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Protein

Integrase

Gene

int

Organism
Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei315O-(3'-phospho-DNA)-tyrosine intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Integrase (EC:2.7.7.-By similarity, EC:3.1.-.-By similarity)
Gene namesi
Name:int
OrganismiHaemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1)
Taxonomic identifieri1289570 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePeduovirinaeHp1virus
Virus hostiHaemophilus [TaxID: 724]
Proteomesi
  • UP000001713 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975101 – 337IntegraseAdd BLAST337

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21442
SMRiP21442
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21442

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

OrthoDBiVOG090000VY

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF00589 Phage_integrase, 2 hits
SUPFAMiSSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P21442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRKDTKNG KWLAEVYVNG NASRKWFLTK GDALRFYNQA KEQTTSAVDS
60 70 80 90 100
VQVLESSDLP ALSFYVQEWF DLHGKTLSDG KARLAKLKNL CSNLGDPPAN
110 120 130 140 150
EFNAKIFADY RKRRLDGEFS VNKNNPPKEA TVNREHAYLR AVFNELKSLR
160 170 180 190 200
KWTTENPLDG VRLFKERETE LAFLYERDIY RLLAECDNSR NPDLGLIVRI
210 220 230 240 250
CLATGARWSE AETLTQSQVM PYKITFTNTK SKKNRTVPIS KELFDMLPKK
260 270 280 290 300
RGRLFNDAYE SFENAVLRAE IELPKGQLTH VLRHTFASHF MMNGGNILVL
310 320 330
KEILGHSTIE MTMRYAHFAP SHLESAVKFN PLSNPAQ
Length:337
Mass (Da):38,598
Last modified:May 1, 1991 - v1
Checksum:iD66C28425899D1A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24159 Genomic DNA Translation: AAB09182.1
PIRiA33857 RSBPHP
RefSeqiNP_043466.1, NC_001697.1

Genome annotation databases

GeneIDi1261146
KEGGivg:1261146

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24159 Genomic DNA Translation: AAB09182.1
PIRiA33857 RSBPHP
RefSeqiNP_043466.1, NC_001697.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AIHX-ray2.50A/B/C/D168-337[»]
ProteinModelPortaliP21442
SMRiP21442
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261146
KEGGivg:1261146

Phylogenomic databases

OrthoDBiVOG090000VY

Miscellaneous databases

EvolutionaryTraceiP21442

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF00589 Phage_integrase, 2 hits
SUPFAMiSSF56349 SSF56349, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVINT_BPHC1
AccessioniPrimary (citable) accession number: P21442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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