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Entry version 197 (07 Oct 2020)
Sequence version 1 (01 May 1991)
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Protein

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

Gene

FUT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:12668675, PubMed:1977660, PubMed:11058871). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:12668675, PubMed:11058871, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme (PubMed:1977660).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 mM for beta-D-Gal-(1->3)-beta-D-GlcNAc-O-CH28-COOCH31 Publication
  2. KM=0.10 mM for fucalpha1->2Galbeta1->3GlcNAcbeta-O-CH28-COOCH31 Publication
  3. KM=0.58 mM for NeuAca2->3GAlb1->3GlcNAcB-O-CH28-COOCH31 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionBlood group antigen, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS10249-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.65, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P21217

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-9037629, Lewis blood group biosynthesis
    R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P21217

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT10, Glycosyltransferase Family 10

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001370

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3Curated (EC:2.4.1.652 Publications)
    Alternative name(s):
    Alpha-3-fucosyltransferase FUT3Curated (EC:2.4.1.-1 Publication)
    Blood group Lewis alpha-4-fucosyltransferase
    Short name:
    Lewis FT
    Fucosyltransferase 3
    Fucosyltransferase III
    Short name:
    FucT-III
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FUT3Imported
    Synonyms:FT3B, LE
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000171124.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4014, FUT3

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    111100, gene+phenotype

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P21217

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysis1 PublicationAdd BLAST19
    Topological domaini35 – 361LumenalSequence analysisAdd BLAST327

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2525
    MIMi111100, gene+phenotype

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA28430

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P21217, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3269

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    FUT3

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    121137

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210961 – 3613-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3Add BLAST361

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineCurated1
    Glycosylationi185N-linked (GlcNAc...) asparagineCurated1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P21217

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P21217

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P21217

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P21217

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P21217

    PeptideAtlas

    More...
    PeptideAtlasi
    P21217

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P21217

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    53853

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    P21217, 2 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P21217

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P21217

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000171124, Expressed in lower esophagus mucosa and 161 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P21217, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P21217, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000171124, Tissue enhanced (esophagus, intestine, lymphoid tissue)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108801, 25 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P21217, 21 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000305603

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P21217, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2619, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_032075_4_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P21217

    KEGG Orthology (KO)

    More...
    KOi
    K00716

    Database of Orthologous Groups

    More...
    OrthoDBi
    551308at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P21217

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF316348

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.11660, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR031481, Glyco_tran_10_N
    IPR001503, Glyco_trans_10
    IPR038577, GT10-like_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11929, PTHR11929, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17039, Glyco_tran_10_N, 1 hit
    PF00852, Glyco_transf_10, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    P21217-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG
    60 70 80 90 100
    SSRQDTTPTR PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY
    110 120 130 140 150
    PQADTVIVHH WDIMSNPKSR LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD
    160 170 180 190 200
    RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA HPPLNLSAKT ELVAWAVSNW
    210 220 230 240 250
    KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR YKFYLAFENS
    260 270 280 290 300
    LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK
    310 320 330 340 350
    DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY
    360
    QTVRSIAAWF T
    Length:361
    Mass (Da):42,117
    Last modified:May 1, 1991 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF4398044F19C284
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7ENT3K7ENT3_HUMAN
    3-galactosyl-N-acetylglucosaminide ...
    FUT3
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ES24K7ES24_HUMAN
    3-galactosyl-N-acetylglucosaminide ...
    FUT3
    100Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EQ20K7EQ20_HUMAN
    3-galactosyl-N-acetylglucosaminide ...
    FUT3
    44Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0222005G → S1 PublicationCorresponds to variant dbSNP:rs28362458Ensembl.1
    Natural variantiVAR_00342620L → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs28362459EnsemblClinVar.1
    Natural variantiVAR_00795968W → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs812936Ensembl.1
    Natural variantiVAR_007960102Q → K in Le(+). 1 PublicationCorresponds to variant dbSNP:rs59796499Ensembl.1
    Natural variantiVAR_003427105T → M in Le(-). 6 PublicationsCorresponds to variant dbSNP:rs778986Ensembl.1
    Natural variantiVAR_007961124S → A in Le(+). 1 PublicationCorresponds to variant dbSNP:rs1175404919Ensembl.1
    Natural variantiVAR_022201160R → C1 PublicationCorresponds to variant dbSNP:rs28362462Ensembl.1
    Natural variantiVAR_007962162D → N in Le(-); about 20% of alpha (1,3/1,4)fucosyltransferase activity. 3 PublicationsCorresponds to variant dbSNP:rs28362463Ensembl.1
    Natural variantiVAR_003428170G → S in Le(-); completely inactive. 3 PublicationsCorresponds to variant dbSNP:rs3745635EnsemblClinVar.1
    Natural variantiVAR_007963223G → R in Le(-); Loss of alpha (1,3/1,4)fucosyltransferase activity.. 3 PublicationsCorresponds to variant dbSNP:rs28362466Ensembl.1
    Natural variantiVAR_007964270V → M in Le(-); Loss of alpha (1,3/1,4)fucosyltransferase activity.. 3 PublicationsCorresponds to variant dbSNP:rs28381968Ensembl.1
    Natural variantiVAR_022202325T → M1 PublicationCorresponds to variant dbSNP:rs28381969Ensembl.1
    Natural variantiVAR_022203327R → Q1 PublicationCorresponds to variant dbSNP:rs28381970Ensembl.1
    Natural variantiVAR_003429336D → A in Le(-). 1 PublicationCorresponds to variant dbSNP:rs151218854Ensembl.1
    Natural variantiVAR_003430356I → K in Le(-); less than 10% reduction in activity. 3 PublicationsCorresponds to variant dbSNP:rs3894326Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X53578 mRNA Translation: CAA37641.1
    U27326 mRNA Translation: AAC50185.1
    U27327 mRNA Translation: AAC50186.1
    U27328 mRNA Translation: AAC50187.1
    D89324 Genomic DNA Translation: BAA13941.1
    D89325 Genomic DNA Translation: BAA13942.1
    AF131913 mRNA Translation: AAD33514.1
    FM210024 Genomic DNA Translation: CAR64692.1
    FM210025 Genomic DNA Translation: CAR64693.1
    AY870341 Genomic DNA Translation: AAW34365.1
    AC024592 Genomic DNA No translation available.
    BC074836 mRNA Translation: AAH74836.1
    BC074837 mRNA Translation: AAH74837.1
    BC108675 mRNA Translation: AAI08676.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12153.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A36669

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000140.1, NM_000149.3
    NP_001091108.1, NM_001097639.1
    NP_001091109.1, NM_001097640.1
    NP_001091110.1, NM_001097641.1
    XP_011526167.1, XM_011527865.1
    XP_011526168.1, XM_011527866.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000303225; ENSP00000305603; ENSG00000171124
    ENST00000458379; ENSP00000416443; ENSG00000171124
    ENST00000589620; ENSP00000465804; ENSG00000171124
    ENST00000589918; ENSP00000468123; ENSG00000171124

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2525

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2525

    UCSC genome browser

    More...
    UCSCi
    uc002mdj.3, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs
    Functional Glycomics Gateway - GTase

    Fucosyltransferase 3

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X53578 mRNA Translation: CAA37641.1
    U27326 mRNA Translation: AAC50185.1
    U27327 mRNA Translation: AAC50186.1
    U27328 mRNA Translation: AAC50187.1
    D89324 Genomic DNA Translation: BAA13941.1
    D89325 Genomic DNA Translation: BAA13942.1
    AF131913 mRNA Translation: AAD33514.1
    FM210024 Genomic DNA Translation: CAR64692.1
    FM210025 Genomic DNA Translation: CAR64693.1
    AY870341 Genomic DNA Translation: AAW34365.1
    AC024592 Genomic DNA No translation available.
    BC074836 mRNA Translation: AAH74836.1
    BC074837 mRNA Translation: AAH74837.1
    BC108675 mRNA Translation: AAI08676.1
    CCDSiCCDS12153.1
    PIRiA36669
    RefSeqiNP_000140.1, NM_000149.3
    NP_001091108.1, NM_001097639.1
    NP_001091109.1, NM_001097640.1
    NP_001091110.1, NM_001097641.1
    XP_011526167.1, XM_011527865.1
    XP_011526168.1, XM_011527866.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi108801, 25 interactors
    IntActiP21217, 21 interactors
    STRINGi9606.ENSP00000305603

    Chemistry databases

    ChEMBLiCHEMBL3269
    SwissLipidsiSLP:000001370

    Protein family/group databases

    CAZyiGT10, Glycosyltransferase Family 10

    PTM databases

    GlyGeniP21217, 2 sites
    iPTMnetiP21217
    PhosphoSitePlusiP21217

    Polymorphism and mutation databases

    BioMutaiFUT3
    DMDMi121137

    Proteomic databases

    EPDiP21217
    jPOSTiP21217
    MassIVEiP21217
    MaxQBiP21217
    PaxDbiP21217
    PeptideAtlasiP21217
    PRIDEiP21217
    ProteomicsDBi53853

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    11767, 505 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    2525

    Genome annotation databases

    EnsembliENST00000303225; ENSP00000305603; ENSG00000171124
    ENST00000458379; ENSP00000416443; ENSG00000171124
    ENST00000589620; ENSP00000465804; ENSG00000171124
    ENST00000589918; ENSP00000468123; ENSG00000171124
    GeneIDi2525
    KEGGihsa:2525
    UCSCiuc002mdj.3, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2525
    DisGeNETi2525
    EuPathDBiHostDB:ENSG00000171124.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    FUT3
    HGNCiHGNC:4014, FUT3
    HPAiENSG00000171124, Tissue enhanced (esophagus, intestine, lymphoid tissue)
    MIMi111100, gene+phenotype
    neXtProtiNX_P21217
    PharmGKBiPA28430

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2619, Eukaryota
    HOGENOMiCLU_032075_4_1_1
    InParanoidiP21217
    KOiK00716
    OrthoDBi551308at2759
    PhylomeDBiP21217
    TreeFamiTF316348

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BioCyciMetaCyc:HS10249-MONOMER
    BRENDAi2.4.1.65, 2681
    PathwayCommonsiP21217
    ReactomeiR-HSA-9037629, Lewis blood group biosynthesis
    R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway
    SIGNORiP21217

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    2525, 2 hits in 867 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    FUT3, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Fucosyltransferase_3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2525
    PharosiP21217, Tbio

    Protein Ontology

    More...
    PROi
    PR:P21217
    RNActiP21217, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000171124, Expressed in lower esophagus mucosa and 161 other tissues
    ExpressionAtlasiP21217, baseline and differential
    GenevisibleiP21217, HS

    Family and domain databases

    Gene3Di3.40.50.11660, 1 hit
    InterProiView protein in InterPro
    IPR031481, Glyco_tran_10_N
    IPR001503, Glyco_trans_10
    IPR038577, GT10-like_sf
    PANTHERiPTHR11929, PTHR11929, 1 hit
    PfamiView protein in Pfam
    PF17039, Glyco_tran_10_N, 1 hit
    PF00852, Glyco_transf_10, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT3_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21217
    Secondary accession number(s): B5U7U9
    , B5U7V0, Q32NE7, Q99448, Q99449
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 7, 2020
    This is version 197 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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