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Entry version 156 (12 Aug 2020)
Sequence version 2 (01 Mar 1992)
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Protein

Proton/glutamate-aspartate symporter

Gene

gltP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Glutamate uptake is inhibited by L-cysteate and beta-hydroxyaspartate. Inhibited by the uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=2.6 nmol/min/mg enzyme with glutamate as substrate1 Publication
    2. Vmax=2.3 nmol/min/mg enzyme with aspartate as substrate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • aspartate transmembrane transport Source: InterPro
    • dicarboxylic acid transport Source: EcoCyc

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Symport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:GLTP-MONOMER
    ECOL316407:JW4038-MONOMER
    MetaCyc:GLTP-MONOMER

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.23.1.1, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Proton/glutamate-aspartate symporterUniRule annotationCurated
    Alternative name(s):
    Glutamate-aspartate carrier proteinCurated
    Proton-glutamate-aspartate transport protein1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:gltP2 PublicationsUniRule annotation
    Ordered Locus Names:b4077, JW4038
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5CytoplasmicCurated5
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
    Topological domaini27 – 50PeriplasmicCuratedAdd BLAST24
    Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
    Topological domaini72 – 84CytoplasmicCuratedAdd BLAST13
    Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
    Topological domaini106 – 159PeriplasmicCuratedAdd BLAST54
    Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
    Topological domaini181 – 210CytoplasmicCuratedAdd BLAST30
    Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
    Topological domaini232PeriplasmicCurated1
    Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
    Topological domaini254 – 292CytoplasmicCuratedAdd BLAST39
    Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
    Topological domaini314 – 324PeriplasmicCuratedAdd BLAST11
    Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
    Topological domaini346 – 361CytoplasmicCuratedAdd BLAST16
    Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
    Topological domaini383 – 387PeriplasmicCurated5
    Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
    Topological domaini409 – 437Cytoplasmic1 PublicationAdd BLAST29

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020881 – 437Proton/glutamate-aspartate symporterAdd BLAST437

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P21345

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P21345

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4262679, 10 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4077

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P21345

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. [View classification]UniRule annotationCurated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG1301, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_019375_7_0_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P21345

    KEGG Orthology (KO)

    More...
    KOi
    K11102

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P21345

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.3860.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_02063, GltP_subfam, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR034703, GltP
    IPR033380, GltP/GltT
    IPR001991, Na-dicarboxylate_symporter
    IPR018107, Na-dicarboxylate_symporter_CS
    IPR036458, Na:dicarbo_symporter_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR42865:SF4, PTHR42865:SF4, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00375, SDF, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF118215, SSF118215, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
    PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P21345-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKNIKFSLAW QILFAMVLGI LLGSYLHYHS DSRDWLVVNL LSPAGDIFIH
    60 70 80 90 100
    LIKMIVVPIV ISTLVVGIAG VGDAKQLGRI GAKTIIYFEV ITTVAIILGI
    110 120 130 140 150
    TLANVFQPGA GVDMSQLATV DISKYQSTTE AVQSSSHGIM GTILSLVPTN
    160 170 180 190 200
    IVASMAKGEM LPIIFFSVLF GLGLSSLPAT HREPLVTVFR SISETMFKVT
    210 220 230 240 250
    HMVMRYAPVG VFALIAVTVA NFGFSSLWPL AKLVLLVHFA ILFFALVVLG
    260 270 280 290 300
    IVARLCGLSV WILIRILKDE LILAYSTASS ESVLPRIIEK MEAYGAPVSI
    310 320 330 340 350
    TSFVVPTGYS FNLDGSTLYQ SIAAIFIAQL YGIDLSIWQE IILVLTLMVT
    360 370 380 390 400
    SKGIAGVPGV SFVVLLATLG SVGIPLEGLA FIAGVDRILD MARTALNVVG
    410 420 430
    NALAVLVIAK WEHKFDRKKA LAYEREVLGK FDKTADQ
    Length:437
    Mass (Da):47,159
    Last modified:March 1, 1992 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62E1A5FC16EA54BE
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M32488 Genomic DNA Translation: AAA23832.1 Sequence problems.
    M84805 Genomic DNA Translation: AAA24323.1
    U00006 Genomic DNA Translation: AAC43171.1
    U00096 Genomic DNA Translation: AAD13460.1
    AP009048 Genomic DNA Translation: BAE78079.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A42384

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418501.1, NC_000913.3
    WP_000789592.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAD13460; AAD13460; b4077
    BAE78079; BAE78079; BAE78079

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948591

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW4038
    eco:b4077

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2626

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M32488 Genomic DNA Translation: AAA23832.1 Sequence problems.
    M84805 Genomic DNA Translation: AAA24323.1
    U00006 Genomic DNA Translation: AAC43171.1
    U00096 Genomic DNA Translation: AAD13460.1
    AP009048 Genomic DNA Translation: BAE78079.1
    PIRiA42384
    RefSeqiNP_418501.1, NC_000913.3
    WP_000789592.1, NZ_LN832404.1

    3D structure databases

    SMRiP21345
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4262679, 10 interactors
    STRINGi511145.b4077

    Protein family/group databases

    TCDBi2.A.23.1.1, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

    Proteomic databases

    PaxDbiP21345
    PRIDEiP21345

    Genome annotation databases

    EnsemblBacteriaiAAD13460; AAD13460; b4077
    BAE78079; BAE78079; BAE78079
    GeneIDi948591
    KEGGiecj:JW4038
    eco:b4077
    PATRICifig|1411691.4.peg.2626

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0400

    Phylogenomic databases

    eggNOGiCOG1301, Bacteria
    HOGENOMiCLU_019375_7_0_6
    InParanoidiP21345
    KOiK11102
    PhylomeDBiP21345

    Enzyme and pathway databases

    BioCyciEcoCyc:GLTP-MONOMER
    ECOL316407:JW4038-MONOMER
    MetaCyc:GLTP-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P21345

    Family and domain databases

    Gene3Di1.10.3860.10, 1 hit
    HAMAPiMF_02063, GltP_subfam, 1 hit
    InterProiView protein in InterPro
    IPR034703, GltP
    IPR033380, GltP/GltT
    IPR001991, Na-dicarboxylate_symporter
    IPR018107, Na-dicarboxylate_symporter_CS
    IPR036458, Na:dicarbo_symporter_sf
    PANTHERiPTHR42865:SF4, PTHR42865:SF4, 1 hit
    PfamiView protein in Pfam
    PF00375, SDF, 1 hit
    SUPFAMiSSF118215, SSF118215, 1 hit
    PROSITEiView protein in PROSITE
    PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
    PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLTP_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21345
    Secondary accession number(s): Q2M6M7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: March 1, 1992
    Last modified: August 12, 2020
    This is version 156 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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