UniProtKB - P21278 (GNA11_MOUSE)
Protein
Guanine nucleotide-binding protein subunit alpha-11
Gene
Gna11
Organism
Mus musculus (Mouse)
Status
Functioni
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | MagnesiumBy similarity | 1 | |
Metal bindingi | 186 | MagnesiumBy similarity | 1 | |
Binding sitei | 331 | GTP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 46 – 53 | GTPBy similarity | 8 | |
Nucleotide bindingi | 180 – 186 | GTPBy similarity | 7 | |
Nucleotide bindingi | 205 – 209 | GTPBy similarity | 5 | |
Nucleotide bindingi | 274 – 277 | GTPBy similarity | 4 |
GO - Molecular functioni
- alkylglycerophosphoethanolamine phosphodiesterase activity Source: MGI
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G protein-coupled receptor binding Source: GO_Central
- GTPase activity Source: MGI
- GTP binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: MGI
- type 2A serotonin receptor binding Source: MGI
GO - Biological processi
- action potential Source: MGI
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cellular response to pH Source: MGI
- developmental pigmentation Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- heart development Source: MGI
- phospholipase C-activating dopamine receptor signaling pathway Source: MGI
- regulation of melanocyte differentiation Source: MGI
- skeletal system development Source: MGI
Keywordsi
Molecular function | Transducer |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-399997, Acetylcholine regulates insulin secretion R-MMU-416476, G alpha (q) signalling events R-MMU-418592, ADP signalling through P2Y purinoceptor 1 R-MMU-428930, Thromboxane signalling through TP receptor R-MMU-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-MMU-456926, Thrombin signalling through proteinase activated receptors (PARs) |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein subunit alpha-11Short name: G alpha-11 Short name: G-protein subunit alpha-11 |
Gene namesi | Name:Gna11 Synonyms:Gna-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95766, Gna11 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- heterotrimeric G-protein complex Source: MGI
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203747 | 1 – 359 | Guanine nucleotide-binding protein subunit alpha-11Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 9 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 10 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
EPDi | P21278 |
jPOSTi | P21278 |
PaxDbi | P21278 |
PeptideAtlasi | P21278 |
PRIDEi | P21278 |
PTM databases
iPTMneti | P21278 |
PhosphoSitePlusi | P21278 |
SwissPalmi | P21278 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034781, Expressed in jejunum and 308 other tissues |
Genevisiblei | P21278, MM |
Interactioni
Subunit structurei
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Interacts with RGS22.
Interacts with NTSR1 (By similarity).
By similarityGO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- type 2A serotonin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199961, 15 interactors |
DIPi | DIP-603N |
IntActi | P21278, 2 interactors |
STRINGi | 10090.ENSMUSP00000043190 |
Miscellaneous databases
RNActi | P21278, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 359 | G-alphaPROSITE-ProRule annotationAdd BLAST | 322 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 54 | G1 motifPROSITE-ProRule annotationAdd BLAST | 14 | |
Regioni | 178 – 186 | G2 motifPROSITE-ProRule annotation | 9 | |
Regioni | 201 – 210 | G3 motifPROSITE-ProRule annotation | 10 | |
Regioni | 270 – 277 | G4 motifPROSITE-ProRule annotation | 8 | |
Regioni | 329 – 334 | G5 motifPROSITE-ProRule annotation | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0085, Eukaryota |
GeneTreei | ENSGT00940000161033 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P21278 |
OMAi | QMRYIHT |
OrthoDBi | 754573at2759 |
PhylomeDBi | P21278 |
TreeFami | TF300673 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
i Sequence
Sequence statusi: Complete.
P21278-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES
60 70 80 90 100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL
110 120 130 140 150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE
160 170 180 190 200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII
210 220 230 240 250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE
260 270 280 290 300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR
310 320 330 340 350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ
LNLKEYNLV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | K → L in AAB36839 (PubMed:8838318).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55411 mRNA Translation: AAA63305.1 U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1 M57617 mRNA Translation: AAA63301.1 |
CCDSi | CCDS24061.1 |
PIRi | B33833 B38414, RGMS11 |
RefSeqi | NP_034431.1, NM_010301.3 |
Genome annotation databases
Ensembli | ENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781 |
GeneIDi | 14672 |
KEGGi | mmu:14672 |
UCSCi | uc007gil.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55411 mRNA Translation: AAA63305.1 U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1 M57617 mRNA Translation: AAA63301.1 |
CCDSi | CCDS24061.1 |
PIRi | B33833 B38414, RGMS11 |
RefSeqi | NP_034431.1, NM_010301.3 |
3D structure databases
SMRi | P21278 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199961, 15 interactors |
DIPi | DIP-603N |
IntActi | P21278, 2 interactors |
STRINGi | 10090.ENSMUSP00000043190 |
PTM databases
iPTMneti | P21278 |
PhosphoSitePlusi | P21278 |
SwissPalmi | P21278 |
Proteomic databases
EPDi | P21278 |
jPOSTi | P21278 |
PaxDbi | P21278 |
PeptideAtlasi | P21278 |
PRIDEi | P21278 |
Protocols and materials databases
Antibodypediai | 53288, 249 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781 |
GeneIDi | 14672 |
KEGGi | mmu:14672 |
UCSCi | uc007gil.1, mouse |
Organism-specific databases
CTDi | 2767 |
MGIi | MGI:95766, Gna11 |
Phylogenomic databases
eggNOGi | KOG0085, Eukaryota |
GeneTreei | ENSGT00940000161033 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P21278 |
OMAi | QMRYIHT |
OrthoDBi | 754573at2759 |
PhylomeDBi | P21278 |
TreeFami | TF300673 |
Enzyme and pathway databases
Reactomei | R-MMU-399997, Acetylcholine regulates insulin secretion R-MMU-416476, G alpha (q) signalling events R-MMU-418592, ADP signalling through P2Y purinoceptor 1 R-MMU-428930, Thromboxane signalling through TP receptor R-MMU-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-MMU-456926, Thrombin signalling through proteinase activated receptors (PARs) |
Miscellaneous databases
BioGRID-ORCSi | 14672, 4 hits in 19 CRISPR screens |
ChiTaRSi | Gna11, mouse |
PROi | PR:P21278 |
RNActi | P21278, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034781, Expressed in jejunum and 308 other tissues |
Genevisiblei | P21278, MM |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNA11_MOUSE | |
Accessioni | P21278Primary (citable) accession number: P21278 Secondary accession number(s): Q61939 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families