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Entry version 163 (13 Feb 2019)
Sequence version 1 (01 May 1991)
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Protein

Myelin and lymphocyte protein

Gene

MAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: UniProtKB
  • peptidase activator activity involved in apoptotic process Source: UniProtKB
  • structural constituent of myelin sheath Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172005.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6817 MAL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
188860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Topological domaini47 – 53ExtracellularSequence analysis7
Transmembranei54 – 75HelicalSequence analysisAdd BLAST22
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Topological domaini148 – 153CytoplasmicSequence analysis6

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4118

Open Targets

More...
OpenTargetsi
ENSG00000172005

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30565

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126719

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001568051 – 153Myelin and lymphocyte proteinAdd BLAST153

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Lipoprotein.

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21145

PeptideAtlas

More...
PeptideAtlasi
P21145

PRoteomics IDEntifications database

More...
PRIDEi
P21145

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53849
53850 [P21145-2]
53851 [P21145-3]
53852 [P21145-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the intermediate and late stages of T-cell differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172005 Expressed in 207 organ(s), highest expression level in esophagus squamous epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21145 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21145 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065691

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110292, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P21145, 75 interactors

Molecular INTeraction database

More...
MINTi
P21145

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310880

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P21145

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 151MARVELPROSITE-ProRule annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4788 Eukaryota
ENOG4111IAF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231752

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000925

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21145

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIQGWVM

Database of Orthologous Groups

More...
OrthoDBi
1518300at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21145

TreeFam database of animal gene trees

More...
TreeFami
TF316174

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013295 MAL
IPR008253 Marvel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01284 MARVEL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01884 MALPROTEIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51225 MARVEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P21145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL
60 70 80 90 100
VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL
110 120 130 140 150
SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW

KSS
Length:153
Mass (Da):16,714
Last modified:May 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF821FC1C0ADBE775
GO
Isoform B (identifier: P21145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.

Show »
Length:111
Mass (Da):12,081
Checksum:i076826F85AF6E58B
GO
Isoform C (identifier: P21145-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,621
Checksum:i831D98D55230C2DC
GO
Isoform D (identifier: P21145-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Show »
Length:55
Mass (Da):5,989
Checksum:iF943BC95A3AF4927
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00316232 – 129Missing in isoform D. CuratedAdd BLAST98
Alternative sequenceiVSP_00316332 – 87Missing in isoform C. CuratedAdd BLAST56
Alternative sequenceiVSP_00316488 – 129Missing in isoform B. CuratedAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15800 mRNA Translation: AAA36196.1
X76678 mRNA Translation: CAA54100.1
X76679 mRNA Translation: CAA54101.1
X76680 mRNA Translation: CAA54102.1
X76681 mRNA Translation: CAA54103.1
X76220
, X76221, X76222, X76223 Genomic DNA Translation: CAA53809.1
AK311844 mRNA Translation: BAG34786.1
CR541879 mRNA Translation: CAG46677.1
AC103563 Genomic DNA Translation: AAY24121.1
CH471219 Genomic DNA Translation: EAX10705.1
BC000458 mRNA Translation: AAH00458.1
BC003006 mRNA Translation: AAH03006.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2006.1 [P21145-1]
CCDS2007.1 [P21145-2]
CCDS2008.1 [P21145-3]
CCDS2009.1 [P21145-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A29472

NCBI Reference Sequences

More...
RefSeqi
NP_002362.1, NM_002371.3 [P21145-1]
NP_071883.1, NM_022438.2 [P21145-2]
NP_071884.1, NM_022439.2 [P21145-3]
NP_071885.1, NM_022440.2 [P21145-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.80395

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309988; ENSP00000310880; ENSG00000172005 [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4118

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4118

UCSC genome browser

More...
UCSCi
uc002stx.3 human [P21145-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15800 mRNA Translation: AAA36196.1
X76678 mRNA Translation: CAA54100.1
X76679 mRNA Translation: CAA54101.1
X76680 mRNA Translation: CAA54102.1
X76681 mRNA Translation: CAA54103.1
X76220
, X76221, X76222, X76223 Genomic DNA Translation: CAA53809.1
AK311844 mRNA Translation: BAG34786.1
CR541879 mRNA Translation: CAG46677.1
AC103563 Genomic DNA Translation: AAY24121.1
CH471219 Genomic DNA Translation: EAX10705.1
BC000458 mRNA Translation: AAH00458.1
BC003006 mRNA Translation: AAH03006.1
CCDSiCCDS2006.1 [P21145-1]
CCDS2007.1 [P21145-2]
CCDS2008.1 [P21145-3]
CCDS2009.1 [P21145-4]
PIRiA29472
RefSeqiNP_002362.1, NM_002371.3 [P21145-1]
NP_071883.1, NM_022438.2 [P21145-2]
NP_071884.1, NM_022439.2 [P21145-3]
NP_071885.1, NM_022440.2 [P21145-4]
UniGeneiHs.80395

3D structure databases

ProteinModelPortaliP21145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110292, 10 interactors
IntActiP21145, 75 interactors
MINTiP21145
STRINGi9606.ENSP00000310880

Polymorphism and mutation databases

BioMutaiMAL
DMDMi126719

Proteomic databases

PaxDbiP21145
PeptideAtlasiP21145
PRIDEiP21145
ProteomicsDBi53849
53850 [P21145-2]
53851 [P21145-3]
53852 [P21145-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309988; ENSP00000310880; ENSG00000172005 [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3]
GeneIDi4118
KEGGihsa:4118
UCSCiuc002stx.3 human [P21145-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4118
DisGeNETi4118
EuPathDBiHostDB:ENSG00000172005.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAL

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0117680
HIX0117687
HGNCiHGNC:6817 MAL
HPAiHPA065691
MIMi188860 gene
neXtProtiNX_P21145
OpenTargetsiENSG00000172005
PharmGKBiPA30565

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00940000154987
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiP21145
OMAiLIQGWVM
OrthoDBi1518300at2759
PhylomeDBiP21145
TreeFamiTF316174

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAL human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAL_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4118

Protein Ontology

More...
PROi
PR:P21145

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172005 Expressed in 207 organ(s), highest expression level in esophagus squamous epithelium
ExpressionAtlasiP21145 baseline and differential
GenevisibleiP21145 HS

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21145
Secondary accession number(s): Q6FH77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 13, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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