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Protein

Cysteine and glycine-rich protein 1

Gene

CSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play a role in neuronal development.

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5660489 MTF1 activates gene expression
SIGNORiP21291

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Epididymis luminal protein 141
Short name:
HEL-141
Gene namesi
Name:CSRP1
Synonyms:CSRP, CYRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159176.13
HGNCiHGNC:2469 CSRP1
MIMi123876 gene
neXtProtiNX_P21291

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1465
OpenTargetsiENSG00000159176
PharmGKBiPA26967

Polymorphism and mutation databases

BioMutaiCSRP1
DMDMi118161

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757151 – 193Cysteine and glycine-rich protein 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1
Modified residuei84N6-acetyllysineBy similarity1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysineCombined sources1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei161N6-acetyllysineBy similarity1
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP21291
PaxDbiP21291
PeptideAtlasiP21291
PRIDEiP21291
ProteomicsDBi53858
TopDownProteomicsiP21291

2D gel databases

OGPiP21291

PTM databases

iPTMnetiP21291
PhosphoSitePlusiP21291
SwissPalmiP21291

Expressioni

Gene expression databases

BgeeiENSG00000159176 Expressed in 243 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_CSRP1
ExpressionAtlasiP21291 baseline and differential
GenevisibleiP21291 HS

Organism-specific databases

HPAiHPA045617

Interactioni

Subunit structurei

Interacts with ASCC1; ASCC2 AND TRIP4.1 Publication

Protein-protein interaction databases

BioGridi107847, 25 interactors
IntActiP21291, 10 interactors
MINTiP21291
STRINGi9606.ENSP00000345079

Structurei

3D structure databases

ProteinModelPortaliP21291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI1 Eukaryota
ENOG4111F3Y LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111233
HOVERGENiHBG051143
InParanoidiP21291
KOiK09377
OMAiRCPRCTQ
OrthoDBiEOG091G11RX
PhylomeDBiP21291
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P21291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP
110 120 130 140 150
TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KACFRCAKCG
160 170 180 190
KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
Length:193
Mass (Da):20,567
Last modified:January 23, 2007 - v3
Checksum:iAC6970255D68D69A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS42E9PS42_HUMAN
Cysteine and glycine-rich protein 1
CSRP1
153Annotation score:
E9PND2E9PND2_HUMAN
Cysteine and glycine-rich protein 1
CSRP1
153Annotation score:
E9PP21E9PP21_HUMAN
Cysteine and glycine-rich protein 1
CSRP1
160Annotation score:
A0A087X134A0A087X134_HUMAN
Cysteine and glycine-rich protein 1
CSRP1
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91K → R in BAF82822 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050144108K → I. Corresponds to variant dbSNP:rs3738283Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33146 mRNA Translation: AAA35720.1
M76378, M76376, M76377 Genomic DNA Translation: AAA58431.1
EU668320 mRNA Translation: ACF94473.1
AK290133 mRNA Translation: BAF82822.1
AK293053 mRNA Translation: BAF85742.1
BT019520 mRNA Translation: AAV38327.1
CH471067 Genomic DNA Translation: EAW91371.1
BC032493 mRNA Translation: AAH32493.1
CCDSiCCDS1413.1
PIRiS12658
RefSeqiNP_001180499.1, NM_001193570.1
NP_001180500.1, NM_001193571.1
NP_001180501.1, NM_001193572.1
NP_004069.1, NM_004078.2
UniGeneiHs.108080

Genome annotation databases

EnsembliENST00000340006; ENSP00000345079; ENSG00000159176
ENST00000367306; ENSP00000356275; ENSG00000159176
ENST00000532460; ENSP00000434147; ENSG00000159176
ENST00000533432; ENSP00000436792; ENSG00000159176
GeneIDi1465
KEGGihsa:1465
UCSCiuc001gws.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33146 mRNA Translation: AAA35720.1
M76378, M76376, M76377 Genomic DNA Translation: AAA58431.1
EU668320 mRNA Translation: ACF94473.1
AK290133 mRNA Translation: BAF82822.1
AK293053 mRNA Translation: BAF85742.1
BT019520 mRNA Translation: AAV38327.1
CH471067 Genomic DNA Translation: EAW91371.1
BC032493 mRNA Translation: AAH32493.1
CCDSiCCDS1413.1
PIRiS12658
RefSeqiNP_001180499.1, NM_001193570.1
NP_001180500.1, NM_001193571.1
NP_001180501.1, NM_001193572.1
NP_004069.1, NM_004078.2
UniGeneiHs.108080

3D structure databases

ProteinModelPortaliP21291
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107847, 25 interactors
IntActiP21291, 10 interactors
MINTiP21291
STRINGi9606.ENSP00000345079

PTM databases

iPTMnetiP21291
PhosphoSitePlusiP21291
SwissPalmiP21291

Polymorphism and mutation databases

BioMutaiCSRP1
DMDMi118161

2D gel databases

OGPiP21291

Proteomic databases

EPDiP21291
PaxDbiP21291
PeptideAtlasiP21291
PRIDEiP21291
ProteomicsDBi53858
TopDownProteomicsiP21291

Protocols and materials databases

DNASUi1465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340006; ENSP00000345079; ENSG00000159176
ENST00000367306; ENSP00000356275; ENSG00000159176
ENST00000532460; ENSP00000434147; ENSG00000159176
ENST00000533432; ENSP00000436792; ENSG00000159176
GeneIDi1465
KEGGihsa:1465
UCSCiuc001gws.4 human

Organism-specific databases

CTDi1465
DisGeNETi1465
EuPathDBiHostDB:ENSG00000159176.13
GeneCardsiCSRP1
HGNCiHGNC:2469 CSRP1
HPAiHPA045617
MIMi123876 gene
neXtProtiNX_P21291
OpenTargetsiENSG00000159176
PharmGKBiPA26967
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITI1 Eukaryota
ENOG4111F3Y LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111233
HOVERGENiHBG051143
InParanoidiP21291
KOiK09377
OMAiRCPRCTQ
OrthoDBiEOG091G11RX
PhylomeDBiP21291
TreeFamiTF313758

Enzyme and pathway databases

ReactomeiR-HSA-5660489 MTF1 activates gene expression
SIGNORiP21291

Miscellaneous databases

ChiTaRSiCSRP1 human
GeneWikiiCSRP1
GenomeRNAii1465
PROiPR:P21291
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159176 Expressed in 243 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_CSRP1
ExpressionAtlasiP21291 baseline and differential
GenevisibleiP21291 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP1_HUMAN
AccessioniPrimary (citable) accession number: P21291
Secondary accession number(s): A8K268, Q5U0J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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