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Protein

Nitrogen regulatory protein P-II

Gene

glnB

Organism
Azospirillum brasilense
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNitrogen fixation, Transcription, Transcription regulation
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein P-II
Gene namesi
Name:glnB
OrganismiAzospirillum brasilense
Taxonomic identifieri192 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeAzospirillum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397691 – 112Nitrogen regulatory protein P-IIAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51O-UMP-tyrosinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP21193

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiP21193, 1 interactor
MINTiP21193

Structurei

3D structure databases

ProteinModelPortaliP21193
SMRiP21193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P(II) protein family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108YZA Bacteria
COG0347 LUCA

Family and domain databases

Gene3Di3.30.70.120, 1 hit
InterProiView protein in InterPro
IPR002187 N-reg_PII
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
IPR017918 N-reg_PII_CS
IPR002332 N-reg_PII_urydylation_site
PANTHERiPTHR30115 PTHR30115, 1 hit
PfamiView protein in Pfam
PF00543 P-II, 1 hit
PIRSFiPIRSF039144 GlnB, 1 hit
PRINTSiPR00340 PIIGLNB
SMARTiView protein in SMART
SM00938 P-II, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
PROSITEiView protein in PROSITE
PS00638 PII_GLNB_CTER, 1 hit
PS51343 PII_GLNB_DOM, 1 hit
PS00496 PII_GLNB_UMP, 1 hit

Sequencei

Sequence statusi: Complete.

P21193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIEAIIKP FKLDEVKEAL HEVGIKGITV TEAKGFGRQK GHTELYRGAE
60 70 80 90 100
YVVDFLPKVK IEVVMEDSLV ERAIEAIQQA AHTGRIGDGK IFVTPVEEVV
110
RIRTGEKGGD AI
Length:112
Mass (Da):12,371
Last modified:May 1, 1991 - v1
Checksum:iB6258EC9C4B63871
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51499 Genomic DNA Translation: CAA35867.1
M26107 Genomic DNA No translation available.
PIRiS13078
RefSeqiWP_014240107.1, NZ_POWG01000023.1

Genome annotation databases

GeneIDi36108274

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51499 Genomic DNA Translation: CAA35867.1
M26107 Genomic DNA No translation available.
PIRiS13078
RefSeqiWP_014240107.1, NZ_POWG01000023.1

3D structure databases

ProteinModelPortaliP21193
SMRiP21193
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21193, 1 interactor
MINTiP21193

Proteomic databases

PRIDEiP21193

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi36108274

Phylogenomic databases

eggNOGiENOG4108YZA Bacteria
COG0347 LUCA

Family and domain databases

Gene3Di3.30.70.120, 1 hit
InterProiView protein in InterPro
IPR002187 N-reg_PII
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
IPR017918 N-reg_PII_CS
IPR002332 N-reg_PII_urydylation_site
PANTHERiPTHR30115 PTHR30115, 1 hit
PfamiView protein in Pfam
PF00543 P-II, 1 hit
PIRSFiPIRSF039144 GlnB, 1 hit
PRINTSiPR00340 PIIGLNB
SMARTiView protein in SMART
SM00938 P-II, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
PROSITEiView protein in PROSITE
PS00638 PII_GLNB_CTER, 1 hit
PS51343 PII_GLNB_DOM, 1 hit
PS00496 PII_GLNB_UMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLNB_AZOBR
AccessioniPrimary (citable) accession number: P21193
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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