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Protein

Myristoylated protein G9

Gene

G9R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation) (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Myristoylated protein G9
Gene namesi
ORF Names:G9R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 319Virion surfaceAdd BLAST318
Transmembranei320 – 340Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Complete loss of myristoylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by host
ChainiPRO_00000995412 – 340Myristoylated protein G9Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by host1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PRIDEiP21030

PTM databases

iPTMnetiP21030

Interactioni

Subunit structurei

Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex. Interacts with A16; this heterodimer further interact with A56/K2 fusion regulatory heterodimer (By similarity).By similarity

Protein-protein interaction databases

ELMiP21030

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae A16/G9/J5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000L3

Family and domain databases

InterProiView protein in InterPro
IPR004251 Pox_virus_G9/A16
PfamiView protein in Pfam
PF03003 Pox_G9-A16, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21030-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGGVSVELP KRDPPPGVPT DEMLLNVDKM HDVIAPAKLL EYVHIGPLAK
60 70 80 90 100
DKEDKVKKRY PEFRLVNTGP GGLSALLRQS YNGTAPNCCR TFNRTHYWKK
110 120 130 140 150
DGKISDKYEE GAVLESCWPD VHDTGKCDVD LFDWCQGDTF DRNICHQWIG
160 170 180 190 200
SAFNRSNRTV EGQQSLINLY NKMQTLCSKD ASVPICESFL HHLRAHNTED
210 220 230 240 250
SKEMIDYILR QQSADFKQKY MRCSYPTRDK LEESLKYAEP RECWDPECSN
260 270 280 290 300
ANVNFLLTRN YNNLGLCNIV RCNTSVNNLQ MDKTSSLRLS CGLSNSDRFS
310 320 330 340
TVPVNRAKVV QHNIKHSFDL KLHLISLLSL LVIWILIVAI
Length:340
Mass (Da):38,786
Last modified:January 23, 2007 - v3
Checksum:i025399172AB9ABC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48075.1
PIRiE42512 QQVZP1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48075.1
PIRiE42512 QQVZP1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP21030

PTM databases

iPTMnetiP21030

Proteomic databases

PRIDEiP21030

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000L3

Family and domain databases

InterProiView protein in InterPro
IPR004251 Pox_virus_G9/A16
PfamiView protein in Pfam
PF03003 Pox_G9-A16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG9_VACCC
AccessioniPrimary (citable) accession number: P21030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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