Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P21401 (GP_RVFVZ)

Entry version 100 (25 May 2022)
Sequence version 1 (01 May 1991)
Previous versions | rss
Add a publicationFeedback
Protein

Envelopment polyprotein

Gene

GP

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the virion that interacts with glycoprotein C (PubMed:18715915).

It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (PubMed:29367607).

The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:18715915, PubMed:29367607).

They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (PubMed:21767814).

Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (PubMed:21445316).

4 Publications

Structural component of the virion that interacts with glycoprotein N (PubMed:18715915).

Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:29367607).

The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:18715915, PubMed:29367607).

They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (PubMed:21767814).

3 Publications

Plays a role in the inhibition of virus-induced apoptosis. Plays a role for virus dissemination in vertebrates.

2 Publications

Plays a role for virus dissemination in mosquitoes. May act as a structural virion protein in insects.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1194Important for glycoprotein C and glycoprotein N subcellular locationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Modulation of host cell apoptosis by virus, Viral attachment to host cell, Viral attachment to host entry receptor, Viral penetration into host cytoplasm, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
NSm-Gn protein1 Publication
Alternative name(s):
p78
Glycoprotein N1 Publication
Short name:
Gn
Alternative name(s):
Glycoprotein G1
Glycoprotein C1 Publication
Short name:
Gc
Alternative name(s):
Glycoprotein G2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11589 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Ellioviricetes › Bunyavirales › Phenuiviridae › Phlebovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000202138 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000002477 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 130Cytoplasmic1 PublicationAdd BLAST114
Topological domaini154 – 582LumenalSequence analysisAdd BLAST429
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 673CytoplasmicBy similarityAdd BLAST70
Topological domaini691 – 1159LumenalSequence analysisAdd BLAST469
Transmembranei1160 – 1180HelicalSequence analysisAdd BLAST21
Topological domaini1181 – 1197CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Host mitochondrion, Host mitochondrion outer membrane, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024701017 – 1197Envelopment polyproteinAdd BLAST1181
ChainiPRO_000043491417 – 690NSm-Gn proteinAdd BLAST674
ChainiPRO_0000036851154 – 690Glycoprotein NSequence analysisAdd BLAST537
ChainiPRO_0000036852691 – 1197Glycoprotein CSequence analysisAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi179 ↔ 188By similarity
Disulfide bondi229 ↔ 239By similarity
Disulfide bondi250 ↔ 281By similarity
Disulfide bondi271 ↔ 284By similarity
Disulfide bondi304 ↔ 456By similarity
Disulfide bondi322 ↔ 332By similarity
Disulfide bondi374 ↔ 434By similarity
Disulfide bondi402 ↔ 413By similarity
Disulfide bondi420 ↔ 425By similarity
Disulfide bondi479 ↔ 482By similarity
Disulfide bondi486 ↔ 556By similarity
Disulfide bondi506 ↔ 511By similarity
Disulfide bondi691 ↔ 7311 Publication
Disulfide bondi704 ↔ 7131 Publication
Disulfide bondi756 ↔ 8521 Publication
Disulfide bondi771 ↔ 9651 Publication
Disulfide bondi777 ↔ 8251 Publication
Disulfide bondi783 ↔ 8321 Publication
Disulfide bondi788 ↔ 8141 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi794N-linked (GlcNAc...) asparagine; by hostBy similarity1
Disulfide bondi818 ↔ 8231 Publication
Disulfide bondi934 ↔ 9471 Publication
Disulfide bondi1029 ↔ 11011 Publication
Glycosylationi1035N-linked (GlcNAc...) asparagine; by hostBy similarity1
Disulfide bondi1039 ↔ 10421 Publication
Disulfide bondi1049 ↔ 10831 Publication
Glycosylationi1077N-linked (GlcNAc...) asparagine; by hostSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including NSm protein, Glycoprotein C, and Glycoprotein N.1 Publication
Glycosylated (PubMed:2728348). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (PubMed:21767814).2 Publications
Glycosylated (PubMed:2728348). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (PubMed:21767814).2 Publications
Palmitoylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei153 – 154Cleavage; by host signal peptidase1 Publication2
Sitei690 – 691Cleavage; by host signal peptidase1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with glycoprotein C (By similarity). Homotrimer (postfusion) (By similarity).

Interacts with nucleocapsid protein N and with the polymerase L in order to package them into virus particles (PubMed:21445316).

Interacts with host E3 ubiquitin-protein ligase UBR4; this interaction is important for viral RNA production (PubMed:35032865).

By similarity2 Publications

Heterodimer with glycoprotein C.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P21401

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 153Internal signal sequence for glycoprotein N1 PublicationAdd BLAST23
Regioni608 – 650Golgi retention signalBy similarityAdd BLAST43
Regioni646 – 650Important for correct targeting of the glycoproteins to the Golgi complex but not for heterodimerizationBy similarity5
Regioni675 – 690Internal signal sequence for glycoprotein CBy similarityAdd BLAST16
Regioni777 – 783Fusion loopBy similarity7
Regioni819 – 830Fusion loop1 PublicationAdd BLAST12

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a Golgi retention signal on its C-terminus (By similarity). The cytoplasmic tail specifically interacts with the ribonucleoproteins and is critical for genome packaging (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phlebovirus envelope glycoprotein family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Database of protein disorder

More...DisProti		DP02493

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016404, M_polyprot_prcur_phlebovir
IPR043603, Phlebo_G2_C
IPR010826, Phlebovirus_G1
IPR009878, Phlebovirus_G2_fusion
IPR009879, Phlebovirus_NSM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19019, Phlebo_G2_C, 1 hit
PF07243, Phlebovirus_G1, 1 hit
PF07245, Phlebovirus_G2, 1 hit
PF07246, Phlebovirus_NSM, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003961, M_poly_PhleboV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform Envelopment polyprotein (identifier: P21401-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYVLLTILTS VLVCEAIIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE 
        60         70         80         90        100
EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI 
       110        120        130        140        150
SLIKGPPHKK RVGIVRCERR RDAKQIGRKT MAGIAMTVLP ALAVFALAPV 
       160        170        180        190        200
VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF 
       210        220        230        240        250
PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LLSAHGNPCM KEKLVMKTHC 
       260        270        280        290        300
PNDYQSAHHL NNDGKMASVK CPPKYELTED CNFCRQMTGA SLKKGSYPLQ 
       310        320        330        340        350
DLFCQSSEDD GSKLKTKMKG VCEVGVQALK KCDGQLSTAH EVVPFAVFKN 
       360        370        380        390        400
SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS 
       410        420        430        440        450
QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV 
       460        470        480        490        500
WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI 
       510        520        530        540        550
SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS 
       560        570        580        590        600
KIVAHCPPQD PCLVHDCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 
       610        620        630        640        650
AILYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA DNINQVNREI 
       660        670        680        690        700
GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR 
       710        720        730        740        750
ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKLKTV 
       760        770        780        790        800
SSELSCREGQ SYWTGSFSPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF 
       810        820        830        840        850
SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF 
       860        870        880        890        900
NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 
       910        920        930        940        950
NSFSFIESPG KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA 
       960        970        980        990       1000
PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ 
      1010       1020       1030       1040       1050
AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL 
      1060       1070       1080       1090       1100
SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS 
      1110       1120       1130       1140       1150
CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM 
      1160       1170       1180       1190 
SWFGGPLKTI LLICLYVALS IGLFFLLIYL GGTGLSKMWL AATKKAS
Length:1,197
Mass (Da):130,805
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i860B822CD968767F
GO
Isoform NSm protein1 Publication (identifier: P21401-3) [UniParc]FASTAAdd to basket
Also known as: P14

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     154-1197: Missing.

Show »
Length:115
Mass (Da):12,615
Checksum:i6A9A17415F6B6232
GO
Isoform NSm' protein1 Publication (identifier: P21401-5) [UniParc]FASTAAdd to basket
Also known as: P13

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     154-1197: Missing.

Show »
Length:102
Mass (Da):11,068
Checksum:i0E794648C9D34777
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9T → I in ABD38819 (PubMed:17192303).Curated1
Sequence conflicti17I → V in ABD38819 (PubMed:17192303).Curated1
Sequence conflicti129K → E in ABD38819 (PubMed:17192303).Curated1
Sequence conflicti259H → Y in ABD38819 (PubMed:17192303).Curated1
Sequence conflicti747L → I in ABD38819 (PubMed:17192303).Curated1
Sequence conflicti1182G → R in ABD38819 (PubMed:17192303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579881 – 51Missing in isoform NSm' protein. Add BLAST51
Alternative sequenceiVSP_0579891 – 38Missing in isoform NSm protein. Add BLAST38
Alternative sequenceiVSP_057990154 – 1197Missing in isoform NSm protein and isoform NSm' protein. Add BLAST1044

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M25276 Genomic RNA Translation: AAA47449.1
DQ380206 Genomic RNA Translation: ABD38819.1

Protein sequence database of the Protein Information Resource

More...PIRi		A30183, VGVURF

NCBI Reference Sequences

More...RefSeqi		YP_003848705.1, NC_014396.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9538296

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:9538296

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25276 Genomic RNA Translation: AAA47449.1
DQ380206 Genomic RNA Translation: ABD38819.1
PIRiA30183, VGVURF
RefSeqiYP_003848705.1, NC_014396.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F8PX-ray1.60A154-469[»]
6F9Belectron microscopy13.30A/C/E/G/I/K/M/O/Q/S/U/X154-469[»]
B/D/F/H/J/L/N/P/R/T/V/Y691-1118[»]
6F9Celectron microscopy8.00A/C/E/G/I/K154-469[»]
B/D/F/H/J/L691-1118[»]
6F9Delectron microscopy13.30A/C/E/G/I/K154-469[»]
B/D/F/H/J/L691-1118[»]
6F9Eelectron microscopy13.30A/C/E/G/I/K154-469[»]
B/D/F/H/J/L691-1118[»]
6F9Felectron microscopy13.30A/C/E/G/I154-469[»]
B/D/F/H/J691-1118[»]
6I9IX-ray1.98C/D154-469[»]
SMRiP21401
ModBaseiSearch...
PDBe-KBiSearch...

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P21401, 3 sequenced antibodies

Genome annotation databases

GeneIDi9538296
KEGGivg:9538296

Family and domain databases

DisProtiDP02493
InterProiView protein in InterPro
IPR016404, M_polyprot_prcur_phlebovir
IPR043603, Phlebo_G2_C
IPR010826, Phlebovirus_G1
IPR009878, Phlebovirus_G2_fusion
IPR009879, Phlebovirus_NSM
PfamiView protein in Pfam
PF19019, Phlebo_G2_C, 1 hit
PF07243, Phlebovirus_G1, 1 hit
PF07245, Phlebovirus_G2, 1 hit
PF07246, Phlebovirus_NSM, 2 hits
PIRSFiPIRSF003961, M_poly_PhleboV, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP_RVFVZ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21401
Secondary accession number(s): A2T075
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 25, 2022
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again