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UniProtKB - P21145 (MAL_HUMAN)

Entry version 170 (17 Jun 2020)
Sequence version 1 (01 May 1991)
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Protein

Myelin and lymphocyte protein

Gene

MAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000172005.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:6817 MAL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188860 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P21145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Topological domaini47 – 53ExtracellularSequence analysis7
Transmembranei54 – 75HelicalSequence analysisAdd BLAST22
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Topological domaini148 – 153CytoplasmicSequence analysis6

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4118

Open Targets

More...OpenTargetsi		ENSG00000172005

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30565

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P21145 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAL

Domain mapping of disease mutations (DMDM)

More...DMDMi		126719

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001568051 – 153Myelin and lymphocyte proteinAdd BLAST153

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Lipoprotein.

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P21145

PeptideAtlas

More...PeptideAtlasi		P21145

PRoteomics IDEntifications database

More...PRIDEi		P21145

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53849 [P21145-1]
53850 [P21145-2]
53851 [P21145-3]
53852 [P21145-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the intermediate and late stages of T-cell differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172005 Expressed in esophagus squamous epithelium and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P21145 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P21145 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172005 Tissue enriched (esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P21145
With#Exp.IntAct
AMHR2 [Q16671]3EBI-3932027,EBI-6423788
AQP6 [Q13520]3EBI-3932027,EBI-13059134
BCL2L13 [Q9BXK5]5EBI-3932027,EBI-747430
BTK [Q06187]5EBI-3932027,EBI-624835
BTN2A1 - isoform 4 [Q7KYR7-4]3EBI-3932027,EBI-17841208
CALN1 [Q9BXU9]3EBI-3932027,EBI-12187137
CD300LG [Q6UXG3]3EBI-3932027,EBI-10254587
CD3G [P09693]3EBI-3932027,EBI-3862428
CD40 [P25942]3EBI-3932027,EBI-525714
CD53 [P19397]3EBI-3932027,EBI-6657396
CD69 [Q07108]3EBI-3932027,EBI-2836595
CLDN14 [O95500]3EBI-3932027,EBI-11742599
CLDN20 [P56880]3EBI-3932027,EBI-23801559
CLDN7 [O95471]3EBI-3932027,EBI-740744
CLDN9 [O95484]3EBI-3932027,EBI-18341636
CLEC4C [Q8WTT0]4EBI-3932027,EBI-12913226
CLSTN3 [Q9BQT9]3EBI-3932027,EBI-11291074
CPLX4 [Q7Z7G2]3EBI-3932027,EBI-18013275
CREB3L1 [Q96BA8]3EBI-3932027,EBI-6942903
CXADR [P78310]3EBI-3932027,EBI-747931
DAGLA [Q9Y4D2]3EBI-3932027,EBI-12808806
EDA [Q92838]7EBI-3932027,EBI-529425
EMP1 [P54849]3EBI-3932027,EBI-4319440
EVI2A [P22794]3EBI-3932027,EBI-2870359
FAM209A [Q5JX71]3EBI-3932027,EBI-18304435
FCRL2 - isoform 2 [Q96LA5-2]3EBI-3932027,EBI-17263163
FIBCD1 [Q8N539]6EBI-3932027,EBI-10200808
FNDC9 [Q8TBE3]3EBI-3932027,EBI-12142257
GJA8 [P48165]3EBI-3932027,EBI-17458373
GJB1 [P08034]3EBI-3932027,EBI-17565645
GPR152 [Q8TDT2]3EBI-3932027,EBI-13345167
GRAMD1A [Q96CP6]3EBI-3932027,EBI-1384139
GSG1L - isoform 4 [Q6UXU4-2]3EBI-3932027,EBI-18632127
HIBADH [P31937]3EBI-3932027,EBI-11427100
IL10RA [Q13651]3EBI-3932027,EBI-1031656
IL20RB [Q6UXL0]3EBI-3932027,EBI-14022792
JAML - isoform 2 [Q86YT9-2]3EBI-3932027,EBI-17244059
KCNA1 [Q09470]3EBI-3932027,EBI-8286599
KCNA10 [Q16322]3EBI-3932027,EBI-12265328
KCNMB4 [Q86W47]3EBI-3932027,EBI-19112227
KLRC1 [P26715]6EBI-3932027,EBI-9018187
LDLRAD1 [Q5T700]7EBI-3932027,EBI-10173166
LMAN2L [Q9H0V9]3EBI-3932027,EBI-9091707
LRRC25 [Q8N386]3EBI-3932027,EBI-11304917
LRTM1 [Q9HBL6]3EBI-3932027,EBI-12825005
LSMEM1 [Q8N8F7]3EBI-3932027,EBI-10200825
MS4A4A [Q96JQ5]3EBI-3932027,EBI-12820341
NCAPH2 - isoform 4 [Q6IBW4-4]3EBI-3932027,EBI-10247000
NKAIN4 [Q8IVV8]3EBI-3932027,EBI-17791123
NPDC1 [Q9NQX5]3EBI-3932027,EBI-748927
OPRM1 - isoform 10 [P35372-10]3EBI-3932027,EBI-12807478
PERP [Q96FX8]3EBI-3932027,EBI-17183069
PLA2G10 [O15496]3EBI-3932027,EBI-726466
PRRT1 - isoform 2 [Q99946-2]3EBI-3932027,EBI-12211089
PTPRN - isoform 3 [Q16849-3]3EBI-3932027,EBI-10200782
RAMP1 [O60894]3EBI-3932027,EBI-962893
SDC4 [P31431]3EBI-3932027,EBI-3913237
SGCB [Q16585]3EBI-3932027,EBI-5663627
SHISA3 [A0PJX4]3EBI-3932027,EBI-10171518
SHISA4 [Q96DD7]3EBI-3932027,EBI-18035902
SLC10A1 [Q14973]3EBI-3932027,EBI-3923031
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-3932027,EBI-17295964
SMIM3 [Q9BZL3]6EBI-3932027,EBI-741850
SPINT1 - isoform 2 [O43278-2]3EBI-3932027,EBI-12078338
STX1A [Q16623]4EBI-3932027,EBI-712466
SYNDIG1 [Q9H7V2]3EBI-3932027,EBI-726331
TEX29 [Q8N6K0]3EBI-3932027,EBI-19027521
TIGIT [Q495A1]3EBI-3932027,EBI-4314807
TM4SF18 [Q96CE8]3EBI-3932027,EBI-13351685
TMEM106C [Q9BVX2]3EBI-3932027,EBI-2821497
TMEM174 [Q8WUU8]3EBI-3932027,EBI-10276729
TMEM207 [Q6UWW9]3EBI-3932027,EBI-13301303
TMEM248 [Q9NWD8]3EBI-3932027,EBI-10314986
TMEM30A - isoform 2 [Q9NV96-2]3EBI-3932027,EBI-12921610
TMEM52B [Q4KMG9]3EBI-3932027,EBI-18178701
TNFSF14 [O43557]5EBI-3932027,EBI-524131
TSPO2 [Q5TGU0]3EBI-3932027,EBI-12195249
USP7 [Q93009]3EBI-3932027,EBI-302474

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110292, 10 interactors

Protein interaction database and analysis system

More...IntActi		P21145, 85 interactors

Molecular INTeraction database

More...MINTi		P21145

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000310880

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P21145 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 151MARVELPROSITE-ProRule annotationAdd BLAST134

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4788 Eukaryota
ENOG4111IAF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_112950_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P21145

Identification of Orthologs from Complete Genome Data

More...OMAi		LIQGWVM

Database for complete collections of gene phylogenies

More...PhylomeDBi		P21145

TreeFam database of animal gene trees

More...TreeFami		TF316174

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013295 MAL
IPR008253 Marvel

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01284 MARVEL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01884 MALPROTEIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51225 MARVEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P21145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL 
        60         70         80         90        100
VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL 
       110        120        130        140        150
SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW 

KSS
Length:153
Mass (Da):16,714
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF821FC1C0ADBE775
GO
Isoform B (identifier: P21145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.

Show »
Length:111
Mass (Da):12,081
Checksum:i076826F85AF6E58B
GO
Isoform C (identifier: P21145-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,621
Checksum:i831D98D55230C2DC
GO
Isoform D (identifier: P21145-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Show »
Length:55
Mass (Da):5,989
Checksum:iF943BC95A3AF4927
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00316232 – 129Missing in isoform D. CuratedAdd BLAST98
Alternative sequenceiVSP_00316332 – 87Missing in isoform C. CuratedAdd BLAST56
Alternative sequenceiVSP_00316488 – 129Missing in isoform B. CuratedAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M15800 mRNA Translation: AAA36196.1
X76678 mRNA Translation: CAA54100.1
X76679 mRNA Translation: CAA54101.1
X76680 mRNA Translation: CAA54102.1
X76681 mRNA Translation: CAA54103.1
X76220 X76223 Genomic DNA Translation: CAA53809.1
AK311844 mRNA Translation: BAG34786.1
CR541879 mRNA Translation: CAG46677.1
AC103563 Genomic DNA Translation: AAY24121.1
CH471219 Genomic DNA Translation: EAX10705.1
BC000458 mRNA Translation: AAH00458.1
BC003006 mRNA Translation: AAH03006.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2006.1 [P21145-1]
CCDS2007.1 [P21145-2]
CCDS2008.1 [P21145-3]
CCDS2009.1 [P21145-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A29472

NCBI Reference Sequences

More...RefSeqi		NP_002362.1, NM_002371.3 [P21145-1]
NP_071883.1, NM_022438.2 [P21145-2]
NP_071884.1, NM_022439.2 [P21145-3]
NP_071885.1, NM_022440.2 [P21145-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309988; ENSP00000310880; ENSG00000172005 [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4118

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4118

UCSC genome browser

More...UCSCi		uc002stx.3 human [P21145-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15800 mRNA Translation: AAA36196.1
X76678 mRNA Translation: CAA54100.1
X76679 mRNA Translation: CAA54101.1
X76680 mRNA Translation: CAA54102.1
X76681 mRNA Translation: CAA54103.1
X76220 X76223 Genomic DNA Translation: CAA53809.1
AK311844 mRNA Translation: BAG34786.1
CR541879 mRNA Translation: CAG46677.1
AC103563 Genomic DNA Translation: AAY24121.1
CH471219 Genomic DNA Translation: EAX10705.1
BC000458 mRNA Translation: AAH00458.1
BC003006 mRNA Translation: AAH03006.1
CCDSiCCDS2006.1 [P21145-1]
CCDS2007.1 [P21145-2]
CCDS2008.1 [P21145-3]
CCDS2009.1 [P21145-4]
PIRiA29472
RefSeqiNP_002362.1, NM_002371.3 [P21145-1]
NP_071883.1, NM_022438.2 [P21145-2]
NP_071884.1, NM_022439.2 [P21145-3]
NP_071885.1, NM_022440.2 [P21145-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110292, 10 interactors
IntActiP21145, 85 interactors
MINTiP21145
STRINGi9606.ENSP00000310880

Polymorphism and mutation databases

BioMutaiMAL
DMDMi126719

Proteomic databases

PaxDbiP21145
PeptideAtlasiP21145
PRIDEiP21145
ProteomicsDBi53849 [P21145-1]
53850 [P21145-2]
53851 [P21145-3]
53852 [P21145-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32290 218 antibodies

Genome annotation databases

EnsembliENST00000309988; ENSP00000310880; ENSG00000172005 [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3]
GeneIDi4118
KEGGihsa:4118
UCSCiuc002stx.3 human [P21145-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4118
DisGeNETi4118
EuPathDBiHostDB:ENSG00000172005.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAL
HGNCiHGNC:6817 MAL
HPAiENSG00000172005 Tissue enriched (esophagus)
MIMi188860 gene
neXtProtiNX_P21145
OpenTargetsiENSG00000172005
PharmGKBiPA30565

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00940000154987
HOGENOMiCLU_112950_0_0_1
InParanoidiP21145
OMAiLIQGWVM
PhylomeDBiP21145
TreeFamiTF316174

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4118 8 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAL human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAL_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4118
PharosiP21145 Tbio

Protein Ontology

More...PROi		PR:P21145
RNActiP21145 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172005 Expressed in esophagus squamous epithelium and 206 other tissues
ExpressionAtlasiP21145 baseline and differential
GenevisibleiP21145 HS

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21145
Secondary accession number(s): Q6FH77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 17, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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