UniProtKB - P21203 (PHEA_BACSU)
Protein
Prephenate dehydratase
Gene
pheA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:4.2.1.51
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.Proteins known to be involved in this subpathway in this organism are:
- Prephenate dehydratase (pheA), Prephenate dehydratase (pheA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 176 | Essential for activityBy similarity | 1 |
GO - Molecular functioni
- chorismate mutase activity Source: InterPro
- prephenate dehydratase activity Source: GO_Central
GO - Biological processi
- L-phenylalanine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
BioCyci | BSUB:BSU27900-MONOMER |
UniPathwayi | UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pheA Ordered Locus Names:BSU27900 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119176 | 1 – 285 | Prephenate dehydrataseAdd BLAST | 285 |
Proteomic databases
PaxDbi | P21203 |
PRIDEi | P21203 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 183 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 204 – 281 | ACTPROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
eggNOGi | COG0077, Bacteria |
InParanoidi | P21203 |
OMAi | HTRFVIL |
PhylomeDBi | P21203 |
Family and domain databases
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P21203-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVGYLGPAA TFTHLAVSSC FQNGAEHVAY RTIPECIDAA VAGEVDFAFV
60 70 80 90 100
PLENALEGSV NLTIDYLIHE QPLPIVGEMT LPIHQHLLVH PSRENAWKEL
110 120 130 140 150
DKIYSHSHAI AQCHKFLHRH FPSVPYEYAN STGAAAKFVS DHPELNIGVI
160 170 180 190 200
ANDMAASTYE LKIVKRDIQD YRDNHTRFVI LSPDENISFE VNSKLSSRPK
210 220 230 240 250
TTLMVMLPQD DQSGALHRVL SAFSWRNLNL SKIESRPTKT GLGHYFFIID
260 270 280
IEKAFDDVLI PGAMQELEAL GCKVRLLGAY QSYQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24537 Genomic DNA Translation: AAA22507.1 AL009126 Genomic DNA Translation: CAB14750.1 M98822 Genomic DNA No translation available. |
PIRi | C32804 |
RefSeqi | NP_390668.1, NC_000964.3 WP_004398512.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14750; CAB14750; BSU27900 |
GeneIDi | 937513 |
KEGGi | bsu:BSU27900 |
PATRICi | fig|224308.179.peg.3031 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24537 Genomic DNA Translation: AAA22507.1 AL009126 Genomic DNA Translation: CAB14750.1 M98822 Genomic DNA No translation available. |
PIRi | C32804 |
RefSeqi | NP_390668.1, NC_000964.3 WP_004398512.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P21203 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU27900 |
Proteomic databases
PaxDbi | P21203 |
PRIDEi | P21203 |
Genome annotation databases
EnsemblBacteriai | CAB14750; CAB14750; BSU27900 |
GeneIDi | 937513 |
KEGGi | bsu:BSU27900 |
PATRICi | fig|224308.179.peg.3031 |
Phylogenomic databases
eggNOGi | COG0077, Bacteria |
InParanoidi | P21203 |
OMAi | HTRFVIL |
PhylomeDBi | P21203 |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00345 |
BioCyci | BSUB:BSU27900-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHEA_BACSU | |
Accessioni | P21203Primary (citable) accession number: P21203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways