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Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins (PubMed:2211613). Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.1 Publication

Cofactori

Co2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi259CobaltCurated1
Metal bindingi261CobaltCurated1
Active sitei371NucleophileBy similarity1
Metal bindingi371CobaltCurated1
Metal bindingi576CobaltCurated1

GO - Molecular functioni

  • alpha-mannosidase activity Source: RGD
  • carbohydrate binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • mannose metabolic process Source: InterPro
  • oligosaccharide catabolic process Source: GO_Central

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandCobalt, Metal-binding

Enzyme and pathway databases

SABIO-RKiP21139

Protein family/group databases

CAZyiGH38 Glycoside Hydrolase Family 38

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase 2C1 (EC:3.2.1.241 Publication)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene namesi
Name:Man2c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628787 Man2c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002069091 – 1040Alpha-mannosidase 2C1Add BLAST1040

Proteomic databases

PaxDbiP21139
PRIDEiP21139

Expressioni

Tissue specificityi

Widely expressed. Highest expression in testis, adrenal gland, and kidney.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi251507, 1 interactor
IntActiP21139, 1 interactor
MINTiP21139
STRINGi10116.ENSRNOP00000041867

Chemistry databases

BindingDBiP21139

Structurei

3D structure databases

ProteinModelPortaliP21139
SMRiP21139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiKOG4342 Eukaryota
COG0383 LUCA
HOGENOMiHOG000048425
HOVERGENiHBG055567
InParanoidiP21139
KOiK01191
PhylomeDBiP21139

Family and domain databases

Gene3Di1.20.1270.50, 1 hit
3.20.110.10, 1 hit
InterProiView protein in InterPro
IPR011013 Gal_mutarotase_sf_dom
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR011682 Glyco_hydro_38_C
IPR015341 Glyco_hydro_38_cen
IPR037094 Glyco_hydro_38_cen_sf
IPR000602 Glyco_hydro_38_N
IPR027291 Glyco_hydro_38_N_sf
IPR028995 Glyco_hydro_57/38_cen_sf
PfamiView protein in Pfam
PF09261 Alpha-mann_mid, 1 hit
PF01074 Glyco_hydro_38, 1 hit
PF07748 Glyco_hydro_38C, 1 hit
SMARTiView protein in SMART
SM00872 Alpha-mann_mid, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P21139-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC PVTLSSFLTP
60 70 80 90 100
ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGKEVHLCW
110 120 130 140 150
ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLHAADPRS LTLYVEVACN
160 170 180 190 200
GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHNLLVD LELLLGVAKG
210 220 230 240 250
LGEDNQRSFQ ALYTANQMVN ICDPAQPETY PAAEALASKF FGQRGGESQH
260 270 280 290 300
TIHATGHCHI DTAWLWPFKE TVRKCARSWS TAVKLMERNT EFTFACSQAQ
310 320 330 340 350
QLEWVKNQYP GLYAQLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL
360 370 380 390 400
QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL
410 420 430 440 450
VNSFPHHTFF WEGLDGSQVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR
460 470 480 490 500
TNHSGFLFGF GDGGGGPTQT MLDRLKRLGN TDGQPRVQLS SPGQLFTALE
510 520 530 540 550
RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVELLSSLAL
560 570 580 590 600
ARSAQFLYPA VQLQRLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS
610 620 630 640 650
HGNTLLSAAA AALCAGEPGP KGLRHYQHTA LEAHRSVGTT QGLVGLTRLA
660 670 680 690 700
LVTVPSIGYA PAPTPTSLQP LLPQQPVFVM QETDGSVTLD NGIIRVRLDP
710 720 730 740 750
TGCLTSLVLV ASGREAIAEG ALGNQFVLFD DVPLYWDAWD VMDYHLETRK
760 770 780 790 800
PVRGQAGTLA VGAEGGLRGS AWFLLQISPN SRLSQEVVLD VGCPYVRFHT
810 820 830 840 850
EVHWHETHKF LKVEFPARVR SPQATYEIQF GHLQEADPQQ HSWDWARYEV
860 870 880 890 900
WAHRWIDLSE CDFGLALLNN CKYGTSVRGN VLSLSLLRAP KAPDVTADMG
910 920 930 940 950
RHEFTYALMP HKGSFQEAGV IQAAYNLNFP LLALPAPGPA PDTTWSAFSV
960 970 980 990 1000
SSPAVVLETI KQAEKSHQHR TLVLRLYEAH GSHVDCWLHT SLPVQEATLC
1010 1020 1030 1040
DLLEQRDPTG HLSLQDNRLK LTFSPFQVRS LLLVLQPPAN
Length:1,040
Mass (Da):115,971
Last modified:May 1, 1991 - v1
Checksum:i144F6EB97C8F7EA7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5M9I2Q5M9I2_RAT
Alpha-mannosidase 2C1
Man2c1
1,039Annotation score:
F1LPQ3F1LPQ3_RAT
Alpha-mannosidase 2C1
Man2c1
1,038Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57547 mRNA Translation: AAA41565.1
PIRiA38306
RefSeqiNP_640349.1, NM_139256.1
UniGeneiRn.11301

Genome annotation databases

GeneIDi246136
KEGGirno:246136
UCSCiRGD:628787 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57547 mRNA Translation: AAA41565.1
PIRiA38306
RefSeqiNP_640349.1, NM_139256.1
UniGeneiRn.11301

3D structure databases

ProteinModelPortaliP21139
SMRiP21139
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251507, 1 interactor
IntActiP21139, 1 interactor
MINTiP21139
STRINGi10116.ENSRNOP00000041867

Chemistry databases

BindingDBiP21139
ChEMBLiCHEMBL2852

Protein family/group databases

CAZyiGH38 Glycoside Hydrolase Family 38

Proteomic databases

PaxDbiP21139
PRIDEiP21139

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246136
KEGGirno:246136
UCSCiRGD:628787 rat

Organism-specific databases

CTDi4123
RGDi628787 Man2c1

Phylogenomic databases

eggNOGiKOG4342 Eukaryota
COG0383 LUCA
HOGENOMiHOG000048425
HOVERGENiHBG055567
InParanoidiP21139
KOiK01191
PhylomeDBiP21139

Enzyme and pathway databases

SABIO-RKiP21139

Miscellaneous databases

PROiPR:P21139

Family and domain databases

Gene3Di1.20.1270.50, 1 hit
3.20.110.10, 1 hit
InterProiView protein in InterPro
IPR011013 Gal_mutarotase_sf_dom
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR011682 Glyco_hydro_38_C
IPR015341 Glyco_hydro_38_cen
IPR037094 Glyco_hydro_38_cen_sf
IPR000602 Glyco_hydro_38_N
IPR027291 Glyco_hydro_38_N_sf
IPR028995 Glyco_hydro_57/38_cen_sf
PfamiView protein in Pfam
PF09261 Alpha-mann_mid, 1 hit
PF01074 Glyco_hydro_38, 1 hit
PF07748 Glyco_hydro_38C, 1 hit
SMARTiView protein in SMART
SM00872 Alpha-mann_mid, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMA2C1_RAT
AccessioniPrimary (citable) accession number: P21139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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