UniProtKB - P21179 (CATE_ECOLI)
Protein
Catalase HPII
Gene
katE
Organism
Escherichia coli (strain K12)
Status
Functioni
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activityi
- EC:1.11.1.6PROSITE-ProRule annotation
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 128 | PROSITE-ProRule annotation | 1 | |
Active sitei | 201 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 415 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- catalase activity Source: EcoCyc
- heme binding Source: EcoliWiki
- identical protein binding Source: EcoCyc
- iron ion binding Source: EcoliWiki
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- hydrogen peroxide catabolic process Source: EcoliWiki
- hyperosmotic response Source: EcoCyc
- response to oxidative stress Source: EcoliWiki
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Hydrogen peroxide |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:HYDROPEROXIDII-MONOMER MetaCyc:HYDROPEROXIDII-MONOMER |
SABIO-RKi | P21179 |
Protein family/group databases
PeroxiBasei | 5321, EcoKat05 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:katE Ordered Locus Names:b1732, JW1721 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084971 | 1 – 753 | Catalase HPIIAdd BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 392 ↔ 415 | 3'-histidyl-3-tyrosine (His-Tyr) |
Proteomic databases
jPOSTi | P21179 |
PaxDbi | P21179 |
PRIDEi | P21179 |
2D gel databases
SWISS-2DPAGEi | P21179 |
Expressioni
Inductioni
By entry into stationary phase.
Interactioni
Subunit structurei
Homotetramer.
Binary interactionsi
P21179
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-549879,EBI-549879 |
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4263059, 36 interactors 850594, 3 interactors |
DIPi | DIP-10052N |
IntActi | P21179, 11 interactors |
STRINGi | 511145.b1732 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P21179 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21179 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0753, Bacteria |
HOGENOMi | CLU_010645_3_0_6 |
InParanoidi | P21179 |
PhylomeDBi | P21179 |
Family and domain databases
Gene3Di | 1.20.1370.20, 1 hit 2.40.180.10, 1 hit 3.40.50.880, 1 hit |
InterProi | View protein in InterPro IPR018028, Catalase IPR024708, Catalase_AS IPR024712, Catalase_clade2 IPR043156, Catalase_clade2_helical IPR011614, Catalase_core IPR037060, Catalase_core_sf IPR002226, Catalase_haem_BS IPR010582, Catalase_immune_responsive IPR041399, Catalase_large_C IPR020835, Catalase_sf IPR029062, Class_I_gatase-like |
PANTHERi | PTHR42821, PTHR42821, 1 hit |
Pfami | View protein in Pfam PF00199, Catalase, 1 hit PF06628, Catalase-rel, 1 hit PF18011, Catalase_C, 1 hit |
PIRSFi | PIRSF038927, Catalase_clade2, 1 hit |
PRINTSi | PR00067, CATALASE |
SMARTi | View protein in SMART SM01060, Catalase, 1 hit |
SUPFAMi | SSF52317, SSF52317, 1 hit SSF56634, SSF56634, 1 hit |
PROSITEi | View protein in PROSITE PS00437, CATALASE_1, 1 hit PS00438, CATALASE_2, 1 hit PS51402, CATALASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P21179-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQHNEKNPH QHQSPLHDSS EAKPGMDSLA PEDGSHRPAA EPTPPGAQPT
60 70 80 90 100
APGSLKAPDT RNEKLNSLED VRKGSENYAL TTNQGVRIAD DQNSLRAGSR
110 120 130 140 150
GPTLLEDFIL REKITHFDHE RIPERIVHAR GSAAHGYFQP YKSLSDITKA
160 170 180 190 200
DFLSDPNKIT PVFVRFSTVQ GGAGSADTVR DIRGFATKFY TEEGIFDLVG
210 220 230 240 250
NNTPIFFIQD AHKFPDFVHA VKPEPHWAIP QGQSAHDTFW DYVSLQPETL
260 270 280 290 300
HNVMWAMSDR GIPRSYRTME GFGIHTFRLI NAEGKATFVR FHWKPLAGKA
310 320 330 340 350
SLVWDEAQKL TGRDPDFHRR ELWEAIEAGD FPEYELGFQL IPEEDEFKFD
360 370 380 390 400
FDLLDPTKLI PEELVPVQRV GKMVLNRNPD NFFAENEQAA FHPGHIVPGL
410 420 430 440 450
DFTNDPLLQG RLFSYTDTQI SRLGGPNFHE IPINRPTCPY HNFQRDGMHR
460 470 480 490 500
MGIDTNPANY EPNSINDNWP RETPPGPKRG GFESYQERVE GNKVRERSPS
510 520 530 540 550
FGEYYSHPRL FWLSQTPFEQ RHIVDGFSFE LSKVVRPYIR ERVVDQLAHI
560 570 580 590 600
DLTLAQAVAK NLGIELTDDQ LNITPPPDVN GLKKDPSLSL YAIPDGDVKG
610 620 630 640 650
RVVAILLNDE VRSADLLAIL KALKAKGVHA KLLYSRMGEV TADDGTVLPI
660 670 680 690 700
AATFAGAPSL TVDAVIVPCG NIADIADNGD ANYYLMEAYK HLKPIALAGD
710 720 730 740 750
ARKFKATIKI ADQGEEGIVE ADSADGSFMD ELLTLMAAHR VWSRIPKIDK
IPA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55161 Genomic DNA Translation: AAA24039.1 U00096 Genomic DNA Translation: AAT48137.1 AP009048 Genomic DNA Translation: BAA15513.1 |
PIRi | A39129 |
RefSeqi | WP_000077872.1, NZ_LN832404.1 YP_025308.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48137; AAT48137; b1732 BAA15513; BAA15513; BAA15513 |
GeneIDi | 946234 |
KEGGi | ecj:JW1721 eco:b1732 |
PATRICi | fig|1411691.4.peg.524 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55161 Genomic DNA Translation: AAA24039.1 U00096 Genomic DNA Translation: AAT48137.1 AP009048 Genomic DNA Translation: BAA15513.1 |
PIRi | A39129 |
RefSeqi | WP_000077872.1, NZ_LN832404.1 YP_025308.1, NC_000913.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CF9 | X-ray | 1.80 | A/B/C/D | 1-753 | [»] | |
1GG9 | X-ray | 1.89 | A/B/C/D | 1-753 | [»] | |
1GGE | X-ray | 1.89 | A/B/C/D | 1-753 | [»] | |
1GGF | X-ray | 2.28 | A/B/C/D | 1-753 | [»] | |
1GGH | X-ray | 2.15 | A/B/C/D | 1-753 | [»] | |
1GGJ | X-ray | 1.92 | A/B/C/D | 1-753 | [»] | |
1GGK | X-ray | 2.26 | A/B/C/D | 1-753 | [»] | |
1IPH | X-ray | 2.80 | A/B/C/D | 1-753 | [»] | |
1P7Y | X-ray | 2.40 | A/B/C/D | 1-753 | [»] | |
1P7Z | X-ray | 2.21 | A/B/C/D | 1-753 | [»] | |
1P80 | X-ray | 1.65 | A/B/C/D | 1-753 | [»] | |
1P81 | X-ray | 1.81 | A/B/C/D | 1-753 | [»] | |
1QF7 | X-ray | 2.20 | A/B/C/D | 1-753 | [»] | |
1QWS | X-ray | 1.90 | A/B/C/D | 1-753 | [»] | |
1YE9 | X-ray | 2.80 | A/B/C/D/I/J/K/L | 75-300 | [»] | |
E/F/G/H/M/N/O/P | 309-567 | [»] | ||||
3P9P | X-ray | 1.50 | A/B/C/D | 1-753 | [»] | |
3P9Q | X-ray | 1.48 | A/B/C/D | 1-753 | [»] | |
3P9R | X-ray | 1.90 | A/B/C/D | 1-753 | [»] | |
3P9S | X-ray | 1.90 | A/B/C/D | 1-753 | [»] | |
3PQ2 | X-ray | 1.79 | A/B/C/D | 1-753 | [»] | |
3PQ3 | X-ray | 1.79 | A/B/C/D | 1-753 | [»] | |
3PQ4 | X-ray | 1.79 | A/B/C/D | 1-753 | [»] | |
3PQ5 | X-ray | 1.80 | A/B/C/D | 1-753 | [»] | |
3PQ6 | X-ray | 1.80 | A/B/C/D | 1-753 | [»] | |
3PQ7 | X-ray | 1.80 | A/B/C/D | 1-753 | [»] | |
3PQ8 | X-ray | 1.80 | A/B/C/D | 1-753 | [»] | |
3TTT | X-ray | 1.58 | A/B/C/D | 1-753 | [»] | |
3TTU | X-ray | 1.89 | A/B/C/D | 1-753 | [»] | |
3TTV | X-ray | 1.45 | A/B/C/D | 1-753 | [»] | |
3TTW | X-ray | 1.62 | A/B/C/D | 1-753 | [»] | |
3TTX | X-ray | 1.74 | A/B/C/D | 1-753 | [»] | |
3VU3 | X-ray | 2.85 | A | 1-753 | [»] | |
4BFL | X-ray | 1.64 | A/B/C/D | 1-753 | [»] | |
4ENP | X-ray | 1.50 | A/B/C/D | 1-753 | [»] | |
4ENQ | X-ray | 1.90 | A/B/C/D | 1-753 | [»] | |
4ENR | X-ray | 1.60 | A/B/C/D | 1-753 | [»] | |
4ENS | X-ray | 1.60 | A/B/C/D | 1-753 | [»] | |
4ENT | X-ray | 1.70 | A/B/C/D | 1-753 | [»] | |
4ENU | X-ray | 1.70 | A/B/C/D | 1-753 | [»] | |
4ENV | X-ray | 1.70 | A/B/C/D | 1-753 | [»] | |
4ENW | X-ray | 1.90 | A/B/C/D | 1-753 | [»] | |
5BV2 | X-ray | 1.53 | P/Q/R/S | 1-753 | [»] | |
6BY0 | X-ray | 2.93 | A/B/C/D | 1-753 | [»] | |
SMRi | P21179 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263059, 36 interactors 850594, 3 interactors |
DIPi | DIP-10052N |
IntActi | P21179, 11 interactors |
STRINGi | 511145.b1732 |
Protein family/group databases
PeroxiBasei | 5321, EcoKat05 |
2D gel databases
SWISS-2DPAGEi | P21179 |
Proteomic databases
jPOSTi | P21179 |
PaxDbi | P21179 |
PRIDEi | P21179 |
Genome annotation databases
EnsemblBacteriai | AAT48137; AAT48137; b1732 BAA15513; BAA15513; BAA15513 |
GeneIDi | 946234 |
KEGGi | ecj:JW1721 eco:b1732 |
PATRICi | fig|1411691.4.peg.524 |
Organism-specific databases
EchoBASEi | EB0504 |
Phylogenomic databases
eggNOGi | COG0753, Bacteria |
HOGENOMi | CLU_010645_3_0_6 |
InParanoidi | P21179 |
PhylomeDBi | P21179 |
Enzyme and pathway databases
BioCyci | EcoCyc:HYDROPEROXIDII-MONOMER MetaCyc:HYDROPEROXIDII-MONOMER |
SABIO-RKi | P21179 |
Miscellaneous databases
EvolutionaryTracei | P21179 |
PROi | PR:P21179 |
Family and domain databases
Gene3Di | 1.20.1370.20, 1 hit 2.40.180.10, 1 hit 3.40.50.880, 1 hit |
InterProi | View protein in InterPro IPR018028, Catalase IPR024708, Catalase_AS IPR024712, Catalase_clade2 IPR043156, Catalase_clade2_helical IPR011614, Catalase_core IPR037060, Catalase_core_sf IPR002226, Catalase_haem_BS IPR010582, Catalase_immune_responsive IPR041399, Catalase_large_C IPR020835, Catalase_sf IPR029062, Class_I_gatase-like |
PANTHERi | PTHR42821, PTHR42821, 1 hit |
Pfami | View protein in Pfam PF00199, Catalase, 1 hit PF06628, Catalase-rel, 1 hit PF18011, Catalase_C, 1 hit |
PIRSFi | PIRSF038927, Catalase_clade2, 1 hit |
PRINTSi | PR00067, CATALASE |
SMARTi | View protein in SMART SM01060, Catalase, 1 hit |
SUPFAMi | SSF52317, SSF52317, 1 hit SSF56634, SSF56634, 1 hit |
PROSITEi | View protein in PROSITE PS00437, CATALASE_1, 1 hit PS00438, CATALASE_2, 1 hit PS51402, CATALASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATE_ECOLI | |
Accessioni | P21179Primary (citable) accession number: P21179 Secondary accession number(s): P76906, P78066, P78168 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families