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Protein

Cyclin-dependent kinase 11B

Gene

CDK11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.4 Publications

Miscellaneous

Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.

Caution

Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Activity regulationi

Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei467ATPPROSITE-ProRule annotation1
Active sitei562Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi444 – 452ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
SignaLinkiP21127
SIGNORiP21127

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11B (EC:2.7.11.22)
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Short name:
CLK-1
Cell division protein kinase 11B
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
p58 CLK-1
Gene namesi
Name:CDK11B
Synonyms:CDC2L1, CDK11, PITSLREA, PK58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000248333.8
HGNCiHGNC:1729 CDK11B
MIMi176873 gene
neXtProtiNX_P21127

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi984
OpenTargetsiENSG00000248333
PharmGKBiPA26262

Chemistry databases

ChEMBLiCHEMBL5808

Polymorphism and mutation databases

BioMutaiCDK11B
DMDMi34978359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000243111 – 795Cyclin-dependent kinase 11BAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei115Phosphoserine1 Publication1
Modified residuei283PhosphoserineBy similarity1
Modified residuei482Phosphoserine; by CDK71 Publication1
Modified residuei488Phosphothreonine; by CDK71 Publication1
Modified residuei589PhosphoserineCombined sources1
Modified residuei594PhosphotyrosineCombined sources1
Modified residuei595PhosphothreonineCombined sources1
Cross-linki641Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei751PhosphothreonineBy similarity1
Modified residuei752PhosphoserineBy similarity1

Post-translational modificationi

During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP21127
MaxQBiP21127
PaxDbiP21127
PeptideAtlasiP21127
PRIDEiP21127
ProteomicsDBi53836
53837 [P21127-10]
53838 [P21127-12]
53839 [P21127-2]
53840 [P21127-3]
53841 [P21127-4]
53842 [P21127-5]
53843 [P21127-6]
53844 [P21127-8]
53845 [P21127-9]

PTM databases

iPTMnetiP21127
PhosphoSitePlusiP21127

Miscellaneous databases

PMAP-CutDBiP21127

Expressioni

Tissue specificityi

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.2 Publications

Inductioni

Isoform 7 is induced in G2/M phase of the cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000248333 Expressed in 91 organ(s), highest expression level in testis

Organism-specific databases

HPAiHPA025061
HPA073626

Interactioni

Subunit structurei

Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A (PubMed:25965346).5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi107421, 48 interactors
ComplexPortaliCPX-345 Cyclin L2-CDK11B(p58) complex [P21127-12]
CPX-346 Cyclin L1-CDK11B(p58) complex [P21127-12]
CPX-348 Cyclin L1-CDK11B(p110) complex [P21127-12]
CPX-349 Cyclin L2-CDK11B(p110) complex [P21127-12]
CORUMiP21127
IntActiP21127, 19 interactors
MINTiP21127
STRINGi9606.ENSP00000384442

Chemistry databases

BindingDBiP21127

Structurei

3D structure databases

ProteinModelPortaliP21127
SMRiP21127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 723Protein kinasePROSITE-ProRule annotationAdd BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 393Glu-richAdd BLAST268

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0663 Eukaryota
ENOG410XQ50 LUCA
GeneTreeiENSGT00910000144030
HOVERGENiHBG014652
InParanoidiP21127
KOiK08818
OMAiHMRKCSI
OrthoDBiEOG091G048P
PhylomeDBiP21127
TreeFamiTF101035

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (10+)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform SV9 (identifier: P21127-1) [UniParc]FASTAAdd to basket
Also known as: CDK11-p110

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR
110 120 130 140 150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER
160 170 180 190 200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE
210 220 230 240 250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK
260 270 280 290 300
PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
310 320 330 340 350
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE
360 370 380 390 400
EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA
410 420 430 440 450
LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG
460 470 480 490 500
VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV
510 520 530 540 550
REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV
560 570 580 590 600
KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
610 620 630 640 650
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV
660 670 680 690 700
FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM
710 720 730 740 750
NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG
760 770 780 790
TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF
Length:795
Mass (Da):92,620
Last modified:March 28, 2018 - v4
Checksum:i8CCB0E688E66DF47
GO
Isoform SV1 (identifier: P21127-2) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-1

The sequence of this isoform differs from the canonical sequence as follows:
     252-265: GEARPAPAQKPAQL → V

Show »
Length:782
Mass (Da):91,303
Checksum:i70E8E7AFCE9D8BF5
GO
Isoform 2 (identifier: P21127-3) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-2

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     165-165: R → RGNDGVCLFR
     252-265: GEARPAPAQKPAQL → V

Show »
Length:781
Mass (Da):91,190
Checksum:i81EC428CB483E973
GO
Isoform 3 (identifier: P21127-4) [UniParc]FASTAAdd to basket
Also known as: Alpha 1

The sequence of this isoform differs from the canonical sequence as follows:
     2-335: Missing.

Show »
Length:461
Mass (Da):51,925
Checksum:i6D054208C50D621C
GO
Isoform SV4 (identifier: P21127-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.

Show »
Length:526
Mass (Da):59,273
Checksum:i3DFF4854ED82B81B
GO
Isoform SV5 (identifier: P21127-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     110-119: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:738
Mass (Da):86,034
Checksum:iEB1469FB69DB2F20
GO
Isoform 8 (identifier: P21127-8) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-3

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:772
Mass (Da):90,228
Checksum:iE0030AD668AD0A5C
GO
Isoform SV10 (identifier: P21127-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     252-265: GEARPAPAQKPAQL → V

Show »
Length:748
Mass (Da):87,110
Checksum:iB27B64E086717A01
GO
Isoform SV11 (identifier: P21127-10) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     252-265: GEARPAPAQKPAQL → V

Show »
Length:565
Mass (Da):63,937
Checksum:i6E088C8322ADB36A
GO
Isoform 7 (identifier: P21127-12) [UniParc]FASTAAdd to basket
Also known as: CDK11-p58

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Note: Produced by alternative initiation at Met-357 of isoform SV9 via an internal ribosomal entry site (IRES).
Show »
Length:439
Mass (Da):49,555
Checksum:i2008B90F6CE66EF6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEN2A0A0D9SEN2_HUMAN
Cyclin-dependent kinase 11B
CDK11B
785Annotation score:
A0A0D9SEI3A0A0D9SEI3_HUMAN
Cyclin-dependent kinase 11B
CDK11B
772Annotation score:
A0A0D9SER5A0A0D9SER5_HUMAN
Cyclin-dependent kinase 11B
CDK11B
783Annotation score:
A0A087X1I0A0A087X1I0_HUMAN
Cyclin-dependent kinase 11B
CDK11B
244Annotation score:
A0A087WYI9A0A087WYI9_HUMAN
Cyclin-dependent kinase 11B
CDK11B
203Annotation score:

Sequence cautioni

The sequence AAB59449 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC83664 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF36538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97A → V in AAA19582 (PubMed:8195233).1
Sequence conflicti97A → V in AAA19583 (PubMed:8195233).1
Sequence conflicti97A → V in AAA19586 (PubMed:8195233).1
Sequence conflicti97A → V in AAC72077 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72079 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72080 (PubMed:9750192).1
Sequence conflicti97A → V in AAC72081 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83662 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83664 (PubMed:9750192).1
Sequence conflicti97A → V in AAC83665 (PubMed:9750192).1
Sequence conflicti109Missing in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAC72079 (PubMed:9750192).Curated1
Sequence conflicti126E → K in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19586 (PubMed:8195233).Curated1
Sequence conflicti258P → R in AAC72080 (PubMed:9750192).1
Sequence conflicti320S → T in AAF36538 (Ref. 6) Curated1
Sequence conflicti324 – 326Missing in AAA19582 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19583 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19584 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19586 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAF36538 (Ref. 6) Curated3
Sequence conflicti411 – 412PA → LP in AAB59449 (PubMed:1639388).Curated2
Sequence conflicti436E → D in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti560H → Q in AAF36538 (Ref. 6) Curated1
Sequence conflicti567N → T in AAF36538 (Ref. 6) Curated1
Sequence conflicti678E → R in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19581 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAA19584 (PubMed:8195233).Curated1
Sequence conflicti678E → R in AAF36538 (Ref. 6) Curated1
Sequence conflicti694D → E in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti697F → C in AAF36538 (Ref. 6) Curated1
Sequence conflicti712I → L in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti715E → Q in AAB59449 (PubMed:1639388).Curated1
Sequence conflicti792S → R in AAF36538 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04195857R → C2 PublicationsCorresponds to variant dbSNP:rs752740049Ensembl.1
Natural variantiVAR_05777593R → W. Corresponds to variant dbSNP:rs1059831Ensembl.1
Natural variantiVAR_062199109R → C. Corresponds to variant dbSNP:rs1059830Ensembl.1
Natural variantiVAR_041959201R → W1 Publication1
Natural variantiVAR_041960414S → L1 PublicationCorresponds to variant dbSNP:rs1241694892Ensembl.1
Natural variantiVAR_045577452V → A1 Publication1
Natural variantiVAR_041961463I → V1 Publication1
Natural variantiVAR_045578506G → S1 Publication1
Natural variantiVAR_041962601L → Q2 PublicationsCorresponds to variant dbSNP:rs200190129Ensembl.1
Natural variantiVAR_041963641K → N1 PublicationCorresponds to variant dbSNP:rs1059815Ensembl.1
Natural variantiVAR_041964670A → V1 PublicationCorresponds to variant dbSNP:rs1059811Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188341 – 356Missing in isoform 7. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_0082751 – 269Missing in isoform SV4. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_0082741 – 217Missing in isoform SV11. 3 PublicationsAdd BLAST217
Alternative sequenceiVSP_0082731 – 34Missing in isoform SV5 and isoform SV10. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_0082762 – 335Missing in isoform 3. 1 PublicationAdd BLAST334
Alternative sequenceiVSP_00827735 – 37LKN → MSQ in isoform SV5 and isoform SV10. 1 Publication3
Alternative sequenceiVSP_008278110 – 119Missing in isoform 2, isoform SV5 and isoform 8. 2 Publications10
Alternative sequenceiVSP_008279165R → RGNDGVCLFR in isoform 2. 1 Publication1
Alternative sequenceiVSP_008280252 – 265GEARP…KPAQL → V in isoform SV1, isoform 2, isoform SV5, isoform 8, isoform SV10 and isoform SV11. 5 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37712 mRNA Translation: AAA36406.1
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA Translation: AAB59449.1 Sequence problems.
U04815 mRNA Translation: AAA19581.1
U04816 mRNA Translation: AAA19582.1
U04817 mRNA Translation: AAA19583.1
U04818 mRNA Translation: AAA19584.1
U04824 mRNA Translation: AAA19586.1
AF067512 mRNA Translation: AAC72077.1
AF067513 mRNA Translation: AAC72078.1
AF067514 mRNA Translation: AAC72079.1
AF067515 mRNA Translation: AAC72080.1
AF067516 mRNA Translation: AAC72081.1
AF067517 mRNA Translation: AAC72082.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83662.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83663.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83665.1
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83666.1
AF174497 mRNA Translation: AAF36538.1 Different initiation.
FO704657 Genomic DNA No translation available.
BC140714 mRNA Translation: AAI40715.1
BC171773 mRNA Translation: AAI71773.1
CCDSiCCDS72682.1 [P21127-9]
CCDS72683.1 [P21127-1]
CCDS72684.1 [P21127-2]
PIRiA38282
B54024
E54024
F54024
H54024
T09568
RefSeqiNP_001278274.1, NM_001291345.1 [P21127-8]
NP_001778.2, NM_001787.2 [P21127-1]
NP_277021.2, NM_033486.2 [P21127-2]
NP_277022.1, NM_033487.2 [P21127-5]
NP_277024.2, NM_033489.2 [P21127-9]
NP_277025.1, NM_033490.2 [P21127-10]
XP_016858415.1, XM_017002926.1 [P21127-3]
UniGeneiHs.651228
Hs.709182

Genome annotation databases

EnsembliENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9]
ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2]
ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]
GeneIDi984
KEGGihsa:984
UCSCiuc031tmi.2 human

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37712 mRNA Translation: AAA36406.1
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA Translation: AAB59449.1 Sequence problems.
U04815 mRNA Translation: AAA19581.1
U04816 mRNA Translation: AAA19582.1
U04817 mRNA Translation: AAA19583.1
U04818 mRNA Translation: AAA19584.1
U04824 mRNA Translation: AAA19586.1
AF067512 mRNA Translation: AAC72077.1
AF067513 mRNA Translation: AAC72078.1
AF067514 mRNA Translation: AAC72079.1
AF067515 mRNA Translation: AAC72080.1
AF067516 mRNA Translation: AAC72081.1
AF067517 mRNA Translation: AAC72082.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83662.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83663.1
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83664.1 Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83665.1
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA Translation: AAC83666.1
AF174497 mRNA Translation: AAF36538.1 Different initiation.
FO704657 Genomic DNA No translation available.
BC140714 mRNA Translation: AAI40715.1
BC171773 mRNA Translation: AAI71773.1
CCDSiCCDS72682.1 [P21127-9]
CCDS72683.1 [P21127-1]
CCDS72684.1 [P21127-2]
PIRiA38282
B54024
E54024
F54024
H54024
T09568
RefSeqiNP_001278274.1, NM_001291345.1 [P21127-8]
NP_001778.2, NM_001787.2 [P21127-1]
NP_277021.2, NM_033486.2 [P21127-2]
NP_277022.1, NM_033487.2 [P21127-5]
NP_277024.2, NM_033489.2 [P21127-9]
NP_277025.1, NM_033490.2 [P21127-10]
XP_016858415.1, XM_017002926.1 [P21127-3]
UniGeneiHs.651228
Hs.709182

3D structure databases

ProteinModelPortaliP21127
SMRiP21127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107421, 48 interactors
ComplexPortaliCPX-345 Cyclin L2-CDK11B(p58) complex [P21127-12]
CPX-346 Cyclin L1-CDK11B(p58) complex [P21127-12]
CPX-348 Cyclin L1-CDK11B(p110) complex [P21127-12]
CPX-349 Cyclin L2-CDK11B(p110) complex [P21127-12]
CORUMiP21127
IntActiP21127, 19 interactors
MINTiP21127
STRINGi9606.ENSP00000384442

Chemistry databases

BindingDBiP21127
ChEMBLiCHEMBL5808

PTM databases

iPTMnetiP21127
PhosphoSitePlusiP21127

Polymorphism and mutation databases

BioMutaiCDK11B
DMDMi34978359

Proteomic databases

EPDiP21127
MaxQBiP21127
PaxDbiP21127
PeptideAtlasiP21127
PRIDEiP21127
ProteomicsDBi53836
53837 [P21127-10]
53838 [P21127-12]
53839 [P21127-2]
53840 [P21127-3]
53841 [P21127-4]
53842 [P21127-5]
53843 [P21127-6]
53844 [P21127-8]
53845 [P21127-9]

Protocols and materials databases

DNASUi984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9]
ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2]
ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1]
GeneIDi984
KEGGihsa:984
UCSCiuc031tmi.2 human

Organism-specific databases

CTDi984
DisGeNETi984
EuPathDBiHostDB:ENSG00000248333.8
GeneCardsiCDK11B
HGNCiHGNC:1729 CDK11B
HPAiHPA025061
HPA073626
MIMi176873 gene
neXtProtiNX_P21127
OpenTargetsiENSG00000248333
PharmGKBiPA26262
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0663 Eukaryota
ENOG410XQ50 LUCA
GeneTreeiENSGT00910000144030
HOVERGENiHBG014652
InParanoidiP21127
KOiK08818
OMAiHMRKCSI
OrthoDBiEOG091G048P
PhylomeDBiP21127
TreeFamiTF101035

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
SignaLinkiP21127
SIGNORiP21127

Miscellaneous databases

ChiTaRSiCDK11B human
GeneWikiiCDC2L1
GenomeRNAii984
PMAP-CutDBiP21127
PROiPR:P21127
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000248333 Expressed in 91 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD11B_HUMAN
AccessioniPrimary (citable) accession number: P21127
Secondary accession number(s): B7ZVY7
, J3KTL7, J3QR29, J3QR44, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 203 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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