UniProtKB - P21447 (MDR1A_MOUSE)

BLAST

>sp|P21447|MDR1A_MOUSE Multidrug resistance protein 1A OS=Mus musculus OX=10090 GN=Abcb1a PE=1 SV=3
MELEEDLKGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIH
GVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAG
VLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINE
GIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKEL
HAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFL
LIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYE
VFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVA
LVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTI
AENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA
LVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGG
VIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIR
RRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGL
QPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEIL
TKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLG
TGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENF
RTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLV
TQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQ
GLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE
RFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEE
IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS
ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQK
GIYFSMVSVQAGAKRS

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History
Entry version 167 (07 Nov 2018)
Sequence version 3 (16 Jun 2009)
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Protein

Multidrug resistance protein 1A

Gene

Abcb1a

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.1 Publication

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Catalytic activityⁱ

ATP + H₂O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	423 – 430	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1066 – 1073	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled
Source: MGI
Inferred from direct assayⁱ
- 11741934
ATP binding Source: UniProtKB-KW
ceramide-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
phosphatidylcholine-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
phosphatidylethanolamine-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
xenobiotic transmembrane transporting ATPase activity
Source: Reactome
Inferred from experimentⁱ
- 17709369

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate export Source: MGI
ceramide translocation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
daunorubicin transport Source: MGI
drug export Source: MGI
drug transmembrane transport Source: MGI
drug transport
Source: MGI
Inferred from direct assayⁱ
- 11741934
drug transport across blood-brain barrier Source: MGI
establishment of blood-brain barrier Source: MGI
establishment of blood-retinal barrier Source: MGI
G2/M transition of mitotic cell cycle Source: MGI
hormone transport Source: MGI
intestinal absorption Source: MGI
maintenance of permeability of blood-brain barrier Source: MGI
negative regulation of cell death Source: MGI
phospholipid translocation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
positive regulation of anion channel activity Source: MGI
positive regulation of establishment of Sertoli cell barrier Source: MGI
positive regulation of response to drug Source: MGI
protein localization to bicellular tight junction Source: MGI
regulation of chloride transport Source: MGI
regulation of intestinal absorption Source: MGI
regulation of response to osmotic stress Source: MGI
stem cell proliferation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-382556 ABC-family proteins mediated transport

Reactomeⁱ

R-MMU-382556 ABC-family proteins mediated transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance protein 1A (EC:7.6.2.2) Alternative name(s): ATP-binding cassette sub-family B member 1A MDR1A Multidrug resistance protein 3 P-glycoprotein 3
Gene namesⁱ	Name:Abcb1a Synonyms:Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:97570 Abcb1a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 43	CytoplasmicBy similarityAdd BLAST	43
Transmembraneⁱ	44 – 66	HelicalAdd BLAST	23
Topological domainⁱ	67 – 112	ExtracellularBy similarityAdd BLAST	46
Transmembraneⁱ	113 – 133	HelicalAdd BLAST	21
Topological domainⁱ	134 – 182	CytoplasmicBy similarityAdd BLAST	49
Transmembraneⁱ	183 – 204	HelicalAdd BLAST	22
Topological domainⁱ	205 – 211	ExtracellularBy similarity	7
Transmembraneⁱ	212 – 232	HelicalAdd BLAST	21
Topological domainⁱ	233 – 290	CytoplasmicBy similarityAdd BLAST	58
Transmembraneⁱ	291 – 312	HelicalAdd BLAST	22
Topological domainⁱ	313 – 326	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	327 – 348	HelicalAdd BLAST	22
Topological domainⁱ	349 – 707	CytoplasmicBy similarityAdd BLAST	359
Transmembraneⁱ	708 – 728	HelicalAdd BLAST	21
Topological domainⁱ	729 – 752	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	753 – 773	HelicalAdd BLAST	21
Topological domainⁱ	774 – 828	CytoplasmicBy similarityAdd BLAST	55
Transmembraneⁱ	829 – 849	HelicalAdd BLAST	21
Topological domainⁱ	850	ExtracellularBy similarity	1
Transmembraneⁱ	851 – 870	HelicalAdd BLAST	20
Topological domainⁱ	871 – 930	CytoplasmicBy similarityAdd BLAST	60
Transmembraneⁱ	931 – 953	HelicalAdd BLAST	23
Topological domainⁱ	954 – 969	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	970 – 991	HelicalAdd BLAST	22
Topological domainⁱ	992 – 1276	CytoplasmicBy similarityAdd BLAST	285

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2573

ChEMBLⁱ

CHEMBL2573

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093336	1 – 1276	Multidrug resistance protein 1AAdd BLAST		1276

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	83	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	87	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	90	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	656	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P21447
PaxDbⁱ	P21447
PeptideAtlas More...PeptideAtlasⁱ	P21447
PRIDEⁱ	P21447

PTM databases

iPTMnetⁱ	P21447
PhosphoSitePlusⁱ	P21447

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040584 Expressed in 215 organ(s), highest expression level in brain blood vessel
Genevisibleⁱ	P21447 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PSMB5.By similarity

Protein-protein interaction databases

IntActⁱ	P21447, 1 interactor
Molecular INTeraction database More...MINTⁱ	P21447
STRINGⁱ	10090.ENSMUSP00000041204

Chemistry databases

BindingDBⁱ

P21447

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 38	Combined sources	4
Turnⁱ	39 – 41	Combined sources	3
Helixⁱ	44 – 82	Combined sources	39
Helixⁱ	84 – 87	Combined sources	4
Helixⁱ	96 – 153	Combined sources	58
Helixⁱ	156 – 161	Combined sources	6
Helixⁱ	164 – 170	Combined sources	7
Turnⁱ	171 – 173	Combined sources	3
Helixⁱ	174 – 180	Combined sources	7
Turnⁱ	181 – 183	Combined sources	3
Helixⁱ	184 – 206	Combined sources	23
Helixⁱ	208 – 232	Combined sources	25
Helixⁱ	234 – 255	Combined sources	22
Helixⁱ	257 – 263	Combined sources	7
Helixⁱ	268 – 275	Combined sources	8
Helixⁱ	279 – 318	Combined sources	40
Helixⁱ	324 – 366	Combined sources	43
Beta strandⁱ	388 – 395	Combined sources	8
Beta strandⁱ	398 – 400	Combined sources	3
Beta strandⁱ	401 – 403	Combined sources	3
Beta strandⁱ	405 – 413	Combined sources	9
Beta strandⁱ	418 – 427	Combined sources	10
Helixⁱ	430 – 436	Combined sources	7
Beta strandⁱ	443 – 449	Combined sources	7
Helixⁱ	454 – 456	Combined sources	3
Helixⁱ	459 – 464	Combined sources	6
Beta strandⁱ	465 – 469	Combined sources	5
Beta strandⁱ	477 – 479	Combined sources	3
Helixⁱ	480 – 485	Combined sources	6
Helixⁱ	493 – 502	Combined sources	10
Helixⁱ	506 – 510	Combined sources	5
Turnⁱ	513 – 516	Combined sources	4
Beta strandⁱ	521 – 524	Combined sources	4
Helixⁱ	529 – 543	Combined sources	15
Beta strandⁱ	546 – 552	Combined sources	7
Beta strandⁱ	555 – 557	Combined sources	3
Helixⁱ	559 – 573	Combined sources	15
Beta strandⁱ	576 – 581	Combined sources	6
Helixⁱ	585 – 588	Combined sources	4
Beta strandⁱ	592 – 598	Combined sources	7
Beta strandⁱ	601 – 606	Combined sources	6
Helixⁱ	608 – 614	Combined sources	7
Helixⁱ	617 – 625	Combined sources	9
Helixⁱ	693 – 698	Combined sources	6
Helixⁱ	699 – 703	Combined sources	5
Helixⁱ	704 – 737	Combined sources	34
Turnⁱ	741 – 743	Combined sources	3
Helixⁱ	744 – 794	Combined sources	51
Helixⁱ	797 – 800	Combined sources	4
Beta strandⁱ	802 – 805	Combined sources	4
Helixⁱ	807 – 815	Combined sources	9
Turnⁱ	816 – 819	Combined sources	4
Helixⁱ	820 – 824	Combined sources	5
Helixⁱ	826 – 849	Combined sources	24
Helixⁱ	851 – 885	Combined sources	35
Helixⁱ	887 – 898	Combined sources	12
Helixⁱ	900 – 906	Combined sources	7
Helixⁱ	909 – 961	Combined sources	53
Beta strandⁱ	962 – 964	Combined sources	3
Helixⁱ	967 – 988	Combined sources	22
Helixⁱ	994 – 1009	Combined sources	16
Beta strandⁱ	1031 – 1038	Combined sources	8
Beta strandⁱ	1049 – 1056	Combined sources	8
Beta strandⁱ	1061 – 1067	Combined sources	7
Helixⁱ	1072 – 1079	Combined sources	8
Beta strandⁱ	1086 – 1092	Combined sources	7
Helixⁱ	1097 – 1099	Combined sources	3
Helixⁱ	1102 – 1107	Combined sources	6
Beta strandⁱ	1109 – 1112	Combined sources	4
Beta strandⁱ	1120 – 1122	Combined sources	3
Helixⁱ	1123 – 1128	Combined sources	6
Helixⁱ	1138 – 1147	Combined sources	10
Helixⁱ	1151 – 1155	Combined sources	5
Beta strandⁱ	1157 – 1159	Combined sources	3
Turnⁱ	1160 – 1162	Combined sources	3
Beta strandⁱ	1164 – 1170	Combined sources	7
Helixⁱ	1174 – 1188	Combined sources	15
Beta strandⁱ	1191 – 1197	Combined sources	7
Helixⁱ	1204 – 1217	Combined sources	14
Turnⁱ	1218 – 1220	Combined sources	3
Beta strandⁱ	1221 – 1226	Combined sources	6
Helixⁱ	1230 – 1233	Combined sources	4
Beta strandⁱ	1237 – 1243	Combined sources	7
Beta strandⁱ	1246 – 1251	Combined sources	6
Helixⁱ	1253 – 1259	Combined sources	7
Helixⁱ	1262 – 1269	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P21447
SMRⁱ	P21447
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P21447

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	50 – 353	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	304
Domainⁱ	388 – 624	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	237
Domainⁱ	707 – 996	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	290
Domainⁱ	1031 – 1269	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	239

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062896
HOVERGENⁱ	HBG080809
InParanoidⁱ	P21447
KEGG Orthology (KO) More...KOⁱ	K05658
OMAⁱ	QAVLFAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HVA
PhylomeDBⁱ	P21447
TreeFamⁱ	TF105193

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P21447-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM 
        60         70         80         90        100
LVGTLAAIIH GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF 
       110        120        130        140        150
AKLEEEMTTY AYYYTGIGAG VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA 
       160        170        180        190        200
IMNQEIGWFD VHDVGELNTR LTDDVSKINE GIGDKIGMFF QAMATFFGGF 
       210        220        230        240        250
IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL HAYAKAGAVA 
       260        270        280        290        300
EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL 
       310        320        330        340        350
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA 
       360        370        380        390        400
FANARGAAYE VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR 
       410        420        430        440        450
KEVQILKGLN LKVKSGQTVA LVGNSGCGKS TTVQLMQRLY DPLDGMVSID 
       460        470        480        490        500
GQDIRTINVR YLREIIGVVS QEPVLFATTI AENIRYGRED VTMDEIEKAV 
       510        520        530        540        550
KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA LVRNPKILLL 
       560        570        580        590        600
DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG 
       610        620        630        640        650
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS 
       660        670        680        690        700
SKDSGSSLIR RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN 
       710        720        730        740        750
STEWPYFVVG IFCAIINGGL QPAFSVIFSK VVGVFTNGGP PETQRQNSNL 
       760        770        780        790        800
FSLLFLILGI ISFITFFLQG FTFGKAGEIL TKRLRYMVFK SMLRQDVSWF 
       810        820        830        840        850
DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG TGIIISLIYG 
       860        870        880        890        900
WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF 
       910        920        930        940        950
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA 
       960        970        980        990       1000
ACFRFGAYLV TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS 
      1010       1020       1030       1040       1050
ASHIIRIIEK TPEIDSYSTQ GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ 
      1060       1070       1080       1090       1100
GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE RFYDPMAGSV FLDGKEIKQL 
      1110       1120       1130       1140       1150
NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE IVRAAKEANI 
      1160       1170       1180       1190       1200
HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS 
      1210       1220       1230       1240       1250
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH 
      1260       1270 
GTHQQLLAQK GIYFSMVSVQ AGAKRS

Length:1,276

Mass (Da):140,647

Last modified:June 16, 2009 - v3

Checksum:ⁱ542E101DF18DDC52

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	526 – 527	QL → HV in AAA39514 (PubMed:1972547).Curated	2
Sequence conflictⁱ	526 – 527	QL → HV in AAA03243 (PubMed:2473069).Curated	2
Sequence conflictⁱ	939	S → F in AAA39517 (PubMed:1969610).Curated	1
Sequence conflictⁱ	1036	V → F in AAA39517 (PubMed:1969610).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30697 mRNA Translation: AAA39517.1 M33581 mRNA Translation: AAA39514.1 M33580 Genomic DNA Translation: AAA39518.1 AY864315 mRNA Translation: AAW56448.1 CH466600 Genomic DNA Translation: EDL14677.1 M24417 mRNA Translation: AAA03243.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19084.1
PIRⁱ	A34175 DVMS1A A34786
NCBI Reference Sequences More...RefSeqⁱ	NP_035206.2, NM_011076.2 XP_006503618.1, XM_006503555.3 XP_006503619.1, XM_006503556.3
UniGeneⁱ	Mm.207354

Genome annotation databases

Ensemblⁱ	ENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584
GeneIDⁱ	18671
KEGGⁱ	mmu:18671
UCSC genome browser More...UCSCⁱ	uc008wkl.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21447	p-glycoprotein (Fragment)		MOUSE		52	UniRef100_P21447
Uncharacterized protein (Fragment)		MOUSE		19
UPI0001986805		MOUSE		1284

Protein	Similar proteins		Species	Score	Length	Source
P21447	Multidrug resistance protein 1	)	CRIGR		1276	UniRef90_P21447
p-glycoprotein (Fragment)		MOUSE		52
Multidrug resistance protein 1a		RAT		1272
p-glycoprotein		Cricetulus sp.		1169
UPI000A322484		MESAU		1280
+22

Protein	Similar proteins		Species	Score	Length	Source
P21447	Phosphatidylcholine translocator ABCB4		HUMAN		1286	UniRef50_P21439
Phosphatidylcholine translocator ABCB4		CRIGR		1281
Phosphatidylcholine translocator ABCB4		RAT		1278
Phosphatidylcholine translocator ABCB4		MOUSE		1276
ATP binding cassette subfamily B member 4		SAIBB		1324
+649

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30697 mRNA Translation: AAA39517.1 M33581 mRNA Translation: AAA39514.1 M33580 Genomic DNA Translation: AAA39518.1 AY864315 mRNA Translation: AAW56448.1 CH466600 Genomic DNA Translation: EDL14677.1 M24417 mRNA Translation: AAA03243.1
CCDSⁱ	CCDS19084.1
PIRⁱ	A34175 DVMS1A A34786
RefSeqⁱ	NP_035206.2, NM_011076.2 XP_006503618.1, XM_006503555.3 XP_006503619.1, XM_006503556.3
UniGeneⁱ	Mm.207354

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3G5U	X-ray	3.80	A/B	1-1276	[»]
	3G60	X-ray	4.40	A/B	1-1276	[»]
	3G61	X-ray	4.35	A/B	1-1276	[»]
	4KSB	X-ray	3.80	A	1-1276	[»]
	4KSC	X-ray	4.00	A	1-1276	[»]
	4KSD	X-ray	4.10	A	1-1276	[»]
	4LSG	X-ray	3.80	A/B	1-1276	[»]
	4M1M	X-ray	3.80	A/B	1-1276	[»]
	4M2S	X-ray	4.40	A/B	1-1276	[»]
	4M2T	X-ray	4.35	A/B	1-1276	[»]
	4Q9H	X-ray	3.40	A	1-1276	[»]
	4Q9I	X-ray	3.78	A	1-1276	[»]
	4Q9J	X-ray	3.60	A	1-1276	[»]
	4Q9K	X-ray	3.80	A	1-1276	[»]
	4Q9L	X-ray	3.80	A	1-1276	[»]
	4XWK	X-ray	3.50	A	1-1276	[»]
	5KO2	X-ray	3.30	A/B	1-1276	[»]
	5KOY	X-ray	3.85	A/B	1-1276	[»]
	5KPD	X-ray	3.35	A/B	1-1276	[»]
	5KPI	X-ray	4.01	A/B	1-1276	[»]
	5KPJ	X-ray	3.50	A	1-1276	[»]
	6GDI	electron microscopy	7.90	A	1-1276	[»]
ProteinModelPortalⁱ	P21447
SMRⁱ	P21447
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P21447, 1 interactor
MINTⁱ	P21447
STRINGⁱ	10090.ENSMUSP00000041204

Chemistry databases

BindingDBⁱ	P21447
ChEMBLⁱ	CHEMBL2573

PTM databases

iPTMnetⁱ	P21447
PhosphoSitePlusⁱ	P21447

Proteomic databases

MaxQBⁱ	P21447
PaxDbⁱ	P21447
PeptideAtlasⁱ	P21447
PRIDEⁱ	P21447

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584
GeneIDⁱ	18671
KEGGⁱ	mmu:18671
UCSCⁱ	uc008wkl.1 mouse

Organism-specific databases

CTDⁱ	18671
MGIⁱ	MGI:97570 Abcb1a

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
GeneTreeⁱ	ENSGT00530000062896
HOVERGENⁱ	HBG080809
InParanoidⁱ	P21447
KOⁱ	K05658
OMAⁱ	QAVLFAK
OrthoDBⁱ	EOG091G0HVA
PhylomeDBⁱ	P21447
TreeFamⁱ	TF105193

Enzyme and pathway databases

Reactomeⁱ	R-MMU-382556 ABC-family proteins mediated transport

Reactomeⁱ

R-MMU-382556 ABC-family proteins mediated transport

Miscellaneous databases

EvolutionaryTraceⁱ	P21447
Protein Ontology More...PROⁱ	PR:P21447
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040584 Expressed in 215 organ(s), highest expression level in brain blood vessel
Genevisibleⁱ	P21447 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 1 hit
Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MDR1A_MOUSE
Accessionⁱ	P21447Primary (citable) accession number: P21447 Secondary accession number(s): Q5I1Y5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	June 16, 2009
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P21447 (MDR1A_MOUSE)

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Multidrug resistance protein 1A

Abcb1a

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Proteomic databases

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Gene expression databases

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Protein-protein interaction databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ