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Protein

ATP synthase subunit epsilon, mitochondrial

Gene

ATP15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34153-MONOMER

Protein family/group databases

TCDBi3.A.2.1.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit epsilon, mitochondrial
Short name:
ATPase subunit epsilon
Gene namesi
Name:ATP15
Ordered Locus Names:YPL271W
ORF Names:P0345
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL271W
SGDiS000006192 ATP15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000716672 – 62ATP synthase subunit epsilon, mitochondrialAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21306
PaxDbiP21306
PRIDEiP21306

PTM databases

iPTMnetiP21306

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi35942, 67 interactors
ComplexPortaliCPX-3281 Mitochondrial proton-transporting ATP synthase complex
DIPiDIP-3031N
IntActiP21306, 12 interactors
MINTiP21306
STRINGi4932.YPL271W

Structurei

Secondary structure

162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 6Combined sources3
Helixi11 – 24Combined sources14
Helixi28 – 30Combined sources3
Helixi33 – 37Combined sources5
Beta strandi44 – 47Combined sources4

3D structure databases

ProteinModelPortaliP21306
SMRiP21306
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21306

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase epsilon family.Curated

Phylogenomic databases

HOGENOMiHOG000214506
InParanoidiP21306
KOiK02135
OMAiPELQTNS
OrthoDBiEOG092C5WS2

Family and domain databases

CDDicd12153 F1-ATPase_epsilon, 1 hit
Gene3Di1.10.1620.20, 1 hit
InterProiView protein in InterPro
IPR006721 ATP_synth_F1_esu_mt
IPR036742 ATP_synth_F1_esu_sf_mt
PANTHERiPTHR12448 PTHR12448, 1 hit
PfamiView protein in Pfam
PF04627 ATP-synt_Eps, 1 hit
SUPFAMiSSF48690 SSF48690, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAWRKAGIS YAAYLNVAAQ AIRSSLKTEL QTASVLNRSQ TDAFYTQYKN
60
GTAASEPTPI TK
Length:62
Mass (Da):6,743
Last modified:January 23, 2007 - v2
Checksum:i0CD754A9DEFFD08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64767 Genomic DNA Translation: CAA46014.1
Z73627 Genomic DNA Translation: CAA98007.1
AY558140 Genomic DNA Translation: AAS56466.1
BK006949 Genomic DNA Translation: DAA11165.1
PIRiA45315
RefSeqiNP_015052.1, NM_001184085.1

Genome annotation databases

EnsemblFungiiYPL271W; YPL271W; YPL271W
GeneIDi855857
KEGGisce:YPL271W

Similar proteinsi

Entry informationi

Entry nameiATP5E_YEAST
AccessioniPrimary (citable) accession number: P21306
Secondary accession number(s): D6W399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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