01615923I → T2 PublicationsCorresponds to variant dbSNP:rs5030920Ensembl.1
Natural variantiVAR_06122147A → T. Corresponds to variant dbSNP:rs57500981Ensembl.1
Natural variantiVAR_061222245M → K7 PublicationsCorresponds to variant dbSNP:rs55953810Ensembl.1
Natural variantiVAR_061223363T → A. Corresponds to variant dbSNP:rs57900755Ensembl.1
Natural variantiVAR_014680375R → H1 PublicationCorresponds to variant dbSNP:rs2229170Ensembl.1
Natural variantiVAR_061224395H → R. Corresponds to variant dbSNP:rs58692969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA Translation: AAC31760.1
M60284
, M57415, M60281, M60282, M60283 Genomic DNA Translation: AAA60347.1
M75105
, M75101, M75102, M75103, M75104 Genomic DNA Translation: AAB05897.1
AB065731 Genomic DNA Translation: BAC05952.1
AK291996 mRNA Translation: BAF84685.1
AY322545 mRNA Translation: AAP84358.1
CH471083 Genomic DNA Translation: EAW54324.1
BC096842 mRNA Translation: AAH96842.1
CCDSiCCDS7293.1
PIRiJQ1059
RefSeqiNP_001048.2, NM_001057.2
UniGeneiHs.88372

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073
GeneIDi6865
KEGGihsa:6865
UCSCiuc001jpn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA Translation: AAC31760.1
M60284
, M57415, M60281, M60282, M60283 Genomic DNA Translation: AAA60347.1
M75105
, M75101, M75102, M75103, M75104 Genomic DNA Translation: AAB05897.1
AB065731 Genomic DNA Translation: BAC05952.1
AK291996 mRNA Translation: BAF84685.1
AY322545 mRNA Translation: AAP84358.1
CH471083 Genomic DNA Translation: EAW54324.1
BC096842 mRNA Translation: AAH96842.1
CCDSiCCDS7293.1
PIRiJQ1059
RefSeqiNP_001048.2, NM_001057.2
UniGeneiHs.88372

3D structure databases

ProteinModelPortaliP21452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112728, 3 interactors
ELMiP21452
IntActiP21452, 1 interactor
STRINGi9606.ENSP00000362403

Chemistry databases

BindingDBiP21452
ChEMBLiCHEMBL2327
GuidetoPHARMACOLOGYi361

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21452
PhosphoSitePlusiP21452

Polymorphism and mutation databases

BioMutaiTACR2
DMDMi229462950

Proteomic databases

PaxDbiP21452
PeptideAtlasiP21452
PRIDEiP21452
ProteomicsDBi53870

Protocols and materials databases

DNASUi6865
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073
GeneIDi6865
KEGGihsa:6865
UCSCiuc001jpn.3 human

Organism-specific databases

CTDi6865
DisGeNETi6865
EuPathDBiHostDB:ENSG00000075073.14
GeneCardsiTACR2
H-InvDBiHIX0008887
HGNCiHGNC:11527 TACR2
HPAiHPA076573
MIMi162321 gene
neXtProtiNX_P21452
OpenTargetsiENSG00000075073
PharmGKBiPA36303
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4219 Eukaryota
ENOG410XSC5 LUCA
GeneTreeiENSGT00930000150872
HOGENOMiHOG000013018
HOVERGENiHBG103412
InParanoidiP21452
KOiK04223
OMAiALHNDWY
OrthoDBiEOG091G0WYG
PhylomeDBiP21452
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
SIGNORiP21452

Miscellaneous databases

GeneWikiiTachykinin_receptor_2
GenomeRNAii6865
PROiPR:P21452
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075073 Expressed in 104 organ(s), highest expression level in esophagus
CleanExiHS_TACR2
ExpressionAtlasiP21452 baseline and differential
GenevisibleiP21452 HS

Family and domain databases

CDDicd16004 7tmA_SKR_NK2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001681 Neurokn_rcpt
IPR000913 NK2_rcpt
PANTHERiPTHR43919:SF4 PTHR43919:SF4, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01025 NEUROKININ2R
PR00244 NEUROKININR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNK2R_HUMAN
AccessioniPrimary (citable) accession number: P21452
Secondary accession number(s): A8K7I1
, Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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