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Protein

Protein N1

Gene

N1L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host NF-kappa-B by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N1
Gene namesi
ORF Names:N1L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996321 – 117Protein N1Add BLAST117

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP21054
SMRiP21054
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21054

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae N1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090001EE

Family and domain databases

InterProiView protein in InterPro
IPR009353 Orthopox_N1
IPR022819 Poxvirus
PfamiView protein in Pfam
PF06227 Poxvirus, 1 hit
PIRSFiPIRSF003784 VAC_N1L, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015763 Orthopox_N1, 1 hit

Sequencei

Sequence statusi: Complete.

P21054-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL
60 70 80 90 100
SDGPLLDRLN QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR
110
MIETYFDDLM IDLYGEK
Length:117
Mass (Da):13,962
Last modified:February 1, 1991 - v1
Checksum:i9050C1FECEB1B90B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48001.1
PIRiE42504

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48001.1
PIRiE42504

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I39X-ray2.20A/B/C/D/E/F1-117[»]
2UXEX-ray2.90A/B/C/D/E/F1-117[»]
4BBBX-ray3.09A/B/C/D/E/F1-117[»]
4BBCX-ray3.10A/B/C/D/E/F1-117[»]
4BBDX-ray3.00A/B/C/D/E/F1-117[»]
ProteinModelPortaliP21054
SMRiP21054
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090001EE

Miscellaneous databases

EvolutionaryTraceiP21054

Family and domain databases

InterProiView protein in InterPro
IPR009353 Orthopox_N1
IPR022819 Poxvirus
PfamiView protein in Pfam
PF06227 Poxvirus, 1 hit
PIRSFiPIRSF003784 VAC_N1L, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015763 Orthopox_N1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiN1_VACCC
AccessioniPrimary (citable) accession number: P21054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 15, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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