CDK11B

Functionⁱ

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.4 Publications

Miscellaneous

Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.

Caution

Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.Curated

Catalytic activityⁱ

Cofactorⁱ

Mg²⁺

Activity regulationⁱ

Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	467	ATPPROSITE-ProRule annotation		1
Active siteⁱ	562	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	444 – 452	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis, Cell cycle
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22, 2681
PathwayCommonsⁱ	P21127
Reactomeⁱ	R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
SignaLinkⁱ	P21127
SIGNORⁱ	P21127

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 11B (EC:2.7.11.22) Alternative name(s): Cell division cycle 2-like protein kinase 1 Short name: CLK-1 Cell division protein kinase 11B Galactosyltransferase-associated protein kinase p58/GTA PITSLRE serine/threonine-protein kinase CDC2L1 p58 CLK-1
Gene namesⁱ	Name:CDK11B Synonyms:CDC2L1, CDK11, PITSLREA, PK58
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1729, CDK11B
MIMⁱ	176873, gene
neXtProtⁱ	NX_P21127
VEuPathDBⁱ	HostDB:ENSG00000248333.8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	984
Open Targets More...OpenTargetsⁱ	ENSG00000248333
PharmGKBⁱ	PA26262

Miscellaneous databases

Pharosⁱ	P21127, Tchem

Pharosⁱ

P21127, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL5808
DrugCentral More...DrugCentralⁱ	P21127

Genetic variation databases

BioMutaⁱ	CDK11B
DMDMⁱ	34978359

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000024311	1 – 795	Cyclin-dependent kinase 11BAdd BLAST		795

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	47	PhosphoserineBy similarity	1
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	115	Phosphoserine1 Publication	1
Modified residueⁱ	283	PhosphoserineBy similarity	1
Modified residueⁱ	482	Phosphoserine; by CDK71 Publication	1
Modified residueⁱ	488	Phosphothreonine; by CDK71 Publication	1
Modified residueⁱ	589	PhosphoserineCombined sources	1
Modified residueⁱ	594	PhosphotyrosineCombined sources	1
Modified residueⁱ	595	PhosphothreonineCombined sources	1
Cross-linkⁱ	641	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	751	PhosphothreonineBy similarity	1
Modified residueⁱ	752	PhosphoserineBy similarity	1

Post-translational modificationⁱ

During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P21127
jPOSTⁱ	P21127
MassIVEⁱ	P21127
PaxDbⁱ	P21127
PeptideAtlas More...PeptideAtlasⁱ	P21127
PRIDEⁱ	P21127
ProteomicsDBⁱ	53836 [P21127-1] 53837 [P21127-10] 53838 [P21127-12] 53839 [P21127-2] 53840 [P21127-3] 53841 [P21127-4] 53842 [P21127-5] 53843 [P21127-6] 53844 [P21127-8] 53845 [P21127-9]

PTM databases

iPTMnetⁱ	P21127
PhosphoSitePlusⁱ	P21127

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.2 Publications

Inductionⁱ

Isoform 7 is induced in G2/M phase of the cell cycle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000248333, Expressed in sural nerve and 113 other tissues
ExpressionAtlasⁱ	P21127, baseline and differential

Interactionⁱ

Subunit structureⁱ

Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3.

Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.

Interacts with isoform 5 of MYO18A (PubMed:25965346).

5 Publications

Binary interactionsⁱ

Hide details

P21127

With	#Exp.	IntAct
EIF3F [O00303]	3	EBI-1298,EBI-711990
PAK1 [Q13153]	4	EBI-1298,EBI-1307

Protein-protein interaction databases

BioGRIDⁱ	107421, 65 interactors
ComplexPortalⁱ	CPX-345, Cyclin L2-CDK11B(p58) complex [P21127-12] CPX-346, Cyclin L1-CDK11B(p58) complex [P21127-12] CPX-348, Cyclin L1-CDK11B(p110) complex [P21127-1] CPX-349, Cyclin L2-CDK11B(p110) complex [P21127-1]
CORUMⁱ	P21127
IntActⁱ	P21127, 29 interactors
Molecular INTeraction database More...MINTⁱ	P21127
STRINGⁱ	9606.ENSP00000464036

Chemistry databases

BindingDBⁱ

P21127

Miscellaneous databases

RNActⁱ	P21127, protein

RNActⁱ

P21127, protein

Structureⁱ

3D structure databases

SMRⁱ	P21127
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	438 – 723	Protein kinasePROSITE-ProRule annotationAdd BLAST		286

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	126 – 393	Glu-richAdd BLAST		268

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0663, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158459
InParanoidⁱ	P21127
OMAⁱ	HMRKCSI
Database of Orthologous Groups More...OrthoDBⁱ	925637at2759
PhylomeDBⁱ	P21127
TreeFamⁱ	TF101035

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit

Sequences (10+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 10 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform SV9 (identifier: P21127-1) [UniParc]FASTA Add to basket

Also known as: CDK11-p110

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR 
       110        120        130        140        150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER 
       160        170        180        190        200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE 
       210        220        230        240        250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK 
       260        270        280        290        300
PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG 
       310        320        330        340        350
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE 
       360        370        380        390        400
EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA 
       410        420        430        440        450
LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG 
       460        470        480        490        500
VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV 
       510        520        530        540        550
REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV 
       560        570        580        590        600
KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT 
       610        620        630        640        650
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV 
       660        670        680        690        700
FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM 
       710        720        730        740        750
NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG 
       760        770        780        790 
TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF

Length:795

Mass (Da):92,620

Last modified:March 28, 2018 - v4

Checksum:ⁱ8CCB0E688E66DF47

GO

Isoform SV1 (identifier: P21127-2) [UniParc]FASTA Add to basket

Also known as: Alpha 2-1

The sequence of this isoform differs from the canonical sequence as follows:
252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR 
       110        120        130        140        150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER 
       160        170        180        190        200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE 
       210        220        230        240        250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK 
       260        270        280        290        300
PVKEEKMEER DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE 
       310        320        330        340        350
EEEGSTSEES EEEEEEEEEE EEETGSNSEE ASEQSAEEVS EEEMSEDEER 
       360        370        380        390        400
ENENHLLVVP ESRFDRDSGE SEEAEEEVGE GTPQSSALTE GDYVPDSPAL 
       410        420        430        440        450
SPIELKQELP KYLPALQGCR SVEEFQCLNR IEEGTYGVVY RAKDKKTDEI 
       460        470        480        490        500
VALKRLKMEK EKEGFPITSL REINTILKAQ HPNIVTVREI VVGSNMDKIY 
       510        520        530        540        550
IVMNYVEHDL KSLMETMKQP FLPGEVKTLM IQLLRGVKHL HDNWILHRDL 
       560        570        580        590        600
KTSNLLLSHA GILKVGDFGL AREYGSPLKA YTPVVVTLWY RAPELLLGAK 
       610        620        630        640        650
EYSTAVDMWS VGCIFGELLT QKPLFPGKSE IDQINKVFKD LGTPSEKIWP 
       660        670        680        690        700
GYSELPAVKK MTFSEHPYNN LRKRFGALLS DQGFDLMNKF LTYFPGRRIS 
       710        720        730        740        750
AEDGLKHEYF RETPLPIDPS MFPTWPAKSE QQRVKRGTSP RPPEGGLGYS 
       760        770        780 
QLGDDDLKET GFHLTTTNQG ASAAGPGFSL KF

Show »

Length:782

Mass (Da):91,303

Checksum:ⁱ70E8E7AFCE9D8BF5

GO

Isoform 2 (identifier: P21127-3) [UniParc]FASTA Add to basket

Also known as: Alpha 2-2

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     165-165: R → RGNDGVCLFR
     252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR 
       110        120        130        140        150
KDEKRKEKRK HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH 
       160        170        180        190        200
SRRERGNDGV CLFRDRLEQL ERKRERERKM REQQKEQREQ KERERRAEER 
       210        220        230        240        250
RKEREARREV SAHHRTMRED YSDKVKASHW SRSPPRPPRE RFELGDGRKP 
       260        270        280        290        300
VKEEKMEERD LLSDLQDISD SERKTSSAES SSAESGSGSE EEEEEEEEEE 
       310        320        330        340        350
EEGSTSEESE EEEEEEEEEE EETGSNSEEA SEQSAEEVSE EEMSEDEERE 
       360        370        380        390        400
NENHLLVVPE SRFDRDSGES EEAEEEVGEG TPQSSALTEG DYVPDSPALS 
       410        420        430        440        450
PIELKQELPK YLPALQGCRS VEEFQCLNRI EEGTYGVVYR AKDKKTDEIV 
       460        470        480        490        500
ALKRLKMEKE KEGFPITSLR EINTILKAQH PNIVTVREIV VGSNMDKIYI 
       510        520        530        540        550
VMNYVEHDLK SLMETMKQPF LPGEVKTLMI QLLRGVKHLH DNWILHRDLK 
       560        570        580        590        600
TSNLLLSHAG ILKVGDFGLA REYGSPLKAY TPVVVTLWYR APELLLGAKE 
       610        620        630        640        650
YSTAVDMWSV GCIFGELLTQ KPLFPGKSEI DQINKVFKDL GTPSEKIWPG 
       660        670        680        690        700
YSELPAVKKM TFSEHPYNNL RKRFGALLSD QGFDLMNKFL TYFPGRRISA 
       710        720        730        740        750
EDGLKHEYFR ETPLPIDPSM FPTWPAKSEQ QRVKRGTSPR PPEGGLGYSQ 
       760        770        780 
LGDDDLKETG FHLTTTNQGA SAAGPGFSLK F

Show »

Length:781

Mass (Da):91,190

Checksum:ⁱ81EC428CB483E973

GO

Isoform 3 (identifier: P21127-4) [UniParc]FASTA Add to basket

Also known as: Alpha 1

The sequence of this isoform differs from the canonical sequence as follows:
2-335: Missing.

« Hide

        10         20         30         40         50
METGSNSEEA SEQSAEEVSE EEMSEDEERE NENHLLVVPE SRFDRDSGES 
        60         70         80         90        100
EEAEEEVGEG TPQSSALTEG DYVPDSPALS PIELKQELPK YLPALQGCRS 
       110        120        130        140        150
VEEFQCLNRI EEGTYGVVYR AKDKKTDEIV ALKRLKMEKE KEGFPITSLR 
       160        170        180        190        200
EINTILKAQH PNIVTVREIV VGSNMDKIYI VMNYVEHDLK SLMETMKQPF 
       210        220        230        240        250
LPGEVKTLMI QLLRGVKHLH DNWILHRDLK TSNLLLSHAG ILKVGDFGLA 
       260        270        280        290        300
REYGSPLKAY TPVVVTLWYR APELLLGAKE YSTAVDMWSV GCIFGELLTQ 
       310        320        330        340        350
KPLFPGKSEI DQINKVFKDL GTPSEKIWPG YSELPAVKKM TFSEHPYNNL 
       360        370        380        390        400
RKRFGALLSD QGFDLMNKFL TYFPGRRISA EDGLKHEYFR ETPLPIDPSM 
       410        420        430        440        450
FPTWPAKSEQ QRVKRGTSPR PPEGGLGYSQ LGDDDLKETG FHLTTTNQGA 
       460 
SAAGPGFSLK F

Show »

Length:461

Mass (Da):51,925

Checksum:ⁱ6D054208C50D621C

GO

Isoform SV4 (identifier: P21127-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-269: Missing.

« Hide

        10         20         30         40         50
MEERDLLSDL QDISDSERKT SSAESSSAES GSGSEEEEEE EEEEEEEGST 
        60         70         80         90        100
SEESEEEEEE EEEEEEETGS NSEEASEQSA EEVSEEEMSE DEERENENHL 
       110        120        130        140        150
LVVPESRFDR DSGESEEAEE EVGEGTPQSS ALTEGDYVPD SPALSPIELK 
       160        170        180        190        200
QELPKYLPAL QGCRSVEEFQ CLNRIEEGTY GVVYRAKDKK TDEIVALKRL 
       210        220        230        240        250
KMEKEKEGFP ITSLREINTI LKAQHPNIVT VREIVVGSNM DKIYIVMNYV 
       260        270        280        290        300
EHDLKSLMET MKQPFLPGEV KTLMIQLLRG VKHLHDNWIL HRDLKTSNLL 
       310        320        330        340        350
LSHAGILKVG DFGLAREYGS PLKAYTPVVV TLWYRAPELL LGAKEYSTAV 
       360        370        380        390        400
DMWSVGCIFG ELLTQKPLFP GKSEIDQINK VFKDLGTPSE KIWPGYSELP 
       410        420        430        440        450
AVKKMTFSEH PYNNLRKRFG ALLSDQGFDL MNKFLTYFPG RRISAEDGLK 
       460        470        480        490        500
HEYFRETPLP IDPSMFPTWP AKSEQQRVKR GTSPRPPEGG LGYSQLGDDD 
       510        520 
LKETGFHLTT TNQGASAAGP GFSLKF

Show »

Length:526

Mass (Da):59,273

Checksum:ⁱ3DFF4854ED82B81B

GO

Isoform SV5 (identifier: P21127-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     110-119: Missing.
     252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MSQSDDRDSK RDSLEEGELR DHRMEITIRN SPYRREDSME DRGEEDDSLA 
        60         70         80         90        100
IKPPQQMSRK EKAHHRKDEK RKEKRKHARV KEKEREHERR KRHREEQDKA 
       110        120        130        140        150
RREWERQKRR EMAREHSRRE RDRLEQLERK RERERKMREQ QKEQREQKER 
       160        170        180        190        200
ERRAEERRKE REARREVSAH HRTMREDYSD KVKASHWSRS PPRPPRERFE 
       210        220        230        240        250
LGDGRKPVKE EKMEERDLLS DLQDISDSER KTSSAESSSA ESGSGSEEEE 
       260        270        280        290        300
EEEEEEEEEG STSEESEEEE EEEEEEEEET GSNSEEASEQ SAEEVSEEEM 
       310        320        330        340        350
SEDEERENEN HLLVVPESRF DRDSGESEEA EEEVGEGTPQ SSALTEGDYV 
       360        370        380        390        400
PDSPALSPIE LKQELPKYLP ALQGCRSVEE FQCLNRIEEG TYGVVYRAKD 
       410        420        430        440        450
KKTDEIVALK RLKMEKEKEG FPITSLREIN TILKAQHPNI VTVREIVVGS 
       460        470        480        490        500
NMDKIYIVMN YVEHDLKSLM ETMKQPFLPG EVKTLMIQLL RGVKHLHDNW 
       510        520        530        540        550
ILHRDLKTSN LLLSHAGILK VGDFGLAREY GSPLKAYTPV VVTLWYRAPE 
       560        570        580        590        600
LLLGAKEYST AVDMWSVGCI FGELLTQKPL FPGKSEIDQI NKVFKDLGTP 
       610        620        630        640        650
SEKIWPGYSE LPAVKKMTFS EHPYNNLRKR FGALLSDQGF DLMNKFLTYF 
       660        670        680        690        700
PGRRISAEDG LKHEYFRETP LPIDPSMFPT WPAKSEQQRV KRGTSPRPPE 
       710        720        730 
GGLGYSQLGD DDLKETGFHL TTTNQGASAA GPGFSLKF

Show »

Length:738

Mass (Da):86,034

Checksum:ⁱEB1469FB69DB2F20

GO

Isoform 8 (identifier: P21127-8) [UniParc]FASTA Add to basket

Also known as: Alpha 2-3

The sequence of this isoform differs from the canonical sequence as follows:
110-119: Missing.
252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR 
       110        120        130        140        150
KDEKRKEKRK HARVKEKERE HERRKRHREE QDKARREWER QKRREMAREH 
       160        170        180        190        200
SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE RRKEREARRE 
       210        220        230        240        250
VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK PVKEEKMEER 
       260        270        280        290        300
DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE EEEGSTSEES 
       310        320        330        340        350
EEEEEEEEEE EEETGSNSEE ASEQSAEEVS EEEMSEDEER ENENHLLVVP 
       360        370        380        390        400
ESRFDRDSGE SEEAEEEVGE GTPQSSALTE GDYVPDSPAL SPIELKQELP 
       410        420        430        440        450
KYLPALQGCR SVEEFQCLNR IEEGTYGVVY RAKDKKTDEI VALKRLKMEK 
       460        470        480        490        500
EKEGFPITSL REINTILKAQ HPNIVTVREI VVGSNMDKIY IVMNYVEHDL 
       510        520        530        540        550
KSLMETMKQP FLPGEVKTLM IQLLRGVKHL HDNWILHRDL KTSNLLLSHA 
       560        570        580        590        600
GILKVGDFGL AREYGSPLKA YTPVVVTLWY RAPELLLGAK EYSTAVDMWS 
       610        620        630        640        650
VGCIFGELLT QKPLFPGKSE IDQINKVFKD LGTPSEKIWP GYSELPAVKK 
       660        670        680        690        700
MTFSEHPYNN LRKRFGALLS DQGFDLMNKF LTYFPGRRIS AEDGLKHEYF 
       710        720        730        740        750
RETPLPIDPS MFPTWPAKSE QQRVKRGTSP RPPEGGLGYS QLGDDDLKET 
       760        770 
GFHLTTTNQG ASAAGPGFSL KF

Show »

Length:772

Mass (Da):90,228

Checksum:ⁱE0030AD668AD0A5C

GO

Isoform SV10 (identifier: P21127-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MSQSDDRDSK RDSLEEGELR DHRMEITIRN SPYRREDSME DRGEEDDSLA 
        60         70         80         90        100
IKPPQQMSRK EKAHHRKDEK RKEKRRHRSH SAEGGKHARV KEKEREHERR 
       110        120        130        140        150
KRHREEQDKA RREWERQKRR EMAREHSRRE RDRLEQLERK RERERKMREQ 
       160        170        180        190        200
QKEQREQKER ERRAEERRKE REARREVSAH HRTMREDYSD KVKASHWSRS 
       210        220        230        240        250
PPRPPRERFE LGDGRKPVKE EKMEERDLLS DLQDISDSER KTSSAESSSA 
       260        270        280        290        300
ESGSGSEEEE EEEEEEEEEG STSEESEEEE EEEEEEEEET GSNSEEASEQ 
       310        320        330        340        350
SAEEVSEEEM SEDEERENEN HLLVVPESRF DRDSGESEEA EEEVGEGTPQ 
       360        370        380        390        400
SSALTEGDYV PDSPALSPIE LKQELPKYLP ALQGCRSVEE FQCLNRIEEG 
       410        420        430        440        450
TYGVVYRAKD KKTDEIVALK RLKMEKEKEG FPITSLREIN TILKAQHPNI 
       460        470        480        490        500
VTVREIVVGS NMDKIYIVMN YVEHDLKSLM ETMKQPFLPG EVKTLMIQLL 
       510        520        530        540        550
RGVKHLHDNW ILHRDLKTSN LLLSHAGILK VGDFGLAREY GSPLKAYTPV 
       560        570        580        590        600
VVTLWYRAPE LLLGAKEYST AVDMWSVGCI FGELLTQKPL FPGKSEIDQI 
       610        620        630        640        650
NKVFKDLGTP SEKIWPGYSE LPAVKKMTFS EHPYNNLRKR FGALLSDQGF 
       660        670        680        690        700
DLMNKFLTYF PGRRISAEDG LKHEYFRETP LPIDPSMFPT WPAKSEQQRV 
       710        720        730        740 
KRGTSPRPPE GGLGYSQLGD DDLKETGFHL TTTNQGASAA GPGFSLKF

Show »

Length:748

Mass (Da):87,110

Checksum:ⁱB27B64E086717A01

GO

Isoform SV11 (identifier: P21127-10) [UniParc]FASTA Add to basket

Also known as: Alpha 2-4

The sequence of this isoform differs from the canonical sequence as follows:
1-217: Missing.
252-265: GEARPAPAQKPAQL → V

« Hide

        10         20         30         40         50
MREDYSDKVK ASHWSRSPPR PPRERFELGD GRKPVKEEKM EERDLLSDLQ 
        60         70         80         90        100
DISDSERKTS SAESSSAESG SGSEEEEEEE EEEEEEGSTS EESEEEEEEE 
       110        120        130        140        150
EEEEEETGSN SEEASEQSAE EVSEEEMSED EERENENHLL VVPESRFDRD 
       160        170        180        190        200
SGESEEAEEE VGEGTPQSSA LTEGDYVPDS PALSPIELKQ ELPKYLPALQ 
       210        220        230        240        250
GCRSVEEFQC LNRIEEGTYG VVYRAKDKKT DEIVALKRLK MEKEKEGFPI 
       260        270        280        290        300
TSLREINTIL KAQHPNIVTV REIVVGSNMD KIYIVMNYVE HDLKSLMETM 
       310        320        330        340        350
KQPFLPGEVK TLMIQLLRGV KHLHDNWILH RDLKTSNLLL SHAGILKVGD 
       360        370        380        390        400
FGLAREYGSP LKAYTPVVVT LWYRAPELLL GAKEYSTAVD MWSVGCIFGE 
       410        420        430        440        450
LLTQKPLFPG KSEIDQINKV FKDLGTPSEK IWPGYSELPA VKKMTFSEHP 
       460        470        480        490        500
YNNLRKRFGA LLSDQGFDLM NKFLTYFPGR RISAEDGLKH EYFRETPLPI 
       510        520        530        540        550
DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL KETGFHLTTT 
       560 
NQGASAAGPG FSLKF

Show »

Length:565

Mass (Da):63,937

Checksum:ⁱ6E088C8322ADB36A

GO

Isoform 7 (identifier: P21127-12) [UniParc]FASTA Add to basket

Also known as: CDK11-p58

The sequence of this isoform differs from the canonical sequence as follows:
1-356: Missing.

« Hide

        10         20         30         40         50
MSEDEERENE NHLLVVPESR FDRDSGESEE AEEEVGEGTP QSSALTEGDY 
        60         70         80         90        100
VPDSPALSPI ELKQELPKYL PALQGCRSVE EFQCLNRIEE GTYGVVYRAK 
       110        120        130        140        150
DKKTDEIVAL KRLKMEKEKE GFPITSLREI NTILKAQHPN IVTVREIVVG 
       160        170        180        190        200
SNMDKIYIVM NYVEHDLKSL METMKQPFLP GEVKTLMIQL LRGVKHLHDN 
       210        220        230        240        250
WILHRDLKTS NLLLSHAGIL KVGDFGLARE YGSPLKAYTP VVVTLWYRAP 
       260        270        280        290        300
ELLLGAKEYS TAVDMWSVGC IFGELLTQKP LFPGKSEIDQ INKVFKDLGT 
       310        320        330        340        350
PSEKIWPGYS ELPAVKKMTF SEHPYNNLRK RFGALLSDQG FDLMNKFLTY 
       360        370        380        390        400
FPGRRISAED GLKHEYFRET PLPIDPSMFP TWPAKSEQQR VKRGTSPRPP 
       410        420        430 
EGGLGYSQLG DDDLKETGFH LTTTNQGASA AGPGFSLKF

Note: Produced by alternative initiation at Met-357 of isoform SV9 via an internal ribosomal entry site (IRES).Curated

Show »

Length:439

Mass (Da):49,555

Checksum:ⁱ2008B90F6CE66EF6

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0D9SEN2	A0A0D9SEN2_HUMAN	Cyclin-dependent kinase 11B Cyclin-dependent kinase 11B	CDK11B	785	Annotation score:
A0A0D9SEI3	A0A0D9SEI3_HUMAN	Cyclin-dependent kinase 11B Cyclin-dependent kinase 11B	CDK11B	772	Annotation score:
A0A0D9SER5	A0A0D9SER5_HUMAN	Cyclin-dependent kinase 11B Cyclin-dependent kinase 11B	CDK11B	783	Annotation score:
A0A087X1I0	A0A087X1I0_HUMAN	Cyclin-dependent kinase 11B Cyclin-dependent kinase 11B	CDK11B	244	Annotation score:
A0A087WYI9	A0A087WYI9_HUMAN	Cyclin-dependent kinase 11B Cyclin-dependent kinase 11B	CDK11B	203	Annotation score:

Sequence cautionⁱ

The sequence AAB59449 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAC83664 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAF36538 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	97	A → V in AAA19582 (PubMed:8195233).	1
Sequence conflictⁱ	97	A → V in AAA19583 (PubMed:8195233).	1
Sequence conflictⁱ	97	A → V in AAA19586 (PubMed:8195233).	1
Sequence conflictⁱ	97	A → V in AAC72077 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC72079 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC72080 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC72081 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC83662 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC83664 (PubMed:9750192).	1
Sequence conflictⁱ	97	A → V in AAC83665 (PubMed:9750192).	1
Sequence conflictⁱ	109	Missing in AAA19582 (PubMed:8195233).Curated	1
Sequence conflictⁱ	109	Missing in AAA19583 (PubMed:8195233).Curated	1
Sequence conflictⁱ	109	Missing in AAC72079 (PubMed:9750192).Curated	1
Sequence conflictⁱ	126	E → K in AAA19582 (PubMed:8195233).Curated	1
Sequence conflictⁱ	126	E → K in AAA19583 (PubMed:8195233).Curated	1
Sequence conflictⁱ	126	E → K in AAA19586 (PubMed:8195233).Curated	1
Sequence conflictⁱ	258	P → R in AAC72080 (PubMed:9750192).	1
Sequence conflictⁱ	320	S → T in AAF36538 (Ref. 6) Curated	1
Sequence conflictⁱ	324 – 326	Missing in AAA19582 (PubMed:8195233).Curated	3
Sequence conflictⁱ	324 – 326	Missing in AAA19583 (PubMed:8195233).Curated	3
Sequence conflictⁱ	324 – 326	Missing in AAA19584 (PubMed:8195233).Curated	3
Sequence conflictⁱ	324 – 326	Missing in AAA19586 (PubMed:8195233).Curated	3
Sequence conflictⁱ	324 – 326	Missing in AAF36538 (Ref. 6) Curated	3
Sequence conflictⁱ	411 – 412	PA → LP in AAB59449 (PubMed:1639388).Curated	2
Sequence conflictⁱ	436	E → D in AAB59449 (PubMed:1639388).Curated	1
Sequence conflictⁱ	560	H → Q in AAF36538 (Ref. 6) Curated	1
Sequence conflictⁱ	567	N → T in AAF36538 (Ref. 6) Curated	1
Sequence conflictⁱ	678	E → R in AAA19582 (PubMed:8195233).Curated	1
Sequence conflictⁱ	678	E → R in AAA19581 (PubMed:8195233).Curated	1
Sequence conflictⁱ	678	E → R in AAA19583 (PubMed:8195233).Curated	1
Sequence conflictⁱ	678	E → R in AAA19584 (PubMed:8195233).Curated	1
Sequence conflictⁱ	678	E → R in AAF36538 (Ref. 6) Curated	1
Sequence conflictⁱ	694	D → E in AAB59449 (PubMed:1639388).Curated	1
Sequence conflictⁱ	697	F → C in AAF36538 (Ref. 6) Curated	1
Sequence conflictⁱ	712	I → L in AAB59449 (PubMed:1639388).Curated	1
Sequence conflictⁱ	715	E → Q in AAB59449 (PubMed:1639388).Curated	1
Sequence conflictⁱ	792	S → R in AAF36538 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041958	57	R → C2 PublicationsCorresponds to variant dbSNP:rs752740049Ensembl.	1
Natural variantⁱVAR_057775	93	R → W. Corresponds to variant dbSNP:rs1059831Ensembl.	1
Natural variantⁱVAR_062199	109	R → C. Corresponds to variant dbSNP:rs1059830Ensembl.	1
Natural variantⁱVAR_041959	201	R → W1 PublicationCorresponds to variant dbSNP:rs1557687207Ensembl.	1
Natural variantⁱVAR_041960	414	S → L1 PublicationCorresponds to variant dbSNP:rs1241694892Ensembl.	1
Natural variantⁱVAR_045577	452	V → A1 Publication	1
Natural variantⁱVAR_041961	463	I → V1 Publication	1
Natural variantⁱVAR_045578	506	G → S1 Publication	1
Natural variantⁱVAR_041962	601	L → Q2 PublicationsCorresponds to variant dbSNP:rs200190129Ensembl.	1
Natural variantⁱVAR_041963	641	K → N1 PublicationCorresponds to variant dbSNP:rs1059815Ensembl.	1
Natural variantⁱVAR_041964	670	A → V1 PublicationCorresponds to variant dbSNP:rs1059811Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018834	1 – 356	Missing in isoform 7. 1 PublicationAdd BLAST	356
Alternative sequenceⁱVSP_008275	1 – 269	Missing in isoform SV4. 1 PublicationAdd BLAST	269
Alternative sequenceⁱVSP_008274	1 – 217	Missing in isoform SV11. 3 PublicationsAdd BLAST	217
Alternative sequenceⁱVSP_008273	1 – 34	Missing in isoform SV5 and isoform SV10. 2 PublicationsAdd BLAST	34
Alternative sequenceⁱVSP_008276	2 – 335	Missing in isoform 3. 1 PublicationAdd BLAST	334
Alternative sequenceⁱVSP_008277	35 – 37	LKN → MSQ in isoform SV5 and isoform SV10. 1 Publication	3
Alternative sequenceⁱVSP_008278	110 – 119	Missing in isoform 2, isoform SV5 and isoform 8. 2 Publications	10
Alternative sequenceⁱVSP_008279	165	R → RGNDGVCLFR in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_008280	252 – 265	GEARP…KPAQL → V in isoform SV1, isoform 2, isoform SV5, isoform 8, isoform SV10 and isoform SV11. 5 PublicationsAdd BLAST	14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37712 mRNA Translation: AAA36406.1 M88563 M88562 Genomic DNA Translation: AAB59449.1 Sequence problems. U04815 mRNA Translation: AAA19581.1 U04816 mRNA Translation: AAA19582.1 U04817 mRNA Translation: AAA19583.1 U04818 mRNA Translation: AAA19584.1 U04824 mRNA Translation: AAA19586.1 AF067512 mRNA Translation: AAC72077.1 AF067513 mRNA Translation: AAC72078.1 AF067514 mRNA Translation: AAC72079.1 AF067515 mRNA Translation: AAC72080.1 AF067516 mRNA Translation: AAC72081.1 AF067517 mRNA Translation: AAC72082.1 AF080683 AF080682 Genomic DNA Translation: AAC83662.1 AF080683 AF080682 Genomic DNA Translation: AAC83663.1 AF080683 AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems. AF080683 AF080682 Genomic DNA Translation: AAC83665.1 AF080683 AF080682 Genomic DNA Translation: AAC83666.1 AF174497 mRNA Translation: AAF36538.1 Different initiation. FO704657 Genomic DNA No translation available. BC140714 mRNA Translation: AAI40715.1 BC171773 mRNA Translation: AAI71773.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS72682.1 [P21127-9] CCDS72683.1 [P21127-1] CCDS72684.1 [P21127-2]
PIRⁱ	A38282 B54024 E54024 F54024 H54024 T09568
NCBI Reference Sequences More...RefSeqⁱ	NP_001278274.1, NM_001291345.1 [P21127-8] NP_001778.2, NM_001787.2 [P21127-1] NP_277021.2, NM_033486.2 [P21127-2] NP_277022.1, NM_033487.2 [P21127-5] NP_277024.2, NM_033489.2 [P21127-9] NP_277025.1, NM_033490.2 [P21127-10] XP_016858415.1, XM_017002926.1 [P21127-3]

Genome annotation databases

Ensemblⁱ	ENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9] ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2] ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]
GeneIDⁱ	984
KEGGⁱ	hsa:984
UCSC genome browser More...UCSCⁱ	uc031tmi.2, human

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P21127-5	Protein kinase domain-containing protein		GORGO		439	UniRef100_P21127-5
Isoform 7 of Cyclin-dependent kinase 11B		HUMAN		439
CDC2L2 protein (Fragment)		HUMAN		475
+2
P21127-10	CDC2L1 protein (Fragment)		HUMAN		542	UniRef100_P21127-10
+1

Protein	Similar proteins		Species	Score	Length	Source
P21127	Cyclin-dependent kinase 11A		HUMAN		783	UniRef90_P21127
Protein kinase domain-containing protein		GORGO		439
CDC2L2 protein (Fragment)		HUMAN		475
Cyclin-dependent kinase 11A (Fragment)		HUMAN		151
Isoform 4 of Cyclin-dependent kinase 11A		HUMAN		439
+10
P21127-4	CDC2L2 protein (Fragment)		HUMAN		464	UniRef90_P21127-4
Protein kinase domain-containing protein (Fragment)		Micrurus lemniscatus lemniscatus		420
Protein kinase domain-containing protein		PODMU		414
Isoform SV7 of Cyclin-dependent kinase 11A		HUMAN		397
+3
P21127-10	CDC2L1 protein (Fragment)		HUMAN		542	UniRef90_P21127-10
+1

Protein	Similar proteins		Species	Score	Length	Source
P21127	Cyclin-dependent kinase 11A		HUMAN		783	UniRef50_P21127
Protein kinase domain-containing protein		GORGO		439
Cyclin-dependent kinase 11B		TINGU		790
cyclin-dependent kinase 11B isoform X3		CARSF		772
Cyclin-dependent kinase 11B		golden-collared manakin		801
+532
P21127-2	Cyclin-dependent kinase 11B		MOUSE		784	UniRef50_P21127-2
cyclin-dependent kinase 11B isoform X5		NEOAA		782
cyclin-dependent kinase 11B isoform X1		DELLE		782
Protein kinase domain-containing protein		COLAP		748
cyclin-dependent kinase 11B isoform X10		SAPAP		783
+317
P21127-4	Cyclin-dependent kinase 11B		RAT		436	UniRef50_P21127-4
CDC2L2 protein (Fragment)		HUMAN		464
Protein kinase domain-containing protein (Fragment)		Micrurus lemniscatus lemniscatus		420
Protein kinase domain-containing protein		PODMU		414
Cyclin-dependent kinase 11-like protein		Leptotrombidium deliense		412
+50
P21127-6	cyclin-dependent kinase 11B isoform X4		Wire-tailed manakin		768	UniRef50_P21127-6
Protein kinase domain-containing protein		BOVIN		763
Protein kinase domain-containing protein		BOBOX		763
cyclin-dependent kinase 11B-like isoform X1		LIPVE		770
Protein kinase domain-containing protein		RHIRO		767
+150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37712 mRNA Translation: AAA36406.1 M88563 M88562 Genomic DNA Translation: AAB59449.1 Sequence problems. U04815 mRNA Translation: AAA19581.1 U04816 mRNA Translation: AAA19582.1 U04817 mRNA Translation: AAA19583.1 U04818 mRNA Translation: AAA19584.1 U04824 mRNA Translation: AAA19586.1 AF067512 mRNA Translation: AAC72077.1 AF067513 mRNA Translation: AAC72078.1 AF067514 mRNA Translation: AAC72079.1 AF067515 mRNA Translation: AAC72080.1 AF067516 mRNA Translation: AAC72081.1 AF067517 mRNA Translation: AAC72082.1 AF080683 AF080682 Genomic DNA Translation: AAC83662.1 AF080683 AF080682 Genomic DNA Translation: AAC83663.1 AF080683 AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems. AF080683 AF080682 Genomic DNA Translation: AAC83665.1 AF080683 AF080682 Genomic DNA Translation: AAC83666.1 AF174497 mRNA Translation: AAF36538.1 Different initiation. FO704657 Genomic DNA No translation available. BC140714 mRNA Translation: AAI40715.1 BC171773 mRNA Translation: AAI71773.1
CCDSⁱ	CCDS72682.1 [P21127-9] CCDS72683.1 [P21127-1] CCDS72684.1 [P21127-2]
PIRⁱ	A38282 B54024 E54024 F54024 H54024 T09568
RefSeqⁱ	NP_001278274.1, NM_001291345.1 [P21127-8] NP_001778.2, NM_001787.2 [P21127-1] NP_277021.2, NM_033486.2 [P21127-2] NP_277022.1, NM_033487.2 [P21127-5] NP_277024.2, NM_033489.2 [P21127-9] NP_277025.1, NM_033490.2 [P21127-10] XP_016858415.1, XM_017002926.1 [P21127-3]

3D structure databases

SMRⁱ	P21127
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	107421, 65 interactors
ComplexPortalⁱ	CPX-345, Cyclin L2-CDK11B(p58) complex [P21127-12] CPX-346, Cyclin L1-CDK11B(p58) complex [P21127-12] CPX-348, Cyclin L1-CDK11B(p110) complex [P21127-1] CPX-349, Cyclin L2-CDK11B(p110) complex [P21127-1]
CORUMⁱ	P21127
IntActⁱ	P21127, 29 interactors
MINTⁱ	P21127
STRINGⁱ	9606.ENSP00000464036

Chemistry databases

BindingDBⁱ	P21127
ChEMBLⁱ	CHEMBL5808
DrugCentralⁱ	P21127

PTM databases

iPTMnetⁱ	P21127
PhosphoSitePlusⁱ	P21127

Genetic variation databases

BioMutaⁱ	CDK11B
DMDMⁱ	34978359

Proteomic databases

EPDⁱ	P21127
jPOSTⁱ	P21127
MassIVEⁱ	P21127
PaxDbⁱ	P21127
PeptideAtlasⁱ	P21127
PRIDEⁱ	P21127
ProteomicsDBⁱ	53836 [P21127-1] 53837 [P21127-10] 53838 [P21127-12] 53839 [P21127-2] 53840 [P21127-3] 53841 [P21127-4] 53842 [P21127-5] 53843 [P21127-6] 53844 [P21127-8] 53845 [P21127-9]

Protocols and materials databases

Antibodypediaⁱ	62301, 111 antibodies
The DNASU plasmid repository More...DNASUⁱ	984

Genome annotation databases

Ensemblⁱ	ENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9] ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2] ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]
GeneIDⁱ	984
KEGGⁱ	hsa:984
UCSCⁱ	uc031tmi.2, human

Organism-specific databases

CTDⁱ	984
DisGeNETⁱ	984
GeneCardsⁱ	CDK11B
HGNCⁱ	HGNC:1729, CDK11B
MIMⁱ	176873, gene
neXtProtⁱ	NX_P21127
OpenTargetsⁱ	ENSG00000248333
PharmGKBⁱ	PA26262
VEuPathDBⁱ	HostDB:ENSG00000248333.8
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0663, Eukaryota
GeneTreeⁱ	ENSGT00940000158459
InParanoidⁱ	P21127
OMAⁱ	HMRKCSI
OrthoDBⁱ	925637at2759
PhylomeDBⁱ	P21127
TreeFamⁱ	TF101035

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22, 2681
PathwayCommonsⁱ	P21127
Reactomeⁱ	R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
SignaLinkⁱ	P21127
SIGNORⁱ	P21127

Miscellaneous databases

BioGRID-ORCSⁱ	984, 37 hits in 183 CRISPR screens
ChiTaRSⁱ	CDK11B, human
GeneWikiⁱ	CDC2L1
GenomeRNAiⁱ	984
Pharosⁱ	P21127, Tchem
Protein Ontology More...PROⁱ	PR:P21127
RNActⁱ	P21127, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000248333, Expressed in sural nerve and 113 other tissues
ExpressionAtlasⁱ	P21127, baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD11B_HUMAN
Accessionⁱ	P21127Primary (citable) accession number: P21127 Secondary accession number(s): B7ZVY7 Q9UP59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	March 28, 2018
	Last modified:	April 7, 2021
	This is version 223 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P21127 (CD11B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cyclin-dependent kinase 11B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoplasm and Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P21127

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ