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Protein

Probable endopeptidase p60

Gene

iap

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei396NucleophileBy similarity1
Active sitei446Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endopeptidase p60 (EC:3.4.-.-)
Alternative name(s):
Invasion-associated protein p60
Gene namesi
Name:iap
Ordered Locus Names:lmo0582
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000001976028 – 484Probable endopeptidase p60Add BLAST457

Proteomic databases

PaxDbiP21171

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo0582

Structurei

3D structure databases

ProteinModelPortaliP21171
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 71LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini80 – 144SH3bPROSITE-ProRule annotationAdd BLAST65
Domaini201 – 244LysM 2PROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 35519 X 2 AA tandem repeats of T-NAdd BLAST45

Domaini

LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the peptidase C40 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105K4H Bacteria
COG0791 LUCA
COG1388 LUCA
COG3103 LUCA
HOGENOMiHOG000244932

Family and domain databases

CDDicd00118 LysM, 2 hits
Gene3Di3.10.350.10, 2 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR000064 NLP_P60_dom
IPR038765 Papain_like_cys_pep_sf
IPR003646 SH3-like_bac-type
PfamiView protein in Pfam
PF01476 LysM, 2 hits
PF00877 NLPC_P60, 1 hit
PF08239 SH3_3, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 2 hits
SM00287 SH3b, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 2 hits
PS51781 SH3B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21171-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMKKATIAA TAGIAVTAFA APTIASASTV VVEAGDTLWG IAQSKGTTVD
60 70 80 90 100
AIKKANNLTT DKIVPGQKLQ VNNEVAAAEK TEKSVSATWL NVRSGAGVDN
110 120 130 140 150
SIITSIKGGT KVTVETTESN GWHKITYNDG KTGFVNGKYL TDKAVSTPVA
160 170 180 190 200
PTQEVKKETT TQQAAPAAET KTEVKQTTQA TTPAPKVAET KETPVVDQNA
210 220 230 240 250
TTHAVKSGDT IWALSVKYGV SVQDIMSWNN LSSSSIYVGQ KLAIKQTANT
260 270 280 290 300
ATPKAEVKTE APAAEKQAAP VVKENTNTNT ATTEKKETAT QQQTAPKAPT
310 320 330 340 350
EAAKPAPAPS TNTNANKTNT NTNTNTNTNN TNTNTPSKNT NTNSNTNTNT
360 370 380 390 400
NSNTNANQGS SNNNSNSSAS AIIAEAQKHL GKAYSWGGNG PTTFDCSGYT
410 420 430 440 450
KYVFAKAGIS LPRTSGAQYA STTRISESQA KPGDLVFFDY GSGISHVGIY
460 470 480
VGNGQMINAQ DNGVKYDNIH GSGWGKYLVG FGRV
Length:484
Mass (Da):50,587
Last modified:November 1, 1995 - v2
Checksum:i3CC0F90591E14E0F
GO

Sequence cautioni

The sequence CAC98661 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti94S → T in strain: Mackaness. 1
Natural varianti167A → V in strain: Mackaness. 1
Natural varianti196V → I in strain: Mackaness. 1
Natural varianti326 – 331Missing in strain: Mackaness. 6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52268 Genomic DNA Translation: CAA36509.1
M80351 Genomic DNA Translation: AAA25280.1
AL591975 Genomic DNA Translation: CAC98661.1 Different initiation.
PIRiA41487
AG1147
RefSeqiNP_464110.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC98661; CAC98661; CAC98661
GeneIDi985140
KEGGilmo:lmo0582
PATRICifig|169963.11.peg.601

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52268 Genomic DNA Translation: CAA36509.1
M80351 Genomic DNA Translation: AAA25280.1
AL591975 Genomic DNA Translation: CAC98661.1 Different initiation.
PIRiA41487
AG1147
RefSeqiNP_464110.1, NC_003210.1

3D structure databases

ProteinModelPortaliP21171
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo0582

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50

Proteomic databases

PaxDbiP21171

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98661; CAC98661; CAC98661
GeneIDi985140
KEGGilmo:lmo0582
PATRICifig|169963.11.peg.601

Phylogenomic databases

eggNOGiENOG4105K4H Bacteria
COG0791 LUCA
COG1388 LUCA
COG3103 LUCA
HOGENOMiHOG000244932

Family and domain databases

CDDicd00118 LysM, 2 hits
Gene3Di3.10.350.10, 2 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR000064 NLP_P60_dom
IPR038765 Papain_like_cys_pep_sf
IPR003646 SH3-like_bac-type
PfamiView protein in Pfam
PF01476 LysM, 2 hits
PF00877 NLPC_P60, 1 hit
PF08239 SH3_3, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 2 hits
SM00287 SH3b, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 2 hits
PS51781 SH3B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP60_LISMO
AccessioniPrimary (citable) accession number: P21171
Secondary accession number(s): Q03493
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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