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Protein

Amine oxidase [flavin-containing] A

Gene

Maoa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Important for substrate specificity1
Sitei374Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCatecholamine metabolism, Neurotransmitter degradation
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14994
BRENDAi1.4.3.4 5301
SABIO-RKiP21396

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:Maoa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61898 Maoa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 497CytoplasmicAdd BLAST497
Transmembranei498 – 518Helical; Anchor for type IV membrane proteinAdd BLAST21
Topological domaini519 – 526Mitochondrial intermembrane8

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi208F → A: Lower affinity for serotonin and tyramine; no change for tryptamine. 1 Publication1
Mutagenesisi208F → I: Lower affinity for serotonin and tyramine; no change for tryptamine. 1 Publication1
Mutagenesisi208F → V: Lower affinity for serotonin and tyramine; no change for tryptamine. 1 Publication1
Mutagenesisi208F → Y: No change in substrate affinity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3358

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998541 – 526Amine oxidase [flavin-containing] AAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei383PhosphoserineCombined sources1
Modified residuei406S-8alpha-FAD cysteine1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21396
PRIDEiP21396

PTM databases

iPTMnetiP21396
PhosphoSitePlusiP21396

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063784

Chemistry databases

BindingDBiP21396

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21396
SMRiP21396
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21396

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 522Interaction with membrane phospholipid headgroupsBy similarity3

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP21396
PhylomeDBiP21396

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P21396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDLEKPNLA GHMFDVGLIG GGISGLAAAK LLSEYKINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPLA YLDYNNLWRT MDEMGKEIPV DAPWQARHAQ
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA REFAYLFVNI NVTSEPHEVS ALWFLWYVRQ
210 220 230 240 250
CGGTARIFSV TNGGQERKFV GGSGQVSEQI MGLLGDKVKL SSPVTYIDQT
260 270 280 290 300
DDNIIVETLN HEHYECKYVI SAIPPILTAK IHFKPELPPE RNQLIQRLPM
310 320 330 340 350
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APIAITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR QAKLHKDIRK RKICELYAKV LGSQEALYPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKVAKKD IWVEEPESKD VPAIEITHTF LERNLPSVPG
510 520
LLKITGVSTS VALLCFVLYK IKKLPC
Length:526
Mass (Da):59,508
Last modified:May 1, 1991 - v1
Checksum:i381AE35D5A73E25B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V9Z3G3V9Z3_RAT
Amine oxidase
Maoa rCG_42932
526Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 18GL → VV in AAB23355 (PubMed:1526120).Curated2
Sequence conflicti361Q → L in AAB23355 (PubMed:1526120).Curated1
Sequence conflicti406C → S in AAB23355 (PubMed:1526120).Curated1
Sequence conflicti451A → R in AAB23355 (PubMed:1526120).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00688 mRNA Translation: BAA00592.1
S45812 mRNA Translation: AAB23355.2
PIRiJT0528
UniGeneiRn.224544

Genome annotation databases

UCSCiRGD:61898 rat

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Approaching happiness - Issue 172 of August 2015

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00688 mRNA Translation: BAA00592.1
S45812 mRNA Translation: AAB23355.2
PIRiJT0528
UniGeneiRn.224544

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O5WX-ray3.20A/B/C/D1-526[»]
ProteinModelPortaliP21396
SMRiP21396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063784

Chemistry databases

BindingDBiP21396
ChEMBLiCHEMBL3358

PTM databases

iPTMnetiP21396
PhosphoSitePlusiP21396

Proteomic databases

PaxDbiP21396
PRIDEiP21396

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61898 rat

Organism-specific databases

RGDi61898 Maoa

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP21396
PhylomeDBiP21396

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14994
BRENDAi1.4.3.4 5301
SABIO-RKiP21396

Miscellaneous databases

EvolutionaryTraceiP21396
PROiPR:P21396

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAOFA_RAT
AccessioniPrimary (citable) accession number: P21396
Secondary accession number(s): Q63817
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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