MAOA

Functionⁱ

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activityⁱ

RCH₂NHR' + H₂O + O₂ = RCHO + R'NH₂ + H₂O₂.

Cofactorⁱ

FAD2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	335	Important for substrate specificityBy similarity		1
Siteⁱ	374	Important for catalytic activity		1

GO - Molecular functionⁱ

primary amine oxidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular biogenic amine metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8211186
cytokine-mediated signaling pathway Source: Reactome
dopamine catabolic process
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24252804
neurotransmitter catabolic process Source: UniProtKB-KW
neurotransmitter metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Catecholamine metabolism, Neurotransmitter degradation
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS01798-MONOMER
BRENDAⁱ	1.4.3.4 2681
Reactomeⁱ	R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-379397 Enzymatic degradation of dopamine by COMT R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-380612 Metabolism of serotonin R-HSA-5579012 Defective MAOA causes Brunner syndrome (BRUNS) R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SABIO-RKⁱ	P21397
SIGNORⁱ	P21397

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amine oxidase [flavin-containing] A (EC:1.4.3.4) Alternative name(s): Monoamine oxidase type A Short name: MAO-A
Gene namesⁱ	Name:MAOA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000189221.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6833 MAOA
MIMⁱ	309850 gene
neXtProtⁱ	NX_P21397

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 497	Cytoplasmic1 PublicationAdd BLAST	497
Transmembraneⁱ	498 – 518	Helical; Anchor for type IV membrane proteinAdd BLAST	21
Topological domainⁱ	519 – 527	Mitochondrial intermembrane1 Publication	9

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Brunner syndrome (BRNRS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	165	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	266	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	306	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	321	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	323	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	374	C → S: Complete loss of activity. 1 Publication	1
Mutagenesisⁱ	398	C → S: No loss of activity. 1 Publication	1
Mutagenesisⁱ	406	C → S: Complete loss of activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4128
MalaCards human disease database More...MalaCardsⁱ	MAOA
MIMⁱ	300615 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000189221
Orphanetⁱ	3057 Monoamine oxidase A deficiency
PharmGKBⁱ	PA236

Chemistry databases

ChEMBLⁱ	CHEMBL1951
Drug and drug target database More...DrugBankⁱ	DB01472 4-Methoxyamphetamine DB07919 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE DB00918 Almotriptan DB00182 Amphetamine DB01445 Bufotenine DB06774 Capsaicin DB05205 CX157 DB07641 DECYL(DIMETHYL)PHOSPHINE OXIDE DB00988 Dopamine DB01363 Ephedra DB03147 Flavin adenine dinucleotide DB00614 Furazolidone DB01247 Isocarboxazid DB00601 Linezolid DB01577 Methamphetamine DB00805 Minaprine DB01442 MMDA DB01171 Moclobemide DB08804 Nandrolone decanoate DB00952 Naratriptan DB04820 Nialamide DB00184 Nicotine DB04821 Nomifensine DB06412 Oxymetholone DB01626 Pargyline DB00780 Phenelzine DB00191 Phentermine DB00388 Phenylephrine DB00397 Phenylpropanolamine DB04850 Posizolid DB00721 Procaine DB01168 Procarbazine DB00852 Pseudoephedrine DB00140 Riboflavin DB00953 Rizatriptan DB06654 Safinamide DB01037 Selegiline DB01104 Sertraline DB00669 Sumatriptan DB00624 Testosterone DB00752 Tranylcypromine DB04832 Zimelidine DB00315 Zolmitriptan DB00909 Zonisamide
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2489

Polymorphism and mutation databases

BioMutaⁱ	MAOA
DMDMⁱ	113978

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000099850	1 – 527	Amine oxidase [flavin-containing] AAdd BLAST		527

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication	1
Modified residueⁱ	383	PhosphoserineBy similarity	1
Modified residueⁱ	406	S-8alpha-FAD cysteine	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P21397
PaxDbⁱ	P21397
PeptideAtlas More...PeptideAtlasⁱ	P21397
PRIDEⁱ	P21397
ProteomicsDBⁱ	53866

PTM databases

iPTMnetⁱ	P21397
PhosphoSitePlusⁱ	P21397
SwissPalmⁱ	P21397

Expressionⁱ

Tissue specificityⁱ

Heart, liver, duodenum, blood vessels and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000189221 Expressed in 227 organ(s), highest expression level in small intestine
CleanExⁱ	HS_MAOA
ExpressionAtlasⁱ	P21397 baseline and differential
Genevisibleⁱ	P21397 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009437 HPA054807 HPA059299

HPAⁱ

CAB009437
HPA054807
HPA059299

Interactionⁱ

Subunit structureⁱ

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.2 Publications

Protein-protein interaction databases

BioGridⁱ	110301, 6 interactors
IntActⁱ	P21397, 3 interactors
Molecular INTeraction database More...MINTⁱ	P21397
STRINGⁱ	9606.ENSP00000340684

Chemistry databases

BindingDBⁱ

P21397

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 19	Combined sources	5
Helixⁱ	23 – 34	Combined sources	12
Beta strandⁱ	39 – 42	Combined sources	4
Beta strandⁱ	44 – 49	Combined sources	6
Beta strandⁱ	54 – 57	Combined sources	4
Turnⁱ	58 – 60	Combined sources	3
Beta strandⁱ	61 – 66	Combined sources	6
Helixⁱ	75 – 83	Combined sources	9
Beta strandⁱ	88 – 90	Combined sources	3
Beta strandⁱ	94 – 101	Combined sources	8
Beta strandⁱ	104 – 108	Combined sources	5
Beta strandⁱ	110 – 112	Combined sources	3
Helixⁱ	118 – 136	Combined sources	19
Helixⁱ	143 – 145	Combined sources	3
Helixⁱ	149 – 154	Combined sources	6
Helixⁱ	157 – 164	Combined sources	8
Helixⁱ	168 – 182	Combined sources	15
Turnⁱ	186 – 188	Combined sources	3
Helixⁱ	191 – 199	Combined sources	9
Turnⁱ	200 – 202	Combined sources	3
Helixⁱ	204 – 208	Combined sources	5
Beta strandⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 219	Combined sources	4
Helixⁱ	224 – 234	Combined sources	11
Helixⁱ	235 – 237	Combined sources	3
Beta strandⁱ	238 – 241	Combined sources	4
Beta strandⁱ	244 – 248	Combined sources	5
Beta strandⁱ	250 – 258	Combined sources	9
Beta strandⁱ	263 – 271	Combined sources	9
Helixⁱ	275 – 278	Combined sources	4
Beta strandⁱ	281 – 285	Combined sources	5
Helixⁱ	289 – 295	Combined sources	7
Beta strandⁱ	303 – 309	Combined sources	7
Helixⁱ	314 – 317	Combined sources	4
Beta strandⁱ	320 – 327	Combined sources	8
Beta strandⁱ	334 – 338	Combined sources	5
Beta strandⁱ	348 – 354	Combined sources	7
Helixⁱ	355 – 361	Combined sources	7
Helixⁱ	366 – 381	Combined sources	16
Helixⁱ	385 – 387	Combined sources	3
Beta strandⁱ	390 – 397	Combined sources	8
Turnⁱ	401 – 403	Combined sources	3
Beta strandⁱ	405 – 407	Combined sources	3
Helixⁱ	415 – 418	Combined sources	4
Helixⁱ	420 – 422	Combined sources	3
Beta strandⁱ	430 – 432	Combined sources	3
Helixⁱ	435 – 437	Combined sources	3
Beta strandⁱ	439 – 441	Combined sources	3
Helixⁱ	445 – 462	Combined sources	18
Beta strandⁱ	464 – 466	Combined sources	3
Helixⁱ	469 – 471	Combined sources	3
Beta strandⁱ	479 – 481	Combined sources	3
Helixⁱ	490 – 494	Combined sources	5
Helixⁱ	498 – 520	Combined sources	23

Show more details

3D structure databases

ProteinModelPortalⁱ	P21397
SMRⁱ	P21397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P21397

EvolutionaryTraceⁱ

P21397

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	520 – 522	Interaction with membrane phospholipid headgroupsCurated		3

Sequence similaritiesⁱ

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0029 Eukaryota ENOG410XSNC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110903
HOGENOMⁱ	HOG000221615
HOVERGENⁱ	HBG004255
InParanoidⁱ	P21397
KEGG Orthology (KO) More...KOⁱ	K00274
OMAⁱ	EWTRGAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G7P
PhylomeDBⁱ	P21397
TreeFamⁱ	TF313314

Family and domain databases

Gene3Dⁱ	3.50.50.60, 1 hit
InterProⁱ	View protein in InterPro IPR002937 Amino_oxidase IPR036188 FAD/NAD-bd_sf IPR001613 Flavin_amine_oxidase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01593 Amino_oxidase, 1 hit
PRINTSⁱ	PR00757 AMINEOXDASEF
SUPFAMⁱ	SSF51905 SSF51905, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P21397-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG 
        60         70         80         90        100
RTYTIRNEHV DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY 
       110        120        130        140        150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT IDNMGKEIPT DAPWEAQHAD 
       160        170        180        190        200
KWDKMTMKEL IDKICWTKTA RRFAYLFVNI NVTSEPHEVS ALWFLWYVKQ 
       210        220        230        240        250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL NHPVTHVDQS 
       260        270        280        290        300
SDNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM 
       310        320        330        340        350
GAVIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM 
       360        370        380        390        400
GFILARKADR LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE 
       410        420        430        440        450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATK WSGYMEGAVE 
       460        470        480        490        500
AGERAAREVL NGLGKVTEKD IWVQEPESKD VPAVEITHTF WERNLPSVSG 
       510        520 
LLKIIGFSTS VTALGFVLYK YKLLPRS

Length:527

Mass (Da):59,682

Last modified:May 1, 1991 - v1

Checksum:ⁱ4270E346928AE832

GO

Isoform 2 (identifier: P21397-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-133: Missing.

« Hide

        10         20         30         40         50
MGKEIPTDAP WEAQHADKWD KMTMKELIDK ICWTKTARRF AYLFVNINVT 
        60         70         80         90        100
SEPHEVSALW FLWYVKQCGG TTRIFSVTNG GQERKFVGGS GQVSERIMDL 
       110        120        130        140        150
LGDQVKLNHP VTHVDQSSDN IIIETLNHEH YECKYVINAI PPTLTAKIHF 
       160        170        180        190        200
RPELPAERNQ LIQRLPMGAV IKCMMYYKEA FWKKKDYCGC MIIEDEDAPI 
       210        220        230        240        250
SITLDDTKPD GSLPAIMGFI LARKADRLAK LHKEIRKKKI CELYAKVLGS 
       260        270        280        290        300
QEALHPVHYE EKNWCEEQYS GGCYTAYFPP GIMTQYGRVI RQPVGRIFFA 
       310        320        330        340        350
GTETATKWSG YMEGAVEAGE RAAREVLNGL GKVTEKDIWV QEPESKDVPA 
       360        370        380        390 
VEITHTFWER NLPSVSGLLK IIGFSTSVTA LGFVLYKYKL LPRS

Show »

Length:394

Mass (Da):44,848

Checksum:ⁱCA2429F72CD7F231

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	397	W → M AA sequence (PubMed:3178846).Curated		1

Mass spectrometryⁱ

Molecular mass is 60512±6 Da from positions 1 - 527. Determined by ESI. 1 Publication

Polymorphismⁱ

A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036545	15	D → E in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_064573	188	E → K1 PublicationCorresponds to variant dbSNP:rs77698881Ensembl.	1
Natural variantⁱVAR_071963	266	C → F Probable disease-associated mutation found in a family with Brunner syndrome-like behavioral disturbances; reduced activity. 1 PublicationCorresponds to variant dbSNP:rs587777457EnsemblClinVar.	1
Natural variantⁱVAR_014795	314	F → V. Corresponds to variant dbSNP:rs1799835Ensembl.	1
Natural variantⁱVAR_014796	520	K → R. Corresponds to variant dbSNP:rs1800466EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045173	1 – 133	Missing in isoform 2. 1 PublicationAdd BLAST		133

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69226 mRNA Translation: AAA59549.1 M68840 mRNA Translation: AAA59548.1 X60806 Genomic DNA No translation available. X60807 Genomic DNA No translation available. X60808 Genomic DNA No translation available. X60809 Genomic DNA No translation available. X60810 Genomic DNA No translation available. X60811 Genomic DNA No translation available. X60812 Genomic DNA No translation available. X60813 Genomic DNA No translation available. X60814 Genomic DNA No translation available. X60815 Genomic DNA No translation available. X60816 Genomic DNA No translation available. X60817 Genomic DNA No translation available. X60818 Genomic DNA No translation available. X60819 Genomic DNA No translation available. M68857 M68856 Genomic DNA Translation: AAA59547.1 AK293926 mRNA Translation: BAG57307.1 AL109855 Genomic DNA No translation available. BX530072 Genomic DNA No translation available. BX537147 Genomic DNA No translation available. BX537148 Genomic DNA No translation available. BC008064 mRNA Translation: AAH08064.1 M89636 Genomic DNA Translation: AAB46385.1 S81371 Genomic DNA Translation: AAD14361.1 S72704 Genomic DNA Translation: AAD14113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14260.1 [P21397-1] CCDS59163.1 [P21397-2]
PIRⁱ	A36175
NCBI Reference Sequences More...RefSeqⁱ	NP_000231.1, NM_000240.3 [P21397-1] NP_001257387.1, NM_001270458.1 [P21397-2]
UniGeneⁱ	Hs.183109

Genome annotation databases

Ensemblⁱ	ENST00000338702; ENSP00000340684; ENSG00000189221 [P21397-1] ENST00000542639; ENSP00000440846; ENSG00000189221 [P21397-2]
GeneIDⁱ	4128
KEGGⁱ	hsa:4128
UCSC genome browser More...UCSCⁱ	uc011mkw.3 human [P21397-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21397	Amine oxidase		HUMAN		527	UniRef100_P21397
Isoform 2 of Amine oxidase [flavin-containing] A		HUMAN		394
Monoamine oxidase A (Fragment)		HUMAN		103
Monoamine oxidase A (Fragment)		HUMAN		65
UPI000181D0C1		HUMAN		513

Protein	Similar proteins		Species	Score	Length	Source
P21397	Amine oxidase		HUMAN		527	UniRef90_P21397
Amine oxidase		Cebus capucinus imitator		527
Amine oxidase		AOTNA		527
Amine oxidase		PANTR		525
Amine oxidase		COLAP		514
+11

Protein	Similar proteins		Species	Score	Length	Source
P21397	Amine oxidase [flavin-containing] B	)	HUMAN		520	UniRef50_P27338
Amine oxidase [flavin-containing] B		PONAB		520
Amine oxidase [flavin-containing] A		MOUSE		526
Amine oxidase [flavin-containing] A	)	RAT		526
Amine oxidase [flavin-containing] A		PIG		527
+386

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Monoamine oxidase entry

Protein Spotlight

Approaching happiness - Issue 172 of August 2015

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69226 mRNA Translation: AAA59549.1 M68840 mRNA Translation: AAA59548.1 X60806 Genomic DNA No translation available. X60807 Genomic DNA No translation available. X60808 Genomic DNA No translation available. X60809 Genomic DNA No translation available. X60810 Genomic DNA No translation available. X60811 Genomic DNA No translation available. X60812 Genomic DNA No translation available. X60813 Genomic DNA No translation available. X60814 Genomic DNA No translation available. X60815 Genomic DNA No translation available. X60816 Genomic DNA No translation available. X60817 Genomic DNA No translation available. X60818 Genomic DNA No translation available. X60819 Genomic DNA No translation available. M68857 M68856 Genomic DNA Translation: AAA59547.1 AK293926 mRNA Translation: BAG57307.1 AL109855 Genomic DNA No translation available. BX530072 Genomic DNA No translation available. BX537147 Genomic DNA No translation available. BX537148 Genomic DNA No translation available. BC008064 mRNA Translation: AAH08064.1 M89636 Genomic DNA Translation: AAB46385.1 S81371 Genomic DNA Translation: AAD14361.1 S72704 Genomic DNA Translation: AAD14113.1
CCDSⁱ	CCDS14260.1 [P21397-1] CCDS59163.1 [P21397-2]
PIRⁱ	A36175
RefSeqⁱ	NP_000231.1, NM_000240.3 [P21397-1] NP_001257387.1, NM_001270458.1 [P21397-2]
UniGeneⁱ	Hs.183109

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1H8Q	model	-	A	14-468	[»]
	2BXR	X-ray	3.00	A/B	1-527	[»]
	2BXS	X-ray	3.15	A/B	1-527	[»]
	2Z5X	X-ray	2.20	A	12-524	[»]
	2Z5Y	X-ray	2.17	A	12-524	[»]
ProteinModelPortalⁱ	P21397
SMRⁱ	P21397
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110301, 6 interactors
IntActⁱ	P21397, 3 interactors
MINTⁱ	P21397
STRINGⁱ	9606.ENSP00000340684

Chemistry databases

BindingDBⁱ	P21397
ChEMBLⁱ	CHEMBL1951
DrugBankⁱ	DB01472 4-Methoxyamphetamine DB07919 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE DB00918 Almotriptan DB00182 Amphetamine DB01445 Bufotenine DB06774 Capsaicin DB05205 CX157 DB07641 DECYL(DIMETHYL)PHOSPHINE OXIDE DB00988 Dopamine DB01363 Ephedra DB03147 Flavin adenine dinucleotide DB00614 Furazolidone DB01247 Isocarboxazid DB00601 Linezolid DB01577 Methamphetamine DB00805 Minaprine DB01442 MMDA DB01171 Moclobemide DB08804 Nandrolone decanoate DB00952 Naratriptan DB04820 Nialamide DB00184 Nicotine DB04821 Nomifensine DB06412 Oxymetholone DB01626 Pargyline DB00780 Phenelzine DB00191 Phentermine DB00388 Phenylephrine DB00397 Phenylpropanolamine DB04850 Posizolid DB00721 Procaine DB01168 Procarbazine DB00852 Pseudoephedrine DB00140 Riboflavin DB00953 Rizatriptan DB06654 Safinamide DB01037 Selegiline DB01104 Sertraline DB00669 Sumatriptan DB00624 Testosterone DB00752 Tranylcypromine DB04832 Zimelidine DB00315 Zolmitriptan DB00909 Zonisamide
GuidetoPHARMACOLOGYⁱ	2489

PTM databases

iPTMnetⁱ	P21397
PhosphoSitePlusⁱ	P21397
SwissPalmⁱ	P21397

Polymorphism and mutation databases

BioMutaⁱ	MAOA
DMDMⁱ	113978

Proteomic databases

EPDⁱ	P21397
PaxDbⁱ	P21397
PeptideAtlasⁱ	P21397
PRIDEⁱ	P21397
ProteomicsDBⁱ	53866

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4128
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000338702; ENSP00000340684; ENSG00000189221 [P21397-1] ENST00000542639; ENSP00000440846; ENSG00000189221 [P21397-2]
GeneIDⁱ	4128
KEGGⁱ	hsa:4128
UCSCⁱ	uc011mkw.3 human [P21397-1]

Organism-specific databases

CTDⁱ	4128
DisGeNETⁱ	4128
EuPathDBⁱ	HostDB:ENSG00000189221.9
GeneCardsⁱ	MAOA
HGNCⁱ	HGNC:6833 MAOA
HPAⁱ	CAB009437 HPA054807 HPA059299
MalaCardsⁱ	MAOA
MIMⁱ	300615 phenotype 309850 gene
neXtProtⁱ	NX_P21397
OpenTargetsⁱ	ENSG00000189221
Orphanetⁱ	3057 Monoamine oxidase A deficiency
PharmGKBⁱ	PA236
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0029 Eukaryota ENOG410XSNC LUCA
GeneTreeⁱ	ENSGT00730000110903
HOGENOMⁱ	HOG000221615
HOVERGENⁱ	HBG004255
InParanoidⁱ	P21397
KOⁱ	K00274
OMAⁱ	EWTRGAY
OrthoDBⁱ	EOG091G0G7P
PhylomeDBⁱ	P21397
TreeFamⁱ	TF313314

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS01798-MONOMER
BRENDAⁱ	1.4.3.4 2681
Reactomeⁱ	R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-379397 Enzymatic degradation of dopamine by COMT R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-380612 Metabolism of serotonin R-HSA-5579012 Defective MAOA causes Brunner syndrome (BRUNS) R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SABIO-RKⁱ	P21397
SIGNORⁱ	P21397

Miscellaneous databases

ChiTaRSⁱ	MAOA human
EvolutionaryTraceⁱ	P21397
GeneWikiⁱ	Monoamine_oxidase_A
GenomeRNAiⁱ	4128
Protein Ontology More...PROⁱ	PR:P21397
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000189221 Expressed in 227 organ(s), highest expression level in small intestine
CleanExⁱ	HS_MAOA
ExpressionAtlasⁱ	P21397 baseline and differential
Genevisibleⁱ	P21397 HS

Family and domain databases

Gene3Dⁱ	3.50.50.60, 1 hit
InterProⁱ	View protein in InterPro IPR002937 Amino_oxidase IPR036188 FAD/NAD-bd_sf IPR001613 Flavin_amine_oxidase
Pfamⁱ	View protein in Pfam PF01593 Amino_oxidase, 1 hit
PRINTSⁱ	PR00757 AMINEOXDASEF
SUPFAMⁱ	SSF51905 SSF51905, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AOFA_HUMAN
Accessionⁱ	P21397Primary (citable) accession number: P21397 Secondary accession number(s): B4DF46, Q16426
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	May 1, 1991
	Last modified:	November 7, 2018
	This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P21397 (AOFA_HUMAN)

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Amine oxidase [flavin-containing] A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

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Keywords - Diseaseⁱ

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Keywords - PTMⁱ

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Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ