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UniProtKB - P21447 (MDR1A_MOUSE)
Protein
ATP-dependent translocase ABCB1
Gene
Abcb1a
Organism
Mus musculus (Mouse)
Status
Functioni
Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203).
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity).
By similarity1 PublicationMiscellaneous
In mouse the MDR gene family includes three or more related but distinct cellular genes.
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H+ + phosphate1 Publication
- a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H+ + phosphate1 Publication
- a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(in) + ATP + H2O = a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(out) + ADP + H+ + phosphate1 Publication
- ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).By similarity EC:7.6.2.2
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication EC:7.6.2.1
Activity regulationi
Translocase activity is inhibited by verapamil and is sensitive to energy depletion.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 423 – 430 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1066 – 1073 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: MGI
- ATPase-coupled transmembrane transporter activity Source: Reactome
- ATP binding Source: MGI
- ATP hydrolysis activity Source: MGI
- carboxylic acid transmembrane transporter activity Source: MGI
- ceramide floppase activity Source: BHF-UCL
- efflux transmembrane transporter activity Source: ARUK-UCL
- floppase activity Source: UniProtKB
- phosphatidylcholine floppase activity Source: BHF-UCL
- phosphatidylethanolamine flippase activity Source: BHF-UCL
- transmembrane transporter activity Source: ARUK-UCL
- ubiquitin protein ligase binding Source: MGI
- xenobiotic transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- brain development Source: Ensembl
- carbohydrate export Source: MGI
- carboxylic acid transmembrane transport Source: MGI
- cellular hyperosmotic salinity response Source: Ensembl
- cellular response to alkaloid Source: Ensembl
- cellular response to antibiotic Source: Ensembl
- cellular response to borneol Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to estradiol stimulus Source: Ensembl
- cellular response to external biotic stimulus Source: Ensembl
- cellular response to L-glutamate Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to mycotoxin Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- ceramide translocation Source: BHF-UCL
- circadian rhythm Source: Ensembl
- daunorubicin transport Source: MGI
- establishment of blood-brain barrier Source: MGI
- establishment of blood-retinal barrier Source: MGI
- export across plasma membrane Source: ARUK-UCL
- G2/M transition of mitotic cell cycle Source: MGI
- hormone transport Source: MGI
- intestinal absorption Source: MGI
- lactation Source: Ensembl
- maintenance of blood-brain barrier Source: MGI
- negative regulation of cell death Source: MGI
- phospholipid translocation Source: BHF-UCL
- placenta development Source: Ensembl
- positive regulation of anion channel activity Source: MGI
- positive regulation of establishment of Sertoli cell barrier Source: MGI
- positive regulation of response to drug Source: MGI
- protein localization to bicellular tight junction Source: MGI
- regulation of chloride transport Source: MGI
- regulation of intestinal absorption Source: MGI
- regulation of response to osmotic stress Source: MGI
- response to antineoplastic agent Source: Ensembl
- response to cadmium ion Source: Ensembl
- response to codeine Source: Ensembl
- response to cyclosporin A Source: Ensembl
- response to glucagon Source: Ensembl
- response to glycoside Source: Ensembl
- response to hypoxia Source: Ensembl
- response to morphine Source: Ensembl
- response to quercetin Source: Ensembl
- response to thyroxine Source: Ensembl
- response to vitamin A Source: Ensembl
- response to vitamin D Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- stem cell proliferation Source: MGI
- terpenoid transport Source: ARUK-UCL
- transepithelial transport Source: MGI
- transmembrane transport Source: MGI
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: MGI
- xenobiotic transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 7.6.2.2, 3474 |
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Chemistry databases
SwissLipidsi | SLP:000000383 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97570, Abcb1a |
VEuPathDBi | HostDB:ENSMUSG00000040584 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Multi-pass membrane protein PROSITE-ProRule annotation
- Apical cell membrane 1 Publication
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- brush border membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- apical part of cell Source: MGI
- cell surface Source: MGI
- integral component of membrane Source: GO_Central
- intercellular canaliculus Source: MGI
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 43 | CytoplasmicBy similarityAdd BLAST | 43 | |
Transmembranei | 44 – 66 | HelicalAdd BLAST | 23 | |
Topological domaini | 67 – 112 | ExtracellularBy similarityAdd BLAST | 46 | |
Transmembranei | 113 – 133 | HelicalAdd BLAST | 21 | |
Topological domaini | 134 – 182 | CytoplasmicBy similarityAdd BLAST | 49 | |
Transmembranei | 183 – 204 | HelicalAdd BLAST | 22 | |
Topological domaini | 205 – 211 | ExtracellularBy similarity | 7 | |
Transmembranei | 212 – 232 | HelicalAdd BLAST | 21 | |
Topological domaini | 233 – 290 | CytoplasmicBy similarityAdd BLAST | 58 | |
Transmembranei | 291 – 312 | HelicalAdd BLAST | 22 | |
Topological domaini | 313 – 326 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 327 – 348 | HelicalAdd BLAST | 22 | |
Topological domaini | 349 – 707 | CytoplasmicBy similarityAdd BLAST | 359 | |
Transmembranei | 708 – 728 | HelicalAdd BLAST | 21 | |
Topological domaini | 729 – 752 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 753 – 773 | HelicalAdd BLAST | 21 | |
Topological domaini | 774 – 828 | CytoplasmicBy similarityAdd BLAST | 55 | |
Transmembranei | 829 – 849 | HelicalAdd BLAST | 21 | |
Topological domaini | 850 | ExtracellularBy similarity | 1 | |
Transmembranei | 851 – 870 | HelicalAdd BLAST | 20 | |
Topological domaini | 871 – 930 | CytoplasmicBy similarityAdd BLAST | 60 | |
Transmembranei | 931 – 953 | HelicalAdd BLAST | 23 | |
Topological domaini | 954 – 969 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 970 – 991 | HelicalAdd BLAST | 22 | |
Topological domaini | 992 – 1276 | CytoplasmicBy similarityAdd BLAST | 285 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2573 |
DrugCentrali | P21447 |
GuidetoPHARMACOLOGYi | 768 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093336 | 1 – 1276 | ATP-dependent translocase ABCB1Add BLAST | 1276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 87 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 656 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P21447 |
jPOSTi | P21447 |
MaxQBi | P21447 |
PaxDbi | P21447 |
PeptideAtlasi | P21447 |
PRIDEi | P21447 |
ProteomicsDBi | 295845 |
PTM databases
GlyGeni | P21447, 3 sites |
iPTMneti | P21447 |
PhosphoSitePlusi | P21447 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040584, Expressed in brain blood vessel and 247 other tissues |
Genevisiblei | P21447, MM |
Interactioni
Subunit structurei
Interacts with PSMB5.
By similarityGO - Molecular functioni
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202140, 1 interactor |
STRINGi | 10090.ENSMUSP00000041204 |
Chemistry databases
BindingDBi | P21447 |
Miscellaneous databases
RNActi | P21447, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P21447 |
SMRi | P21447 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21447 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 353 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 304 | |
Domaini | 388 – 624 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 707 – 996 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 290 | |
Domaini | 1031 – 1269 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 646 – 681 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 666 – 681 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000155287 |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P21447 |
OMAi | FSTEFFC |
OrthoDBi | 186078at2759 |
PhylomeDBi | P21447 |
TreeFami | TF105193 |
Family and domain databases
DisProti | DP02756 |
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR030258, MDR1 IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF251, PTHR24221:SF251, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P21447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM
60 70 80 90 100
LVGTLAAIIH GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF
110 120 130 140 150
AKLEEEMTTY AYYYTGIGAG VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA
160 170 180 190 200
IMNQEIGWFD VHDVGELNTR LTDDVSKINE GIGDKIGMFF QAMATFFGGF
210 220 230 240 250
IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL HAYAKAGAVA
260 270 280 290 300
EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL
310 320 330 340 350
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA
360 370 380 390 400
FANARGAAYE VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR
410 420 430 440 450
KEVQILKGLN LKVKSGQTVA LVGNSGCGKS TTVQLMQRLY DPLDGMVSID
460 470 480 490 500
GQDIRTINVR YLREIIGVVS QEPVLFATTI AENIRYGRED VTMDEIEKAV
510 520 530 540 550
KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA LVRNPKILLL
560 570 580 590 600
DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG
610 620 630 640 650
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS
660 670 680 690 700
SKDSGSSLIR RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN
710 720 730 740 750
STEWPYFVVG IFCAIINGGL QPAFSVIFSK VVGVFTNGGP PETQRQNSNL
760 770 780 790 800
FSLLFLILGI ISFITFFLQG FTFGKAGEIL TKRLRYMVFK SMLRQDVSWF
810 820 830 840 850
DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG TGIIISLIYG
860 870 880 890 900
WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF
910 920 930 940 950
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA
960 970 980 990 1000
ACFRFGAYLV TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS
1010 1020 1030 1040 1050
ASHIIRIIEK TPEIDSYSTQ GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ
1060 1070 1080 1090 1100
GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE RFYDPMAGSV FLDGKEIKQL
1110 1120 1130 1140 1150
NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE IVRAAKEANI
1160 1170 1180 1190 1200
HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS
1210 1220 1230 1240 1250
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH
1260 1270
GTHQQLLAQK GIYFSMVSVQ AGAKRS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 526 – 527 | QL → HV in AAA39514 (PubMed:1972547).Curated | 2 | |
Sequence conflicti | 526 – 527 | QL → HV in AAA03243 (PubMed:2473069).Curated | 2 | |
Sequence conflicti | 939 | S → F in AAA39517 (PubMed:1969610).Curated | 1 | |
Sequence conflicti | 1036 | V → F in AAA39517 (PubMed:1969610).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30697 mRNA Translation: AAA39517.1 M33581 mRNA Translation: AAA39514.1 M33580 Genomic DNA Translation: AAA39518.1 AY864315 mRNA Translation: AAW56448.1 CH466600 Genomic DNA Translation: EDL14677.1 M24417 mRNA Translation: AAA03243.1 |
CCDSi | CCDS19084.1 |
PIRi | A34175, DVMS1A A34786 |
RefSeqi | NP_035206.2, NM_011076.2 XP_006503618.1, XM_006503555.3 XP_006503619.1, XM_006503556.3 |
Genome annotation databases
Ensembli | ENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584 |
GeneIDi | 18671 |
KEGGi | mmu:18671 |
UCSCi | uc008wkl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30697 mRNA Translation: AAA39517.1 M33581 mRNA Translation: AAA39514.1 M33580 Genomic DNA Translation: AAA39518.1 AY864315 mRNA Translation: AAW56448.1 CH466600 Genomic DNA Translation: EDL14677.1 M24417 mRNA Translation: AAA03243.1 |
CCDSi | CCDS19084.1 |
PIRi | A34175, DVMS1A A34786 |
RefSeqi | NP_035206.2, NM_011076.2 XP_006503618.1, XM_006503555.3 XP_006503619.1, XM_006503556.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3G5U | X-ray | 3.80 | A/B | 1-1276 | [»] | |
3G60 | X-ray | 4.40 | A/B | 1-1276 | [»] | |
3G61 | X-ray | 4.35 | A/B | 1-1276 | [»] | |
4KSB | X-ray | 3.80 | A | 1-1276 | [»] | |
4KSC | X-ray | 4.00 | A | 1-1276 | [»] | |
4KSD | X-ray | 4.10 | A | 1-1276 | [»] | |
4LSG | X-ray | 3.80 | A/B | 1-1276 | [»] | |
4M1M | X-ray | 3.80 | A/B | 1-1276 | [»] | |
4M2S | X-ray | 4.40 | A/B | 1-1276 | [»] | |
4M2T | X-ray | 4.35 | A/B | 1-1276 | [»] | |
4Q9H | X-ray | 3.40 | A | 1-1276 | [»] | |
4Q9I | X-ray | 3.78 | A | 1-1276 | [»] | |
4Q9J | X-ray | 3.60 | A | 1-1276 | [»] | |
4Q9K | X-ray | 3.80 | A | 1-1276 | [»] | |
4Q9L | X-ray | 3.80 | A | 1-1276 | [»] | |
4XWK | X-ray | 3.50 | A | 1-1276 | [»] | |
5KO2 | X-ray | 3.30 | A/B | 1-1276 | [»] | |
5KOY | X-ray | 3.85 | A/B | 1-1276 | [»] | |
5KPD | X-ray | 3.35 | A/B | 1-1276 | [»] | |
5KPI | X-ray | 4.01 | A/B | 1-1276 | [»] | |
5KPJ | X-ray | 3.50 | A | 1-1276 | [»] | |
6GDI | electron microscopy | 7.90 | A | 1-1276 | [»] | |
6Q81 | electron microscopy | 7.90 | A | 1-1276 | [»] | |
6UJN | X-ray | 3.98 | A | 1-1276 | [»] | |
6UJP | X-ray | 3.98 | A | 1-1276 | [»] | |
6UJR | X-ray | 4.10 | A | 1-1276 | [»] | |
6UJS | X-ray | 4.17 | A | 1-1276 | [»] | |
6UJT | X-ray | 4.17 | A | 1-1276 | [»] | |
6UJW | X-ray | 4.15 | A | 1-1276 | [»] | |
7OTG | electron microscopy | 5.40 | A | 1-1276 | [»] | |
7OTI | electron microscopy | 4.20 | A | 1-1276 | [»] | |
AlphaFoldDBi | P21447 | |||||
SMRi | P21447 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202140, 1 interactor |
STRINGi | 10090.ENSMUSP00000041204 |
Chemistry databases
BindingDBi | P21447 |
ChEMBLi | CHEMBL2573 |
DrugCentrali | P21447 |
GuidetoPHARMACOLOGYi | 768 |
SwissLipidsi | SLP:000000383 |
PTM databases
GlyGeni | P21447, 3 sites |
iPTMneti | P21447 |
PhosphoSitePlusi | P21447 |
Proteomic databases
EPDi | P21447 |
jPOSTi | P21447 |
MaxQBi | P21447 |
PaxDbi | P21447 |
PeptideAtlasi | P21447 |
PRIDEi | P21447 |
ProteomicsDBi | 295845 |
Protocols and materials databases
ABCDi | P21447, 2 sequenced antibodies |
DNASUi | 18671 |
Genome annotation databases
Ensembli | ENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584 |
GeneIDi | 18671 |
KEGGi | mmu:18671 |
UCSCi | uc008wkl.1, mouse |
Organism-specific databases
CTDi | 18671 |
MGIi | MGI:97570, Abcb1a |
VEuPathDBi | HostDB:ENSMUSG00000040584 |
Phylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000155287 |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P21447 |
OMAi | FSTEFFC |
OrthoDBi | 186078at2759 |
PhylomeDBi | P21447 |
TreeFami | TF105193 |
Enzyme and pathway databases
BRENDAi | 7.6.2.2, 3474 |
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Miscellaneous databases
BioGRID-ORCSi | 18671, 4 hits in 72 CRISPR screens |
EvolutionaryTracei | P21447 |
PROi | PR:P21447 |
RNActi | P21447, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040584, Expressed in brain blood vessel and 247 other tissues |
Genevisiblei | P21447, MM |
Family and domain databases
DisProti | DP02756 |
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR030258, MDR1 IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF251, PTHR24221:SF251, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MDR1A_MOUSE | |
Accessioni | P21447Primary (citable) accession number: P21447 Secondary accession number(s): Q5I1Y5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | June 16, 2009 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families