UniProtKB - P21451 (EDNRB_RAT)
Protein
Endothelin receptor type B
Gene
Ednrb
Organism
Rattus norvegicus (Rat)
Status
Functioni
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- endothelin receptor activity Source: RGD
- G protein-coupled receptor activity Source: RGD
- peptide hormone binding Source: RGD
- signaling receptor activity Source: RGD
- type 1 angiotensin receptor binding Source: RGD
GO - Biological processi
- aging Source: RGD
- calcium-mediated signaling Source: UniProtKB
- cellular response to lipopolysaccharide Source: RGD
- cGMP-mediated signaling Source: RGD
- developmental pigmentation Source: RGD
- endothelin receptor signaling pathway Source: RGD
- enteric nervous system development Source: RGD
- enteric smooth muscle cell differentiation Source: RGD
- epithelial fluid transport Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- macrophage chemotaxis Source: RGD
- melanocyte differentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cellular protein metabolic process Source: RGD
- negative regulation of neuron maturation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neural crest cell migration Source: RGD
- peripheral nervous system development Source: RGD
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGD
- pigmentation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of penile erection Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of renal sodium excretion Source: RGD
- positive regulation of urine volume Source: RGD
- posterior midgut development Source: RGD
- regulation of blood pressure Source: RGD
- regulation of epithelial cell proliferation Source: RGD
- regulation of fever generation Source: RGD
- regulation of pH Source: RGD
- regulation of sensory perception of pain Source: RGD
- response to endothelin Source: RGD
- response to lipopolysaccharide Source: RGD
- response to organic cyclic compound Source: RGD
- response to pain Source: RGD
- sensory perception of pain Source: RGD
- vasoconstriction Source: RGD
- vasodilation Source: RGD
- vein smooth muscle contraction Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin receptor type BCuratedShort name: ET-B Short name: ET-BR Alternative name(s): Endothelin receptor non-selective type |
Gene namesi | Name:EdnrbImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2536, Ednrb |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein
Note: internalized after activation by endothelins.By similarity
Nucleus
- nuclear membrane Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: RGD
- membrane raft Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 101 | ExtracellularSequence analysisAdd BLAST | 75 | |
Transmembranei | 102 – 126 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 127 – 137 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 138 – 163 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 164 – 175 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 176 – 197 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 198 – 218 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 219 – 243 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 244 – 271 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 272 – 296 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 297 – 324 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 325 – 350 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 351 – 362 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 363 – 389 | Helical; Name=7Sequence analysisAdd BLAST | 27 | |
Topological domaini | 390 – 442 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4631 |
DrugCentrali | P21451 |
GuidetoPHARMACOLOGYi | 220 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012733 | 27 – 442 | Endothelin receptor type BAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 174 ↔ 255 | PROSITE-ProRule annotation | ||
Modified residuei | 305 | PhosphoserineBy similarity | 1 | |
Lipidationi | 402 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 403 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 405 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 419 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 440 | PhosphoserineBy similarity | 1 | |
Modified residuei | 441 | PhosphoserineBy similarity | 1 | |
Modified residuei | 442 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P21451 |
PRIDEi | P21451 |
PTM databases
GlyGeni | P21451, 2 sites |
PhosphoSitePlusi | P21451 |
Expressioni
Tissue specificityi
Widely distributed in cell types of a variety of tissues.
Gene expression databases
Bgeei | ENSRNOG00000010997, Expressed in lung and 21 other tissues |
Genevisiblei | P21451, RN |
Interactioni
GO - Molecular functioni
- type 1 angiotensin receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014747 |
Chemistry databases
BindingDBi | P21451 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P21451 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
PhylomeDBi | P21451 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P21451-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINAY KLLAGDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DVITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPQRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 – 69 | SSAP → FRT in CAA40916 (PubMed:2175397).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57764 mRNA Translation: CAA40916.1 S65355 mRNA Translation: AAB28172.1 |
PIRi | S13425 |
RefSeqi | NP_059029.1, NM_017333.1 XP_006252493.1, XM_006252431.3 XP_017455275.1, XM_017599786.1 |
Genome annotation databases
Ensembli | ENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997 |
GeneIDi | 50672 |
KEGGi | rno:50672 |
UCSCi | RGD:2536, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57764 mRNA Translation: CAA40916.1 S65355 mRNA Translation: AAB28172.1 |
PIRi | S13425 |
RefSeqi | NP_059029.1, NM_017333.1 XP_006252493.1, XM_006252431.3 XP_017455275.1, XM_017599786.1 |
3D structure databases
SMRi | P21451 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014747 |
Chemistry databases
BindingDBi | P21451 |
ChEMBLi | CHEMBL4631 |
DrugCentrali | P21451 |
GuidetoPHARMACOLOGYi | 220 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P21451, 2 sites |
PhosphoSitePlusi | P21451 |
Proteomic databases
PaxDbi | P21451 |
PRIDEi | P21451 |
Genome annotation databases
Ensembli | ENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997 |
GeneIDi | 50672 |
KEGGi | rno:50672 |
UCSCi | RGD:2536, rat |
Organism-specific databases
CTDi | 1910 |
RGDi | 2536, Ednrb |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P21451 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
PhylomeDBi | P21451 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:P21451 |
Gene expression databases
Bgeei | ENSRNOG00000010997, Expressed in lung and 21 other tissues |
Genevisiblei | P21451, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EDNRB_RAT | |
Accessioni | P21451Primary (citable) accession number: P21451 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families