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Protein

Galactoside 3(4)-L-fucosyltransferase

Gene

FUT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cell-cell recognition Source: BHF-UCL
  • ceramide metabolic process Source: BHF-UCL
  • macromolecule glycosylation Source: BHF-UCL
  • oligosaccharide biosynthetic process Source: BHF-UCL
  • protein glycosylation Source: UniProtKB-UniPathway

Keywordsi

Molecular functionBlood group antigen, Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS10249-MONOMER
BRENDAi2.4.1.65 2681
ReactomeiR-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORiP21217
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Chemistry databases

SwissLipidsiSLP:000001370

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 3(4)-L-fucosyltransferase (EC:2.4.1.65)
Alternative name(s):
Blood group Lewis alpha-4-fucosyltransferase
Short name:
Lewis FT
Fucosyltransferase 3
Fucosyltransferase III
Short name:
FucT-III
Gene namesi
Name:FUT3
Synonyms:FT3B, LE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171124.12
HGNCiHGNC:4014 FUT3
MIMi111100 gene+phenotype
neXtProtiNX_P21217

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini35 – 361LumenalSequence analysisAdd BLAST327

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2525
MIMi111100 gene+phenotype
PharmGKBiPA28430

Chemistry databases

ChEMBLiCHEMBL3269

Polymorphism and mutation databases

BioMutaiFUT3
DMDMi121137

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210961 – 361Galactoside 3(4)-L-fucosyltransferaseAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineCurated1
Glycosylationi185N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP21217
MaxQBiP21217
PaxDbiP21217
PeptideAtlasiP21217
PRIDEiP21217
ProteomicsDBi53853

PTM databases

iPTMnetiP21217
PhosphoSitePlusiP21217

Expressioni

Tissue specificityi

Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

Gene expression databases

BgeeiENSG00000171124
CleanExiHS_FUT3
ExpressionAtlasiP21217 baseline and differential
GenevisibleiP21217 HS

Organism-specific databases

HPAiHPA046966

Interactioni

Protein-protein interaction databases

BioGridi108801, 20 interactors
IntActiP21217, 5 interactors
STRINGi9606.ENSP00000305603

Structurei

3D structure databases

ProteinModelPortaliP21217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiP21217
KOiK00716
OrthoDBiEOG091G0846
PhylomeDBiP21217
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequencei

Sequence statusi: Complete.

P21217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG
60 70 80 90 100
SSRQDTTPTR PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY
110 120 130 140 150
PQADTVIVHH WDIMSNPKSR LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD
160 170 180 190 200
RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA HPPLNLSAKT ELVAWAVSNW
210 220 230 240 250
KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR YKFYLAFENS
260 270 280 290 300
LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK
310 320 330 340 350
DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY
360
QTVRSIAAWF T
Length:361
Mass (Da):42,117
Last modified:May 1, 1991 - v1
Checksum:iBF4398044F19C284
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0222005G → S1 PublicationCorresponds to variant dbSNP:rs28362458Ensembl.1
Natural variantiVAR_00342620L → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs28362459EnsemblClinVar.1
Natural variantiVAR_00795968W → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs812936Ensembl.1
Natural variantiVAR_007960102Q → K in Le(+). 1 PublicationCorresponds to variant dbSNP:rs59796499Ensembl.1
Natural variantiVAR_003427105T → M in Le(-). 6 PublicationsCorresponds to variant dbSNP:rs778986Ensembl.1
Natural variantiVAR_007961124S → A in Le(+). 1 Publication1
Natural variantiVAR_022201160R → C1 PublicationCorresponds to variant dbSNP:rs28362462Ensembl.1
Natural variantiVAR_007962162D → N in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28362463Ensembl.1
Natural variantiVAR_003428170G → S in Le(-); completely inactive. 3 PublicationsCorresponds to variant dbSNP:rs3745635EnsemblClinVar.1
Natural variantiVAR_007963223G → R in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28362466Ensembl.1
Natural variantiVAR_007964270V → M in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28381968Ensembl.1
Natural variantiVAR_022202325T → M1 PublicationCorresponds to variant dbSNP:rs28381969Ensembl.1
Natural variantiVAR_022203327R → Q1 PublicationCorresponds to variant dbSNP:rs28381970Ensembl.1
Natural variantiVAR_003429336D → A in Le(-). 1 Publication1
Natural variantiVAR_003430356I → K in Le(-); less than 10% reduction in activity. 3 PublicationsCorresponds to variant dbSNP:rs3894326Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53578 mRNA Translation: CAA37641.1
U27326 mRNA Translation: AAC50185.1
U27327 mRNA Translation: AAC50186.1
U27328 mRNA Translation: AAC50187.1
D89324 Genomic DNA Translation: BAA13941.1
D89325 Genomic DNA Translation: BAA13942.1
AF131913 mRNA Translation: AAD33514.1
FM210024 Genomic DNA Translation: CAR64692.1
FM210025 Genomic DNA Translation: CAR64693.1
AY870341 Genomic DNA Translation: AAW34365.1
AC024592 Genomic DNA No translation available.
BC074836 mRNA Translation: AAH74836.1
BC074837 mRNA Translation: AAH74837.1
BC108675 mRNA Translation: AAI08676.1
CCDSiCCDS12153.1
PIRiA36669
RefSeqiNP_000140.1, NM_000149.3
NP_001091108.1, NM_001097639.1
NP_001091109.1, NM_001097640.1
NP_001091110.1, NM_001097641.1
XP_011526167.1, XM_011527865.1
XP_011526168.1, XM_011527866.1
XP_011526169.1, XM_011527867.1
UniGeneiHs.169238

Genome annotation databases

EnsembliENST00000303225; ENSP00000305603; ENSG00000171124
ENST00000458379; ENSP00000416443; ENSG00000171124
ENST00000589620; ENSP00000465804; ENSG00000171124
ENST00000589918; ENSP00000468123; ENSG00000171124
GeneIDi2525
KEGGihsa:2525
UCSCiuc002mdj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFUT3_HUMAN
AccessioniPrimary (citable) accession number: P21217
Secondary accession number(s): B5U7U9
, B5U7V0, Q32NE7, Q99448, Q99449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 18, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. SIMILARITY comments
    Index of protein domains and families

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