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Protein

Morphogenesis-related protein MSB1

Gene

MSB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in polarity establishment and bud formation. The MSB1 gene may be functionally redundant.

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • establishment of cell polarity Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-33698-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Morphogenesis-related protein MSB1
Alternative name(s):
Multicopy suppressor of bud emergence 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSB1
Ordered Locus Names:YOR188W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005714 MSB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965881 – 1137Morphogenesis-related protein MSB1Add BLAST1137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei538PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P21339

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P21339

PRoteomics IDEntifications database

More...
PRIDEi
P21339

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-11322,EBI-18140

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34583, 72 interactors

Database of interacting proteins

More...
DIPi
DIP-2687N

Protein interaction database and analysis system

More...
IntActi
P21339, 5 interactors

Molecular INTeraction database

More...
MINTi
P21339

STRING: functional protein association networks

More...
STRINGi
4932.YOR188W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21339

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113660

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21339

Identification of Orthologs from Complete Genome Data

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OMAi
CIENISH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012965 DUF1708
IPR037508 Msb1/Mug8

The PANTHER Classification System

More...
PANTHERi
PTHR28093 PTHR28093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08101 DUF1708, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P21339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDMAKPLPT PPTAEIRKSR SNSPKKAQKT NLSPNKNQNN EKNVPRSNGR
60 70 80 90 100
TKNEHNSMDD EEFEFFHQFS REKVKGVIHV ITAELKEKGP DVEFLMIPFR
110 120 130 140 150
PEQTNDKLLT LLNQLFPLGN GQPVNEKKQL RIVSKADVWT LFQCLKYIWC
160 170 180 190 200
RLPNSEIIGW KSYLEFKFRE EDKKFPRKSF LEIMPQCLAS PNHASIVYDF
210 220 230 240 250
FDLIISISSN SRVNKMSARK ISKMCAIWAF SKQIPNSDIQ DYDFESAAMK
260 270 280 290 300
SFAPNNSIQD GLDQWIPASD AMFHLLLAFL RSFVPQDLES AKLPRTLKSL
310 320 330 340 350
LFNNQYPPRK STAYTSETIL TIPLVTLKTD VFSRKPWQLL ERCNDLLDFS
360 370 380 390 400
DHDAFEARED YALLKSLFRK KNTVEGISRK MSQESRRLMK AMSTKHSTFQ
410 420 430 440 450
PGWAPRECIE NISHLKECIE VKRLDIDDYF IWTWLSSLSF EQTSEKKKIF
460 470 480 490 500
GRSIILEFEF DGFKKWVVFQ ECDITLDYNK KGQLKKKTSA QSPTTEKELP
510 520 530 540 550
PDDFELEDPP LSKSPTLSQT YKKFQAEVPQ QSTVRRDSAP DNQGIYHTVI
560 570 580 590 600
SKNALTKNKH NVNLHSFEHK ISKWNPLNNL RKKSGSNSSS SSFEEKSKDA
610 620 630 640 650
PIREEYHTNK NHKSKKEERV LSQFSTLNPD EYQLPVIETG SSNFKIEIPE
660 670 680 690 700
LMYEHDDDDS DKLKNSQKRA TDSAIEELNG MVEEMMINEP DDVKISITEA
710 720 730 740 750
ETFESLTKFD QYKPSNITDD DLQSSHSSAV HSLKLSTNTN DSCADSSKYT
760 770 780 790 800
ADRKLAEPRK ISEESKVNDD SSSYYSPNIN NLPASRMPSQ PTYSNSDSKK
810 820 830 840 850
AFTNESRLNV LQGAVSPSQQ VTPKPYKNAP GDCVSPVQQK YYQNDRRNEM
860 870 880 890 900
SPASAPVPPS AYSPARSPQF STNSAGFKQN TINVPVGYND PAHVLANQPH
910 920 930 940 950
MTYRDQHNYP SHQQKQRPFQ NNIVPPELKS RNQRADASPI PQHMVPVKQG
960 970 980 990 1000
VPNLPSNVPL YQQMERMNPN HQHPVNTYKV TQPPYHNNTT NAYGNSRAGN
1010 1020 1030 1040 1050
AHMLDGKWSN NPPQMVPKGV RPNQYPQQHV NRYSPQAQPV VPAEYYNGPP
1060 1070 1080 1090 1100
PMRAPPMMSH MVPAQEPIRY TAGANRRSFP QGMQQNAYSV PAQPMGAVNS
1110 1120 1130
EFYLPEAPQG NKLHGNINKR QERKKLYDNI RSGNFGI
Length:1,137
Mass (Da):129,971
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59CDD6E0F1E43F8A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37767 Genomic DNA Translation: AAA34797.1
Z75096 Genomic DNA Translation: CAA99397.1
BK006948 Genomic DNA Translation: DAA10960.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S13759

NCBI Reference Sequences

More...
RefSeqi
NP_014831.3, NM_001183607.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR188W_mRNA; YOR188W_mRNA; YOR188W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR188W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37767 Genomic DNA Translation: AAA34797.1
Z75096 Genomic DNA Translation: CAA99397.1
BK006948 Genomic DNA Translation: DAA10960.1
PIRiS13759
RefSeqiNP_014831.3, NM_001183607.3

3D structure databases

ProteinModelPortaliP21339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34583, 72 interactors
DIPiDIP-2687N
IntActiP21339, 5 interactors
MINTiP21339
STRINGi4932.YOR188W

PTM databases

iPTMnetiP21339

Proteomic databases

MaxQBiP21339
PaxDbiP21339
PRIDEiP21339

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR188W_mRNA; YOR188W_mRNA; YOR188W
GeneIDi854360
KEGGisce:YOR188W

Organism-specific databases

SGDiS000005714 MSB1

Phylogenomic databases

HOGENOMiHOG000113660
InParanoidiP21339
OMAiCIENISH

Enzyme and pathway databases

BioCyciYEAST:G3O-33698-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P21339

Family and domain databases

InterProiView protein in InterPro
IPR012965 DUF1708
IPR037508 Msb1/Mug8
PANTHERiPTHR28093 PTHR28093, 1 hit
PfamiView protein in Pfam
PF08101 DUF1708, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSB1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21339
Secondary accession number(s): D6W2P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: January 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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