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Entry version 210 (05 Jun 2019)
Sequence version 4 (28 Mar 2018)
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Protein

Cyclin-dependent kinase 11B

Gene

CDK11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.4 Publications

Miscellaneous

Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.

Caution

Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei467ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei562Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi444 – 452ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.22 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P21127

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P21127

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 11B (EC:2.7.11.22)
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Short name:
CLK-1
Cell division protein kinase 11B
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
p58 CLK-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK11B
Synonyms:CDC2L1, CDK11, PITSLREA, PK58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1729 CDK11B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176873 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
984

Open Targets

More...
OpenTargetsi
ENSG00000248333

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26262

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5808

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDK11B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34978359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000243111 – 795Cyclin-dependent kinase 11BAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei115Phosphoserine1 Publication1
Modified residuei283PhosphoserineBy similarity1
Modified residuei482Phosphoserine; by CDK71 Publication1
Modified residuei488Phosphothreonine; by CDK71 Publication1
Modified residuei589PhosphoserineCombined sources1
Modified residuei594PhosphotyrosineCombined sources1
Modified residuei595PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki641Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei751PhosphothreonineBy similarity1
Modified residuei752PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21127

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21127

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21127

PeptideAtlas

More...
PeptideAtlasi
P21127

PRoteomics IDEntifications database

More...
PRIDEi
P21127

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53836
53837 [P21127-10]
53838 [P21127-12]
53839 [P21127-2]
53840 [P21127-3]
53841 [P21127-4]
53842 [P21127-5]
53843 [P21127-6]
53844 [P21127-8]
53845 [P21127-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21127

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21127

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P21127

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 7 is induced in G2/M phase of the cell cycle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000248333 Expressed in 91 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21127 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA025061
HPA073626

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A (PubMed:25965346).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107421, 55 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-345 Cyclin L2-CDK11B(p58) complex [P21127-12]
CPX-346 Cyclin L1-CDK11B(p58) complex [P21127-12]
CPX-348 Cyclin L1-CDK11B(p110) complex [P21127-1]
CPX-349 Cyclin L2-CDK11B(p110) complex [P21127-1]

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P21127

Protein interaction database and analysis system

More...
IntActi
P21127, 19 interactors

Molecular INTeraction database

More...
MINTi
P21127

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000464036

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21127

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21127

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 723Protein kinasePROSITE-ProRule annotationAdd BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi126 – 393Glu-richAdd BLAST268

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0663 Eukaryota
ENOG410XQ50 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158459

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21127

KEGG Orthology (KO)

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KOi
K08818

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMRKCSI

Database of Orthologous Groups

More...
OrthoDBi
925637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21127

TreeFam database of animal gene trees

More...
TreeFami
TF101035

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform SV9 (identifier: P21127-1) [UniParc]FASTAAdd to basket
Also known as: CDK11-p110

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR
110 120 130 140 150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER
160 170 180 190 200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE
210 220 230 240 250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK
260 270 280 290 300
PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
310 320 330 340 350
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE
360 370 380 390 400
EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA
410 420 430 440 450
LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG
460 470 480 490 500
VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV
510 520 530 540 550
REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV
560 570 580 590 600
KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
610 620 630 640 650
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV
660 670 680 690 700
FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM
710 720 730 740 750
NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG
760 770 780 790
TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF
Length:795
Mass (Da):92,620
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CCB0E688E66DF47
GO
Isoform SV1 (identifier: P21127-2) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-1

The sequence of this isoform differs from the canonical sequence as follows:
     252-265: GEARPAPAQKPAQL → V

Show »
Length:782
Mass (Da):91,303
Checksum:i70E8E7AFCE9D8BF5
GO
Isoform 2 (identifier: P21127-3) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-2

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     165-165: R → RGNDGVCLFR
     252-265: GEARPAPAQKPAQL → V

Show »
Length:781
Mass (Da):91,190
Checksum:i81EC428CB483E973
GO
Isoform 3 (identifier: P21127-4) [UniParc]FASTAAdd to basket
Also known as: Alpha 1

The sequence of this isoform differs from the canonical sequence as follows:
     2-335: Missing.

Show »
Length:461
Mass (Da):51,925
Checksum:i6D054208C50D621C
GO
Isoform SV4 (identifier: P21127-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.

Show »
Length:526
Mass (Da):59,273
Checksum:i3DFF4854ED82B81B
GO
Isoform SV5 (identifier: P21127-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     110-119: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:738
Mass (Da):86,034
Checksum:iEB1469FB69DB2F20
GO
Isoform 8 (identifier: P21127-8) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-3

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:772
Mass (Da):90,228
Checksum:iE0030AD668AD0A5C
GO
Isoform SV10 (identifier: P21127-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     252-265: GEARPAPAQKPAQL → V

Show »
Length:748
Mass (Da):87,110
Checksum:iB27B64E086717A01
GO
Isoform SV11 (identifier: P21127-10) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:565
Mass (Da):63,937
Checksum:i6E088C8322ADB36A
GO
Isoform 7 (identifier: P21127-12) [UniParc]FASTAAdd to basket
Also known as: CDK11-p58

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Note: Produced by alternative initiation at Met-357 of isoform SV9 via an internal ribosomal entry site (IRES).
Show »
Length:439
Mass (Da):49,555
Checksum:i2008B90F6CE66EF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEN2A0A0D9SEN2_HUMAN
Cyclin-dependent kinase 11B
CDK11B
785Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SEI3A0A0D9SEI3_HUMAN
Cyclin-dependent kinase 11B
CDK11B
772Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SER5A0A0D9SER5_HUMAN
Cyclin-dependent kinase 11B
CDK11B
783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1I0A0A087X1I0_HUMAN
Cyclin-dependent kinase 11B
CDK11B
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYI9A0A087WYI9_HUMAN
Cyclin-dependent kinase 11B
CDK11B
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB59449 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC83664 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF36538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97A → V in AAA19582 (PubMed:8195233).1
Sequence conflicti97A → V in AAA19583 (PubMed:8195233).1
Sequence conflicti97A → V in AAA19586 (PubMed:8195233).1
Sequence conflicti97A → V in AAC72077 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72079 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72080 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72081 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83662 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83664 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83665 (PubMed:9750192).1
Sequence conflicti109Missing in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAC72079 (PubMed:9750192).Curated1
Sequence conflicti126E → K in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19586 (PubMed:8195233).Curated1
Sequence conflicti258P → R in AAC72080 (PubMed:9750192).1
Sequence conflicti320S → T in AAF36538 (Ref. 6) Curated1
Sequence conflicti324 – 326Missing in AAA19582 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19583 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19584 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19586 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAF36538 (Ref. 6) Curated3
Sequence conflicti411 – 412PA → LP in AAB59449 (PubMed:1639388).Curated2
Sequence conflicti436E → D in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti560H → Q in AAF36538 (Ref. 6) Curated1
Sequence conflicti567N → T in AAF36538 (Ref. 6) Curated1
Sequence conflicti678E → R in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19581 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19584 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAF36538 (Ref. 6) Curated1
Sequence conflicti694D → E in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti697F → C in AAF36538 (Ref. 6) Curated1
Sequence conflicti712I → L in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti715E → Q in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti792S → R in AAF36538 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04195857R → C2 PublicationsCorresponds to variant dbSNP:rs752740049Ensembl.1
Natural variantiVAR_05777593R → W. Corresponds to variant dbSNP:rs1059831Ensembl.1
Natural variantiVAR_062199109R → C. Corresponds to variant dbSNP:rs1059830Ensembl.1
Natural variantiVAR_041959201R → W1 Publication1
Natural variantiVAR_041960414S → L1 PublicationCorresponds to variant dbSNP:rs1241694892Ensembl.1
Natural variantiVAR_045577452V → A1 Publication1
Natural variantiVAR_041961463I → V1 Publication1
Natural variantiVAR_045578506G → S1 Publication1
Natural variantiVAR_041962601L → Q2 PublicationsCorresponds to variant dbSNP:rs200190129Ensembl.1
Natural variantiVAR_041963641K → N1 PublicationCorresponds to variant dbSNP:rs1059815Ensembl.1
Natural variantiVAR_041964670A → V1 PublicationCorresponds to variant dbSNP:rs1059811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188341 – 356Missing in isoform 7. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_0082751 – 269Missing in isoform SV4. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_0082741 – 217Missing in isoform SV11. 3 PublicationsAdd BLAST217
Alternative sequenceiVSP_0082731 – 34Missing in isoform SV5 and isoform SV10. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_0082762 – 335Missing in isoform 3. 1 PublicationAdd BLAST334
Alternative sequenceiVSP_00827735 – 37LKN → MSQ in isoform SV5 and isoform SV10. 1 Publication3
Alternative sequenceiVSP_008278110 – 119Missing in isoform 2, isoform SV5 and isoform 8. 2 Publications10
Alternative sequenceiVSP_008279165R → RGNDGVCLFR in isoform 2. 1 Publication1
Alternative sequenceiVSP_008280252 – 265GEARP…KPAQL → V in isoform SV1, isoform 2, isoform SV5, isoform 8, isoform SV10 and isoform SV11. 5 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37712 mRNA Translation: AAA36406.1
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA Translation: AAB59449.1 Sequence problems.
U04815 mRNA Translation: AAA19581.1
U04816 mRNA Translation: AAA19582.1
U04817 mRNA Translation: AAA19583.1
U04818 mRNA Translation: AAA19584.1
U04824 mRNA Translation: AAA19586.1
AF067512 mRNA Translation: AAC72077.1
AF067513 mRNA Translation: AAC72078.1
AF067514 mRNA Translation: AAC72079.1
AF067515 mRNA Translation: AAC72080.1
AF067516 mRNA Translation: AAC72081.1
AF067517 mRNA Translation: AAC72082.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83662.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83663.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83665.1
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83666.1
AF174497 mRNA Translation: AAF36538.1 Different initiation.
FO704657 Genomic DNA No translation available.
BC140714 mRNA Translation: AAI40715.1
BC171773 mRNA Translation: AAI71773.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72682.1 [P21127-9]
CCDS72683.1 [P21127-1]
CCDS72684.1 [P21127-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A38282
B54024
E54024
F54024
H54024
T09568

NCBI Reference Sequences

More...
RefSeqi
NP_001278274.1, NM_001291345.1 [P21127-8]
NP_001778.2, NM_001787.2 [P21127-1]
NP_277021.2, NM_033486.2 [P21127-2]
NP_277022.1, NM_033487.2 [P21127-5]
NP_277024.2, NM_033489.2 [P21127-9]
NP_277025.1, NM_033490.2 [P21127-10]
XP_016858415.1, XM_017002926.1 [P21127-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9]
ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2]
ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:984

UCSC genome browser

More...
UCSCi
uc031tmi.2 human

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37712 mRNA Translation: AAA36406.1
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA Translation: AAB59449.1 Sequence problems.
U04815 mRNA Translation: AAA19581.1
U04816 mRNA Translation: AAA19582.1
U04817 mRNA Translation: AAA19583.1
U04818 mRNA Translation: AAA19584.1
U04824 mRNA Translation: AAA19586.1
AF067512 mRNA Translation: AAC72077.1
AF067513 mRNA Translation: AAC72078.1
AF067514 mRNA Translation: AAC72079.1
AF067515 mRNA Translation: AAC72080.1
AF067516 mRNA Translation: AAC72081.1
AF067517 mRNA Translation: AAC72082.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83662.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83663.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83665.1
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83666.1
AF174497 mRNA Translation: AAF36538.1 Different initiation.
FO704657 Genomic DNA No translation available.
BC140714 mRNA Translation: AAI40715.1
BC171773 mRNA Translation: AAI71773.1
CCDSiCCDS72682.1 [P21127-9]
CCDS72683.1 [P21127-1]
CCDS72684.1 [P21127-2]
PIRiA38282
B54024
E54024
F54024
H54024
T09568
RefSeqiNP_001278274.1, NM_001291345.1 [P21127-8]
NP_001778.2, NM_001787.2 [P21127-1]
NP_277021.2, NM_033486.2 [P21127-2]
NP_277022.1, NM_033487.2 [P21127-5]
NP_277024.2, NM_033489.2 [P21127-9]
NP_277025.1, NM_033490.2 [P21127-10]
XP_016858415.1, XM_017002926.1 [P21127-3]

3D structure databases

SMRiP21127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107421, 55 interactors
ComplexPortaliCPX-345 Cyclin L2-CDK11B(p58) complex [P21127-12]
CPX-346 Cyclin L1-CDK11B(p58) complex [P21127-12]
CPX-348 Cyclin L1-CDK11B(p110) complex [P21127-1]
CPX-349 Cyclin L2-CDK11B(p110) complex [P21127-1]
CORUMiP21127
IntActiP21127, 19 interactors
MINTiP21127
STRINGi9606.ENSP00000464036

Chemistry databases

BindingDBiP21127
ChEMBLiCHEMBL5808

PTM databases

iPTMnetiP21127
PhosphoSitePlusiP21127

Polymorphism and mutation databases

BioMutaiCDK11B
DMDMi34978359

Proteomic databases

EPDiP21127
jPOSTiP21127
PaxDbiP21127
PeptideAtlasiP21127
PRIDEiP21127
ProteomicsDBi53836
53837 [P21127-10]
53838 [P21127-12]
53839 [P21127-2]
53840 [P21127-3]
53841 [P21127-4]
53842 [P21127-5]
53843 [P21127-6]
53844 [P21127-8]
53845 [P21127-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9]
ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2]
ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]
GeneIDi984
KEGGihsa:984
UCSCiuc031tmi.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
984
DisGeNETi984

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDK11B
HGNCiHGNC:1729 CDK11B
HPAiHPA025061
HPA073626
MIMi176873 gene
neXtProtiNX_P21127
OpenTargetsiENSG00000248333
PharmGKBiPA26262

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0663 Eukaryota
ENOG410XQ50 LUCA
GeneTreeiENSGT00940000158459
InParanoidiP21127
KOiK08818
OMAiHMRKCSI
OrthoDBi925637at2759
PhylomeDBiP21127
TreeFamiTF101035

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
SignaLinkiP21127
SIGNORiP21127

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDK11B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CDC2L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
984
PMAP-CutDBiP21127

Protein Ontology

More...
PROi
PR:P21127

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000248333 Expressed in 91 organ(s), highest expression level in testis
ExpressionAtlasiP21127 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD11B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21127
Secondary accession number(s): B7ZVY7
, J3KTL7, J3QR29, J3QR44, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 28, 2018
Last modified: June 5, 2019
This is version 210 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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