Gna11

Functionⁱ

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	53	MagnesiumBy similarity	1
Metal bindingⁱ	186	MagnesiumBy similarity	1
Binding siteⁱ	331	GTP; via amide nitrogenBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	46 – 53	GTPBy similarity	8
Nucleotide bindingⁱ	180 – 186	GTPBy similarity	7
Nucleotide bindingⁱ	205 – 209	GTPBy similarity	5
Nucleotide bindingⁱ	274 – 277	GTPBy similarity	4

GO - Molecular functionⁱ

alkylglycerophosphoethanolamine phosphodiesterase activity
Source: MGI
Inferred from sequence orthologyⁱ
- 21812758
G-protein beta/gamma-subunit complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTPase activity
Source: MGI
Inferred from sequence alignmentⁱ
- 2508088
GTP binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein-containing complex binding Source: MGI
type 2A serotonin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

action potential
Source: MGI
Inferred from direct assayⁱ
- 10818132
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to pH
Source: MGI
Inferred from mutant phenotypeⁱ
- 22733973
developmental pigmentation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15322542
G protein-coupled receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 9687499
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 9687499
phospholipase C-activating dopamine receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 17194762
protein heterotrimerization
Source: MGI
Inferred from sequence orthologyⁱ
- 21812758
regulation of melanocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15322542
skeletal system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 9687499

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transducer
Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-399997 Acetylcholine regulates insulin secretion R-MMU-416476 G alpha (q) signalling events R-MMU-418592 ADP signalling through P2Y purinoceptor 1 R-MMU-428930 Thromboxane signalling through TP receptor R-MMU-432142 Platelet sensitization by LDL R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Reactomeⁱ

R-MMU-399997 Acetylcholine regulates insulin secretion
R-MMU-416476 G alpha (q) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432142 Platelet sensitization by LDL
R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein subunit alpha-11 Short name: G alpha-11 Short name: G-protein subunit alpha-11
Gene namesⁱ	Name:Gna11 Synonyms:Gna-11
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:95766 Gna11

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000203747	1 – 359	Guanine nucleotide-binding protein subunit alpha-11Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	9	S-palmitoyl cysteineBy similarity		1
Lipidationⁱ	10	S-palmitoyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Palmitate

Proteomic databases

EPDⁱ	P21278
PaxDbⁱ	P21278
PeptideAtlas More...PeptideAtlasⁱ	P21278
PRIDEⁱ	P21278

PTM databases

iPTMnetⁱ	P21278
PhosphoSitePlusⁱ	P21278
SwissPalmⁱ	P21278

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034781 Expressed in 293 organ(s), highest expression level in jejunum
CleanExⁱ	MM_GNA11
ExpressionAtlasⁱ	P21278 baseline and differential
Genevisibleⁱ	P21278 MM

Interactionⁱ

Subunit structureⁱ

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 (By similarity).By similarity

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type 2A serotonin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199961, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-603N
IntActⁱ	P21278, 2 interactors
STRINGⁱ	10090.ENSMUSP00000043190

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P21278
SMRⁱ	P21278
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118851
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P21278
KEGG Orthology (KO) More...KOⁱ	K04635
OMAⁱ	YKDEQNE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P21278
TreeFamⁱ	TF300673

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P21278-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES 
        60         70         80         90        100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL 
       110        120        130        140        150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE 
       160        170        180        190        200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII 
       210        220        230        240        250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 
       260        270        280        290        300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 
       310        320        330        340        350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 

LNLKEYNLV

Length:359

Mass (Da):42,024

Last modified:May 1, 1991 - v1

Checksum:ⁱA33D2D6C6C62F8D5

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	77	K → L in AAB36839 (PubMed:8838318).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55411 mRNA Translation: AAA63305.1 U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1 M57617 mRNA Translation: AAA63301.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24061.1
PIRⁱ	B33833 B38414 RGMS11
NCBI Reference Sequences More...RefSeqⁱ	NP_034431.1, NM_010301.3
UniGeneⁱ	Mm.260925 Mm.471081

Genome annotation databases

Ensemblⁱ	ENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781
GeneIDⁱ	14672
KEGGⁱ	mmu:14672
UCSC genome browser More...UCSCⁱ	uc007gil.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21278	Guanine nucleotide binding protein, alpha 11		MOUSE		359	UniRef100_P21278
Guanine nucleotide binding protein alpha 11		CRIGR		359

Protein	Similar proteins		Species	Score	Length	Source
P21278	Guanine nucleotide-binding protein subunit alpha-11		HUMAN		359	UniRef90_P29992
Guanine nucleotide-binding protein subunit alpha-11		BOVIN		359
Guanine nucleotide-binding protein subunit alpha-11		MELGA		359
Guanine nucleotide-binding protein subunit alpha-11		PIG		359
Guanine nucleotide-binding protein subunit alpha-11		RAT		359
+186

Protein	Similar proteins		Species	Score	Length	Source
P21278	Guanine nucleotide-binding protein subunit alpha-11		HUMAN		359	UniRef50_P29992
Guanine nucleotide-binding protein subunit alpha-11		MELGA		359
Guanine nucleotide-binding protein G(q) subunit alpha		XENLA		359
Guanine nucleotide-binding protein subunit alpha-11		RAT		359
Guanine nucleotide-binding protein subunit alpha-11		PIG		359
+427

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55411 mRNA Translation: AAA63305.1 U37413, U37411, U37412 Genomic DNA Translation: AAB36839.1 M57617 mRNA Translation: AAA63301.1
CCDSⁱ	CCDS24061.1
PIRⁱ	B33833 B38414 RGMS11
RefSeqⁱ	NP_034431.1, NM_010301.3
UniGeneⁱ	Mm.260925 Mm.471081

3D structure databases

ProteinModelPortalⁱ	P21278
SMRⁱ	P21278
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199961, 3 interactors
DIPⁱ	DIP-603N
IntActⁱ	P21278, 2 interactors
STRINGⁱ	10090.ENSMUSP00000043190

PTM databases

iPTMnetⁱ	P21278
PhosphoSitePlusⁱ	P21278
SwissPalmⁱ	P21278

Proteomic databases

EPDⁱ	P21278
PaxDbⁱ	P21278
PeptideAtlasⁱ	P21278
PRIDEⁱ	P21278

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781
GeneIDⁱ	14672
KEGGⁱ	mmu:14672
UCSCⁱ	uc007gil.1 mouse

Organism-specific databases

CTDⁱ	2767
MGIⁱ	MGI:95766 Gna11

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
GeneTreeⁱ	ENSGT00760000118851
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P21278
KOⁱ	K04635
OMAⁱ	YKDEQNE
OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P21278
TreeFamⁱ	TF300673

Enzyme and pathway databases

Reactomeⁱ	R-MMU-399997 Acetylcholine regulates insulin secretion R-MMU-416476 G alpha (q) signalling events R-MMU-418592 ADP signalling through P2Y purinoceptor 1 R-MMU-428930 Thromboxane signalling through TP receptor R-MMU-432142 Platelet sensitization by LDL R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Reactomeⁱ

R-MMU-399997 Acetylcholine regulates insulin secretion
R-MMU-416476 G alpha (q) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432142 Platelet sensitization by LDL
R-MMU-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

ChiTaRSⁱ	Gna11 mouse
Protein Ontology More...PROⁱ	PR:P21278
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034781 Expressed in 293 organ(s), highest expression level in jejunum
CleanExⁱ	MM_GNA11
ExpressionAtlasⁱ	P21278 baseline and differential
Genevisibleⁱ	P21278 MM

Family and domain databases

CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GNA11_MOUSE
Accessionⁱ	P21278Primary (citable) accession number: P21278 Secondary accession number(s): Q61939
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	May 1, 1991
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P21278 (GNA11_MOUSE)

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Guanine nucleotide-binding protein subunit alpha-11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ