Endothelin receptor type B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• endothelin receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor."
    Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K., Masaki T.
    Nature 348:732-735(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• G protein-coupled receptor activity Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors."
    Perry M.G., Molero M.M., Giulumian A.D., Katakam P.V., Pollock J.S., Pollock D.M., Fuchs L.C.
    Am J Physiol Heart Circ Physiol 281:H2680-6(2001) [PubMed] [Europe PMC] [Abstract]
• peptide hormone binding Source: RGD
• signaling receptor activity Source: RGDTraceable author statementⁱ
  • "ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors."
    Perry M.G., Molero M.M., Giulumian A.D., Katakam P.V., Pollock J.S., Pollock D.M., Fuchs L.C.
    Am J Physiol Heart Circ Physiol 281:H2680-6(2001) [PubMed] [Europe PMC] [Abstract]
• type 1 angiotensin receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats."
    Zeng C., Wang Z., Asico L.D., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Kidney Int 68:623-631(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system."
    Ishihata A., Katano Y.
    Ann N Y Acad Sci 1067:173-181(2006) [PubMed] [Europe PMC] [Abstract]
• aldosterone metabolic process Source: RGD
• calcium ion transmembrane transport Source: RGD
• calcium-mediated signaling Source: UniProtKB
• canonical Wnt signaling pathway Source: RGD
• cellular response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase."
    Dschietzig T., Alexiou K., Richter C., Bobzin M., Baumann G., Stangl K., Brunner F.
    Shock 30:189-196(2008) [PubMed] [Europe PMC] [Abstract]
• cGMP-mediated signaling Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Multiple signaling pathways involved in the effect of endothelin type B receptor in rat median eminence."
    Mathison Y., del Garrido M.R., Israel A.
    Acta Biol Hung 58:139-150(2007) [PubMed] [Europe PMC] [Abstract]
• developmental pigmentation Source: RGD
• endothelin receptor signaling pathway Source: RGD
• enteric nervous system development Source: RGD
• enteric smooth muscle cell differentiation Source: RGD
• epithelial fluid transport Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor."
    Comellas A.P., Briva A., Dada L.A., Butti M.L., Trejo H.E., Yshii C., Azzam Z.S., Litvan J., Chen J., Lecuona E., Pesce L.M., Yanagisawa M., Sznajder J.I.
    Am J Respir Crit Care Med 179:113-122(2009) [PubMed] [Europe PMC] [Abstract]
• establishment of endothelial barrier Source: RGD
• gene expression Source: RGD
• glomerular visceral epithelial cell differentiation Source: RGD
• G protein-coupled receptor signaling pathway Source: RGD
• heparin metabolic process Source: RGD
• I-kappaB kinase/NF-kappaB signaling Source: RGD
• macrophage chemotaxis Source: RGD
• melanocyte differentiation Source: RGDInferred from direct assayⁱ
  • "ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors."
    Perry M.G., Molero M.M., Giulumian A.D., Katakam P.V., Pollock J.S., Pollock D.M., Fuchs L.C.
    Am J Physiol Heart Circ Physiol 281:H2680-6(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Deficiency in endothelin receptor B reduces proliferation of neuronal progenitors and increases apoptosis in postnatal rat cerebellum."
    Vidovic M., Chen M.M., Lu Q.Y., Kalloniatis K.F., Martin B.M., Tan A.H., Lynch C., Croaker G.D., Cass D.T., Song Z.M.
    Cell Mol Neurobiol 28:1129-1138(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cellular protein metabolic process Source: RGD
• negative regulation of neuron maturation Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• neural crest cell migration Source: RGD
• peripheral nervous system development Source: RGD
• pharynx development Source: RGD
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus."
    Jaureguiberry M.S., di Nunzio A.S., Dattilo M.A., Bianciotti L.G., Vatta M.S.
    Peptides 25:1133-1138(2004) [PubMed] [Europe PMC] [Abstract]
• pigmentation Source: RGDInferred from mutant phenotypeⁱ
  • "Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color."
    Gariepy C.E., Cass D.T., Yanagisawa M.
    Proc Natl Acad Sci U S A 93:867-872(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Deficiency in endothelin receptor B reduces proliferation of neuronal progenitors and increases apoptosis in postnatal rat cerebellum."
    Vidovic M., Chen M.M., Lu Q.Y., Kalloniatis K.F., Martin B.M., Tan A.H., Lynch C., Croaker G.D., Cass D.T., Song Z.M.
    Cell Mol Neurobiol 28:1129-1138(2008) [PubMed] [Europe PMC] [Abstract]
  • "Calcitonin gene-related peptide selectively relaxes contractile responses to endothelin-1 in rat mesenteric resistance arteries."
    Meens M.J., Fazzi G.E., van Zandvoort M.A., De Mey J.G.
    J Pharmacol Exp Ther 331:87-95(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from direct assayⁱ
  • Ref.2

    "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor."
    Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K., Masaki T.
    Nature 348:732-735(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of penile erection Source: RGDInferred from mutant phenotypeⁱ
  • "Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium."
    Carneiro F.S., Carneiro Z.N., Giachini F.R., Lima V.V., Nogueira E., Rainey W.E., Tostes R.C., Webb R.C.
    J Am Soc Hypertens 2:439-447(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from direct assayⁱ
  • "Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats."
    Zeng C., Wang Z., Asico L.D., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Kidney Int 68:623-631(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • "Renal medullary ETB receptors produce diuresis and natriuresis via NOS1."
    Nakano D., Pollock J.S., Pollock D.M.
    Am J Physiol Renal Physiol 294:F1205-11(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of urine volume Source: RGDInferred from mutant phenotypeⁱ
  • "Renal medullary ETB receptors produce diuresis and natriuresis via NOS1."
    Nakano D., Pollock J.S., Pollock D.M.
    Am J Physiol Renal Physiol 294:F1205-11(2008) [PubMed] [Europe PMC] [Abstract]
• posterior midgut development Source: RGD
• protein transmembrane transport Source: RGD
• regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet."
    Kopp U.C., Cicha M.Z., Smith L.A.
    Am J Physiol Regul Integr Comp Physiol 291:R1545-56(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease."
    Hocher B., Kalk P., Slowinski T., Godes M., Mach A., Herzfeld S., Wiesner D., Arck P.C., Neumayer H.H., Nafz B.
    J Am Soc Nephrol 14:367-376(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of fever generation Source: RGDInferred from mutant phenotypeⁱ
  • "Central endothelin ET(B) receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat."
    Fabricio A.S., Rae G.A., Zampronio A.R., D'Orleans-Juste P., Souza G.E.
    Am J Physiol Regul Integr Comp Physiol 290:R164-71(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of heart rate Source: RGD
• regulation of pH Source: RGD
• regulation of sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury."
    Khodorova A., Navarro B., Jouaville L.S., Murphy J.E., Rice F.L., Mazurkiewicz J.E., Long-Woodward D., Stoffel M., Strichartz G.R., Yukhananov R., Davar G.
    Nat Med 9:1055-1061(2003) [PubMed] [Europe PMC] [Abstract]
• renal albumin absorption Source: RGD
• renal sodium excretion Source: RGD
• renal sodium ion absorption Source: RGD
• renin secretion into blood stream Source: RGD
• response to endothelin Source: RGDInferred from mutant phenotypeⁱ
  • "Salt-sensitive hypertension in endothelin-B receptor-deficient rats."
    Gariepy C.E., Ohuchi T., Williams S.C., Richardson J.A., Yanagisawa M.
    J Clin Invest 105:925-933(2000) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from mutant phenotypeⁱ
  • "LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET(B)) receptors in cultured endothelium-intact rat coronary arteries."
    Ghorbani B., Holmstrup P., Edvinsson L., Kristiansen K.A., Sheykhzade M.
    Vascul Pharmacol 53:250-257(2010) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation."
    Dingemann J., Doi T., Ruttenstock E., Puri P.
    Pediatr Surg Int 26:65-69(2010) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: RGD
• response to pain Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury."
    Khodorova A., Navarro B., Jouaville L.S., Murphy J.E., Rice F.L., Mazurkiewicz J.E., Long-Woodward D., Stoffel M., Strichartz G.R., Yukhananov R., Davar G.
    Nat Med 9:1055-1061(2003) [PubMed] [Europe PMC] [Abstract]
• response to sodium phosphate Source: RGD
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors."
    Chichorro J.G., Fiuza C.R., Bressan E., Claudino R.F., Leite D.F., Rae G.A.
    Brain Res 1345:73-83(2010) [PubMed] [Europe PMC] [Abstract]
• sodium ion homeostasis Source: RGD
• vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors."
    Just A., Olson A.J., Arendshorst W.J.
    Am J Physiol Renal Physiol 286:F660-8(2004) [PubMed] [Europe PMC] [Abstract]
• vasodilation Source: RGDInferred from mutant phenotypeⁱ
  • "Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors."
    Just A., Olson A.J., Arendshorst W.J.
    Am J Physiol Renal Physiol 286:F660-8(2004) [PubMed] [Europe PMC] [Abstract]
• vein smooth muscle contraction Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• type 1 angiotensin receptor binding Source: RGDInferred from physical interactionⁱ
  • "Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats."
    Zeng C., Wang Z., Asico L.D., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Kidney Int 68:623-631(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP 
        60         70         80         90        100
TKTSWTRGSN SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF 
       110        120        130        140        150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 
       160        170        180        190        200
IIIDIPINAY KLLAGDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY 
       210        220        230        240        250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DVITSDYKGK 
       260        270        280        290        300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM 
       310        320        330        340        350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY 
       360        370        380        390        400
DQSNPQRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 
       410        420        430        440 
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families