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Entry version 164 (16 Oct 2019)
Sequence version 1 (01 May 1991)
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Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (PubMed:8139657, PubMed:15486301, PubMed:17023662, PubMed:27457814, PubMed:29909994).5 Publications
BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) (PubMed:27457814). Binding to NGFR and SORCS2 promotes neuronal apoptosis (PubMed:24908487). Promotes neuronal growth cone collapse (PubMed:24908487, PubMed:27457814).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-MMU-9032759 NTRK2 activates RAC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brain-derived neurotrophic factor1 Publication
Short name:
BDNF1 Publication
Cleaved into the following chain:
BDNF precursor formCurated
Short name:
ProBDNFCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bdnf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88145 Bdnf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice are smaller than wild-type littermates, and most die during the second week after birth. They exhibit impaired motor coordination and balance, head bobbing and tilting, and spinning during perionds of hyperactivity. Mutant mice display a strongly reduced number of neurons in the dorsal root ganglion, trigeminal ganglion, mesencephalic trigeminal nucleus, vestibular ganglion and nodose ganglion. Cell death of vestibular ganglion neurons is strongly increased 14 days after birth. The number of facial motor neurons and sympathetic superior cervical ganglion neurons are not decreased. Mutant mice display defects in the innervation of the inner ear, but respond to auditory stimuli. Tne inner ear from mutant mice has fewer nerve fibers that enter the sacculus, utricle and ampulla of the semicircular ducts, and axons fail to contact their target cells and terminate in the connective tissue adjacent to the sensory epithelia of the sacculus.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68V → M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Decreased density of dendritic mushroom spines and synapses. Impaired fear extinction. Increased anxiety-related behaviors. 2 Publications1
Mutagenesisi130R → K: Forms homodimers processed at L-112 that seem more stable than the wild-type. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044753619 – 249BDNF precursor formCuratedAdd BLAST231
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001963519 – 1301 PublicationAdd BLAST112
ChainiPRO_0000019636131 – 249Brain-derived neurotrophic factorCuratedAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contrary to mature BDNF, the propeptide is N-glycosylated and glycosulfated.By similarity
Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (By similarity). Can be converted into mature BDNF by plasmin (PLG) (PubMed:15486301).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60Cleavage; by MBTPS1By similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21237

PRoteomics IDEntifications database

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PRIDEi
P21237

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21237

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21237

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:28111162). Detected in brain, especially in brain cortex, hippocampus, midbrain and cerebellum (PubMed:2369898, PubMed:8139657).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain (PubMed:23785138). Expressed at higher levels during the dark period and at lower levels during the light period (PubMed:23785138). Up-regulated after sciatic nerve injury (PubMed:28111162).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048482 Expressed in 190 organ(s), highest expression level in dentate gyrus of hippocampal formation

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P21237 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P21237 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomers and homodimers (PubMed:7957235). Binds to NTRK2/TRKB (By similarity). Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (PubMed:24908487).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-5724N

Protein interaction database and analysis system

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IntActi
P21237, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000057989

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH7X Eukaryota
ENOG410XRPH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231516

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P21237

KEGG Orthology (KO)

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KOi
K04355

Database of Orthologous Groups

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OrthoDBi
1156054at2759

TreeFam database of animal gene trees

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TreeFami
TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS

The PANTHER Classification System

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PANTHERi
PTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00243 NGF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001789 NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01912 BDNFACTOR
PR00268 NGF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140 NGF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P21237-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,123
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90CE1F16BB235C97
GO
Isoform 2 (identifier: P21237-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFHQVRRVM

Show »
Length:257
Mass (Da):29,178
Checksum:i45A76B4E72559CA9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9H9S8H9H9S8_MOUSE
Brain-derived neurotrophic factor
Bdnf
289Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232F → L in BAC28164 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0602021M → MFHQVRRVM in isoform 2. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X55573 mRNA Translation: CAA39159.1
AK033127 mRNA Translation: BAC28164.1
AL732477 Genomic DNA No translation available.
BC034862 mRNA Translation: AAH34862.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38193.1 [P21237-2]
CCDS38194.1 [P21237-1]

Protein sequence database of the Protein Information Resource

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PIRi
S12555

NCBI Reference Sequences

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RefSeqi
NP_001041604.1, NM_001048139.1 [P21237-1]
NP_001041606.1, NM_001048141.1 [P21237-1]
NP_001041607.1, NM_001048142.1 [P21237-1]
NP_001272345.1, NM_001285416.1 [P21237-1]
NP_001272346.1, NM_001285417.1 [P21237-1]
NP_001272347.1, NM_001285418.1 [P21237-1]
NP_001272348.1, NM_001285419.1 [P21237-1]
NP_001272349.1, NM_001285420.1 [P21237-1]
NP_001272350.1, NM_001285421.1 [P21237-1]
NP_001272351.1, NM_001285422.1 [P21237-1]
NP_001303239.1, NM_001316310.1 [P21237-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000053317; ENSMUSP00000057989; ENSMUSG00000048482 [P21237-2]
ENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482 [P21237-1]
ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482 [P21237-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
12064

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:12064

UCSC genome browser

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UCSCi
uc008lme.1 mouse [P21237-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55573 mRNA Translation: CAA39159.1
AK033127 mRNA Translation: BAC28164.1
AL732477 Genomic DNA No translation available.
BC034862 mRNA Translation: AAH34862.1
CCDSiCCDS38193.1 [P21237-2]
CCDS38194.1 [P21237-1]
PIRiS12555
RefSeqiNP_001041604.1, NM_001048139.1 [P21237-1]
NP_001041606.1, NM_001048141.1 [P21237-1]
NP_001041607.1, NM_001048142.1 [P21237-1]
NP_001272345.1, NM_001285416.1 [P21237-1]
NP_001272346.1, NM_001285417.1 [P21237-1]
NP_001272347.1, NM_001285418.1 [P21237-1]
NP_001272348.1, NM_001285419.1 [P21237-1]
NP_001272349.1, NM_001285420.1 [P21237-1]
NP_001272350.1, NM_001285421.1 [P21237-1]
NP_001272351.1, NM_001285422.1 [P21237-1]
NP_001303239.1, NM_001316310.1 [P21237-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-5724N
IntActiP21237, 2 interactors
STRINGi10090.ENSMUSP00000057989

PTM databases

iPTMnetiP21237
PhosphoSitePlusiP21237

Proteomic databases

PaxDbiP21237
PRIDEiP21237

Genome annotation databases

EnsembliENSMUST00000053317; ENSMUSP00000057989; ENSMUSG00000048482 [P21237-2]
ENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482 [P21237-1]
ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482 [P21237-1]
ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482 [P21237-1]
GeneIDi12064
KEGGimmu:12064
UCSCiuc008lme.1 mouse [P21237-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
627
MGIiMGI:88145 Bdnf

Phylogenomic databases

eggNOGiENOG410IH7X Eukaryota
ENOG410XRPH LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
InParanoidiP21237
KOiK04355
OrthoDBi1156054at2759
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-MMU-9032759 NTRK2 activates RAC1

Miscellaneous databases

Protein Ontology

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PROi
PR:P21237

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000048482 Expressed in 190 organ(s), highest expression level in dentate gyrus of hippocampal formation
ExpressionAtlasiP21237 baseline and differential
GenevisibleiP21237 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBDNF_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21237
Secondary accession number(s): A2AII2, Q8CCH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 16, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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