Guanine nucleotide-binding protein subunit alpha-11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alkylglycerophosphoethanolamine phosphodiesterase activity Source: MGIInferred from sequence orthologyⁱ
  • "The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity."
    Aoyama C., Sugimoto H., Ando H., Yamashita S., Horibata Y., Sugimoto S., Satou M.
    Biochem. J. 440:241-250(2011) [PubMed] [Europe PMC] [Abstract]
• G-protein beta/gamma-subunit complex binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• GTPase activity Source: MGIInferred from sequence alignmentⁱ
  • Ref.4

    "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
    Strathmann M., Wilkie T.M., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.
• GTP binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• protein-containing complex binding Source: MGI
• type 2A serotonin receptor binding Source: MGI

GO - Biological processⁱ

• action potential Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Muscarinic inhibition of calcium current and M current in Galpha q-deficient mice."
    Haley J.E., Delmas P., Offermanns S., Abogadie F.C., Simon M.I., Buckley N.J., Brown D.A.
    J. Neurosci. 20:3973-3979(2000) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to pH Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion."
    Nakakura T., Mogi C., Tobo M., Tomura H., Sato K., Kobayashi M., Ohnishi H., Tanaka S., Wayama M., Sugiyama T., Kitamura T., Harada A., Okajima F.
    Endocrinology 153:4171-4180(2012) [PubMed] [Europe PMC] [Abstract]
• developmental pigmentation Source: MGIInferred from mutant phenotypeⁱ
  • "Effects of G-protein mutations on skin color."
    Van Raamsdonk C.D., Fitch K.R., Fuchs H., de Angelis M.H., Barsh G.S.
    Nat. Genet. 36:961-968(2004) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice."
    Offermanns S., Zhao L.P., Gohla A., Sarosi I., Simon M.I., Wilkie T.M.
    EMBO J. 17:4304-4312(1998) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • "Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice."
    Offermanns S., Zhao L.P., Gohla A., Sarosi I., Simon M.I., Wilkie T.M.
    EMBO J. 17:4304-4312(1998) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating dopamine receptor signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum."
    Rashid A.J., So C.H., Kong M.M., Furtak T., El-Ghundi M., Cheng R., O'Dowd B.F., George S.R.
    Proc. Natl. Acad. Sci. U.S.A. 104:654-659(2007) [PubMed] [Europe PMC] [Abstract]
• protein heterotrimerization Source: MGIInferred from sequence orthologyⁱ
  • "The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity."
    Aoyama C., Sugimoto H., Ando H., Yamashita S., Horibata Y., Sugimoto S., Satou M.
    Biochem. J. 440:241-250(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of melanocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Effects of G-protein mutations on skin color."
    Van Raamsdonk C.D., Fitch K.R., Fuchs H., de Angelis M.H., Barsh G.S.
    Nat. Genet. 36:961-968(2004) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • "Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice."
    Offermanns S., Zhao L.P., Gohla A., Sarosi I., Simon M.I., Wilkie T.M.
    EMBO J. 17:4304-4312(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• G protein-coupled receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• type 2A serotonin receptor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES 
        60         70         80         90        100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL 
       110        120        130        140        150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE 
       160        170        180        190        200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII 
       210        220        230        240        250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 
       260        270        280        290        300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 
       310        320        330        340        350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 

LNLKEYNLV                                              

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot