UniProtKB - P21127 (CD11B_HUMAN)
Cyclin-dependent kinase 11B
CDK11B
Functioni
Miscellaneous
Caution
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 467 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 562 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 444 – 452 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein kinase activity Source: ProtInc
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- protein threonine kinase activity Source: RHEA
- RNA binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of mitotic cell cycle Source: GO_Central
- regulation of mRNA processing Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P21127 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes |
SignaLinki | P21127 |
SIGNORi | P21127 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 11B (EC:2.7.11.22)Alternative name(s): Cell division cycle 2-like protein kinase 1 Short name: CLK-1 Cell division protein kinase 11B Galactosyltransferase-associated protein kinase p58/GTA PITSLRE serine/threonine-protein kinase CDC2L1 p58 CLK-1 |
Gene namesi | Name:CDK11B Synonyms:CDC2L1, CDK11, PITSLREA, PK58 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1729, CDK11B |
MIMi | 176873, gene |
neXtProti | NX_P21127 |
VEuPathDBi | HostDB:ENSG00000248333.8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 984 |
OpenTargetsi | ENSG00000248333 |
PharmGKBi | PA26262 |
Miscellaneous databases
Pharosi | P21127, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5808 |
DrugCentrali | P21127 |
Genetic variation databases
BioMutai | CDK11B |
DMDMi | 34978359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000024311 | 1 – 795 | Cyclin-dependent kinase 11BAdd BLAST | 795 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | PhosphoserineBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 115 | Phosphoserine1 Publication | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 482 | Phosphoserine; by CDK71 Publication | 1 | |
Modified residuei | 488 | Phosphothreonine; by CDK71 Publication | 1 | |
Modified residuei | 589 | PhosphoserineCombined sources | 1 | |
Modified residuei | 594 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 595 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 641 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 751 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 752 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P21127 |
jPOSTi | P21127 |
MassIVEi | P21127 |
PaxDbi | P21127 |
PeptideAtlasi | P21127 |
PRIDEi | P21127 |
ProteomicsDBi | 53836 [P21127-1] 53837 [P21127-10] 53838 [P21127-12] 53839 [P21127-2] 53840 [P21127-3] 53841 [P21127-4] 53842 [P21127-5] 53843 [P21127-6] 53844 [P21127-8] 53845 [P21127-9] |
PTM databases
iPTMneti | P21127 |
PhosphoSitePlusi | P21127 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000248333, Expressed in sural nerve and 113 other tissues |
ExpressionAtlasi | P21127, baseline and differential |
Interactioni
Subunit structurei
Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3.
Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.
Interacts with isoform 5 of MYO18A (PubMed:25965346).
5 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 107421, 65 interactors |
ComplexPortali | CPX-345, Cyclin L2-CDK11B(p58) complex [P21127-12] CPX-346, Cyclin L1-CDK11B(p58) complex [P21127-12] CPX-348, Cyclin L1-CDK11B(p110) complex [P21127-1] CPX-349, Cyclin L2-CDK11B(p110) complex [P21127-1] |
CORUMi | P21127 |
IntActi | P21127, 29 interactors |
MINTi | P21127 |
STRINGi | 9606.ENSP00000464036 |
Chemistry databases
BindingDBi | P21127 |
Miscellaneous databases
RNActi | P21127, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 438 – 723 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 286 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 126 – 393 | Glu-richAdd BLAST | 268 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0663, Eukaryota |
GeneTreei | ENSGT00940000158459 |
InParanoidi | P21127 |
OMAi | HMRKCSI |
OrthoDBi | 925637at2759 |
PhylomeDBi | P21127 |
TreeFami | TF101035 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (10+)i Sequence
Sequence statusi: Complete.
This entry describes 10 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 10 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR
110 120 130 140 150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER
160 170 180 190 200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE
210 220 230 240 250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK
260 270 280 290 300
PGEARPAPAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
310 320 330 340 350
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE
360 370 380 390 400
EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA
410 420 430 440 450
LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG
460 470 480 490 500
VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV
510 520 530 540 550
REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV
560 570 580 590 600
KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
610 620 630 640 650
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV
660 670 680 690 700
FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM
710 720 730 740 750
NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG
760 770 780 790
TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF
The sequence of this isoform differs from the canonical sequence as follows:
252-265: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
1-269: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.
35-37: LKN → MSQ
110-119: Missing.
252-265: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.
35-37: LKN → MSQ
252-265: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
1-217: Missing.
252-265: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
1-356: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0D9SEN2 | A0A0D9SEN2_HUMAN | Cyclin-dependent kinase 11B | CDK11B | 785 | Annotation score: | ||
A0A0D9SEI3 | A0A0D9SEI3_HUMAN | Cyclin-dependent kinase 11B | CDK11B | 772 | Annotation score: | ||
A0A0D9SER5 | A0A0D9SER5_HUMAN | Cyclin-dependent kinase 11B | CDK11B | 783 | Annotation score: | ||
A0A087X1I0 | A0A087X1I0_HUMAN | Cyclin-dependent kinase 11B | CDK11B | 244 | Annotation score: | ||
A0A087WYI9 | A0A087WYI9_HUMAN | Cyclin-dependent kinase 11B | CDK11B | 203 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | A → V in AAA19582 (PubMed:8195233). | 1 | |
Sequence conflicti | 97 | A → V in AAA19583 (PubMed:8195233). | 1 | |
Sequence conflicti | 97 | A → V in AAA19586 (PubMed:8195233). | 1 | |
Sequence conflicti | 97 | A → V in AAC72077 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC72079 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC72080 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC72081 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC83662 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC83664 (PubMed:9750192). | 1 | |
Sequence conflicti | 97 | A → V in AAC83665 (PubMed:9750192). | 1 | |
Sequence conflicti | 109 | Missing in AAA19582 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 109 | Missing in AAA19583 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 109 | Missing in AAC72079 (PubMed:9750192).Curated | 1 | |
Sequence conflicti | 126 | E → K in AAA19582 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 126 | E → K in AAA19583 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 126 | E → K in AAA19586 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 258 | P → R in AAC72080 (PubMed:9750192). | 1 | |
Sequence conflicti | 320 | S → T in AAF36538 (Ref. 6) Curated | 1 | |
Sequence conflicti | 324 – 326 | Missing in AAA19582 (PubMed:8195233).Curated | 3 | |
Sequence conflicti | 324 – 326 | Missing in AAA19583 (PubMed:8195233).Curated | 3 | |
Sequence conflicti | 324 – 326 | Missing in AAA19584 (PubMed:8195233).Curated | 3 | |
Sequence conflicti | 324 – 326 | Missing in AAA19586 (PubMed:8195233).Curated | 3 | |
Sequence conflicti | 324 – 326 | Missing in AAF36538 (Ref. 6) Curated | 3 | |
Sequence conflicti | 411 – 412 | PA → LP in AAB59449 (PubMed:1639388).Curated | 2 | |
Sequence conflicti | 436 | E → D in AAB59449 (PubMed:1639388).Curated | 1 | |
Sequence conflicti | 560 | H → Q in AAF36538 (Ref. 6) Curated | 1 | |
Sequence conflicti | 567 | N → T in AAF36538 (Ref. 6) Curated | 1 | |
Sequence conflicti | 678 | E → R in AAA19582 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 678 | E → R in AAA19581 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 678 | E → R in AAA19583 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 678 | E → R in AAA19584 (PubMed:8195233).Curated | 1 | |
Sequence conflicti | 678 | E → R in AAF36538 (Ref. 6) Curated | 1 | |
Sequence conflicti | 694 | D → E in AAB59449 (PubMed:1639388).Curated | 1 | |
Sequence conflicti | 697 | F → C in AAF36538 (Ref. 6) Curated | 1 | |
Sequence conflicti | 712 | I → L in AAB59449 (PubMed:1639388).Curated | 1 | |
Sequence conflicti | 715 | E → Q in AAB59449 (PubMed:1639388).Curated | 1 | |
Sequence conflicti | 792 | S → R in AAF36538 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041958 | 57 | R → C2 PublicationsCorresponds to variant dbSNP:rs752740049Ensembl. | 1 | |
Natural variantiVAR_057775 | 93 | R → W. Corresponds to variant dbSNP:rs1059831Ensembl. | 1 | |
Natural variantiVAR_062199 | 109 | R → C. Corresponds to variant dbSNP:rs1059830Ensembl. | 1 | |
Natural variantiVAR_041959 | 201 | R → W1 PublicationCorresponds to variant dbSNP:rs1557687207Ensembl. | 1 | |
Natural variantiVAR_041960 | 414 | S → L1 PublicationCorresponds to variant dbSNP:rs1241694892Ensembl. | 1 | |
Natural variantiVAR_045577 | 452 | V → A1 Publication | 1 | |
Natural variantiVAR_041961 | 463 | I → V1 Publication | 1 | |
Natural variantiVAR_045578 | 506 | G → S1 Publication | 1 | |
Natural variantiVAR_041962 | 601 | L → Q2 PublicationsCorresponds to variant dbSNP:rs200190129Ensembl. | 1 | |
Natural variantiVAR_041963 | 641 | K → N1 PublicationCorresponds to variant dbSNP:rs1059815Ensembl. | 1 | |
Natural variantiVAR_041964 | 670 | A → V1 PublicationCorresponds to variant dbSNP:rs1059811Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018834 | 1 – 356 | Missing in isoform 7. 1 PublicationAdd BLAST | 356 | |
Alternative sequenceiVSP_008275 | 1 – 269 | Missing in isoform SV4. 1 PublicationAdd BLAST | 269 | |
Alternative sequenceiVSP_008274 | 1 – 217 | Missing in isoform SV11. 3 PublicationsAdd BLAST | 217 | |
Alternative sequenceiVSP_008273 | 1 – 34 | Missing in isoform SV5 and isoform SV10. 2 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_008276 | 2 – 335 | Missing in isoform 3. 1 PublicationAdd BLAST | 334 | |
Alternative sequenceiVSP_008277 | 35 – 37 | LKN → MSQ in isoform SV5 and isoform SV10. 1 Publication | 3 | |
Alternative sequenceiVSP_008278 | 110 – 119 | Missing in isoform 2, isoform SV5 and isoform 8. 2 Publications | 10 | |
Alternative sequenceiVSP_008279 | 165 | R → RGNDGVCLFR in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_008280 | 252 – 265 | GEARP…KPAQL → V in isoform SV1, isoform 2, isoform SV5, isoform 8, isoform SV10 and isoform SV11. 5 PublicationsAdd BLAST | 14 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9] ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2] ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1] |
GeneIDi | 984 |
KEGGi | hsa:984 |
UCSCi | uc031tmi.2, human |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P21127 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107421, 65 interactors |
ComplexPortali | CPX-345, Cyclin L2-CDK11B(p58) complex [P21127-12] CPX-346, Cyclin L1-CDK11B(p58) complex [P21127-12] CPX-348, Cyclin L1-CDK11B(p110) complex [P21127-1] CPX-349, Cyclin L2-CDK11B(p110) complex [P21127-1] |
CORUMi | P21127 |
IntActi | P21127, 29 interactors |
MINTi | P21127 |
STRINGi | 9606.ENSP00000464036 |
Chemistry databases
BindingDBi | P21127 |
ChEMBLi | CHEMBL5808 |
DrugCentrali | P21127 |
PTM databases
iPTMneti | P21127 |
PhosphoSitePlusi | P21127 |
Genetic variation databases
BioMutai | CDK11B |
DMDMi | 34978359 |
Proteomic databases
EPDi | P21127 |
jPOSTi | P21127 |
MassIVEi | P21127 |
PaxDbi | P21127 |
PeptideAtlasi | P21127 |
PRIDEi | P21127 |
ProteomicsDBi | 53836 [P21127-1] 53837 [P21127-10] 53838 [P21127-12] 53839 [P21127-2] 53840 [P21127-3] 53841 [P21127-4] 53842 [P21127-5] 53843 [P21127-6] 53844 [P21127-8] 53845 [P21127-9] |
Protocols and materials databases
Antibodypediai | 62301, 111 antibodies |
DNASUi | 984 |
Genome annotation databases
Ensembli | ENST00000340677; ENSP00000464016; ENSG00000248333 [P21127-9] ENST00000341832; ENSP00000463048; ENSG00000248333 [P21127-2] ENST00000407249; ENSP00000464036; ENSG00000248333 [P21127-1] |
GeneIDi | 984 |
KEGGi | hsa:984 |
UCSCi | uc031tmi.2, human |
Organism-specific databases
CTDi | 984 |
DisGeNETi | 984 |
GeneCardsi | CDK11B |
HGNCi | HGNC:1729, CDK11B |
MIMi | 176873, gene |
neXtProti | NX_P21127 |
OpenTargetsi | ENSG00000248333 |
PharmGKBi | PA26262 |
VEuPathDBi | HostDB:ENSG00000248333.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0663, Eukaryota |
GeneTreei | ENSGT00940000158459 |
InParanoidi | P21127 |
OMAi | HMRKCSI |
OrthoDBi | 925637at2759 |
PhylomeDBi | P21127 |
TreeFami | TF101035 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P21127 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes |
SignaLinki | P21127 |
SIGNORi | P21127 |
Miscellaneous databases
BioGRID-ORCSi | 984, 37 hits in 183 CRISPR screens |
ChiTaRSi | CDK11B, human |
GeneWikii | CDC2L1 |
GenomeRNAii | 984 |
Pharosi | P21127, Tchem |
PROi | PR:P21127 |
RNActi | P21127, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000248333, Expressed in sural nerve and 113 other tissues |
ExpressionAtlasi | P21127, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD11B_HUMAN | |
Accessioni | P21127Primary (citable) accession number: P21127 Secondary accession number(s): B7ZVY7 Q9UP59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | March 28, 2018 | |
Last modified: | April 7, 2021 | |
This is version 223 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families