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Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

Gna11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53MagnesiumBy similarity1
Metal bindingi186MagnesiumBy similarity1
Binding sitei331GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 53GTPBy similarity8
Nucleotide bindingi180 – 186GTPBy similarity7
Nucleotide bindingi205 – 209GTPBy similarity5
Nucleotide bindingi274 – 277GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-399997 Acetylcholine regulates insulin secretion
R-MMU-416476 G alpha (q) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432142 Platelet sensitization by LDL
R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name:
G alpha-11
Short name:
G-protein subunit alpha-11
Gene namesi
Name:Gna11
Synonyms:Gna-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95766 Gna11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037471 – 359Guanine nucleotide-binding protein subunit alpha-11Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi9S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP21278
PaxDbiP21278
PeptideAtlasiP21278
PRIDEiP21278

PTM databases

iPTMnetiP21278
PhosphoSitePlusiP21278
SwissPalmiP21278

Expressioni

Gene expression databases

BgeeiENSMUSG00000034781 Expressed in 293 organ(s), highest expression level in jejunum
CleanExiMM_GNA11
ExpressionAtlasiP21278 baseline and differential
GenevisibleiP21278 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199961, 3 interactors
DIPiDIP-603N
IntActiP21278, 2 interactors
STRINGi10090.ENSMUSP00000043190

Structurei

3D structure databases

ProteinModelPortaliP21278
SMRiP21278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiP21278
KOiK04635
OMAiYKDEQNE
OrthoDBiEOG091G0VUT
PhylomeDBiP21278
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P21278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES
60 70 80 90 100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL
110 120 130 140 150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE
160 170 180 190 200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII
210 220 230 240 250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE
260 270 280 290 300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR
310 320 330 340 350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ

LNLKEYNLV
Length:359
Mass (Da):42,024
Last modified:May 1, 1991 - v1
Checksum:iA33D2D6C6C62F8D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → L in AAB36839 (PubMed:8838318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA Translation: AAA63305.1
U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1
M57617 mRNA Translation: AAA63301.1
CCDSiCCDS24061.1
PIRiB33833
B38414 RGMS11
RefSeqiNP_034431.1, NM_010301.3
UniGeneiMm.260925
Mm.471081

Genome annotation databases

EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781
GeneIDi14672
KEGGimmu:14672
UCSCiuc007gil.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA Translation: AAA63305.1
U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1
M57617 mRNA Translation: AAA63301.1
CCDSiCCDS24061.1
PIRiB33833
B38414 RGMS11
RefSeqiNP_034431.1, NM_010301.3
UniGeneiMm.260925
Mm.471081

3D structure databases

ProteinModelPortaliP21278
SMRiP21278
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199961, 3 interactors
DIPiDIP-603N
IntActiP21278, 2 interactors
STRINGi10090.ENSMUSP00000043190

PTM databases

iPTMnetiP21278
PhosphoSitePlusiP21278
SwissPalmiP21278

Proteomic databases

EPDiP21278
PaxDbiP21278
PeptideAtlasiP21278
PRIDEiP21278

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781
GeneIDi14672
KEGGimmu:14672
UCSCiuc007gil.1 mouse

Organism-specific databases

CTDi2767
MGIiMGI:95766 Gna11

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiP21278
KOiK04635
OMAiYKDEQNE
OrthoDBiEOG091G0VUT
PhylomeDBiP21278
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-MMU-399997 Acetylcholine regulates insulin secretion
R-MMU-416476 G alpha (q) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432142 Platelet sensitization by LDL
R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

ChiTaRSiGna11 mouse
PROiPR:P21278
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034781 Expressed in 293 organ(s), highest expression level in jejunum
CleanExiMM_GNA11
ExpressionAtlasiP21278 baseline and differential
GenevisibleiP21278 MM

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNA11_MOUSE
AccessioniPrimary (citable) accession number: P21278
Secondary accession number(s): Q61939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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