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UniProtKB - P21145 (MAL_HUMAN)
Protein
Myelin and lymphocyte protein
Gene
MAL
Organism
Homo sapiens (Human)
Status
Functioni
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
GO - Molecular functioni
- lipid binding Source: UniProtKB
- peptidase activator activity involved in apoptotic process Source: UniProtKB
- structural constituent of myelin sheath Source: UniProtKB
GO - Biological processi
- apical protein localization Source: UniProtKB
- apoptotic process Source: UniProtKB
- cell differentiation Source: UniProtKB
- central nervous system development Source: UniProtKB
- central nervous system myelination Source: Ensembl
- membrane raft polarization Source: UniProtKB
- myelination Source: GO_Central
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- protein insertion into plasma membrane Source: Ensembl
- protein localization to paranode region of axon Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P21145 |
SignaLinki | P21145 |
Protein family/group databases
TCDBi | 1.A.64.2.2, the plasmolipin (plasmolipin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Myelin and lymphocyte proteinAlternative name(s): T-lymphocyte maturation-associated protein |
Gene namesi | Name:MAL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6817, MAL |
MIMi | 188860, gene |
neXtProti | NX_P21145 |
VEuPathDBi | HostDB:ENSG00000172005 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- hinge region between urothelial plaques of apical plasma membrane Source: Ensembl
- plasma membrane raft Source: Ensembl
Other locations
- extrinsic component of membrane Source: Ensembl
- integral component of membrane Source: GO_Central
- membrane raft Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 46 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 47 – 53 | ExtracellularSequence analysis | 7 | |
Transmembranei | 54 – 75 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 76 – 92 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 93 – 114 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 115 – 125 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 126 – 147 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 148 – 153 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4118 |
MalaCardsi | MAL |
OpenTargetsi | ENSG00000172005 |
PharmGKBi | PA30565 |
Miscellaneous databases
Pharosi | P21145, Tbio |
Genetic variation databases
BioMutai | MAL |
DMDMi | 126719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156805 | 1 – 153 | Myelin and lymphocyte proteinAdd BLAST | 153 |
Post-translational modificationi
Lipoprotein.
Keywords - PTMi
LipoproteinProteomic databases
MassIVEi | P21145 |
PaxDbi | P21145 |
PeptideAtlasi | P21145 |
PRIDEi | P21145 |
ProteomicsDBi | 53849 [P21145-1] 53851 [P21145-3] |
Expressioni
Developmental stagei
Expressed in the intermediate and late stages of T-cell differentiation.
Gene expression databases
Bgeei | ENSG00000172005, Expressed in esophagus squamous epithelium and 219 other tissues |
ExpressionAtlasi | P21145, baseline and differential |
Genevisiblei | P21145, HS |
Organism-specific databases
HPAi | ENSG00000172005, Tissue enhanced (esophagus, vagina) |
Interactioni
Binary interactionsi
P21145
Protein-protein interaction databases
BioGRIDi | 110292, 81 interactors |
IntActi | P21145, 85 interactors |
MINTi | P21145 |
STRINGi | 9606.ENSP00000310880 |
Miscellaneous databases
RNActi | P21145, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 151 | MARVELPROSITE-ProRule annotationAdd BLAST | 134 |
Sequence similaritiesi
Belongs to the MAL family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000154987 |
HOGENOMi | CLU_112950_0_0_1 |
InParanoidi | P21145 |
OMAi | QEGYTYK |
PhylomeDBi | P21145 |
TreeFami | TF316174 |
Family and domain databases
InterProi | View protein in InterPro IPR013295, MAL IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR01884, MALPROTEIN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform A (identifier: P21145-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL
60 70 80 90 100
VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL
110 120 130 140 150
SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW
KSS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003162 | 32 – 129 | Missing in isoform D. CuratedAdd BLAST | 98 | |
Alternative sequenceiVSP_003163 | 32 – 87 | Missing in isoform C. CuratedAdd BLAST | 56 | |
Alternative sequenceiVSP_003164 | 88 – 129 | Missing in isoform B. CuratedAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15800 mRNA Translation: AAA36196.1 X76678 mRNA Translation: CAA54100.1 X76679 mRNA Translation: CAA54101.1 X76680 mRNA Translation: CAA54102.1 X76681 mRNA Translation: CAA54103.1 X76220 , X76221, X76222, X76223 Genomic DNA Translation: CAA53809.1 AK311844 mRNA Translation: BAG34786.1 CR541879 mRNA Translation: CAG46677.1 AC103563 Genomic DNA Translation: AAY24121.1 CH471219 Genomic DNA Translation: EAX10705.1 BC000458 mRNA Translation: AAH00458.1 BC003006 mRNA Translation: AAH03006.1 |
CCDSi | CCDS2006.1 [P21145-1] CCDS2007.1 [P21145-2] CCDS2008.1 [P21145-3] CCDS2009.1 [P21145-4] |
PIRi | A29472 |
RefSeqi | NP_002362.1, NM_002371.3 [P21145-1] NP_071883.1, NM_022438.2 [P21145-2] NP_071884.1, NM_022439.2 [P21145-3] NP_071885.1, NM_022440.2 [P21145-4] |
Genome annotation databases
Ensembli | ENST00000309988; ENSP00000310880; ENSG00000172005 ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4] ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2] ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3] |
GeneIDi | 4118 |
KEGGi | hsa:4118 |
MANE-Selecti | ENST00000309988.9; ENSP00000310880.4; NM_002371.4; NP_002362.1 |
UCSCi | uc002stx.3, human [P21145-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15800 mRNA Translation: AAA36196.1 X76678 mRNA Translation: CAA54100.1 X76679 mRNA Translation: CAA54101.1 X76680 mRNA Translation: CAA54102.1 X76681 mRNA Translation: CAA54103.1 X76220 , X76221, X76222, X76223 Genomic DNA Translation: CAA53809.1 AK311844 mRNA Translation: BAG34786.1 CR541879 mRNA Translation: CAG46677.1 AC103563 Genomic DNA Translation: AAY24121.1 CH471219 Genomic DNA Translation: EAX10705.1 BC000458 mRNA Translation: AAH00458.1 BC003006 mRNA Translation: AAH03006.1 |
CCDSi | CCDS2006.1 [P21145-1] CCDS2007.1 [P21145-2] CCDS2008.1 [P21145-3] CCDS2009.1 [P21145-4] |
PIRi | A29472 |
RefSeqi | NP_002362.1, NM_002371.3 [P21145-1] NP_071883.1, NM_022438.2 [P21145-2] NP_071884.1, NM_022439.2 [P21145-3] NP_071885.1, NM_022440.2 [P21145-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110292, 81 interactors |
IntActi | P21145, 85 interactors |
MINTi | P21145 |
STRINGi | 9606.ENSP00000310880 |
Protein family/group databases
TCDBi | 1.A.64.2.2, the plasmolipin (plasmolipin) family |
Genetic variation databases
BioMutai | MAL |
DMDMi | 126719 |
Proteomic databases
MassIVEi | P21145 |
PaxDbi | P21145 |
PeptideAtlasi | P21145 |
PRIDEi | P21145 |
ProteomicsDBi | 53849 [P21145-1] 53851 [P21145-3] |
Protocols and materials databases
Antibodypediai | 32290, 234 antibodies from 30 providers |
DNASUi | 4118 |
Genome annotation databases
Ensembli | ENST00000309988; ENSP00000310880; ENSG00000172005 ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4] ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2] ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3] |
GeneIDi | 4118 |
KEGGi | hsa:4118 |
MANE-Selecti | ENST00000309988.9; ENSP00000310880.4; NM_002371.4; NP_002362.1 |
UCSCi | uc002stx.3, human [P21145-1] |
Organism-specific databases
CTDi | 4118 |
DisGeNETi | 4118 |
GeneCardsi | MAL |
HGNCi | HGNC:6817, MAL |
HPAi | ENSG00000172005, Tissue enhanced (esophagus, vagina) |
MalaCardsi | MAL |
MIMi | 188860, gene |
neXtProti | NX_P21145 |
OpenTargetsi | ENSG00000172005 |
PharmGKBi | PA30565 |
VEuPathDBi | HostDB:ENSG00000172005 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000154987 |
HOGENOMi | CLU_112950_0_0_1 |
InParanoidi | P21145 |
OMAi | QEGYTYK |
PhylomeDBi | P21145 |
TreeFami | TF316174 |
Enzyme and pathway databases
PathwayCommonsi | P21145 |
SignaLinki | P21145 |
Miscellaneous databases
BioGRID-ORCSi | 4118, 10 hits in 1038 CRISPR screens |
ChiTaRSi | MAL, human |
GeneWikii | MAL_(gene) |
GenomeRNAii | 4118 |
Pharosi | P21145, Tbio |
PROi | PR:P21145 |
RNActi | P21145, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172005, Expressed in esophagus squamous epithelium and 219 other tissues |
ExpressionAtlasi | P21145, baseline and differential |
Genevisiblei | P21145, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013295, MAL IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR01884, MALPROTEIN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAL_HUMAN | |
Accessioni | P21145Primary (citable) accession number: P21145 Secondary accession number(s): Q6FH77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | May 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families