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Protein

Soluble inorganic pyrophosphatase 2

Gene

PPA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateBy similarity1
Binding sitei82SubstrateBy similarity1
Active sitei90Proton donorBy similarity1
Binding sitei94SubstrateBy similarity1
Metal bindingi104Magnesium 1By similarity1
Metal bindingi109Magnesium 1By similarity1
Metal bindingi109Magnesium 2By similarity1
Metal bindingi141Magnesium 1By similarity1
Binding sitei178SubstrateBy similarity1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: TAIR
  • magnesium ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble inorganic pyrophosphatase 21 Publication (EC:3.6.1.1By similarity)
Alternative name(s):
Pyrophosphate phospho-hydrolase 21 Publication
Short name:
PPase 21 Publication
Gene namesi
Name:PPA21 Publication
Synonyms:PPA11 Publication
Ordered Locus Names:At2g18230Imported
ORF Names:T30D6.26Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18230
TAIRilocus:2062195 AT2G18230

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375741 – 218Soluble inorganic pyrophosphatase 2Add BLAST218

Proteomic databases

PaxDbiP21216
PRIDEiP21216

Expressioni

Gene expression databases

ExpressionAtlasiP21216 baseline and differential
GenevisibleiP21216 AT

Interactioni

Protein-protein interaction databases

BioGridi1695, 1 interactor
STRINGi3702.AT2G18230.1

Structurei

3D structure databases

ProteinModelPortaliP21216
SMRiP21216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiKOG1626 Eukaryota
COG0221 LUCA
HOGENOMiHOG000236472
InParanoidiP21216
KOiK01507
OMAiNTENMAN
OrthoDBiEOG09360MB0
PhylomeDBiP21216

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
HAMAPiMF_00209 Inorganic_PPase, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

P21216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIKDEGSA KGYAFPLRNP NVTLNERNFA AFTHRSAAAH PWHDLEIGPE
60 70 80 90 100
APTVFNCVVE ISKGGKVKYE LDKNSGLIKV DRVLYSSIVY PHNYGFIPRT
110 120 130 140 150
ICEDSDPMDV LVLMQEPVLT GSFLRARAIG LMPMIDQGEK DDKIIAVCAD
160 170 180 190 200
DPEFRHYRDI KELPPHRLAE IRRFFEDYKK NENKKVDVEA FLPAQAAIDA
210
IKDSMDLYAA YIKAGLQR
Length:218
Mass (Da):24,671
Last modified:December 6, 2002 - v2
Checksum:i884DCFAB6B1B239A
GO

Sequence cautioni

The sequence CAA40764 differs from that shown. Reason: Frameshift at position 209.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12G → A in AAM66110 (Ref. 5) Curated1
Sequence conflicti37A → S in AAM66110 (Ref. 5) Curated1
Sequence conflicti58V → A in CAA40764 (PubMed:1654155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57545 mRNA Translation: CAA40764.1 Frameshift.
AC006439 Genomic DNA Translation: AAD15513.1
CP002685 Genomic DNA Translation: AEC06742.1
AY048209 mRNA Translation: AAK82472.1
AY091698 mRNA Translation: AAM10297.1
AY088579 mRNA Translation: AAM66110.1
PIRiH84561
S13379
RefSeqiNP_179415.1, NM_127380.4
UniGeneiAt.22749

Genome annotation databases

EnsemblPlantsiAT2G18230.1; AT2G18230.1; AT2G18230
GeneIDi816338
GrameneiAT2G18230.1; AT2G18230.1; AT2G18230
KEGGiath:AT2G18230

Similar proteinsi

Entry informationi

Entry nameiIPYR2_ARATH
AccessioniPrimary (citable) accession number: P21216
Secondary accession number(s): Q8L988, Q9ZPV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 6, 2002
Last modified: April 25, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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