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Protein

Myelin and lymphocyte protein

Gene

MAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

GO - Molecular functioni

  • lipid binding Source: UniProtKB
  • peptidase activator activity involved in apoptotic process Source: UniProtKB
  • structural constituent of myelin sheath Source: UniProtKB

GO - Biological processi

  • apical protein localization Source: UniProtKB
  • apoptotic process Source: UniProtKB
  • cell differentiation Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • membrane raft polarization Source: UniProtKB
  • myelination Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  • protein insertion into plasma membrane Source: Ensembl
  • protein localization to paranode region of axon Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene namesi
Name:MAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000172005.10
HGNCiHGNC:6817 MAL
MIMi188860 gene
neXtProtiNX_P21145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Topological domaini47 – 53ExtracellularSequence analysis7
Transmembranei54 – 75HelicalSequence analysisAdd BLAST22
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Topological domaini148 – 153CytoplasmicSequence analysis6

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4118
OpenTargetsiENSG00000172005
PharmGKBiPA30565

Polymorphism and mutation databases

BioMutaiMAL
DMDMi126719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568051 – 153Myelin and lymphocyte proteinAdd BLAST153

Post-translational modificationi

Lipoprotein.

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiP21145
PeptideAtlasiP21145
PRIDEiP21145
ProteomicsDBi53849
53850 [P21145-2]
53851 [P21145-3]
53852 [P21145-4]

Expressioni

Developmental stagei

Expressed in the intermediate and late stages of T-cell differentiation.

Gene expression databases

BgeeiENSG00000172005
CleanExiHS_MAL
ExpressionAtlasiP21145 baseline and differential
GenevisibleiP21145 HS

Organism-specific databases

HPAiHPA065691

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110292, 10 interactors
IntActiP21145, 74 interactors
STRINGi9606.ENSP00000310880

Structurei

3D structure databases

ProteinModelPortaliP21145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 151MARVELPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiP21145
OMAiVPIPLIQ
OrthoDBiEOG091G0OS1
PhylomeDBiP21145
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P21145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL
60 70 80 90 100
VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL
110 120 130 140 150
SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW

KSS
Length:153
Mass (Da):16,714
Last modified:May 1, 1991 - v1
Checksum:iF821FC1C0ADBE775
GO
Isoform B (identifier: P21145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.

Show »
Length:111
Mass (Da):12,081
Checksum:i076826F85AF6E58B
GO
Isoform C (identifier: P21145-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,621
Checksum:i831D98D55230C2DC
GO
Isoform D (identifier: P21145-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Show »
Length:55
Mass (Da):5,989
Checksum:iF943BC95A3AF4927
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00316232 – 129Missing in isoform D. CuratedAdd BLAST98
Alternative sequenceiVSP_00316332 – 87Missing in isoform C. CuratedAdd BLAST56
Alternative sequenceiVSP_00316488 – 129Missing in isoform B. CuratedAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15800 mRNA Translation: AAA36196.1
X76678 mRNA Translation: CAA54100.1
X76679 mRNA Translation: CAA54101.1
X76680 mRNA Translation: CAA54102.1
X76681 mRNA Translation: CAA54103.1
X76220
, X76221, X76222, X76223 Genomic DNA Translation: CAA53809.1
AK311844 mRNA Translation: BAG34786.1
CR541879 mRNA Translation: CAG46677.1
AC103563 Genomic DNA Translation: AAY24121.1
CH471219 Genomic DNA Translation: EAX10705.1
BC000458 mRNA Translation: AAH00458.1
BC003006 mRNA Translation: AAH03006.1
CCDSiCCDS2006.1 [P21145-1]
CCDS2007.1 [P21145-2]
CCDS2008.1 [P21145-3]
CCDS2009.1 [P21145-4]
PIRiA29472
RefSeqiNP_002362.1, NM_002371.3 [P21145-1]
NP_071883.1, NM_022438.2 [P21145-2]
NP_071884.1, NM_022439.2 [P21145-3]
NP_071885.1, NM_022440.2 [P21145-4]
UniGeneiHs.80395

Genome annotation databases

EnsembliENST00000309988; ENSP00000310880; ENSG00000172005 [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005 [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005 [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005 [P21145-3]
GeneIDi4118
KEGGihsa:4118
UCSCiuc002stx.3 human [P21145-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAL_HUMAN
AccessioniPrimary (citable) accession number: P21145
Secondary accession number(s): Q6FH77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 18, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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