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Protein

Galactoside 3(4)-L-fucosyltransferase

Gene

FUT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell-cell recognition Source: BHF-UCL
  • ceramide metabolic process Source: BHF-UCL
  • fucosylation Source: GO_Central
  • macromolecule glycosylation Source: BHF-UCL
  • oligosaccharide biosynthetic process Source: BHF-UCL
  • protein glycosylation Source: UniProtKB-UniPathway

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10249-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.65 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21217

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT10 Glycosyltransferase Family 10

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001370

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galactoside 3(4)-L-fucosyltransferase (EC:2.4.1.65)
Alternative name(s):
Blood group Lewis alpha-4-fucosyltransferase
Short name:
Lewis FT
Fucosyltransferase 3
Fucosyltransferase III
Short name:
FucT-III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUT3
Synonyms:FT3B, LE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171124.12

Human Gene Nomenclature Database

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HGNCi
HGNC:4014 FUT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
111100 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21217

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini35 – 361LumenalSequence analysisAdd BLAST327

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2525
MIMi111100 gene+phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28430

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3269

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUT3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121137

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210961 – 361Galactoside 3(4)-L-fucosyltransferaseAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineCurated1
Glycosylationi185N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21217

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21217

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21217

PeptideAtlas

More...
PeptideAtlasi
P21217

PRoteomics IDEntifications database

More...
PRIDEi
P21217

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21217

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21217

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171124 Expressed in 144 organ(s), highest expression level in lower esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_FUT3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21217 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21217 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046966

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108801, 20 interactors

Protein interaction database and analysis system

More...
IntActi
P21217, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P21217

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2619 Eukaryota
ENOG410ZIMX LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045583

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000274

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21217

KEGG Orthology (KO)

More...
KOi
K00716

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0846

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21217

TreeFam database of animal gene trees

More...
TreeFami
TF316348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11929 PTHR11929, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P21217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG
60 70 80 90 100
SSRQDTTPTR PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY
110 120 130 140 150
PQADTVIVHH WDIMSNPKSR LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD
160 170 180 190 200
RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA HPPLNLSAKT ELVAWAVSNW
210 220 230 240 250
KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR YKFYLAFENS
260 270 280 290 300
LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK
310 320 330 340 350
DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY
360
QTVRSIAAWF T
Length:361
Mass (Da):42,117
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF4398044F19C284
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENT3K7ENT3_HUMAN
Galactoside 3(4)-L-fucosyltransfera...
FUT3
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES24K7ES24_HUMAN
Galactoside 3(4)-L-fucosyltransfera...
FUT3
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ20K7EQ20_HUMAN
Galactoside 3(4)-L-fucosyltransfera...
FUT3
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0222005G → S1 PublicationCorresponds to variant dbSNP:rs28362458Ensembl.1
Natural variantiVAR_00342620L → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs28362459EnsemblClinVar.1
Natural variantiVAR_00795968W → R in Le(-). 5 PublicationsCorresponds to variant dbSNP:rs812936Ensembl.1
Natural variantiVAR_007960102Q → K in Le(+). 1 PublicationCorresponds to variant dbSNP:rs59796499Ensembl.1
Natural variantiVAR_003427105T → M in Le(-). 6 PublicationsCorresponds to variant dbSNP:rs778986Ensembl.1
Natural variantiVAR_007961124S → A in Le(+). 1 Publication1
Natural variantiVAR_022201160R → C1 PublicationCorresponds to variant dbSNP:rs28362462Ensembl.1
Natural variantiVAR_007962162D → N in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28362463Ensembl.1
Natural variantiVAR_003428170G → S in Le(-); completely inactive. 3 PublicationsCorresponds to variant dbSNP:rs3745635EnsemblClinVar.1
Natural variantiVAR_007963223G → R in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28362466Ensembl.1
Natural variantiVAR_007964270V → M in Le(-). 2 PublicationsCorresponds to variant dbSNP:rs28381968Ensembl.1
Natural variantiVAR_022202325T → M1 PublicationCorresponds to variant dbSNP:rs28381969Ensembl.1
Natural variantiVAR_022203327R → Q1 PublicationCorresponds to variant dbSNP:rs28381970Ensembl.1
Natural variantiVAR_003429336D → A in Le(-). 1 Publication1
Natural variantiVAR_003430356I → K in Le(-); less than 10% reduction in activity. 3 PublicationsCorresponds to variant dbSNP:rs3894326Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53578 mRNA Translation: CAA37641.1
U27326 mRNA Translation: AAC50185.1
U27327 mRNA Translation: AAC50186.1
U27328 mRNA Translation: AAC50187.1
D89324 Genomic DNA Translation: BAA13941.1
D89325 Genomic DNA Translation: BAA13942.1
AF131913 mRNA Translation: AAD33514.1
FM210024 Genomic DNA Translation: CAR64692.1
FM210025 Genomic DNA Translation: CAR64693.1
AY870341 Genomic DNA Translation: AAW34365.1
AC024592 Genomic DNA No translation available.
BC074836 mRNA Translation: AAH74836.1
BC074837 mRNA Translation: AAH74837.1
BC108675 mRNA Translation: AAI08676.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36669

NCBI Reference Sequences

More...
RefSeqi
NP_000140.1, NM_000149.3
NP_001091108.1, NM_001097639.1
NP_001091109.1, NM_001097640.1
NP_001091110.1, NM_001097641.1
XP_011526167.1, XM_011527865.1
XP_011526168.1, XM_011527866.1
XP_011526169.1, XM_011527867.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.169238

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303225; ENSP00000305603; ENSG00000171124
ENST00000458379; ENSP00000416443; ENSG00000171124
ENST00000589620; ENSP00000465804; ENSG00000171124
ENST00000589918; ENSP00000468123; ENSG00000171124

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2525

UCSC genome browser

More...
UCSCi
uc002mdj.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Functional Glycomics Gateway - GTase

Fucosyltransferase 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53578 mRNA Translation: CAA37641.1
U27326 mRNA Translation: AAC50185.1
U27327 mRNA Translation: AAC50186.1
U27328 mRNA Translation: AAC50187.1
D89324 Genomic DNA Translation: BAA13941.1
D89325 Genomic DNA Translation: BAA13942.1
AF131913 mRNA Translation: AAD33514.1
FM210024 Genomic DNA Translation: CAR64692.1
FM210025 Genomic DNA Translation: CAR64693.1
AY870341 Genomic DNA Translation: AAW34365.1
AC024592 Genomic DNA No translation available.
BC074836 mRNA Translation: AAH74836.1
BC074837 mRNA Translation: AAH74837.1
BC108675 mRNA Translation: AAI08676.1
CCDSiCCDS12153.1
PIRiA36669
RefSeqiNP_000140.1, NM_000149.3
NP_001091108.1, NM_001097639.1
NP_001091109.1, NM_001097640.1
NP_001091110.1, NM_001097641.1
XP_011526167.1, XM_011527865.1
XP_011526168.1, XM_011527866.1
XP_011526169.1, XM_011527867.1
UniGeneiHs.169238

3D structure databases

ProteinModelPortaliP21217
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108801, 20 interactors
IntActiP21217, 5 interactors
STRINGi9606.ENSP00000305603

Chemistry databases

ChEMBLiCHEMBL3269
SwissLipidsiSLP:000001370

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

PTM databases

iPTMnetiP21217
PhosphoSitePlusiP21217

Polymorphism and mutation databases

BioMutaiFUT3
DMDMi121137

Proteomic databases

EPDiP21217
MaxQBiP21217
PaxDbiP21217
PeptideAtlasiP21217
PRIDEiP21217
ProteomicsDBi53853

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2525
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303225; ENSP00000305603; ENSG00000171124
ENST00000458379; ENSP00000416443; ENSG00000171124
ENST00000589620; ENSP00000465804; ENSG00000171124
ENST00000589918; ENSP00000468123; ENSG00000171124
GeneIDi2525
KEGGihsa:2525
UCSCiuc002mdj.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2525
DisGeNETi2525
EuPathDBiHostDB:ENSG00000171124.12

GeneCards: human genes, protein and diseases

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GeneCardsi
FUT3
HGNCiHGNC:4014 FUT3
HPAiHPA046966
MIMi111100 gene+phenotype
neXtProtiNX_P21217
PharmGKBiPA28430

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiP21217
KOiK00716
OrthoDBiEOG091G0846
PhylomeDBiP21217
TreeFamiTF316348

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS10249-MONOMER
BRENDAi2.4.1.65 2681
ReactomeiR-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORiP21217

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FUT3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Fucosyltransferase_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2525

Protein Ontology

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PROi
PR:P21217

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171124 Expressed in 144 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_FUT3
ExpressionAtlasiP21217 baseline and differential
GenevisibleiP21217 HS

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21217
Secondary accession number(s): B5U7U9
, B5U7V0, Q32NE7, Q99448, Q99449
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: December 5, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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